Identifying the Personalized Innate Immune System Strength - Brainstorming session at Bina
We held a cross-institutional brainstorm at Bina - Bridge Innovate Nurture Advance to scope a new collaboration between Meir Medical Center's Hemato-Oncology Unit and the Weizmann Institute of Science.The challenge: Managing neutropenia today relies largely on neutrophil counts, but count≠function. There’s an unmet need to characterize neutrophil functionality, not just quantity, to better predict which patients are at highest risk of severe infections after chemotherapy and guide treatment decisions.Our goal: To co-develop a diagnostic toolbox that integrates mathematical modeling and biomarker identification to measure neutrophil function and count, enabling more precise risk stratification and patient-specific prevention and treatment decisions.What’s next: finalizing study design, selecting functional assays, and planning clinical validation.With thanks to the participants:Prof. Vered Rom-Kedar, who conceived and initiated this project.Prof. Tony Futerman, Head of the Bina Steering Committee; Weizmann Institute of Science Immunology Researchers: Prof. Roi Avraham, Prof. Liran Shlush, Prof. Steffen Jung, and Dr. Noa Bossel Ben-MosheFrom Meir Medical Center: Dr. Gilad Itchaki, Dr. Tali Tohami, Dr. Rona Ortenberg, and Uri Goren.Bina's scientific advisor: Dr. Vered Gigi, PhDFrom Bina unit: Dr. Merav Marom, Dr. Ronny Peri Naor, PhD Naor, Dr. Reut Mashiach