August 31, 2015
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Date:31MondayAugust 2015Lecture
A Trajectory's Tale: Kinetic Trap Analysis Identifies Coexisting Origins of Anomalous Dynamics in Proteins
More information Time 11:00Location Edna and K.B. Weissman Building of Physical Sciences
Room ALecturer Yasmine Meroz
Harvard UniversityOrganizer Faculty of Physics
Special SeminarContact Abstract Show full text abstract about Subdiffusion is a hallmark of protein dynamics. Several mode...» Subdiffusion is a hallmark of protein dynamics. Several models predict subdiffusive dynamics, generally either due to some fractional noise or due to trapping dynamics in the underlying energy landscape. However the connection remains unclear, particularly to the underlying energy landscape. We reassess the assumption of a constant single subdiffusive exponent, identifying plateaus in the mean-squared displacement of molecular dynamics trajectories. We associate these with kinetic traps on a minimal model we develop of a hierarchical multibarrier energy landscape, exhibiting a separation of scales in both energy and space. We employ the model to extract the characteristic free energy barriers and length scales associated with the kinetic traps which lead to arrested dynamics. Moreover we identify a second subdiffusive mechanism inherent to the underlying fluctuating process. Lastly we find a relationship between the characteristic energy barriers and the rate of their appea! rance, allowing to reconstruct the effective subdiffusive mean-squared displacement. -
Date:31MondayAugust 2015Lecture
Development of cardiac CEST MRI as a powerful in vivo tool for cell tracking, metabolic imaging, and clinical fibrosis imaging
More information Time 14:00 - 15:00Location Max and Lillian Candiotty Building
Seminar RoomLecturer Moriel Vandsburger, PhD
Assistant Professor Departments of Physiology and Biomedical Engineering Saha Cardiovascular Research Center Center for Muscle Biology University of KentuckyOrganizer Life SciencesContact -
Date:01TuesdaySeptember 2015Lecture
"Metallo-Supramolecular Polymers: Structure and Functions"
More information Time 11:00Location Helen and Milton A. Kimmelman Building
Dov Elad RoomLecturer Prof. Dirk G. Kurth
from Julius-Maximilians Universität, GermanyOrganizer Department of Molecular Chemistry and Materials ScienceContact -
Date:01TuesdaySeptember 2015Lecture
Cryo-electron microscopy for in situ structural biology
More information Time 14:00 - 15:00Location Helen and Milton A. Kimmelman Building
Dov Elad RoomLecturer Dr. Tanmay Bharat
MRCOrganizer Department of Chemical and Structural BiologyContact -
Date:02WednesdaySeptember 2015Lecture
G-INCPM Special Seminar - Dr. Michael Angelo, MD, Instructor, Department of Pathology, Stanford University School of Medicine - High dimensional, immunohistochemical imaging in clinical tissue biopsies using multiplexed ion beam imaging (MIBI)
More information Time 11:00 - 12:30Location Nancy and Stephen Grand Israel National Center for Personalized Medicine
AuditoriumLecturer Dr. Michael Angelo, MD
Instructor, Department of Pathology Stanford University School of MedicineOrganizer Department of Biomolecular Sciences
System BiologyContact Abstract Show full text abstract about Multiplexed ion beam imaging (MIBI) is a novel approach to i...» Multiplexed ion beam imaging (MIBI) is a novel approach to immunohistochemistry (IHC) that uses secondary ion mass spectrometry (SIMS) and antibodies labeled with elemental mass tags to visualize dozens of proteins simultaneously in a single tissue section. MIBI is compatible with standard formalin-fixed, paraffin-embedded (FFPE) tissue specimens, the most common sample type in clinical repositories worldwide, and can achieve single molecule sensitivity across a five log dynamic range at resolutions equivalent to brightfield microscopy. In recent work, MIBI was validated for imaging breast tumor tissue sections stained with clinically relevant metal-conjugated antibodies via side-by-side comparison with an FDA-approved quantitative image analysis platform. Since that time, my lab has validated over sixty antibodies and has constructed a 45-plex MIBI panel for characterizing phenotypic and epigenetic features of epithelial, stromal, and infiltrating immune cells in clinical breast tumor biopsies. Analogous approaches with metal conjugated oligonucleotides have also been used for multiplexed DNA and RNA ISH. Finally, to permit broader use of this method, we have designed and constructed novel instrumentation optimized for MIBI that is capable of super resolution imaging and one hundred fold faster sample throughput. Taken together, these tools are being used by lab to comprehensively enumerate immune cell populations in normal and neoplastic solid tissues, to develop clinical classifiers for predicting disease progression in pre-invasive cancer lesions, and to discover epigenetic drivers of epithelial to mesenchymal transition.
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Date:02WednesdaySeptember 2015Lecture
“Recent advances in optical bio-sensing”
More information Time 11:00 - 12:00Location Perlman Chemical Sciences Building
Room 404Lecturer Prof. Alexei Nabok
Materials Engineering Research Institute, Sheffield Hallam UniversityOrganizer Department of Molecular Chemistry and Materials ScienceContact Details Show full text description of In this talk I am going to outline our recent works in chemi...» In this talk I am going to outline our recent works in chemical and bio-sensing, particularly in detection of low molecular weight analytes, such as mycotoxins, using the method of total internal reflection ellipsometry.
I’ll also review some other optical methods using the detection of phase of electromagnetic waves which could be exploited for scaling down the spectroscopic ellipsometry instrumentation. The application of methods of LSPR and SERS in gold nanostructures for bio-sensing will be discussed as well as our joint recent results in spectroscopic ellipsometry study of gold nano-islands formed by annealing of thin gold films.
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Date:02WednesdaySeptember 2015Lecture
Chemical Physics Guest Seminar
More information Time 13:00Location Perlman Chemical Sciences Building
Seminar RoomLecturer Richard Rosenberg
Argonne National LabOrganizer Department of Chemical and Biological PhysicsContact