2021 research activities
Overview
The Department of Biological Regulation is comprised of approximately 170 people organized in 14 research groups. We are located in the Candiotty and Britannia buildings, which are equipped with all the cutting-edge facilities required for running excellent research endeavors. Our research is concentrated on the regulation of processes responsible for the concerted action of cells, tissues, and organs. A diversity of methodologies and experimental approaches are being used in order to tackle these pivotal issues in biology. These include biochemical, molecular and physiological methods, organ and tissue cultures, and whole animal studies utilizing mice and fish. In addition, some researchers of the Department are using methodologies and concepts of systems biology, host-pathogen interactions and a variety of imaging methods, including magnetic resonance imaging (MRI). Since de-regulation of biological control circuits often underlies human diseases (e.g., malignant transformation, stroke, infertility, and defective tissue regeneration after injury), we make many efforts to implement the results of our studies in research projects leading to the development of new tools for early diagnosis, along with novel compounds suitable for pharmacological interventions.
The main projects that are currently performed in the department are:
Host-pathogen interactions - Dr. Roi Avraham
Cell metabolism in health and disease - Dr. Ayelet Erez
Gut tissue dynamics -Dr. Moshe Biton
Mitochondria Biology- Prof. Atan Gross
Protein degradation by the ubiquitin/proteasome system - Prof. Ami Navon
Vascularization during pregnancy and cancer development - Prof. Michal Neeman
ECM remodeling: from biophysical principles to drug design - Prof. Irit Sagi
Intracellular signaling cascades in health and disease - Prof. Rony Seger
Epigenetics in stem cells and cancer: developing and applying single-molecule imaging technologies to study the epigenetic code - Dr. Efrat Shema
Epigenetics in development and disease - Prof. Amos Tanay
Cellular functions of long noncoding RNAs - Dr. Igor Ulitsky
The development of the vascular system - Dr. Karina Yaniv
Growth factors and their receptors in cancer - Prof. Yossi Yarden
Cellular structural biology of human amyloid proteins - Prof. Philipp Selenko
Investigating functional, metabolic and architectural features of normal and malignant tissues with magnetic resonance techniques - Prof. Hadassa Degani
The meiotic cell cycle, angiogenic events associated with follicle development and embryo plantation - Prof. Nava Dekel
Investigating ovarian follicle physiology, regulation and demise in mammals with emphasis on the ovulatory response, including the control of oocyte maturation, transformation of the follicle into corpus luteum and culminating with the release of the fertilizable ovum - Prof. Alex Tsafriri
ScientistsShow details
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Dr. Avraham Roi
The lab of host-pathogen genomics is interested in how individual encounters between host and pathogenic bacteria can ultimately define the outcome of infection. This is achieved by applying cross-disciplinary single-cell analysis platforms that collectively enable us to extensively profile and precisely monitor host-pathogen interactions within the context of in vivo infections.The work in the lab centers on salmonella infection of mouse macrophages as a tractable in vitro host-pathogen system. We use this model to develop state of the art high throughput genomic tools and interdisciplinary approaches, and then apply them to various in vivo infection models to address critical biological aspects of host-pathogen biology.Using comprehensive, quantitative, unbiased tools to analyse the molecular interactions that underlie distinct host-pathogen subpopulations and their impact on disease outcome.Using a powerful combination of cutting-edge single cell genetic and genomic approaches, we wish to address what forms the basis for successful immune clearance, from the level of individual infected cells to that of the whole organism, and why, in some cases, sterilization is incomplete?
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Dr. Moshe Biton
Stem cell - Immune interactionsEpithelial stem cell biology.The role of epithelial MHCII in maintaining tissue homeostasis and in tissue pathologies such as IBD and cancer.Understanding the role of epithelial cells in shaping the landscape of mucosal adaptive immunity.Exploring novel cell-cell interactions in food allergies, IBD and cancer.T helper cells' role in maintaining tissue homeostasis.
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Prof. Hadassa Degani
Perfusion and angiogensis in lung cancer: The role of the bronchial and pulmonary vascular network using Fluorescence and magnetic resonance imaging methodsMolecular magnetic resonance imaging of the estrogen receptorCollaboration with: Professors David Milstein and Joel Sussman, Weizmann InstituteSynthesis of new, high affinity ligands of the estrogen receptor as probes for molecular imagingStructuaral studies (x-ray crystalography and NMR) of the estrogen receptor - targeted ligands complexFunctional activities and molecular imaging of the new targeted ligands in estrogen receptor positive huaman breast cancer cellsMechanisms of lymphatic metastasis in breast cancer; In vivo fluorescence and magnetic resonanc imagingAdvanced non invasive MRI methods for breast cancer detection and diagnosis ; clinical investigationsCollaboration with: Dr. Myra Shapiro, Meir medical Center3D Tracking of the mammary tree using diffusion tensor magnetic resonance imagingAdvanced methods for analysis of dynamic contrast enhanced MRI based on a combined model free and model based method.Hyperpolarized magnetic resonance spectroscopy and imaging of cancer metabolism; searching for novel metabolic markers of cancerCollaboration with: Professor Lucio Frydman, Weizmann InstituteRenal function through sodium grandients; Non-invasive, high resolution sodium MRI.Collaboration with: Dr. Edna Haran, Weizmann InstituteEstrogen regulation of angiogenesis and perfusion of breast cancer; from molecular mechanisms to functional MRI of the microvascular physiology
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Prof. Nava Dekel
Molecular characterization of the ovulatory cascadeMechanisms involved in successful implantation.Regulation of the meiotic cell cycle: use of rodent oocytes as a model system.Cell-to-cell communication: regulation of expression, posttranslational modification, degradation and function of the gap junction proteins, Cx43 and Cx37.
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Dr. Erez Ayelet
Collaboration with: Eytan Ruppin Uri Tabori Angel ProgadorCancer Metabolic RewiringMetabolic regulation of anti-cancer immune responseMetabolic adaptations during cancer cachexiaMetabolism in senescenceMetabolic cross talks in the tumor miceroenvironment
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Prof. Atan Gross
How do changes in mitochondria function effect the initiation/progression of Parkinson's Disease?How do changes in mitochondria function effect the initiation/progression of Fibromyalgia?Establishing the role of mitochondrial carrier homolog 2 (MTCH2) in regulating the shape of mitochondria, metabolism and apoptosisDevelop inhibitors for MTCH2 as potential therapies of diseases such as acute myeloid leukemia (AML) and obesity
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Prof. Michal Neeman
MRI of angiogenesisCollaboration with: Prof Nava Dekel, Weizmann Prof Lucio Frydman, Weizmann Prof Joel Garbow, Washington Univ. St Louis Prof Silvio Aime, Univ TorinoCOVID-19 in pregnancyVascular remodelling in cancerVascular remodelling in reproduction and developmentProtocols, Reporter genes and Probes for molecular imaging
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Prof. Rony Seger
The nuclear translocation of signaling protein as a drug target for cancer and inflammationThe nuclear translocation of ERKThe nuclear translocation of JNK and p38Develop peptide inhibitors of the nuclear translocation of ERK/JNK/p38 for the cure of cancer and inflammationDevelopment of small molecular weight inhibitors of the nuclear translocation of ERK for the cure of cancerThe subcellular localisation of AKTThe mechanisms and roles of MEK nuclear translocationERK1c in the regulation of Golgi fragmentationThe mechanisms of golgi translocation of ERK1cSubstrates of ERK1c in the GolgiMechanism of ERK1c-regulated Golgi architecture
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Prof. Philipp Selenko
Neuronal alpha-synuclein aggregation in Parkinson's diseaseCollaboration with: Daniella Goldfarb, Hagen Hofmann, Ori Avinoam, Atan Gross, Ami NavonStructural Biology, Cell Biology, Neurobiology, BiophysicsNMR, EPR, smFRET, cryoEM, CLEM, optical microscopy, correlative imaging methods, advanced mammalian cell models.Cellular regulation of CPEB4 liquid-liquid phase separationCollaboration with: Daniella Goldfarb, Hagen Hofmann, Koby LeviStructural Biology, Cell Biology, Neurobiology, BiophysicsNMR, EPR, smFRET, cryoEM, CLEM, optical microscopy, correlative imaging methods, advanced mammalian cell models.
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Prof. Alex Tsafriri
Molecular regulation of ovulatory changes in mammals.Collaboration with: Helena Ashkenazi, Shmulik Motola, Xiumei Cao, Malka Popliker, Seymour Pomerantz, Marco Conti, StanfordThe roles of gonadotropins and EGF-like factors in triggering ovulation.The resumption of meiosis and its regulation.Ovulation as a tissue remodeling process.The development and demise of ovarian follicles <I>in vivo</I> and <I>in vitro</I>: the role of apoptosis.Collaboration with: Atan Gross, KerenYacobi
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Dr. Igor Ulitsky
Functions and modes of action of long RNAsFunctions of long noncoding RNAs in establishing cell identifySequence determinants RNA functionsGenome evolutionRNA localization within cellsRegulation of RNA turnoverChromatin modifiers in neurological disease
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Prof. Yosef Yarden
Combination of kinase inhibitors and monoclonal antibodies for cancer therapyCollaboration with: Julian Downward Nadege Gaborit Belinda Sanchez Raya Eilam Eli Pikarsky Luis Paz-AresMolecular bases of tumor progression and roles for growth factorsEytan Ruppin Aaron Ciechanover Carlos Caldas
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