2018 research activities

Head Prof. Yosef Yarden

Picture of Prof. Yosef Yarden
Head

Prof. Yosef Yarden

Office +972-8-934-3974

Overview

The Department of Biological Regulation is comprised of approximately 170 people organized in 13 research groups. We are located in the Candiotty and Britannia buildings, which are equipped with all the cutting-edge facilities required for running excellent research endeavors. Our research is concentrated on the regulation of processes responsible for the concerted action of cells, tissues, and organs. A diversity of methodologies and experimental approaches are being used in order to tackle these pivotal issues in biology. These include biochemical, molecular and physiological methods, organ and tissue cultures, and whole animal studies utilizing mice, flies, and fish. In addition, some researchers of the Department are using methodologies and concepts of systems biology, host-pathogen interactions and a variety of imaging methods, including magnetic resonance imaging (MRI). Since de-regulation of biological control circuits often underlays human diseases (e.g., malignant transformation, heart failure, stroke, infertility, and defective tissue regeneration after injury), we make many efforts to implement the results of our studies in research projects leading to the development of new tools for early diagnosis, along with novel compounds suitable for pharmacological interventions.

 The main projects that are currently performed in the department are:
 

Host-pathogen interactions - Dr. Roi Avraham
Cell metabolism in health and disease - Dr. Ayelet Erez
Cell death and metabolism - Prof. Atan Gross
Protein degradation by the ubiquitin/proteasome system - Prof. Ami Navon
Vascularization during pregnancy and cancer development - Prof. Michal Neeman
ECM remodeling: from biophysical principles to drug design - Prof. Irit Sagi
Intracellular signaling cascades in health and disease - Prof. Rony Seger
Epigenetics in stem cells and cancer: developing and applying single-molecule imaging technologies to study the epigenetic code - Dr. Efrat Shema
Genome and epigenome regulation - Prof. Amos Tanay
Cellular functions of long noncoding RNAs - Dr. Igor Ulitsky
The development of the vascular system - Dr. Karina Yaniv
Growth factors and their receptors in cancer - Prof. Yossi Yarden

Investigating functional, metabolic and architectural features of normal and malignant tissues with magnetic resonance techniques - Prof. Hadassa Degani
The control of reproduction - Prof. Nava Dekel
Investigating ovarian follicle physiology, regulation and demise in mammals with emphasis on the ovulatory response, including the control of oocyte maturation, transformation of the follicle into corpus luteum and culminating with the release of the fertilizable ovum - Prof. Alex Tsafriri

 In October 2018, we expect to welcome Dr. Philipp Selenko and his team – Dr. Selenko is interested in cellular structural biology of human amyloid proteins.

ScientistsShow details

  • Picture of Dr. Avraham Roi

    Dr. Avraham Roi

    The lab of host-pathogen genomics is interested in how individual encounters between host and pathogenic bacteria can ultimately define the outcome of infection. This is achieved by applying cross-disciplinary single-cell analysis platforms that collectively enable us to extensively profile and precisely monitor host-pathogen interactions within the context of in vivo infections.
    The work in the lab centers on salmonella infection of mouse macrophages as a tractable in vitro host-pathogen system. We use this model to develop state of the art high throughput genomic tools and interdisciplinary approaches, and then apply them to various in vivo infection models to address critical biological aspects of host-pathogen biology.
    Using comprehensive, quantitative, unbiased tools to analyse the molecular interactions that underlie distinct host-pathogen subpopulations and their impact on disease outcome.
    Using a powerful combination of cutting-edge single cell genetic and genomic approaches, we wish to address what forms the basis for successful immune clearance, from the level of individual infected cells to that of the whole organism, and why, in some cases, sterilization is incomplete?

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  • Picture of Prof. Hadassa Degani

    Prof. Hadassa Degani

    Perfusion and angiogensis in lung cancer: The role of the bronchial and pulmonary vascular network using Fluorescence and magnetic resonance imaging methods
    Molecular magnetic resonance imaging of the estrogen receptor
    Collaboration with:  Professors David Milstein and Joel Sussman, Weizmann Institute
    Synthesis of new, high affinity ligands of the estrogen receptor as probes for molecular imaging
    Structuaral studies (x-ray crystalography and NMR) of the estrogen receptor - targeted ligands complex
    Functional activities and molecular imaging of the new targeted ligands in estrogen receptor positive huaman breast cancer cells
    Mechanisms of lymphatic metastasis in breast cancer; In vivo fluorescence and magnetic resonanc imaging
    Advanced non invasive MRI methods for breast cancer detection and diagnosis ; clinical investigations
    Collaboration with:  Dr. Myra Shapiro, Meir medical Center
    3D Tracking of the mammary tree using diffusion tensor magnetic resonance imaging
    Advanced methods for analysis of dynamic contrast enhanced MRI based on a combined model free and model based method.
    Hyperpolarized magnetic resonance spectroscopy and imaging of cancer metabolism; searching for novel metabolic markers of cancer
    Collaboration with:  Professor Lucio Frydman, Weizmann Institute
    Renal function through sodium grandients; Non-invasive, high resolution sodium MRI.
    Collaboration with:  Dr. Edna Haran, Weizmann Institute
    Estrogen regulation of angiogenesis and perfusion of breast cancer; from molecular mechanisms to functional MRI of the microvascular physiology

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  • Picture of Prof. Nava Dekel

    Prof. Nava Dekel

    Molecular characterization of the ovulatory cascade
    Mechanisms involved in successful implantation.
    Regulation of the meiotic cell cycle: use of rodent oocytes as a model system.
    Cell-to-cell communication: regulation of expression, posttranslational modification, degradation and function of the gap junction proteins, Cx43 and Cx37.

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  • Picture of Prof. Atan Gross

    Prof. Atan Gross

    How do mitochondria process stress signals and communicate them to the nucleus?
    The role of mitochondria in regulating the fate of embryonic and hematopoietic stem cells
    Establishing the role of mitochondrial carrier homolog 2 (MTCH2) in regulating the shape of mitochondria, metabolism and apoptosis
    Develop inhibitors for MTCH2 as potential therapies of diseases such as acute myeloid leukemia (AML) and obesity

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  • Picture of Prof. Rony Seger

    Prof. Rony Seger

    The nuclear translocation of signaling protein as a drug target for cancer and inflammation
    The nuclear translocation of ERK
    The nuclear translocation of JNK and p38
    Develop peptide inhibitors of the nuclear translocation of ERK/JNK/p38 for the cure of cancer and inflammation
    Development of small molecular weight inhibitors of the nuclear translocation of ERK for the cure of cancer
    The subcellular localisation of AKT
    The mechanisms and roles of MEK nuclear translocation
    ERK1c in the regulation of Golgi fragmentation
    The mechanisms of golgi translocation of ERK1c
    Substrates of ERK1c in the Golgi
    Mechanism of ERK1c-regulated Golgi architecture

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  • Picture of Prof. Alex Tsafriri

    Prof. Alex Tsafriri

    Molecular regulation of ovulatory changes in mammals.
    Collaboration with:  Helena Ashkenazi, Shmulik Motola, Xiumei Cao, Malka Popliker, Seymour Pomerantz, Marco Conti, Stanford
    The roles of gonadotropins and EGF-like factors in triggering ovulation.
    The resumption of meiosis and its regulation.
    Ovulation as a tissue remodeling process.
    The development and demise of ovarian follicles <I>in vivo</I> and <I>in vitro</I>: the role of apoptosis.
    Collaboration with:  Atan Gross, KerenYacobi

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  • Picture of Dr. Igor Ulitsky

    Dr. Igor Ulitsky

    Roles of long noncoding RNAs in gene regulation
    Functions of long noncoding RNAs in establishing cell identify
    Sequence determinants in long noncoding RNAs
    Evolution of intergenic regions in vertebrates
    Subcellular localization determinants in long RNAs

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  • Picture of Prof. Yosef Yarden

    Prof. Yosef Yarden

    Epigenetics of growth factor action on taerget cells
    Collaboration with:  Prof. Moshe Szyf (Montreal)
    Roles for growth factors in tumor progression and in metastases
    Collaboration with:  Prof. Eytan Ruppin (Maryland)
    Development of proof-of-concept therapies to treat lung cancer
    Collaboration with:  Prof. Julian Downward (London)

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