Department of Biological Regulation
MSc rotation
Available Rotations: 1st,2nd,3rd
Live imaging of tumor angiogenesis in zebrafish embryos
Department of Biological Regulation
MSc rotation
Available Rotations: 1st,2nd,3rd
Mechanisms of vascular development, angiogenesis and lymphangiogenesis
Department of Molecular Genetics
MSc rotation
Available Rotations: 3rd
The role of DNA damage in differentiation
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we have identified a new signaling pathway that is activated in response to DNA damage. the major players of this signaling pathway are the tyrosine kinase c-Abl (a proto-oncogene), p73 (a member of p53 tumor suppressor proteins), and Yap (the downstream effector of Hippo pathway that regulates organ size). we have preliminary data to show that this pathway is involved in differentiation of muscle and Fat cells.
Department of Molecular Genetics
MSc rotation
Available Rotations: 3rd
on the linkage between cancer and proteosomal degradation
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we have identified a new pathway for proteasomal degradation. we have evidence for this pathway to be modified in cancer cells. We found that this pathway to be regulated by metabolism. cancer cells display a unique behavior in regard to metabolism (the Warburg effect). we are investigating the possibility that the Warburg effect is important for the shift in proteasomal degradation.
Department of Biological Regulation
MSc rotation
Available Rotations: 1st,2nd,3rd
Biology of noncoding RNAs and their roles in gene regulation, with a particular focus on long intervening noncoding RNAs (lincRNAs)
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We use genomic and biochemical approaches alongside computational methods for studying functions and modes of actions of long intervening noncoding RNAs, and also examine their evolution and work to place them in higher-order regulatory networks. To do so we will use various combinations of novel and existing experimental and computational methods.
Candidates with background in computational or molecular biology are sought, and those with a multidisciplinary background, spanning both life sciences and computer sciences, are especially encouraged to apply.
Department of Molecular Chemistry and Materials Science
MSc rotation
Available Rotations: 1st,2nd,3rd
Bioorganic studies of retinal proteins, including bacteriorhodopsin, bovine rhodopsin, halorhodopsin and sensory rhodopsin.
Department of Molecular Genetics
MSc rotation
Available Rotations: 1st,2nd,3rd
Variability and robustness in embryonic patterning
Department of Molecular Genetics
MSc rotation
Available Rotations: 1st,2nd,3rd
Control of morphogenesis by actin nucleation
Department of Plant and Environmental Sciences
PhD position
The Vardi lab is seeking highly motivated candidates to join an exciting project in the field of chemical ecology, focusing on host-pathogen interactions and chemical communication in the ocean.
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The Vardi lab is seeking highly motivated candidates to join an exciting project in the field of chemical ecology, focusing on host-pathogen interactions and chemical communication in the ocean. The project will involve diverse analytical chemistry tools for metabolomics and lipidomics analyses to identify new molecules that mediate virulence and host defence in lab-based model systems and in the marine environment.
Department of Immunology
MSc rotation
Available Rotations: 1st,2nd,3rd
Cellular dynamics and molecular control of the antibody immune response.
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If you are interested in how the immune system provides us with long lasting protection from pathogens, you are most welcome here.
We image the immune response by novel techniques that include whole-organ imaging as well as dynamic live imaging of T and B cells. We also study gene expression and chromatin changes that control formation of long lasting immunological memory.
Prof. Jacob Sagiv
Department of Molecular Chemistry and Materials Science
Postdoc position
Development and study of a novel class of unconventional organic-inorganic single-layer materials, their multiscale (nanometer-to-centimeter) patterning, and investigation of their unusual electrical properties.
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A postdoctoral position is available for an unconventional, interdisciplinary project. It involves research work with highly ordered self-assembling monolayers, their in-situ nondestructive surface functionalization and multiscale (nanometer-to-centimeter) patterning by a novel e-beam based methodology developed as part of the project, and their structural-functional characterization by a combination of different modes of AFM imaging, electrical and electrochemical measurements, and chemical and spectroscopic methods. Some relevant publications: 1. Constructive Nanolithography: Inert Monolayers as Patternable Templates for In-Situ Nanofabrication of Metal-Semiconductor-Organic Surface Structures - A Generic Approach, R. Maoz, E. Frydman, S. R. Cohen, J. Sagiv. Adv. Mater. 2000, 12, 725-731. 2. Planned Nanostructures of Colloidal Gold via Self-Assembly on Hierarchically Assembled Organic Bilayer Template Patterns with In-situ Generated Terminal Amino Functionality, S. Liu, R. Maoz, J. Sagiv. Nano. Lett. 2004, 4, 845-851. 3. A Bipolar Electrochemical Approach to Constructive Lithography: Metal on Monolayer Patterns via Consecutive Site-Defined Oxidation and Reduction, A. Zeira, J. Berson, I. Feldman, R. Maoz, J. Sagiv. Langmuir 2011, 27, 8562-8575. 4. Parallel and Serial Contact Electrochemical Metallization of Monolayer Nanopatterns: A Versatile Synthetic Tool en Route to Bottom-up Assembly of Electric Nanocircuits, J. Berson, A. Zeira, R. Maoz, J. Sagiv. Beilstein J. Nanotechnol. 2012, 3, 134-143. 5. Single-Layer Ionic Conduction on Carboxyl-Terminated Silane Monolayers Patterned by Constructive Lithography, J. Berson, D. Burshtain, A. Zeira, A. Yoffe, R. Maoz, J. Sagiv. Nature Mater. 2015, 14, 613-621. 6. Site-Targeted Interfacial Solid-Phase Chemistry: Surface Functionalization of Organic Monolayers via Chemical Transformations Locally Induced at the Boundary between Two Solids, R. Maoz, D. Burshtain, H. Cohen, P. Nelson, J. Berson, A. Yoffe, J. Sagiv. Angew. Chem. Int. Ed. 2016, 55, 12366-12371. 7. Interfacial Electron Beam Lithography: Chemical Monolayer Nanopatterning via Electron Beam-Induced Interfacial Solid-Phase Oxidation, R.Maoz, J. Berson, D. Burshtain, P. Nelson, A. Zinger, O. Bitton, ACS Nano 2018, 12, 9680-9692.
Department of Molecular Genetics
MSc rotation
Available Rotations: 1st,2nd,3rd
We study microbial genomes using high throughput sequencing. Projects in our lab include computational discovery of antibiotics, microbial RNAomics, and RNAi in bacteria. Wet/dry rotations available. Please send CV - thanks.
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We study microbial genomes using high throughput sequencing. Projects in our lab include computational discovery of antibiotics, microbial RNAomics, and RNAi in bacteria. Our lab utilizes the new Solexa ultra-high-throughput sequencing technology, which produces massive amounts (giga-bases) of DNA data in just a few days. Wet and dry rotations are available.
Department of Neurobiology
MSc rotation
Available Rotations: 1st,2nd,3rd
Genomic regulation of neural circuit plasticity
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Our ability to adapt to and learn from experiences underlies many of our cognitive capabilities but how do our experiences alter the structure and function of the neural circuits in our brain in a manner that gives rise to adaptive behaviors? To answer this fundamental question in neuroscience we study transcriptional networks and genomic mechanisms that are regulated by neuronal activity and by an animal's experiences. Our work is highly interdisciplinary, ranging from genomics and systems biology approaches to synaptic electrophysiology and optogenetics and in vivo calcium imaging and electrophysiology.
Currently we are seeking to rotation students for two projects:
(1) Regulation of neural circuit plasticity by GABAergic interneuron subtypes in the adult cortex. This project combines various systems neuroscience approaches, including longitudinal in vivo 2-photon GCaMP imaging and optogenetics, with advanced mouse genetics.
(2) The role of non-coding genomic regulatory regions in neural circuit plasticity. This project co advanced genomic techniques such RNA-Seq and ChIP-Seq and a novel approach for reversibly in-/activating expression of specific genes.
A strong background in computational approaches and/or MatLab-/R-/Python-programming are advantageous.
Please note that research in our lab generally requires work with rodent animal models.
Department of Physics of Complex Systems
MSc rotation
Available Rotations: 1st,2nd,3rd
Development and synchronization in a model multicellular cyanobacterial organism
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Development and synchronization in a model multicellular cyanobacterial organism
Department of Physics of Complex Systems
MSc rotation
Available Rotations: 1st,2nd,3rd
Architecture of information in bacterial genomes
Department of Physics of Complex Systems
MSc position
Target location during horizontal gene transfer in bacteria
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Study at the single molecule level the search processes of imported pieces of DNA until their integration in a bacterial chromosome, using fluorescence microscopy
Department of Physics of Complex Systems
MSc position
Modeling pattern formation in a natural two dimensional system with stochastic Turing instabilities
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Using methods of Statistical Mechanics and stochastic processes, as well as Gillespie simulations, the project aims at understanding two-dimensional trichome patterns in Arabidopsis leaves
Department of Physics of Complex Systems
MSc position
The interactions of small RNAs in bacteria with antibiotics
Department of Physics of Complex Systems
MSc position
Study the interplay of coupled circadian clocks in multicellular cyanobacterial filaments with differentiation processes.
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The project includes both experiments following circadian clocks at the single cell level as well as theoretical modeling.
Department of Chemical and Biological Physics
PhD position
PhD in magnetic resonance imaging and spectroscopy of the human brain
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Our lab develops new methods for trying to understand the biochemistry of the human brain in-vivo, using the Institute's cutting edge 3 Tesla MRI for human research (yes, we scan humans, mostly volunteers). We currently focus on what happens to the brain's chemistry during functional activation. We are at the intersection between physics and neurobiology: We develop the necessary spin physics from theory, through computer simulations, all the way to programming the MRI scanner, running the experiments, and analyzing the data. Prospective students should be independent, inquisitive and have a strong quantitative background. Since imaging is an interdisciplinary field, physicists, physical chemists, computer scientists, neuroscientists and mathematicians can all contribute significantly. Projects will vary depending on candidate's background and interests.
Department of Chemical and Biological Physics
MSc position
M.Sc. in magnetic resonance spectroscopy of the human brain
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Our lab develops new methods for trying to understand the biochemistry of the human brain in-vivo, using the Institute's cutting edge 3 Tesla MRI for human research (yes, we scan humans, mostly volunteers). We are at the intersection between physics and neurobiology: We develop the necessary spin physics from theory, through computer simulations, all the way to programming the MRI scanner, running the experiments and posing the neurophysiological question. Prospective students should be independent, inquisitive and have a quantitative background. Since imaging is an interdisciplinary field, physicists, physical chemists, computer scientists, neurobiologists and mathematicians can all contribute significantly. Projects vary depending on candidate's background and interests.
Department of Chemical and Biological Physics
MSc rotation
Available Rotations: 1st,2nd,3rd
Magnetic resonance spectroscopy (MRS) and imaging (MRI) of the human brain
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Magnetic resonance spectroscopy (MRS) can be used to acquire spectra from the human brain, offering a window into its underlying biochemistry non-invasively in-vivo. My lab focuses on developing new methodologies for for imaging (MRI) and spectroscopy (MRS), by manipulating the electromagnetic fields in the (human) MRI scanner, an area of research known as pulse sequence development.
There are several possible projects for rotations students in the lab, including preparing and scanning samples used to validate some of the new techniques we develop, and running computer simulations of the underlying physics. The underlying work is very multidisciplinary in nature and I encourage students from other faculties (physics, computer science and mathematics, neuroscience) to apply as well.
Department of Chemical and Biological Physics
Postdoc position
Sustainable energy conversion
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In this project we will study the convention of wasted heat to useful electric energy at the molecular scale.
Department of Chemical and Biological Physics
Postdoc position
Sustainable energy conversion
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Convention of wasted heat to useful electric energy at the atomic and molecular scale.
Department of Chemical and Biological Physics
PhD position
Sustainable energy conversion
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Convention of wasted heat to useful electric energy at the atomic and molecular scale.
Department of Chemical and Biological Physics
PhD position
Sustainable energy conversion
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In this project we will study the convention of wasted heat to useful electric energy at the molecular scale.
Department of Chemical and Biological Physics
Postdoc position
Quantum machines at the atomic and molecular scale.
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In this project we will fabricate quantum machines at the atomic and molecular scale and study their operation. This project is expected to shed a new light on the interface between quantum mechanics and thermodynamics.
Department of Chemical and Biological Physics
Postdoc position
Quantum machines at the atomic and molecular scale.
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Fabrication quantum machines at the atomic and molecular scale and the study of their operation. This project is expected to shed a new light on the interface between quantum mechanics and thermodynamics.
Department of Chemical and Biological Physics
PhD position
Quantum machines at the atomic and molecular scale.
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Fabrication quantum machines at the atomic and molecular scale and the study of their operation. This project is expected to shed a new light on the interface between quantum mechanics and thermodynamics.
Department of Chemical and Biological Physics
PhD position
Quantum machines at the atomic and molecular scale.
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In this project we will fabricate quantum machines at the atomic and molecular scale and study their operation. This project is expected to shed a new light on the interface between quantum mechanics and thermodynamics.
Department of Chemical and Biological Physics
MSc rotation
Available Rotations: 1st,2nd,3rd
Experimental research in:
(I) Molecular electronics; (II) Molecules as electro-mechanical systems; (III) Nanoscale heat transport; (IV) Sustainable energy and heat to electricity conversion; and (V) Spin transport at the molecular scale.
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The specific research project is chosen according to the natural skills and interest of the student. The research includes electronic transport measurements. In some cases the research may involve designing and building of equipment and measurement setups. The actual work can focus on single-molecule junctions, atomic contacts or electronic transport via chains of atoms and nanoscale oxides.
Department of Biomolecular Sciences
MSc rotation
Available Rotations: 1st,2nd,3rd
The goal of our research is to understand how pancreatic beta cells perform their unique functions, and how beta cell dysfunction may lead to diabetes.
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We focus on 1) the mechanisms underlying the embryonic development of beta cells both in vivo and in vitro and 2) the transcriptional and post-transcriptional mechanisms that permit beta cells to fulfill their role of releasing insulin in response to physiological needs.
Department of Biomolecular Sciences
Postdoc position
Molecular signaling in control of immune defense: regulation of programmed cell death and signaling for gene activation.
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Motivated and creative students with background in molecular biology are invited to join our studies of the mechanisms by which signaling by the TNF family contributes to immune defense, to chronic inflammatory and autoimmune diseases and to cancer, and our attempts to derive from this knowledge new ways of therapy.
See our website and list of publications for the range of research subjects that we are exploring and for the range of experimental approaches that we are applying. (http://www.weizmann.ac.il/Biological_Chemistry/scientist/Wallach/home.html).
Department of Biomolecular Sciences
PhD position
Molecular signaling in control of immune defense: regulation of programmed cell death and signaling for gene activation.
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Motivated and creative students with background in molecular biology are invited to join our studies of the mechanisms by which signaling by the TNF family contributes to immune defense, to chronic inflammatory and autoimmune diseases and to cancer, and our attempts to derive from this knowledge new ways of therapy.
See our website and list of publications for the range of research subjects that we are exploring and for the range of experimental approaches that we are applying. (http://www.weizmann.ac.il/Biological_Chemistry/scientist/Wallach/home.html).
Department of Biomolecular Sciences
MSc rotation
Available Rotations: 1st,2nd,3rd
Exploring the tumor-suppressor role of caspase-8, particularly in lung cancer.
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Caspase-8, a cysteine protease discovered in our laboratory, is the main proximal signaling enzyme in the activation of the extrinsic cell-death pathway by receptors of the TNF/NGF family. In certain cells it also participates in the regulation of cell growth, differentiation and survival. A number of different human tumors, including small cell lung carcinoma, neuroblastoma, hepatocellular carcinoma, and others, are frequently deficient of caspase-8. This deficiency occurs by several different mechanisms, indicating that it is not a consequence of the oncogenic transformation but is rather causal to it. Applying molecular approaches, cell-culture and animal models we explore the mechanisms accounting for the tumor suppressor role of caspase-8 and the functional consequences of its deletion in cancer cells.
Department of Biomolecular Sciences
MSc rotation
Available Rotations: 1st,2nd,3rd
Exploring the physiological function of signaling proteins that are activated by receptors of the TNF/NGF family.
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Transgenic and conditional-knockout mouse models are applied to gain better knowledge of the physiological and pathophysiological function of the following signaling proteins that were discovered in our laboratory:
(a) Caspase-8, a cysteine protease that we have initially found to serve as the main proximal signaling protein in the initiation of death induction by the receptors (the extrinsic cell-death pathway), yet has more recently found also to serve various non-apoptotic roles. We are mainly interested in further exploring its function in the cross-talk between the epidermal and dermal layers of the skin, in the liver, and in the insulin-producing beta Langerhans cells.
(b) NIK, a protein kinase (a MAP3K) that signals for activation of transcription factors of the NF kappa B family, specifically by receptors that, through activation of NF kappa B, control adaptive immunity and lymph-node generation.
(c) CYLD, a deubiquitination enzyme that acts specifically to reverse K63-linked ubiquitination and thus serves to arrest initiation of several signaling cascades.
(d) IREN, a member of the sorting-nexins family that mediates trafficking of signaling proteins activated by the receptors of the TNF/NGF family.
Department of Molecular Cell Biology
MSc rotation
Available Rotations: 1st,2nd,3rd
We are looking for curious, motivated and excellent individuals. Our lab utilizes state-of-the-art technologies to functionally dissect the roles of epigenetics during development and disease.
Department of Biomolecular Sciences
Postdoc position
Spatiotemporal regulation of differential type I interferon signaling in a multicellular context
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Type I interferons (IFNs) are proteins produced and secreted in all higher vertebrates as a result of viral and bacterial attacks. Secreted IFNs bind cell surface receptors initiating a cascade of signals that activate cellular protection machineries against pathogens. In addition, specific immune cells are activated to establish long-term defense of the organism. These properties have been successfully exploited for IFNs to serve as a drug for a variety of complex diseases including viral infections, cancer and multiple sclerosis. Despite the proven success of IFN therapies, their use is currently limited because of their severe side effects. Better understanding of the fundamental principles that determine how IFNs induce their responses in a multicellular context will enable to optimize their use. To this end, we will take advantage of polarized epithelial cell layers and spheroids that mimic the intestine tissue. We will generate genetically engineered cell lines to incorporate a range of fluorescence reporters that monitor IFN signaling at the level of receptor engagement, effector activation and feedback regulation. In collaboration with a German partner we will apply these reporters for volumetric imaging of IFN signaling in the multicellular context using highly advanced microscopy techniques that resolve signaling at the single cell level with utmost spatial and temporal resolution. This highly defined and controlled approach will allow us to unravel the rules of IFN signal activation in tissues upon systemic and local stimulation by IFNs and viruses. Next to a fundamental understanding of signal integration in tissues, this work will also have potential medical implications for improving therapeutic application of IFNs.
Department of Biomolecular Sciences
PhD position
Spatiotemporal regulation of differential type I interferon signaling in a multicellular context
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Type I interferons (IFNs) are proteins produced and secreted in all higher vertebrates as a result of viral and bacterial attacks. Secreted IFNs bind cell surface receptors initiating a cascade of signals that activate cellular protection machineries against pathogens. In addition, specific immune cells are activated to establish long-term defense of the organism. These properties have been successfully exploited for IFNs to serve as a drug for a variety of complex diseases including viral infections, cancer and multiple sclerosis. Despite the proven success of IFN therapies, their use is currently limited because of their severe side effects. Better understanding of the fundamental principles that determine how IFNs induce their responses in a multicellular context will enable to optimize their use. To this end, we will take advantage of polarized epithelial cell layers and spheroids that mimic the intestine tissue. We will generate genetically engineered cell lines to incorporate a range of fluorescence reporters that monitor IFN signaling at the level of receptor engagement, effector activation and feedback regulation. In collaboration with a German partner we will apply these reporters for volumetric imaging of IFN signaling in the multicellular context using highly advanced microscopy techniques that resolve signaling at the single cell level with utmost spatial and temporal resolution. This highly defined and controlled approach will allow us to unravel the rules of IFN signal activation in tissues upon systemic and local stimulation by IFNs and viruses. Next to a fundamental understanding of signal integration in tissues, this work will also have potential medical implications for improving therapeutic application of IFNs.
Department of Biomolecular Sciences
MSc rotation
Available Rotations: 1st,2nd,3rd
Axon to soma communication in nerve growth and regeneration.
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Nerve axons are extremely long in cellular terms, extending many orders of magnitude longer than the diameters of their parent cell bodies. How then is the cell body informed of an injury in distant portions of the axon? We are working on the molecular mechanisms of long distance communication within neurons, and their implications for neuronal growth and regeneration. People can integrate to a range of projects within this theme. For an overview of our research topics please visit the group home page at http://www.weizmann.ac.il/Biomolecular_Sciences/Fainzilber/ . Also please note that research in our group requires work in animal models (mice, rats).
Department of Biomolecular Sciences
MSc rotation
Available Rotations: 1st,2nd,3rd
Size and growth control in neurons and other large cells
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Size matters, especially in neurons. Differentiated cells in higher eukaryotes exhibit a wide variety of shapes and sizes, while maintaining defined size ranges within cell subtypes. How do they do that? Genome expression must be matched to different cell sizes, with rapidly growing cells likely requiring higher transcriptional and translational output than cells in slow growth or maintenance phase. Neurons exhibit the greatest size differences of any class of cells, with process lengths ranging from a few microns in central interneurons to a meter in human peripheral neurons, and even longer in larger mammals. We are working on mechanisms of cell length and size sensing in neurons and other large cells, and how these mechanisms control growth and regeneration. People can integrate to a range of projects within this theme. For general information on our research please see the group home page at http://www.weizmann.ac.il/Biomolecular_Sciences/Fainzilber/ . Please note that research in our group requires work in animal models (mice, rats).
Department of Biomolecular Sciences
MSc rotation
Available Rotations: 2nd,3rd
Molecular Biology, protein biophysics and bioinformatics
Department of Biomolecular Sciences
MSc rotation
Available Rotations: 2nd,3rd
Investigating protein-protein interactions and interferon actions
Department of Molecular Cell Biology
MSc rotation
Available Rotations: 1st,2nd,3rd
Developmental Neurobiology: Molecular mechanisms of neuronal remodeling
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Neuronal remodeling is an essential process used to sculpt the mature nervous system in vertebrates and invertebrates. One major mechanism is axon pruning in which neurons eliminate specific sections of their axons in a stereotypic manner. Not much is know about the molecular mechanisms that underlie this process. Defects in pruning may result in neurological conditions such as synesthesia or autism and the molecular mechanisms involved in axon pruning during development are also involved in axon fragmentation during neurodegenerative diseases such as Alzheimer's, Parkinson's and ALS. Therefore, uncovering the molecular mechanisms underlying axon pruning during development should increase our knowledge more broadly on axon fragmentation during development, disease and after injury.
We are studying this process in the fly as it is an awesome genetic model organism with cutting edge techniques that enable us to mutate and visualize single neurons within a whole brain. We are looking for bright and enthusiastic rotation students to join and push forward one of our ongoing research projects. Looking forward to see you!
Department of Molecular Genetics
MSc rotation
Available Rotations: 1st,2nd,3rd
Elucidating the role of post-transcriptional modifications on mRNA.
Department of Computer Science and Applied Mathematics
MSc rotation
Available Rotations: 1st,2nd,3rd
Single cell approaches to epigenetics
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We are an interdisciplinary group developing models and experimental systems for understanding the relations between genome and epigenome structure and function. Experimentally we are building a system for perturbing chromosomal organization and systematically monitoring the resulting phenotypes, gene expression, and epigenetic makeup. This involves development of novel techniques for quantifying interaction between remote chromosomal locations (4C-seq). Computationally we are busy with analysis of genomic sequences and epigenomic organization using primary ChIP-seq, MeDIP-seq and 4C-seq data, with a particular interest in evolutionary analysis of such organization through comparison of related species.
Department of Molecular Cell Biology
Postdoc position
Looking for postdocs with computational background to study tumor biology
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Our lab combines computational and experimental approaches to discover sub-populations of human tumor cells, study their biological functions and the therapeutic implications. For more details please see the lab website.
Department of Molecular Cell Biology
MSc rotation
Available Rotations: 2nd,3rd
Looking for students with computational or experimental background to study tumor biology
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Our lab combines computational and experimental approaches to discover sub-populations of human tumor cells, study their biological functions and the therapeutic implications. For more details please see the lab website.
Department of Computer Science and Applied Mathematics
MSc rotation
Available Rotations: 1st,2nd,3rd
We combine experimental and computational approaches towards the goal of developing personalized nutrition and personalized medicine approaches based on gene regulation, microbiome, genetics, and nutrition. Please send CV.
Department of Biological Regulation
MSc rotation
Available Rotations: 1st,2nd,3rd
Intracellular signaling pathways
Department of Biomolecular Sciences
MSc rotation
Available Rotations: 1st,2nd,3rd
A multidisciplinary approach to study parameters involved in the recognition between transmembrane domains of receptors.
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Within the systems described, we study self- and hetero-assembly of membrane-bound peptides derived from membrane proteins. Interestingly, although it is generally accepted that the chiral nature of most biologically relevant macromolecules restricts specific interactions to ֲ“chiral partnersֲ”, we found that the lipid bilayer environment allows the interaction of two transmembrane (TM) domains with opposite chiralities, and between an all L-amino acid TM and its D,L-amino acid analog (diastereomer). Furthermore, we recently developed a new assay that allows for the in vivo detection of hetero-association between proteins within the membrane milieu. Hence, we are able to extend our experimental results to in vivo systems adding important insights. Besides giving us important basic information, these findings serve as new tools for the design of novel compounds to combat infectious diseases.
For more details go to the following web site (A new site is under construction) http://www.weizmann.ac.il/Biological_Chemistry/scientist/Shai/yechiel_shai.html
Department of Biomolecular Sciences
MSc rotation
Available Rotations: 1st,2nd,3rd
Regulation of innate immune responses by transmembrane domains interactions: Studies with the Toll-like receptor (TLR) family
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The mammalian innate immune response is responsible for the early stages of defense against invading pathogens. One of the major receptor families facilitating innate immune activation is the Toll-like receptor (TLR) family, type I membrane proteins. All TLRs form homo- and hetero-dimers within membranes and we showed that the single transmembrane domain (TMD) of some of these receptors is involved in their dimerization and signaling regulation. Uncontrolled or untimely activation of TLRs is related to a large number of pathologies ranging from cystic fibrosis, sepsis, Crohnֲ’s disease and cancer. We focus on the contribution of the TMDs of the TLRs, involved in these diseases, to their activation. Furthermore we demonstrate that interfering with the dimerization by synthetic TMD peptides in-vivo can cure these diseases.
Department of Biomolecular Sciences
MSc rotation
Available Rotations: 1st,2nd,3rd
Innate Immunity Host Defense Antimicrobial Peptides: Potentially new generation antibiotics to overcome bacterial biofilms, sepsis and bacterial resistance.
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(i) Antibacterial and antifungal peptides - Living organisms of all types produce a large repertoire of gene-encoded antimicrobial peptides that serve as part of the innate immunity. Since 1991 we have established the ֲ“carpetֲ” mechanism as an efficient model describing membrane permeation by many antimicrobial peptides. Most importantly, we disproved accepted dogmas on the role of specific structure, sequence or chirality in biological function. Furthermore, we found parameter controlling target cell specificity. The success of our model is also reflected by our ability to develop a novel family of cell selective antimicrobial diastereomeric peptides and lipopeptides based on predictions not possible by other models. This new family seems to have very high potential for future therapeutics urgently needed due to increasing resistance of bacteria and fungi to available antibiotics. Indeed, they presented the first example of antimicrobial peptides that were active against bacterial infection when inject intravenously.
(ii) Anticancer peptides - Our immune system is geared to recognize and destroy cancer cells mainly through receptor-mediated mechanisms. Despite evidence that immune effectors can play a significant role in controlling tumor growth under natural conditions or in response to therapeutic manipulation, cancer cells usually evade immune surveillance. In that regard, antimicrobial peptides seem to overcome these limitations via a yet unknown non-receptor-mediated mechanism. We have designed cancer selective lytic peptides composed of D,L-amino acids that can specifically target and lyse cancer cells. These peptides can cure both primary and methastatic tumors in mice xenografts. In contrast, a peptide with the same amino acid composition but composed of all L-amino acid was active only on cell lines but not in animal models.
For more details go to the following web site (A new site is under construction) http://www.weizmann.ac.il/Biological_Chemistry/scientist/Shai/yechiel_shai.html
Department of Chemical and Biological Physics
MSc rotation
Available Rotations: 2nd,3rd
Investigation of biomineralization pathways using low-frequency Raman spectroscopy.
Department of Earth and Planetary Sciences
MSc rotation
Available Rotations: 1st,2nd,3rd
Biosphere-atmosphere interactions. In particular, leaf to canopy gas exchange associated with photosynthesis under stress and the use of novel tracers, such as carbonyl sulfide (COS) and techniques, such as Sun Induced Fluorescence (SIF).
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The successful candidate will join a dynamic and international research team that investigates the interactions between climate change and vegetation. He/She will use novel field techniques to understand photosynthesis response to change, using leaf, branch and ecosystem scales gas exchange of CO2, and carbonyl sulfide (COS; a new atmospheric tracer) and remote sensing (SIF). Background is required in at least one of the following areas: Plant physiology, gas exchange, photosynthesis, atmospheric chemistry, micro-meteorology, operating analytical equipment, willingness to carry out research both in the lab and in the field
Department of Earth and Planetary Sciences
Postdoc position
Biosphere-atmosphere interactions. In particular, leaf to canopy gas exchange associated with photosynthesis under stress and the use of novel tracers, such as carbonyl sulfide (COS) and techniques, such as Sun Induced Fluorescence (SIF).
More Information about Postdoc position
The successful candidate will join a dynamic and international research team that investigates the interactions between climate change and vegetation. He/She will use novel field techniques to understand photosynthesis response to change, using leaf, branch and ecosystem scales gas exchange of CO2, and carbonyl sulfide (COS; a new atmospheric tracer) and remote sensing (SIF). Background is required in at least one of the following areas: Plant physiology, gas exchange, photosynthesis, atmospheric chemistry, micro-meteorology, operating analytical equipment, willingness to carry out research both in the lab and in the field.
Department of Earth and Planetary Sciences
MSc position
Biosphere-atmosphere interactions. In particular, leaf to canopy gas exchange associated with photosynthesis under stress and the use of novel tracers, such as carbonyl sulfide (COS) and remote sensing techniques, such as Sun Induced Fluorescence (SIF).
More Information about MSc position
The successful candidate will join a dynamic and international research team that investigates the interactions between climate change and vegetation. He/She will use novel field techniques to understand photosynthesis response to change, using leaf, branch and ecosystem scales gas exchange of CO2, and carbonyl sulfide (COS; a new atmospheric tracer) and remote sensing (SIF). Background is required in at least one of the following areas: Plant physiology, gas exchange, photosynthesis, atmospheric chemistry, micro-meteorology, operating analytical equipment, willingness to carry out research both in the lab and in the field
Department of Earth and Planetary Sciences
PhD position
Biosphere-atmosphere interactions. In particular, leaf to canopy gas exchange associated with photosynthesis under stress and the use of novel tracers, such as carbonyl sulfide (COS) and techniques, such as Sun Induced Fluorescence (SIF).
More Information about PhD position
The successful candidate will join a dynamic and international research team that investigates the interactions between climate change and vegetation. He/She will use novel field techniques to understand photosynthesis response to change, using leaf, branch and ecosystem scales gas exchange of CO2, and carbonyl sulfide (COS; a new atmospheric tracer) and remote sensing (SIF). Background is required in at least one of the following areas: Plant physiology, gas exchange, photosynthesis, atmospheric chemistry, micro-meteorology, operating analytical equipment, willingness to carry out research both in the lab and in the field.
Department of Biological Regulation
MSc rotation
Available Rotations: 1st,2nd,3rd
Mechanisms of signal transduction by growth factors and their relevance to cancer therapy.
More Information about MSc rotation
The rotation will deal with the biochemical pathways underlying cell activation by growth factors. This relates to both cell proliferation and cell migration. We use DNA-arrays, yeast 2-hybrid and immunological methods to resolve specific pathways. Currently we concentrate on mechanisms that inactivate cellular signals as part of negative feedback loops. These pathways are related to pharmacological attempts to block growth factor and tyrosine kinase signaling in human cancer. In this context, the work involves several novel drugs aimed at inhibiting breast and colon cancer.
Department of Biomolecular Sciences
MSc rotation
Available Rotations: 1st,2nd,3rd
Master's Rotation positions in developmental neurobiology
More Information about MSc rotation
Positions are available joining the work on exciting ongoing projects in the lab:
1. The role of axonal mRNA translation during development.
2. Signaling mechanisms of axon guidance receptors.
3. Mechanisms of axonal degeneration
Department of Computer Science and Applied Mathematics
MSc rotation
Available Rotations: 2nd,3rd
Development of advanced next-generation sequencing (NGS) technologies for single cell analysis.
More Information about MSc rotation
We seek for highly motivated students for an exciting project which involves molecular biology engineering, NGS, single cell manipulation, FACS sorting and/or bioinformatic analysis. Both biologists and bioinformaticians are welcome.
Department of Computer Science and Applied Mathematics
MSc rotation
Available Rotations: 1st,2nd,3rd
Algorithms development for Next-Generation-Sequencing analysis
More Information about MSc rotation
See details in the Cell Lineage project web site: http://www.lineage-flagship.eu/.
Department of Computer Science and Applied Mathematics
MSc rotation
Available Rotations: 1st,2nd,3rd
For a new Synthetic Biology project, whose goal is to become a new medical treatment, we are looking for a motivated & bright student to be a part of our team.
More Information about MSc rotation
For a new Synthetic Biology project, whose goal is to become a new medical treatment, we are looking for a motivated & bright student to be a part of our team. Please contact ehud.shpiro@weizmann.ac.il or tom.ran@weizmann.ac.il |||| Previous "semi"-relevant papers by our lab ("Biological Computers"):(*) Bacteria which compute logic gates (Nature's Scientific reports, 2012) --> www.nature.com/srep/2012/120907/srep00641/full/srep00641.html (*) DNA Computation Gets Logical (Nature Nanotechnology 2009) --> http://www.wisdom.weizmann.ac.il/~lbn/new_pages/SimpleLogicProgram/new_pages/press_releases/press_eng.html (*) Biological computer diagnoses cancer and produces the drug - in a test tube (Nature, 2004) --> http://www.wisdom.weizmann.ac.il/~udi/PressRoom/new_pages/press_eng.html (*) A paper in Hebrew about Biological Computers --> http://www.wisdom.weizmann.ac.il/~tomr/index_files/tom_ran.pdf ||| External relevant links: (*) Synthetic Biology --> http://sciencebuz.com/articles/synthetic-biology-engineering-life-or-engineering-for-better-life/ (*) iGem --> http://igem.org/Main_Page
Department of Computer Science and Applied Mathematics
MSc rotation
Available Rotations: 1st,2nd,3rd
For a new Synthetic Biology project, whose goal is to become a new medical treatment, we are looking for a motivated & bright student to be a part of our team.
More Information about MSc rotation
For a new Synthetic Biology project, whose goal is to become a new medical treatment, we are looking for a motivated & bright student to be a part of our team. Please contact ehud.shpiro@weizmann.ac.il or tom.ran@weizmann.ac.il |||| Previous "semi"-relevant papers by our lab ("Biological Computers"):(*) Bacteria which compute logic gates (Nature's Scientific reports, 2012) --> www.nature.com/srep/2012/120907/srep00641/full/srep00641.html (*) DNA Computation Gets Logical (Nature Nanotechnology 2009) --> http://www.wisdom.weizmann.ac.il/~lbn/new_pages/SimpleLogicProgram/new_pages/press_releases/press_eng.html (*) Biological computer diagnoses cancer and produces the drug - in a test tube (Nature, 2004) --> http://www.wisdom.weizmann.ac.il/~udi/PressRoom/new_pages/press_eng.html (*) A paper in Hebrew about Biological Computers --> http://www.wisdom.weizmann.ac.il/~tomr/index_files/tom_ran.pdf ||| External relevant links: (*) Synthetic Biology --> http://sciencebuz.com/articles/synthetic-biology-engineering-life-or-engineering-for-better-life/ (*) iGem --> http://igem.org/Main_Page
Department of Biomolecular Sciences
MSc rotation
Available Rotations: 1st,2nd,3rd
Mechanism of autophagy in yeast and mammals
More Information about MSc rotation
Study different aspects of the mechanism involved in the formation and maturation of an autophagosome.
Department of Biomolecular Sciences
MSc rotation
Available Rotations: 1st,2nd,3rd
Signaling processes and autophagy
More Information about MSc rotation
Study the role of autophagy in the regulation of different signaling pathways
Department of Biomolecular Sciences
MSc rotation
Available Rotations: 1st,2nd,3rd
Autophagy and neurodegenration
More Information about MSc rotation
Study the role of TECOR2, a novel autophagic related factor.
Department of Particle Physics and Astrophysics
MSc position
Availability for MSc and PhD positions in Kfir Blum's group (theoretical particle/astrophysics).
Department of Neurobiology
MSc rotation
Available Rotations: 1st,2nd,3rd
Theoretical, empirical and synthetic studies of perception in touch and vision
Department of Plant and Environmental Sciences
MSc rotation
Available Rotations: 1st,2nd,3rd
Redox signals in molecular adaptation.
More Information about MSc rotation
Redox signals in molecular adaptation.
We are studying redox-modulated signal transduction pathway regulating post-transcriptional gene expression. A combination of genetic and biochemical approaches is being used to elucidate the pathway of redox signaling which controls synthesis of proteins in the chloroplast.
Department of Immunology
MSc rotation
Available Rotations: 2nd,3rd
Biochemical and genetic approaches for dissection of immune cell migration across blood vessel derived cells: Ex vivo live imaging, fluorescence microscopy, as well as electron microscopic readouts are utilized in combination with animal models
Department of Molecular Chemistry and Materials Science
MSc rotation
Available Rotations: 1st,2nd,3rd
Our lab aims to develop new reporter genes, biosensors and tracers for magnetic resonance imaging (MRI) applications by using synthetic chemistry and molecular biology approaches.
More Information about MSc rotation
Biosensors have become the highlighter felt pens of modern science; they enable scientists to tag molecules of interest and have them stand out in striking contrast to show their location or function in cells and tissues in colorful relief.
Our lab aims to develop new reporter genes, biosensors and tracers for magnetic resonance imaging (MRI) applications by using synthetic chemistry and molecular biology approaches. Such developed imaging tools will help us to study unrevealed biological
events longitudinally and non-invasively in deep tissues of a live subject.
We are looking for highly motivated, talented and creative people from various fields of science (Chemistry, Biology, Medicine, etc.)
to join us.
Department of Molecular Chemistry and Materials Science
MSc rotation
Available Rotations: 1st,2nd,3rd
Our lab aims to develop new reporter genes, biosensors and tracers for magnetic resonance imaging (MRI) applications by using synthetic chemistry and molecular biology approaches.
More Information about MSc rotation
Biosensors have become the highlighter felt pens of modern science; they enable scientists to tag molecules of interest and have them stand out in striking contrast to show their location or function in cells and tissues in colorful relief.
Our lab aims to develop new reporter genes, biosensors and tracers for magnetic resonance imaging (MRI) applications by using synthetic chemistry and molecular biology approaches. Such developed imaging tools will help us to study unrevealed biological
events longitudinally and non-invasively in deep tissues of a live subject.
We are looking for highly motivated, talented and creative people from various fields of science (Chemistry, Biology, Medicine, etc.)
to join us.
Department of Immunology
MSc rotation
Available Rotations: 1st,2nd,3rd
The Amit lab will be focused on gene regulation in mammals and will use novel state of the art systematic approaches that combine automation next generation sequencing and various high throughput approaches for both screening and readouts.
More Information about MSc rotation
We are looking for talented and motivated graduate students, with various backgrounds (computer science, molecular biology, system biology, physics, etc). The Amit lab will be focused on gene regulation in mammals and will use novel state of the art systematic approaches that combine automation next generation sequencing and various high throughput approaches for both screening and readouts. We believe that the strategies, methods and small molecule we develop will impact the future of personalized medicine. For more info check our website: http://www.weizmann.ac.il/immunology/AmitLab/.
If this sounds interesting and you would like to take a part of the lab please send your CV to: iamit@broadinstitute.org or ido.amit@weizmann.ac.il
All my very best
Ido Amit
Department of Chemical and Biological Physics
MSc rotation
Available Rotations: 2nd,3rd
1) Detection and measurement of nano-structures with chip-based optical micro-resonators
2) Interactions between single photons and single atoms using laser-cooled atoms and chip-based micro-resonators
Department of Chemical and Structural Biology
MSc rotation
Available Rotations: 1st,2nd,3rd
NMR studies of HIV-1 envelope glycoprotein
and its interactions.
More Information about MSc rotation
The work involves expression and purification of the HIV-1 envelope glycoprotein from a cell-line expressing the protein. Preparation of NMR samples. Learning the principles of NMR studies of proteins. Measurements of NMR spectra and their analysis.
Department of Molecular Genetics
MSc rotation
Available Rotations: 1st,2nd,3rd
The Language of Cellular Communication
More Information about MSc rotation
Join us in using quantitative experimental and computational methods to decipher the combinatorial code of signals - how cells integrate multiple extracellular messages into an intracellular picture which ultimately control the cell decisions and its behavior.
Department of Biomolecular Sciences
MSc rotation
Available Rotations: 1st,2nd,3rd
Studies on the assembly, function and structure of the cellulosome, a multi-enzyme complex produced by cellulolytic bacteria that efficiently degrades cellulose, utilizing molecular biology, biochemistry and structural biology tools.
More Information about MSc rotation
The research in our group involves the study of cohesin-dockerin interactions, the assembly of the cellulosome components, enzymatic activity and analysis, protein design and structural characterization of cellulosomal modules. The motivated individual that will join us can gain experience in the following methods: cloning, expression and purification methods, biochemical and biophysical protein-binding measurements, crystallization and X-ray crystallography, and enzymatic activity assays.
Advantage: a good sense of humor.
Department of Chemical and Structural Biology
MSc rotation
Available Rotations: 3rd
Rapid response against Zika Virus
More Information about MSc rotation
Join our recently initiated effort to combat Zika Virus
Department of Chemical and Structural Biology
MSc rotation
Available Rotations: 1st,2nd,3rd
Combating deadly viruses
More Information about MSc rotation
Arenavirueses are a group of viruses that can cause severe human disease with high mortality rates.
We study the recognition of cellular receptors by arenaviruses to understand the biology of the cell entry process and to develop future therapy.
During a rotation project you will utilize molecular and structural biology techniques, tissue culture, protein expression and purification via chromatography and other general lab techniques, providing you with a comprehensive overview of our research.
Please contact me for additional details.
Department of Physics of Complex Systems
MSc rotation
Available Rotations: 1st,2nd,3rd
work with members of my group on bioinformatics, with emphasis on clinical applications. See webpage for more details:
www.weizmann.ac.il/physics/complex/compphys
Department of Molecular Genetics
MSc rotation
Available Rotations: 1st,2nd,3rd
Caspases without death and death without caspases
More Information about MSc rotation
Mechanisms underlying developmental paradigms of caspase dependent non-lethal cellular processes (CDPs) and alternative cell death pathways (ACDs) in Drosophila.
For more information:
1. Gorelick-Ashkenazi et al., Nature Communications, 2018
2. Aram et al., Cell Death and Differentiation, 2017
3. Aram et al., Developmental Cell, 2016
Department of Biomolecular Sciences
MSc rotation
Available Rotations: 1st,2nd,3rd
Biochemical identification of metabolic sensors
Department of Biomolecular Sciences
MSc rotation
Available Rotations: 1st,2nd,3rd
Computational analyses of rhythmic outputs (e.g. metabolites, gases)
Department of Biomolecular Sciences
MSc rotation
Available Rotations: 1st,2nd,3rd
The relationship between hypoxia and the core circadian clock
Department of Biomolecular Sciences
MSc rotation
Available Rotations: 1st,2nd,3rd
The interplay between circadian clocks and exercise performance
Department of Biomolecular Sciences
PhD position
Available Rotations: 1st,2nd,3rd
Examining the metabolic consequences and disease states due to misalignment between feeding-activity and disrupted circadian clock
Department of Biomolecular Sciences
PhD position
Available Rotations: 1st,2nd,3rd
Studying circadian clock communication through exosomes mediated signaling
Department of Biomolecular Sciences
PhD position
Available Rotations: 1st,2nd,3rd
Establishing a system for studying the effect of dissolved gases (oxygen/carbon dioxide) on cyanobacteria clock
Department of Biomolecular Sciences
PhD position
Available Rotations: 1st,2nd,3rd
Investigating the effect of time of the day on exercise performance and related metabolic pathways.
Department of Biomolecular Sciences
MSc rotation
Available Rotations: 1st
Super-resolution imaging of macromolecular assemblies in living cells
More Information about MSc rotation
The student will apply a new analytical approach, super-resolution radial fluctuations (SRRF), to study vesicular trafficking in vivo.
Department of Biomolecular Sciences
MSc rotation
Available Rotations: 1st,2nd,3rd
Using light and electron microscopy to understand the relationship between membrane shape transformation and cellular communication through signaling.
More Information about MSc rotation
We are interested in the universal process of membrane remodeling, when subdomains of the membrane are reshaped into functional structures that allow cells to take up material, sense and communicate with the environment. We are particularly interested in understanding how membrane ultrastructure is established during muscle differentiation and homeostasis. To this end we study membrane remodeling in cell culture and in the small, transparent, and rapidly developing nematode Caenorhabditis elegans using a combination of advanced imaging techniques that include total internal reflection fluorescence microscopy (TIRF-M), confocal microscopy and correlated light and electron microscopy (CLEM).
Department of Molecular Chemistry and Materials Science
Postdoc position
Applications that show that the candidate did "due diligence" and understands the problem, will be answered
PD in understanding the fundamentals by studying electron transport through proteins. Work collaboration with M. Sheves and I. Pecht
More Information about Postdoc position
Proteins turn out to be, at least in the form of ultra-thin films (i.e., a form that is potentially useful for electronics) to be remarkable conductors and in some ways defy what we know about solid state electronics.
They are dynamically disordered systems, but can conduct like rigid conjugated polymers or better. They show a lack of temperature dependence that fits quantum tunneling.
Indeed, we have shown that for small proteins such process is likely the dominant one.
However, the temperature independence is found also for large proteins, i.e., over distances where we know that such mechanism cannot be efficient enough for us to be able to measure.
These findings, made here and reproduced by other groups, could well be the result of a novel mechanism, a tantalizing prospect that explains the fundamental science interest in protein electronics.
Parts of our are collaborations with experimentalists and theorists abroad.
iScience, 23, 101099 (2020)
Rep. Progr. Physics, 81, 026601 (2018)
Department of Molecular Chemistry and Materials Science
MSc rotation
Available Rotations: 3rd
Photovoltaic (Solar) Cells
More Information about MSc rotation
Solar to electrical energy conversion is being revolutionized and you can be part of it; we work mainly on halide perovskite solar cells but also try to learn new materials chemistry and physics secrets from these to see if, and how their amazing properties can be generalized. The work is in collaboration with Prof. Gary Hodes and parts also with Profs. Igor Lubomirsky, Boris Rybtchinsky and Leeor Kronik.
Department of Molecular Chemistry and Materials Science
MSc rotation
Available Rotations: 1st,2nd,3rd
Making,analyzing and understanding solar cells.
More Information about MSc rotation
Molecular electronics needs, in many cases, methods to make electrical contacts to molecules in a soft way so as not to damage the molecules. We have developed several methods for this,which appear to leave the molecules intact. However, it is very hard to get information on the chemical interactions between the molecules and the metal above them or between the molecules and the substrate, after contact deposition.
In this project you will be using a combination of physical and chemical methods to accomplish this.
Department of Molecular Chemistry and Materials Science
MSc rotation
Available Rotations: 1st,2nd,3rd
Bio-opto-electronics:
Understanding the fundamentals by studying electron transport through proteins
with M. Sheves, I. Pecht
More Information about MSc rotation
cf.
http://wis-wander.weizmann.ac.il/site/en/weizman.asp?pi=422&doc_id=4585&interID=4578&sq=4578
Hebrew: http://wis-wander.weizmann.ac.il/site/he/weizman.asp?pi=439&doc_id=4565&interID=4547&sq=4547
Department of Neurobiology
MSc rotation
Available Rotations: 2nd,3rd
Neurobiology of Stress: Regulation of neuroendocrine stress by the CRF/Urocortin peptide family and their receptors.
More Information about MSc rotation
Maintenance of homeostasis in the presence of real or perceived challenges requires numerous adaptive responses involving changes in the central nervous, endocrine and immune systems.
The neuropeptide corticotropin releasing factor (CRF), originally isolated from the hypothalamus, plays an important and well-established role in the regulation of the hypothalamus-pituitary-adrenal (HPA) axis under basal and stress conditions. It has been proposed that CRF integrates the endocrine, autonomic and behavioral responses to stressors. Dysregulation of the stress response can have severe psychological and physiological consequences. Chronic hyperactivation of the CRF system has been linked to many affective disorders such as anxiety, anorexia nervosa and melancholic depression. In addition to CRF, the mammalian CRF-peptide family contains urocortin 1, and the recently isolated peptides, urocortin 2, also known as stresscopin-related peptide, and urocortin 3, also known as stresscopin. The effects of CRF-related peptides are mediated through activation of two high affinity membrane receptors, CRF receptor 1 (CRFR1) and CRFR2. CRF has relatively lower affinity for CRFR2 compared to its affinity for CRFR1, Urocortin 1 has equal affinities for both receptors and Urocortin 2 and Urocortin 3 appear to be selective for CRFR2.
Specifying the contributions of the CRF family of ligands and receptors to the maintenance of homeostasis and to stress-linked allostasis may improve our ability to design therapeutic interventions and thus manage affective and other disorders.
We will use integrative molecular, biochemical, cellular and behavioral methods, with focus on the generation of transgenic mice models as an in vivo tool to study the physiological roles of CRF family neuropeptides and receptors in coordinating the endocrine, autonomic and behavioral responses to stress. Genetic manipulation of CRF signaling pathways in the whole animal context will permit us to understand their role in behavioral and physiological functions.
Department of Earth and Planetary Sciences
MSc rotation
Available Rotations: 1st,2nd,3rd
Theoretical/numerical modelling, and laboratory experiments, to investigate a wide range of physical and biogeochemical transport processes in geological materials and other porous materials.
More Information about MSc rotation
A variety of tools from physics, mathematics and chemistry are integrated in our theoretical/numerical and experimental studies. Our projects range from analysis of fluid flow and chemical transport in geological formations, to development of physico-chemical methods to remediate water polluted by organic and metal compounds, to theoretical analyses of transport processes using methods of statistical physics. Methods to analyze transport and diffusion can be applied also to tissues and cells.
Department of Earth and Planetary Sciences
MSc rotation
Available Rotations: 1st,2nd,3rd
Theoretical/numerical modelling, and laboratory experiments, to investigate a wide range of physical and biogeochemical transport processes in geological materials and other porous materials.
More Information about MSc rotation
A variety of tools from physics, mathematics and chemistry are integrated in our theoretical/numerical and experimental studies. Our projects range from analysis of fluid flow and chemical transport in geological formations, to development of physico-chemical methods to remediate water polluted by organic and metal compounds, to consideration of biological processes in soils. Methods to analyze transport and diffusion can be applied also to tissues and cells.
Department of Biomolecular Sciences
MSc rotation
Available Rotations: 1st,2nd,3rd
Molecular mechanisms of chemotactic signal transduction in bacteria
More Information about MSc rotation
We are exploring signal transduction strategies using bacterial chemotaxis as a model. In chemotaxis of bacteria such as Escherichia coli or Salmonella typhimurium, the direction of rotation of the bacterial flagella is modulated so that the bacteria approach attractants and retreat from repellents. We are trying to understand how chemotactic signals are processed within less than a second, and how the response regulator of this system transmits this signal to the flagella. Of all the known signal transduction systems, this is the system that is best understood. However, even here, many major questions are still open and many of the mechanisms are still a ֲ‘black boxֲ’. Findings made in this system are likely to have implications to many other signal transduction systems, both in prokaryotes and eukaryotes.
Department of Biomolecular Sciences
MSc rotation
Available Rotations: 1st,2nd,3rd
Sperm-egg communication in humans and relation to fertility
More Information about MSc rotation
Observations made in our laboratory suggest that in humans, the egg and sperm communicate prior to fertilization by way of chemotaxis. This process is mediated by a factor secreted from the egg or its surrounding cells and detected by the sperm cells. We are trying to identify and characterize the chemotactic factors and their receptors on the sperm and to understand the molecular and physiological mechanisms of this process.
Department of Molecular Genetics
MSc rotation
Available Rotations: 2nd,3rd
Analysis of transcription in response to mechanical inputs applied on the nuclear envelope.
More Information about MSc rotation
My lab is interested to reveal the influence of mechanical forces on nuclear output. We study how forces produced in the cytoplasm are transduced into the nucleus and affect transcription. We hypothesize that mechanical forces applied on the nuclear envelope affect the 3D organization of the chromatin, and that this further influences the epigenetic state of the chromatin, and the extent of transcription. Our studies are based on numerous imaging analyses of chromatin 3D organization and quantitative analyses of the outcome.
Department of Molecular Genetics
Postdoc position
Transcriptional sensitivity to nuclear mechanical outputs in muscle fibres.
More Information about Postdoc position
The lab studies how mechanical inputs applied on the nucleus affect chromatin organization and transcription in muscle fibres in vivo. For our studies we use Drosophila larval muscles as a model which is sensitive to mechanical inputs, and in addition is amenable genetically, and enables live imaging at high resolution. A genomic analysis using the DamId methodology has been performed to uncover the binding profile of RNA-Pol II, Polycomb and HP1 in a mutant in which the transduction of mechanical inputs into the nuclei is impaired. The project involves the analysis of these profiles and further revealing their functional significance. The work involves molecular studies as well as high resolution imaging.
Department of Molecular Genetics
MSc rotation
Available Rotations: 1st,2nd,3rd
A new lab dealing with stem cell reprograming studies is looking for computational biology students.
More Information about MSc rotation
The lab is conducting basic and applied research in molecular mechanisms responsible for pluripotency. The research is done using cutting-edge high throughput technologies such as next-generation sequencing and single-cell microscopy, presenting many opportunities for systems-biology computational research. Please contact us for further information.
Department of Molecular Genetics
MSc rotation
Available Rotations: 1st,2nd,3rd
How life arose on earth is the greatest enigma in biology and chemistry. Our laboratory has developed a computerized model with deep roots in chemistry and biochamistry for an early emergence of life based on the unique, rarely realized propeties of lipid molecules. The model shows a much higher robability of life's emergence than what characterizes the popular but problematic "RNA World" model". Candidates with interst in evolutionary pathways and with multidisiplinary inclination are wolcome.
Department of Molecular Genetics
MSc rotation
Available Rotations: 1st,2nd,3rd
How life arose on earth is the greatest enigma in biology and chemistry. Our laboratory has developed a computerized model with deep roots in chemistry and biochamistry for an early emergence of life based on the unique, rarely realized propeties of lipid molecules. The model shows a much higher robability of life's emergence than what characterizes the popular but problematic "RNA World" model". Candidates with interst in evolutionary pathways and with multidisiplinary inclination are welcome.
Department of Immunology
MSc rotation
Available Rotations: 1st,2nd,3rd
Functional Pre-Clinical Models for Normal and Leukemic Human Stem Cells:
Molecular and cellular communication between stem cells and the bone marrow microenvironment.
Department of Molecular Genetics
Postdoc position
Intracellular and intercellular RNA trafficking
Department of Molecular Genetics
MSc rotation
Available Rotations: 1st,2nd,3rd
Intracellular and intercellular mRNA trafficking
Department of Molecular Genetics
PhD position
Intracellular and intercellular mRNA trafficking
Department of Molecular Genetics
MSc rotation
Available Rotations: 1st,2nd,3rd
Intracellular and intercellular mRNA trafficking
Department of Chemical and Biological Physics
MSc rotation
Available Rotations: 2nd,3rd
Nanoplasmonics- interaction of light with small metallic particles and molecules
Department of Chemical and Biological Physics
MSc rotation
Available Rotations: 2nd,3rd
Single-molecule fluorescence experiments to study protein folding and dynamics.
Department of Molecular Genetics
MSc rotation
Available Rotations: 1st,2nd,3rd
How do fusing cells known when to stop fusing?
More Information about MSc rotation
Cell-cell fusion is an uncommon but essential process in our bodies. While a lot is known about how cell fusion initiates, very little is known about how the process is regulated and eventually terminated when "enough" fusion has occurred. We study these issues in osteoclasts, multi-nucleated cells that degrade bone and which are formed by fusion of monocyte precursor cells. Our studies focus on fusion of osteoclasts from wild-type mice and also from mice carrying mutated forms of sorting nexin 10 (SNX10), which fuse continuously and uncontrollably. Join us to characterize the molecular and cellular mechanisms that regulate osteoclast fusion!
Department of Molecular Genetics
MSc position
How do fusing cells know when to stop fusing?
More Information about MSc position
Cell-cell fusion is an uncommon but essential process in our bodies. While a lot is known about how cell fusion initiates, very little is known about how the process is regulated and eventually terminated when "enough" fusion has occurred. We study these issues in osteoclasts, multi-nucleated cells that degrade bone and which are formed by fusion of monocyte precursor cells. Our studies focus on fusion of osteoclasts from wild-type mice and also from mice carrying mutated forms of sorting nexin 10 (SNX10), which fuse continuously and uncontrollably. Join us to characterize the molecular and cellular mechanisms that regulate osteoclast fusion!
Department of Molecular Genetics
Postdoc position
How do fusing cells stop fusing?
More Information about Postdoc position
Cell-cell fusion is an uncommon but essential process in our bodies. While a lot is known about how cell fusion initiates, very little is known about how the process is regulated and eventually terminated when "enough" fusion has occurred. We study these issues in osteoclasts, multi-nucleated cells that degrade bone and which are formed by fusion of monocyte precursor cells. Our studies focus on fusion of osteoclasts from wild-type mice and also from mice carrying mutated forms of sorting nexin 10 (SNX10), which fuse continuously and uncontrollably. Join us to characterize the molecular and cellular mechanisms that regulate osteoclast fusion! Preference will be given to individuals with experience in proteomics and in advanced molecular techniques.
Department of Molecular Genetics
PhD position
How do fusing cells stop fusing?
More Information about PhD position
Cell-cell fusion is an uncommon but essential process in our bodies. While a lot is known about how cell fusion initiates, very little is known about how the process is regulated and eventually terminated when "enough" fusion has occurred. We study these issues in osteoclasts, multi-nucleated cells that degrade bone and which are formed by fusion of monocyte precursor cells. Our studies focus on fusion of osteoclasts from wild-type mice and also from mice carrying mutated forms of sorting nexin 10 (SNX10), which fuse continuously and uncontrollably. Join us to characterize the molecular and cellular mechanisms that regulate osteoclast fusion!
Department of Molecular Genetics
MSc position
Formation and function of osteoclasts (bone resorbing cells) in vitro and in vivo, in health and disease.
More Information about MSc position
Bone degradation by specialized cells (osteoclasts) is a normal process and helps maintain normal bone structure and function; it's absence, as in the genetic disease osteopetrosis, is lethal. Our group studies how specific proteins (tyrosine phosphatases and others) affect production and function of these critical cells, using advanced molecular, cellular, and whole-organism approaches.
Department of Molecular Genetics
MSc rotation
Available Rotations: 1st,2nd,3rd
Formation and function of osteoclasts (bone resorbing cells) in vitro and in vivo, in health and in disease.
More Information about MSc rotation
Bone degradation by specialized cells (osteoclasts) is a normal process and helps maintain normal bone structure and function; it's absence, as in the genetic disease osteopetrosis, is lethal. Our group studies how specific proteins (tyrosine phosphatases and others) affect production and function of these critical cells, using advanced molecular, cellular, and whole-organism approaches.
Department of Molecular Genetics
PhD position
Formation and function of osteoclasts (bone resorbing cells) in vitro and in vivo, in health and in disease.
More Information about PhD position
Bone degradation by specialized cells (osteoclasts) is a normal process and helps maintain normal bone structure and function; it's absence, as in the genetic disease osteopetrosis, is lethal. Our group studies how specific proteins (tyrosine phosphatases and others) affect production and function of these critical cells, using advanced molecular, cellular, and whole-organism approaches.
Department of Molecular Chemistry and Materials Science
MSc rotation
Available Rotations: 1st,2nd,3rd
Infinite three-dimensional porous networks incorporating photoswitchable molecules
More Information about MSc rotation
In this project we will develop a family of highly porous, ultralight materials incorporating photoswitchable molecules - that is, molecules which can exist in two different conformations (isomers), depending on the wavelength of light that the system is exposed to. These materials will have potential applications in light-controlled uptake and release of different "guest" molecules.
Department of Molecular Chemistry and Materials Science
MSc rotation
Available Rotations: 1st,2nd,3rd
Chemical reactivity in confined spaces
More Information about MSc rotation
Hi! We are a multidisciplinary lab working in the fields spanning from organic synthesis to nanotechnology. M.Sc. students interested in organic, physical, materials, and colloidal chemistry should find our research appealing, and we invite them to participate in it! The ultimate goal of this project is to develop synthetic analogues of enzymes. We will prepare molecular architectures featuring confined spaces, similar to the enzymatic active sites. We expect that the behavior of chemical species placed inside these confined environments will be modified. Consequently we aim to demonstrate the possibility to accelerate chemical reactions inside these environments, and to show that the selectivies of reactions can be different from those occurring in solution.
Department of Molecular Chemistry and Materials Science
MSc rotation
Available Rotations: 1st,2nd,3rd
Properties and applications of metallic nanobowls
More Information about MSc rotation
This project is a continuation of a M.Sc. project of a student who developed a synthesis of metallic nanoparticles with a unique shape of bowls (we call them "nanobowls") (the M.Sc. thesis was published as: http://www.weizmann.ac.il/Organic_Chemistry/Rafal/pub/Metallic_nanobowls_by_galvanic_replacement_reaction_on_heterodimeric_nanoparticles.pdf). We now aim to demonstrate some useful applications of the nanobowls - most importantly, we will load the bowls with nanoscale cargo (e.g., drug molecules) for controlled delivery and release.
Department of Biomolecular Sciences
Postdoc position
Size and growth control in neurons and other large cells - do cells sense their own size and how can they do that?
More Information about Postdoc position
Size matters, especially in neurons. Differentiated cells in higher eukaryotes exhibit a wide variety of shapes and sizes, while maintaining defined size ranges within cell subtypes. How do they do that? Genome expression must be matched to different cell sizes, with rapidly growing cells likely requiring higher transcriptional and translational output than cells in slow growth or maintenance phase. Neurons exhibit the greatest size differences of any class of cells, with process lengths ranging from a few microns in central interneurons to a meter in human peripheral neurons, and even longer in larger mammals. We are working on mechanisms of cell length and size sensing in neurons and other large cells, and how these mechanisms control growth and regeneration. People can integrate to a range of projects within this theme. For general information on our research please see the group home page at http://www.weizmann.ac.il/Biomolecular_Sciences/Fainzilber/ . Please note that research in our group requires work in animal models (mice, rats).
Position available from March 1, 2021
Department of Biomolecular Sciences
PhD position
Size and growth control in neurons and other large cells - do cells sense their own size and how can they do that?
More Information about PhD position
Size matters, especially in neurons. Differentiated cells in higher eukaryotes exhibit a wide variety of shapes and sizes, while maintaining defined size ranges within cell subtypes. How do they do that? Genome expression must be matched to different cell sizes, with rapidly growing cells likely requiring higher transcriptional and translational output than cells in slow growth or maintenance phase. Neurons exhibit the greatest size differences of any class of cells, with process lengths ranging from a few microns in central interneurons to a meter in human peripheral neurons, and even longer in larger mammals. We are working on mechanisms of cell length and size sensing in neurons and other large cells, and how these mechanisms control growth and regeneration. People can integrate to a range of projects within this theme. For general information on our research please see the group home page at http://www.weizmann.ac.il/Biomolecular_Sciences/Fainzilber/ . Please note that research in our group requires work in animal models (mice, rats).
Position available from March 1, 2021
Department of Biomolecular Sciences
MSc rotation
Available Rotations: 1st,2nd,3rd
Size and growth control in neurons and other large cells - do cells sense their own size and how can they do that?
More Information about MSc rotation
Size matters, especially in neurons. Differentiated cells in higher eukaryotes exhibit a wide variety of shapes and sizes, while maintaining defined size ranges within cell subtypes. How do they do that? Genome expression must be matched to different cell sizes, with rapidly growing cells likely requiring higher transcriptional and translational output than cells in slow growth or maintenance phase. Neurons exhibit the greatest size differences of any class of cells, with process lengths ranging from a few microns in central interneurons to a meter in human peripheral neurons, and even longer in larger mammals. We are working on mechanisms of cell length and size sensing in neurons and other large cells, and how these mechanisms control growth and regeneration. People can integrate to a range of projects within this theme. For general information on our research please see the group home page at http://www.weizmann.ac.il/Biomolecular_Sciences/Fainzilber/ . Please note that research in our group requires work in animal models (mice, rats).
Department of Biological Regulation
MSc rotation
Available Rotations: 1st,2nd,3rd
Does MTCH2 function as a bridge between metabolism and apoptosis?
More Information about MSc rotation
Mitochondrial Carrier Homolog 2 (MTCH2) functions as a receptor-like protein for the pro-apoptotic BID protein (Zaltsman et al. Nat Cell Biol 2010), and was recently also identified as a new gene loci associated with obesity in humans. To assess the involvement of MTCH2 in metabolism, we initially examined its role in the skeletal muscle using a MTCH2 conditional knockout mouse. Our initial studies demonstrate that MTCH2 bridges bewteen metabolism and apoptosis and this position is open to further characterize the nature of this bridge.
Department of Molecular Chemistry and Materials Science
MSc rotation
Available Rotations: 1st,2nd,3rd
Nanoporous solar cells,
Quantum dot solar cells,
Solution deposition of semiconductors for solar cells
Department of Chemical and Structural Biology
MSc rotation
Available Rotations: 1st,2nd,3rd
Single-molecule fluorescence spectroscopy of protein interactions and dynamics
Department of Chemical and Structural Biology
MSc rotation
Available Rotations: 1st,2nd,3rd
Single-molecule fluorescence spectroscopy of protein interaction and dynamics
Department of Chemical and Structural Biology
MSc rotation
Available Rotations: 3rd
We study the DNA-binding dynamics of transcription factors using single-molecule fluorescence spectroscopy. In your rotation, you will express, purify, and fluorescently label proteins and DNA.
Department of Chemical and Structural Biology
MSc rotation
Available Rotations: 3rd
Single-molecule dynamics in stochastic phenotype switching.
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You will recombinantly express and purify the transcription factor ComK, which is responsible for a stochastic phenotype switch in bacteria. After labeling DNA with fluorophores, you will use single-molecule FRET experiments to investigate the affinity of ComK for its promoter sequence.
Department of Molecular Genetics
Postdoc position
Molecular mechanisms of neurodegeneration.
More Information about Postdoc position
Are you looking for postdoctoral training in molecular neuroscience / neurodegeneration?
Join our exploration of how RNA and microRNA keep brain integrity.
Our projects integrate human genetics, bioinformatics, proteomics and animal disease models of ALS to uncover the functions of regulatory RNAs, including microRNAs, in the central nervous system. Our longstanding mission is to understand the mechanisms of RNA malfunction in neurodegeneration.=========
keywords: RNA * membraneless organelles * stress granules * neurodegeneration * ageing * brain integrity * motor neuron * proteomics * transcriptomics * genomics * human genetics * non-coding
Department of Earth and Planetary Sciences
MSc rotation
Available Rotations: 1st,2nd,3rd
Research projects on:
Climate change
Physics and Mathematics of Clouds
Cloud aerosol interactions
Radiation transfer and remote sensing of the atmosphere
Pattern recognition and computer vision of the atmosphere
Department of Physics of Complex Systems
MSc rotation
Available Rotations: 1st,2nd,3rd
A variety of projects in the context of ant collective behavior are available. Projects can be experimental, computational , or both and will be tailored to the background and interests of the student.
Department of Physics of Complex Systems
MSc rotation
Available Rotations: 1st,2nd,3rd
A variety of projects in the context of ant collective behavior are available. Projects can be experimental, computational or both and will be tailored to the background and interests of the rotation student.
Department of Chemical and Biological Physics
MSc rotation
Available Rotations: 1st,2nd,3rd
AFM functionality in a confocal fluorescence microscope
Department of Chemical and Biological Physics
MSc rotation
Available Rotations: 2nd,3rd
Encapsulated cell on diamond
Department of Chemical and Biological Physics
PhD position
Hybrid quantum devices - combining NV centers in diamond with superconducting resonators via mechanical oscillators
More Information about PhD position
The QuEST lab is searching for an PhD student for a project combining NV centers in diamond with superconducting resonators via mechanical oscillators. You will fabricate nanobridges in diamond and then characterize them by optical means. The work will be conducted in collaboration with groups in the Technion and Bar-Ilan University in the framework of a Quantum Science and Technologies project funded by the Israel Science Foundation. For more details, please contact: Amit Finkler, amit.finkler@weizmann.ac.il, ext. 2021 or visit our lab on the second floor of the Schmidt building!
Dr. Markus Huecker
Department of Condensed Matter Physics
Postdoc position
Postdoctoral Fellowship:
Synthesis and study of topological Weyl semimetals and van der Waals heterostructures
More Information about Postdoc position
There are two classes of quantum materials that take the condensed matter community by storm, topological materials, and van der Waals heterostructures. In these materials specific electronic band structures, magnetic properties, and confinement of electrons to two dimensions lead to new states of matter that can only be described through quantum physics. Our group specializes in the synthesis and in-depth study of these materials, using the facilities of our recently established quantum materials laboratory. The project focuses on topological Weyl semimetals which are of great interest, first as playground for new types of topology protected surface states in bulk crystals, and second as important building blocks for van der Waals heterostructures when exfoliated down to few-layer or monolayer crystal sheets. The candidate will engage in synthesis and detailed experimental study of high purity single crystals, develop advanced synthesis methods, and closely collaborate with our ab-initio materials simulation group, as well as our nano-probe microscopy groups. Our infrastructure offers a wide range of facilities for chemical, structural and physical property analysis, and all aspects of device fabrication. Synchrotron x-ray scattering at international facilities, high pressure experiments, and involvement in nano-probe microscopy experiments are further options, depending on background and inclination. The candidate should have extensive experience in materials synthesis and characterization, device fabrication, and the physics of topological materials or van der Waals heterostructures. The initial contract is for one year with possibility of extension up to three years pending on progress. Interested candidates should send a CV with list of publications to markus.huecker@weizmann.ac.il.
Department of Biomolecular Sciences
MSc rotation
Available Rotations: 1st,2nd,3rd
Computational design of protein function
More Information about MSc rotation
Our lab uses computer algorithms to design the structure and sequence of proteins to obtain new function. We work on antibodies, enzymes, and membrane proteins. For more details on current research directions, please see our website: http://www.fleishmanlab.org/
Department of Molecular Cell Biology
Postdoc position
The dynamics of senescent cells during ageing - computational (bioinformatic) approach
More Information about Postdoc position
Senescent cells (SnCs) are cells that become damaged and stop dividing, secreting factors called senescence associated secreted profile (SASP). In young organisms, formation of SnCs is necessary in order to prevent cancer and repair wounds, keeping the tissue intact while the immune system removes the SnCs. However SnCs accumulate exponentially with age, becoming so abundant in old organisms that they cause chronic inflammation and slow regeneration to such an extent that they contribute to disease and death. We want to understand the timing of the accumulation of senescent cells and how it is regulated. If you are interested in ageing research and highly motivated to contribute to extension of health-span you are welcome to apply. We look for someone with strong background in mathematical and computational approaches who would be able to integrate data analysis into understanding of molecular and cellular mechanisms of ageing.
Department of Molecular Cell Biology
MSc rotation
Available Rotations: 1st,2nd,3rd
The role of cellular senescence in cancer, aging and embryonic development
More Information about MSc rotation
The rotation projects aim to answer the following questions:
How senescence contributes to normal embryonic development? What are the mechanisms regulating the interactions of senescent cells with their microenvironment? How presence of senescent cells is regulated in the organism?
Department of Molecular Cell Biology
Postdoc position
We are looking for highly motivated post-doctoral fellow or research associate to an ERC funded project studying the "Biology of Ageing"
More Information about Postdoc position
We are looking for highly motivated post-doctoral fellow or research associate to an ERC funded project studying the "Biology of Ageing" at Weizmann Institute. The project is a collaboration of laboratories of Uri Alon, Tali Kimchi and Valery Krizhanovsky. It will combine cutting edge methods in molecular and cellular biology, behavioral neuroscience and system biology in mouse models. An expertise in behavioral neuroscience, molecular biology and mouse models is a plus.
Department of Chemical and Biological Physics
Postdoc position
Development of new scanning methods in nuclear magnetic resonance for biomolecular research, and of magnetic resonance imaging with applications on ultrahighfield preclinical and clinical research and diagnosis
Department of Chemical and Biological Physics
MSc position
Available Rotations: 1st,2nd,3rd
Development and applications of new methods in in vivo magnetic resonance, including clinical MRI
More Information about MSc position
Development of new scanning methods in magnetic resonance imaging, with applications in ultrahighfield preclinical and clinical research and diagnosis - including human scanning at 3T and 7T with advanced acquisition techniques
Department of Chemical and Biological Physics
PhD position
New scanning methods in magnetic resonance imaging, with applications on ultrahighfield preclinical and clinical research and diagnosis
More Information about PhD position
Development of new scanning methods in nuclear magnetic resonance spectroscopy and magnetic resonance imaging, with applications in ultrahighfield preclinical and clinical research and diagnosis - including human scanning at 3T and 7T with advanced acquisition techniques
Department of Chemical and Biological Physics
MSc rotation
Available Rotations: 1st,2nd,3rd
Development of new methods in multidimensional magnetic resonance (NMR and MRI)
Department of Biomolecular Sciences
MSc rotation
Available Rotations: 1st,2nd,3rd
Please see my web site at https://www.weizmann.ac.il/Biomolecular_Sciences/Futerman/
More Information about MSc rotation
See my lab web page
Department of Biomolecular Sciences
MSc rotation
Available Rotations: 1st,2nd,3rd
Please see my website at http://www.weizmann.ac.il/Biomolecular_Sciences/Futerman/
More Information about MSc rotation
See my web page
Department of Biomolecular Sciences
Postdoc position
We are looking for a postdoctoral fellow to work on a new and exciting project on lipid complexity. There are many more lipids in cells and in cell membranes than once thought and this complexity has significant ramifications for understanding both the roles of lipids in the origin of life and also in modern cell function. A position is available for an enthusiastic candidate to work on lipids in the origin of life, lipid fine-tuning, and functional studies of lipid complexity. For publications and details see the lab web page at
https://www.weizmann.ac.il/Biomolecular_Sciences/Futerman/
More Information about Postdoc position
See short description
Department of Biomolecular Sciences
Postdoc position
We are looking for a postdoctoral fellow to work on a new and exciting project on lipid complexity. There are many more lipids in cells and in cell membranes than once thought and this complexity has significant ramifications for understanding both the roles of lipids in the origin of life and also in modern cell function. A position is available for an enthusiastic candidate to work on lipids in the origin of life, lipid fine-tuning, and functional studies of lipid complexity. For publications and details see the lab web page at
https://www.weizmann.ac.il/Biomolecular_Sciences/Futerman/
More Information about Postdoc position
See short description
Department of Biomolecular Sciences
MSc rotation
Available Rotations: 1st,2nd,3rd
Sphingolipids in health and disease
More Information about MSc rotation
See my web page for more details of our work http://www.weizmann.ac.il/Biological_Chemistry/scientist/futerman/ We are an active lab with at least one opening for a rotation/MSC student
Department of Molecular Cell Biology
MSc rotation
Available Rotations: 1st,2nd,3rd
Mathematical modelling of mammalian tissues
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Our lab studies how single cells cooperate in complex tissues to bring about physiological goals. A range of computational projects ranging from single molecules through single cells to the entire organism in health and disease are available. Matlab programming skills are essential.
Department of Molecular Genetics
MSc position
Chameleons, copepods, fish, and many other organisms, use organic crystals for an astonishing variety of optical functions. These crystals are formed by specialized cells, in which remarkable control over crystal shape, size, and assembly is obtained using strategies that are beyond the state of the art in materials science. While these cells were identified many years ago, almost nothing is known about their biology, particularly the cellular processes involved in organic crystal formation. We use biological tools and physical and chemical methodologies to study the processes organisms use to produce either optically functional or pathological bio-organic crystals. Our primary model organisms for these studies are zebrafish and medaka.
Department of Molecular Genetics
PhD position
Chameleons, copepods, fish, and many other organisms, use organic crystals for an astonishing variety of optical functions. These crystals are formed by specialized cells, in which remarkable control over crystal shape, size, and assembly is obtained using strategies that are beyond the state of the art in materials science. While these cells were identified many years ago, almost nothing is known about their biology, particularly the cellular processes involved in organic crystal formation. We use biological tools and physical and chemical methodologies to study the processes organisms use to produce either optically functional or pathological bio-organic crystals. Our primary model organisms for these studies are zebrafish and medaka.
Department of Molecular Genetics
MSc rotation
Available Rotations: 1st,2nd,3rd
Chameleons, copepods, fish, and many other organisms, use organic crystals for an astonishing variety of optical functions. These crystals are formed by specialized cells, in which remarkable control over crystal shape, size, and assembly is obtained using strategies that are beyond the state of the art in materials science. While these cells were identified many years ago, almost nothing is known about their biology, particularly the cellular processes involved in organic crystal formation. We use biological tools and physical and chemical methodologies to study the processes organisms use to produce either optically functional or pathological bio-organic crystals. Our primary model organisms for these studies are zebrafish and medaka.
Department of Molecular Genetics
Postdoc position
Chameleons, copepods, fish, and many other organisms, use organic crystals for an astonishing variety of optical functions. These crystals are formed by specialized cells, in which remarkable control over crystal shape, size, and assembly is obtained using strategies that are beyond the state of the art in materials science. While these cells were identified many years ago, almost nothing is known about their biology, particularly the cellular processes involved in organic crystal formation. We use biological tools and physical and chemical methodologies to study the processes organisms use to produce either optically functional or pathological bio-organic crystals. Our primary model organisms for these studies are zebrafish and medaka.
Department of Plant and Environmental Sciences
MSc rotation
Available Rotations: 1st,2nd,3rd
We follow mineralization pathways in marine phytoplankton using state-of-the-art microscopy, and apply various in vitro techniques to understand mineral formation mechanisms.
Department of Plant and Environmental Sciences
PhD position
Advanced electron microscopy project on fundamentals aspects of biomineralization in marine organisms
Department of Plant and Environmental Sciences
PhD position
An exciting new project on the cellular mechanisms of diatom silicification
Department of Plant and Environmental Sciences
MSc rotation
Available Rotations: 1st,2nd,3rd
Title: Reserach on signaling cascades regulating plant metabolism. Description: using molecular biology and microscopy tools to identify an interaction between a map kinase and a highly regulatory enzyme of amino acid metabolism in plants
Department of Plant and Environmental Sciences
MSc rotation
Available Rotations: 1st,2nd,3rd
Bio-silicification in wheat
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Silica is a unique biological material in the sense that it is not soluble within the tissue and its deposition is irreversible. Nevertheless the chemical condition for its deposition and the deposition location seem to be loosely controlled sometimes. This situation is untypical to biological systems. We use a combination of material sciences approach and genetic manipulations methods to study the bio-mineralization of this enigmatic material.
Department of Plant and Environmental Sciences
MSc rotation
Available Rotations: 1st,2nd,3rd
Combining Analytical Chemistry and Molecular Genetics for Studying the Genetic Regulation of Metabolic Pathways in Plants
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Plants produce thousands of different compounds helping them in adapting to changing environmental conditions. These so-called ֲ“secondary metabolitesֲ” are formed during plant development as well as upon diverse endogenous and environmental stimuli. Human beings encounter such compounds in their daily life as for example food flavors, color dyes, perfumes, scented oils and industrial products such as rubber and oils.
Asaph Aharoni recently set-up a new group which investigates regulatory networks controlling the biosynthesis of these compounds in the course of plant development and under stress conditions. New tools are currently being developed in the lab which will allow extensive metabolic profiling and the integration of metabolic data with information derived from other levels of regulation such as the transcriptome. This type of research activity requires a multidisciplinary approach combining molecular biology and chemistry.
During the period in our lab the student will acquire know-how either in molecular biology or analytical chemistry techniques to study a particular plant genotype, mutant or transgenic line. The student could also combine and experience both research fields.
We study the regulation of several key metabolic pathways in plants including:
A. The isoprenoid biosynthesis pathway that generates carotenoids (among them the compound lycopene that provides tomato its red color) in the course of tomato fruit ripening.
B. The shikimate pathway that directs carbon flow towards the biosynthesis of the three aromatic amino acids, phenylalanine, tryptophan and tyrosine. These three amino acids are the most important precursors for the production of secondary metabolites in plants.
C. The metabolic pathways leading to the formation of the four group of metabolites that make up the plant outer surface constituent, the cuticle. We study the regulation of plant surface pathways in both vegetative tissues (in the model plant Arabidopsis) and in reproductive organs (in tomato fruit peel).
Department of Plant and Environmental Sciences
MSc rotation
Available Rotations: 1st,2nd,3rd
Environmental stress eg. disease, drought and cold are major reasons for reduced plant productivity. Projects will develop and test novel mutants that will enhance our understanding of plant responses to stress.
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Local programmed cell death (PCD) is a major defense against types of pathogens that require living plant cells to thrive. Cell death and concomitant induction of additional defenses is part of the plant immune responses. However, excessive cell death caused by acute biotic and abiotic stress responses can be deleterious to plant survival. Furthermore, disease development or insect feeding in one part of the plant will generate a systemic response that will, within minutes, alter the transcriptome status of the whole-plant. We have identified novel molecular components involved in the signal transduction of the defense response and further downstream components that impact on cell death. These include receptor-like molecules, reactive oxygen species and regulators of protease cascades. Thus, at the molecular level and cellular level, understanding how plants decide and operate these defense pathways is revealing for fundamental aspects of plant biology and of great importance to agriculture. To understand the biology of plant responses we incorporate technologies that include: transgene expression in wild type and knock out plants, confocal fluorescent microscopy and luminescent gene reporting, molecular biology of regulatory protein complex formation with proteome and transcriptome analysis under dynamic states of stress.
Department of Immunology
MSc rotation
Available Rotations: 2nd
Study of monocyte-derived macrophages that are key players in IBD, incl. gene end epigenetic profiling, as well as novel manipulation strategies
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We are looking for highly motivated students that are interested to join us in our efforts to understand the generation of intestinal macrophages from circulating blood monocytes. Our key questions are (1) to define the molecular cues these cells receive in the small and large intestine, respectively, and (2) how the latter confer on the cells the specific and stable cell identities (transcriptomes, epigenetic profiles). Our approaches rely on novel cell ablation and reconstitution techniques, classical multiparameter fluorescence-based flow cytometry, as well as mass spectometry-based flowcytometry (CyTOFF). The ex vivo isolates will be coupled to next generation sequencing population and single cell sequencing for expression and epigenetic profiling. Monocyte-derived macrophages are key players in inflammatory bowel disorders and in depth understanding of their in vivo differentiation might pave the way for their therapeutic manipulation.
Department of Immunology
MSc rotation
Available Rotations: 1st
Study of monocyte-derived macrophages that are key players in IBD, incl. gene end epigenetic profiling, as well as novel manipulation strategies
Department of Immunology
MSc rotation
Available Rotations: 3rd
Study of monocyte-derived macrophages that are key players in IBD, incl. gene end epigenetic profiling, as well as novel manipulation strategies
More Information about MSc rotation
We are looking for highly motivated students that are interested to join us in our efforts to understand the generation of intestinal macrophages from circulating blood monocytes. Our key questions are (1) to define the molecular cues these cells receive in the small and large intestine, respectively, and (2) how the latter confer on the cells the specific and stable cell identities (transcriptomes, epigenetic profiles). Our approaches rely on novel cell ablation and reconstitution techniques, classical multiparameter fluorescence-based flow cytometry, as well as mass spectometry-based flowcytometry (CyTOFF). The ex vivo isolates will be coupled to next generation sequencing population and single cell sequencing for expression and epigenetic profiling. Monocyte-derived macrophages are key players in inflammatory bowel disorders and in depth understanding of their in vivo differentiation might pave the way for their therapeutic manipulation.
Department of Biomolecular Sciences
Postdoc position
We are looking for a postdoc to study microscopic and mesoscopic re-arrangements of photosynthetic complexes that govern the plant's response to high-light stress using high-end electron microscopy techniques.
Department of Biomolecular Sciences
MSc rotation
Available Rotations: 1st,2nd,3rd
We are interested in photosynthetic communities, their behaviour under fluctuating and stressful conditions, and their diversity and evolution.
More Information about MSc rotation
Our group is interested in the changes that occur in photosynthetic organisms when faced with varying conditions. Whereas organisms are usually grown in the lab under constant, well controlled conditions, real life organisms face vast changes in their environment that occur at time scales ranging from seconds to months. The ability of photosynthetic organisms to efficiently utilize a capricious energy source such as ambient light is remarkable. Even more impressive is their ability to withstand stress conditions. The group includes chemists, biologists, agronomists and physicists that use structural, omic, biophysical and molecular techniques to study photosynthetic organisms exposed to various environmental dynamics. At the machine level, our interests include the structure and function of the energy-transducing devices, their modulation by environmental parameters and their formation and breakdown. At the system or organismal level, we are interested in the mechanisms that enable photosynthetic organisms to withstand varying conditions and different stresses. We are also interested in understanding the complex structure and response of populations of organisms made to experience different levels of environmental dynamics and stresses.
Department of Molecular Cell Biology
MSc rotation
Available Rotations: 1st,2nd,3rd
Studies on stem cell differentiation, de-differentiation and tumorigenesis
Department of Neurobiology
MSc rotation
Available Rotations: 2nd,3rd
Physiology of the serotonin system
Department of Molecular Chemistry and Materials Science
MSc rotation
Available Rotations: 1st,2nd,3rd
Nanomaterials; nanostructured metal films; nanoparticles; nanoplasmonic systems; localized plasmon sensing; optical biosensors; study of biological interactions; thin films; electrochemistry.
Department of Chemical and Structural Biology
MSc rotation
Available Rotations: 2nd,3rd
Artificial "nose" for biomolecules
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Design of novel molecular sensing devices that operate similar to the mammalian Olfactory neural system.
We will prepare an array of non-specific receptors that can "smell" and diagnose biomolecules involved in particular diseases
Department of Chemical and Structural Biology
MSc rotation
Available Rotations: 2nd,3rd
Molecular-based "decision making" biocomputing devices
More Information about MSc rotation
We will design synthetic receptors mimic the function of digital computers.
Unlike the electronic devices, these molecules could operate in a liquid solution
and hence, will be able to respond in a logical way to changes that occur in the natural cell signaling pathways
Department of Chemical and Biological Physics
MSc rotation
Available Rotations: 1st,2nd,3rd
Studying electronic and spin properties of organic-inorganic interfaces
More Information about MSc rotation
We are studying the interaction of electrons with organic and bio-molecules applying various methods like laser spectroscopy, photoemission spectroscopy and transport (conduction). We produce hybrid supra-molecular structures that involve nanoparticles and chiral molecules and produce spin based devices.
For recent references please see:
1. B. G?hler,V. Hamelbeck, T.Z. Markus, M. Kettner, G.F. Hanne, Z. Vager,
R. Naaman, H. Zacharias, Spin Selectivity in Electron Transmission Through Self-Assembled Monolayers of dsDNA, Science 331, 894-897 (2011).
2. Zouti Xie, Tal Z. Markus, Sidney R. Cohen, Zeev Vager, Rafael Gutierrez, Ron Naaman, Spin specific electron conduction through DNA oligomers, Nano Letters, 11, 4652?4655 (2011).
Department of Computer Science and Applied Mathematics
MSc rotation
Available Rotations: 1st,2nd,3rd
Research project in mathematical statistics, analysis of high dimensional data and model selection
Department of Chemical and Biological Physics
Postdoc position
Positions are for development of lower bounds to energies which compete with the Ritz variational method in accuracy. They are for one year with option of renewal for another year. For more information visit my website: http://www.weizmann.ac.il/chemphys/pollak/positions
Department of Chemical and Biological Physics
Postdoc position
Positions are for development of lower bounds to energies which compete with the Ritz variational method in accuracy. They are for one year with option of renewal for another year. For more information visit my website: http://www.weizmann.ac.il/chemphys/pollak/positions
Department of Molecular Cell Biology
MSc rotation
Available Rotations: 1st,2nd,3rd
Development and function of the zebrafish hypothalamus (see: http://www.weizmann.ac.il/mcb/GLevkowitz/research)
Department of Chemical and Structural Biology
Postdoc position
Post-doc position in structural and/or systems biology
More Information about Postdoc position
We are: a fun, creative, and interdisciplinary team working at the interface of systems biology, protein structure, and synthetic biology. Our lab has excellent funding and state-of-the-art instruments.
We are now looking for: a post-doc to embark on ambitious ERC-funded research projects on the general topic of protein assembly in health and disease.
Your profile: you have a passion for biological systems, a solid publication track record, and you're motivated to solve nature's riddles.
Interested? Please send an email with your CV, a letter explaining your motivation, and the PDF of your most important paper to emmanuel.levy@weizmann.ac.il with the subject "Application for the Post-doc position in structural and/or systems biology"
About the Weizmann Institute: It is a world-leading institution with 250+ research groups. Ranked worldwide #3 by Nature index, #6 by Nature innovation index, and #9 by the Leiden Ranking for research quality. It offers an outstanding environment with state-of-the-art equipment and facilities. Situated on a beautiful campus with a vibrant and international atmosphere. It is well suited for families.
Department of Chemical and Structural Biology
MSc rotation
Available Rotations: 2nd,3rd
Discover new principles of protein organization in cells using a mixture of computational and experimental approaches.
Keywords: protein structure, protein evolution, protein interactions, yeast genetics, structural systems biology
More Information about MSc rotation
In a single yeast cell, the protein machinery is made of an estimated 50,000,000 protein molecules. Understanding how these proteins are organized in space and time with respect to each other to bring about life is a tremendous challenge central to biology, and at the core of our research.
In order to understand principles of protein organization inside cells, we use both in vivo and in silico approaches. These involve biochemistry, protein engineering, genetics, high-throughput screens, as well as in silico analyses of biological data - in particular of structural and network data.
You can check the web-site for more information: www.elevylab.org Department of Chemical and Structural Biology
MSc rotation
Available Rotations: 1st,2nd,3rd
Synthetic biology: Design of a protein chaperone
More Information about MSc rotation
The classic quote from Richard Feynman "What I cannot create I do not understand" best summarizes the motivation for this project, which goal is to design a chaperone based on a protein that is not itself a chaperone. This should reveal what properties are key to chaperones and thereby provide a proof that we understand how chaperones function.
Department of Particle Physics and Astrophysics
MSc rotation
Available Rotations: 2nd,3rd
Heavy Ion Physics with ATLAS at LHC
More Information about MSc rotation
For a student who likes challenges.
Department of Chemical and Structural Biology
MSc rotation
Available Rotations: 1st,2nd,3rd
Getting hands-on structural and diverse microscopic methods for studying cellular and viral processes.
Department of Biomolecular Sciences
MSc rotation
Available Rotations: 1st,2nd,3rd
We study how mammalian cells cope with DNA damage, and how they balance between accurate and mutagenic DNA repair, to reduce the load of mutations, genome instability, and cancer risk.
More Information about MSc rotation
Current projects:
(1) Principles of operation of mammalian error-prone DNA repair.
(2) Analysis of novel genes involved in mammalian DNA damage tolerance.
(3) Effect of nuclear architecture on DNA damage tolerance in mammalian cells.
(4) Mechanisms and regulation of DNA repair in embryonic stem cells.
(5) DNA repair in risk assessment and early detection of cancer.
Department of Chemical and Structural Biology
MSc rotation
Available Rotations: 1st,2nd,3rd
Developing and applying computational and experimental methods to design and discover new compounds for applications in chemical biology and drug discovery.
Department of Molecular Chemistry and Materials Science
MSc rotation
Available Rotations: 1st,2nd,3rd
Skills to master:
a) micromachining: films deposition, patterning, management of mechanical stress in MEMS;
b) impedance spectroscopy, pyroelectric and piezoelectric measurements);
c) advanced ellipsometry;
d) polarity engineering in organic crystals;
More Information about MSc rotation
Development of novel materials:
1. Point defect engineering in ceramics to create rubber-like ceramics and ceramic with large electromechanical effects;
2. Engineering of polarity in organic crystals; Pyroelectricity and piezoelectricity in organic crystals;
3. Measurements of ultra-low diffusion coefficients at room temperature in ionic and electronic conductors
Electrochemistry in high temperature melt for large scale Energy technologies (project requires special skills and responsibility);
Department of Particle Physics and Astrophysics
Postdoc position
The Large Array Survey Telescope (LAST) is an under construction
modular and cost-effective survey telescope.
The telescope will be composed of 48 telescopes, each of 28 cm diameter.
The array can act either as a 28 cm telescope, with a huge field of view of 355 deg^2,
or as a single 1.9 m telescope with a 7.4 deg^2 field of view.
When completed, in March 2021, it will be the survey telescope with
the highest grasp (observable volume per unit time) in the world.
Indeed, its grasp will be about four times that of the best available system today.
LAST science cases include:
(1) Searching for optical counterparts of gravitational wave events in order to study the physics of these explosions and the production of the heaviest elements in the Universe;
(2) The early detection of supernovae and transients; a search for rare short-duration events powered by radioactivity; and a search for shock cooling events that enable us to study supernova progenitors;
(3) Developing methods for high precision photometry from the ground,
that are critical for exoplanets detection;
(4) A search for the optical counterparts of short-duration gamma-ray bursts
in order to test the hypothesis that these are related to Neutron Stars merger events; and more.
We are looking for M.Sc./Ph.D. students and postdocs that will lead
some of these science topics with LAST.
Department of Particle Physics and Astrophysics
MSc position
The Large Array Survey Telescope (LAST) is an under construction
modular and cost-effective survey telescope.
The telescope will be composed of 48 telescopes, each of 28 cm diameter.
The array can act either as a 28 cm telescope, with a huge field of view of 355 deg^2,
or as a single 1.9 m telescope with a 7.4 deg^2 field of view.
When completed, in March 2021, it will be the survey telescope with
the highest grasp (observable volume per unit time) in the world.
Indeed, its grasp will be about four times that of the best available system today.
LAST science cases include:
(1) Searching for optical counterparts of gravitational wave events in order to study the physics of these explosions and the production of the heaviest elements in the Universe;
(2) The early detection of supernovae and transients; a search for rare short-duration events powered by radioactivity; and a search for shock cooling events that enable us to study supernova progenitors;
(3) Developing methods for high precision photometry from the ground,
that are critical for exoplanets detection;
(4) A search for the optical counterparts of short-duration gamma-ray bursts
in order to test the hypothesis that these are related to Neutron Stars merger events; and more.
We are looking for M.Sc./Ph.D. students and postdocs that will lead
some of these science topics with LAST.
Department of Particle Physics and Astrophysics
PhD position
The Large Array Survey Telescope (LAST) is an under construction
modular and cost-effective survey telescope.
The telescope will be composed of 48 telescopes, each of 28 cm diameter.
The array can act either as a 28 cm telescope, with a huge field of view of 355 deg^2,
or as a single 1.9 m telescope with a 7.4 deg^2 field of view.
When completed, in March 2021, it will be the survey telescope with
the highest grasp (observable volume per unit time) in the world.
Indeed, its grasp will be about four times that of the best available system today.
LAST science cases include:
(1) Searching for optical counterparts of gravitational wave events in order to study the physics of these explosions and the production of the heaviest elements in the Universe;
(2) The early detection of supernovae and transients; a search for rare short-duration events powered by radioactivity; and a search for shock cooling events that enable us to study supernova progenitors;
(3) Developing methods for high precision photometry from the ground,
that are critical for exoplanets detection;
(4) A search for the optical counterparts of short-duration gamma-ray bursts
in order to test the hypothesis that these are related to Neutron Stars merger events; and more.
We are looking for M.Sc./Ph.D. students and postdocs that will lead
some of these science topics with LAST.
Department of Particle Physics and Astrophysics
PhD position
The Large Array Survey Telescope (LAST) is an under construction
modular and cost-effective survey telescope.
The telescope will be composed of 48 telescopes, each of 28 cm diameter.
The array can act either as a 28 cm telescope, with a huge field of view of 355 deg^2,
or as a single 1.9 m telescope with a 7.4 deg^2 field of view.
When completed, in March 2021, it will be the survey telescope with
the highest grasp (observable volume per unit time) in the world.
Indeed, its grasp will be about four times that of the best available system today.
LAST science cases include:
(1) Searching for optical counterparts of gravitational wave events in order to study the physics of these explosions and the production of the heaviest elements in the Universe;
(2) The early detection of supernovae and transients; a search for rare short-duration events powered by radioactivity; and a search for shock cooling events that enable us to study supernova progenitors;
(3) Developing methods for high precision photometry from the ground,
that are critical for exoplanets detection;
(4) A search for the optical counterparts of short-duration gamma-ray bursts
in order to test the hypothesis that these are related to Neutron Stars merger events; and more.
We are looking for M.Sc./Ph.D. students and postdocs that will lead
some of these science topics with LAST.
Department of Molecular Cell Biology
MSc position
Deconvoluting bulk expression data from human breast tumors to infer breast cancer heterogeneity
More Information about MSc position
Breast cancer is the most common cancer and the second leading cause of cancer-related death in women worldwide. One of the main complications of the disease is heterogeneity of the cell populations that comprise each tumor. This heterogeneity may lead to breast cancer aggressiveness and challenges in treatment, since different cell populations may respond differently to treatments and confound prognosis.
By profiling single cells in a complex tumor population mix, single cell transcriptomics (scRNA-seq) imparts great advantages over traditional sequencing methods in dissecting heterogeneity in cell populations. Indeed, scRNA-seq studies have enabled the identification of distinct populations that correlate with poor prognosis and drug resistance. In contrast, bulk transcriptomic analyses can mask rare cell types that may be important in driving disease progression and/or metastases. Unfortunately, historically, the vast majority of patient samples has been analyzed in bulk.
The Oren (cancer biology) and Eldar (signal processing and AI) labs are uniting their expertise to tackle this important challenge in the field. We propose to deconvolute bulk transcriptomic data into virtual single cell data by using signal processing ideas of optimization and deconvolution combined with model-based deep learning methods. Success in this task will harness vast amounts of existing patient-derived data and will be a highly important contribution to our understanding of breast cancer. It will also lead more generally to the combination of transcriptomic models and deep learning methods in solving various clinical and biological problems.
Department of Molecular Cell Biology
MSc rotation
Available Rotations: 1st,2nd,3rd
Cancer molecular biology, with special emphasis on the role of the p53 tumor suppressor, regulation of cell proliferation and cell death, regulation and function of microRNAs, and the role of chromatin modifications in cancer.
More Information about MSc rotation
Specific research topics:
Regulation of p53 activity in normal & cancer cells.
Role of p53 in the cross-talk between cancer cells and their microenvironment.
Tumor suppressor networks, with emphasis on the cross-talk between the p53 and Lats2 tumor suppressors.
Regulation of nuclear import in cancer.
microRNAs and cancer, with emphasis on p53 as a regulator and a target of miRNAs.
Chromatin modifications and cancer, with emphasis on histone H2B ubiquitination as a new regulator of cancer-related processes and of stem cell biology.
Inflammation and cancer, with emphasis on the cross-talk between p53 and NF-kB
Involvement of p53 in the regulation of metabolic processes, including mitochondrial function, autophagy and oxidative stress-response.
Department of Biomolecular Sciences
MSc rotation
Available Rotations: 1st,2nd,3rd
Regulation of electrical signaling in cells, ion channels, GPCRs and calcium
More Information about MSc rotation
We are interested in signaling in excitable cells.
Ion channels physiology.
G protein coupled receptors signaling and regulation.
Ca signaling and homeostasis.
Department of Biomolecular Sciences
MSc rotation
Available Rotations: 1st,2nd,3rd
Regulation of electrical signaling in cells by Ion channels, GPCRs and Calcium
More Information about MSc rotation
We are interested in signaling in excitable cells. Ion channels physiology. G protein coupled receptors signaling and regulation. Ca signaling and homeostasis.
Department of Molecular Cell Biology
MSc rotation
Available Rotations: 1st,2nd,3rd
Development of myelinated nerves
Department of Condensed Matter Physics
PhD position
Scanning probe microscopy of quantum and topological states of matter
More Information about PhD position
Study of quantum and topological states of matter using novel scanning probe microscopy tools. We have recently developed a nano-SQUID (Superconducting Quantum Interference Device) that resides on a very sharp tip and allows imaging of local magnetic fields with single electron spin sensitivity. This device provides also a unique tool for nanoscale cryogenic thermal imaging with 1 ֲµK sensitivity allowing imaging of inelastic electron scattering from a single atomic defect. The project will focus on utilizing these new techniques for investigation of magnetism and dissipation in graphene, superconductors, and topological and quantum states of matter.
Department of Condensed Matter Physics
Postdoc position
More Information about Postdoc position
Study of quantum and topological states of matter using novel scanning probe microscopy tools. We have recently developed a nano-SQUID (Superconducting Quantum Interference Device) that resides on a very sharp tip and allows imaging of the local magnetic fields with sensitivity that is sufficient for detection of the magnetic field of a spin of a single electron. This device provides also a unique tool for nanoscale cryogenic thermal imaging with 1 ֲµK sensitivity sufficient for imaging of inelastic electron scattering from a single atomic defect. The project will focus on utilizing these new techniques for investigation of magnetism and dissipation in graphene devices, superconductors, and topological insulators. Funding is available for three years. Contract is for one year, and will be renewed with good progress. The candidate should have a demonstrated potential for excellence in research. Advantage for background in transport and magnetization measurements, cryogenic systems, scanning probe systems, programming and computationally intensive data analysis; microfabrication techniques and clean room facilities; comfort working in a collaborative setting. Interested candidates should send CV and list of publications to eli.zeldov@weizmann.ac.il
Department of Molecular Genetics
MSc rotation
Available Rotations: 1st,2nd,3rd
I am looking for partners to join me on my journey to a deeper understanding of the development of the musculoskeletal system. Must bring along your own curiosity and passion.
Department of Molecular Chemistry and Materials Science
MSc rotation
Available Rotations: 1st,2nd,3rd
Design of organic reaction-diffusion systems
More Information about MSc rotation
Reaction-diffusion mechanisms are important for many biological functions such as embryo development, pattern formation, cell division, etc. Nevertheless, our ability to design synthetic reaction-diffusion systems is very limited. In this project, we use our ability to make molecules through organic synthesis to rationally design reaction-diffusion structures. By designing molecular structures we can control both rate constants of reactions in which these molecules participate and diffusion coefficients of these molecules. Thus, by combining organic synthesis with numerical models, which are based on rate constants and diffusion coefficients, we develop new ways to mimic biological functions in the synthetic systems.
Department of Molecular Chemistry and Materials Science
MSc rotation
Available Rotations: 1st,2nd,3rd
Chemoselective synthesis of guanidines
More Information about MSc rotation
In this project, you will explore the synthetic potential of the reaction between thiouronium salts and aminothiols that we have recently discovered. This reaction is, in a way, similar to the famous native chemical ligation reaction but forms guanidines instead of amides. Guanidine fragment is a common motif in biomolecules (e.g., in arginine) and in farmaceuticals. Therefore, its orthogonal synthesis (e.g., in the presence of amine groups in a substrate) will benefit areas of the protein modification and synthesis of pharmaceuticals.
Department of Molecular Genetics
MSc rotation
Available Rotations: 1st
How to pattern an embryo? use methods from statistical physics to try and shed light on early developmental processes
Department of Molecular Genetics
MSc rotation
Available Rotations: 1st
מה מותר האדם מן הקוף
Department of Molecular Genetics
MSc rotation
Available Rotations: 1st
How to pattern an embryo? use methods from statistical mechanics to try and shed light on early developmental processes
Department of Chemical and Structural Biology
MSc rotation
Available Rotations: 1st,3rd
Biomineralization or
antibodies against structured surfaces
Department of Physics of Complex Systems
MSc position
The study of quantum information unveils new possibilities for remarkable forms of computation, communication, and cryptography. We study the fundamental aspects of quantum entanglement and the unique ways of using them in quantum information processing tasks, such as quantum cryptography. We work on the theory side, utilizing insights and tools from the study of quantum physics, theoretical computer science and classical information theory.
The positions are relevant for students with physics, computer science and/or mathematics background.
Students from the Physics Department-- no need to come with background in computer science.
Students from the Computer Science Department-- no need to come with background in physics.
Department of Immunology
MSc rotation
Available Rotations: 1st,2nd,3rd
Anti tumor vaccines
Tumor Associated Antigens
Interferon stimulated genes
Tumor metastasis
More Information about MSc rotation
See homepage.
Department of Biological Regulation
Postdoc position
Cancer metabolism
More Information about Postdoc position
Working on metabolic changes that accompany carcinogenesis in cancer cells, mouse models, and human patients for translational relevance.
Department of Biological Regulation
PhD position
Available Rotations: 1st,2nd,3rd
Cancer metabolism
More Information about PhD position
Working on metabolic changes that accompany carcinogenesis in cancer cells, mouse models and human patients for translational relevance.
Department of Biological Regulation
MSc rotation
Available Rotations: 1st,2nd,3rd
Cancer genetic and metabolic analysis
Department of Computer Science and Applied Mathematics
MSc position
The Signal Acquisition, Modeling,Processing and Learning (SAMPL) lab headed by Prof. Yonina Eldar at the Weizmann Institute of Science is recruiting PhD, MSc and post-doctoral students for cutting-edge research applying machine learning and deep networks to clinical problems in collaboration with leading hospitals in Israel and abroad.
Candidates with strong algorithmic background are invited to send their CV to yonina.eldar@weizmann.ac.il.
Department of Computer Science and Applied Mathematics
MSc rotation
Available Rotations: 1st,2nd,3rd
Detecting unseen markers for disease using machine-learning image analysis:
inflammatory bowel disease (IBD) is a serious clinical condition affecting millions around the world. It is evident that some properties of the disease manifest before the onset of clinical symptoms. To date, these properties where shown on the molecular scale. To use them for clinical diagnosis would require adapting them to existing medical imaging methods.
In this project, we intend to detect the earliest signs of IBD in colonoscopy. Therefore, a machine learning solution capable to find the pre-clinical stages of inflammation through image analysis is required. This would include developing the algorithm and training it, while also tagging the training dataset.
The work will be performed in collaboration with the groups of Prof. Irit Sagi and Yonina Eldar.
Department of Computer Science and Applied Mathematics
MSc position
Detecting unseen markers for disease using machine-learning image analysis:
inflammatory bowel disease (IBD) is a serious clinical condition affecting millions around the world. It is evident that some properties of the disease manifest before the onset of clinical symptoms. To date, these properties where shown on the molecular scale. To use them for clinical diagnosis would require adapting them to existing medical imaging methods.
In this project, we intend to detect the earliest signs of IBD in colonoscopy. Therefore, a machine learning solution capable to find the pre-clinical stages of inflammation through image analysis is required. This would include developing the algorithm and training it, while also tagging the training dataset.
The work will be performed in collaboration with the groups of Prof. Irit Sagi and Yonina Eldar.
More Information about MSc position
Detecting unseen markers for disease using machine-learning image analysis:
inflammatory bowel disease (IBD) is a serious clinical condition affecting millions around the world. It is evident that some properties of the disease manifest before the onset of clinical symptoms. To date, these properties where shown on the molecular scale. To use them for clinical diagnosis would require adapting them to existing medical imaging methods.
In this project, we intend to detect the earliest signs of IBD in colonoscopy. Therefore, a machine learning solution capable to find the pre-clinical stages of inflammation through image analysis is required. This would include developing the algorithm and training it, while also tagging the training dataset.
The work will be performed in collaboration with the groups of Prof. Irit Sagi and Yonina Eldar.
Department of Computer Science and Applied Mathematics
PhD position
The Signal Acquisition, Modeling, Processing and Learning (SAMPL) lab headed by Prof. Yonina Eldar at the Weizmann Institute of Science is recruiting PhD, MSc and post-doctoral students for cutting-edge research applying signal processing and machine learning for communication and radar systems.
Department of Computer Science and Applied Mathematics
MSc position
The Signal Acquisition, Modeling, Processing and Learning (SAMPL) lab headed by Prof. Yonina Eldar at the Weizmann Institute of Science is recruiting PhD, MSc and post-doctoral students for cutting-edge research applying signal processing and machine learning, AI for communication and radar systems.
Department of Computer Science and Applied Mathematics
Postdoc position
The Signal Acquisition, Modeling,Processing and Learning (SAMPL) lab headed by Prof. Yonina Eldar at the Weizmann Institute of Science is recruiting PhD, MSc and post-doctoral students for cutting-edge research applying machine learning and deep networks to clinical problems in collaboration with leading hospitals in Israel and abroad.
Candidates with strong algorithmic background are invited to send their CV to yonina.eldar@weizmann.ac.il.
Department of Computer Science and Applied Mathematics
Postdoc position
The Signal Acquisition, Modeling, Processing and Learning (SAMPL) lab headed by Prof. Yonina Eldar at the Weizmann Institute of Science is recruiting PhD, MSc and post-doctoral students for cutting-edge research applying signal processing and machine learning for communication and radar systems.
Department of Computer Science and Applied Mathematics
PhD position
The Signal Acquisition, Modeling,Processing and Learning (SAMPL) lab headed by Prof. Yonina Eldar at the Weizmann Institute of Science is recruiting PhD, MSc and post-doctoral students for cutting-edge research applying machine learning and deep networks to clinical problems in collaboration with leading hospitals in Israel and abroad.
Candidates with strong algorithmic background are invited to send their CV to yonina.eldar@weizmann.ac.il.
Department of Computer Science and Applied Mathematics
MSc position
Available Rotations: 1st
Signal processing and communication students? We are looking for you!
The Signal Acquisition, Modeling, Processing, and Learning (SAMPL) lab headed by prof. Yonina Eldar is recruiting Masters and PhD students for cutting edge research in radar, communications, and analog-to-digital conversion.
More Information about MSc position
Candidates with strong electrical engineering or communication systems engineering background are invited to send their CV to Yonina.eldar@weizmann.ac.il
Department of Computer Science and Applied Mathematics
PhD position
Signal processing and communication students? We are looking for you!
The Signal Acquisition, Modeling, Processing, and Learning (SAMPL) lab headed by prof. Yonina Eldar is recruiting Masters and PhD students for cutting edge research in radar, communications, and analog-to-digital conversion.
More Information about PhD position
Candidates with strong electrical engineering or communication systems engineering background are invited to send their CV to Yonina.eldar@weizmann.ac.il
Department of Computer Science and Applied Mathematics
PhD position
PhD students and Postdocs in the areas of signal processing, machine learning, medical imaging, communications and radar processing
More Information about PhD position
Host Professor: Yonina Eldar, department of mathematics and computer science, Weizmann Institute Position Description: The Signal Acquisition Measurement Processing and Learning (SAMPL) Lab invites applications for doctoral/postdoctoral positions in the areas of signal processing and machine learning with applications in communications, radar, medical imaging and optical imaging. In the area of medical imaging, the work will be performed in close collaboration with leading hospitals in Israel and abroad. Some of the topics will be in close collaboration with PIs at MIT, Stanford, Princeton and the Broad Institute.
We are looking for thought leaders in these fields who can develop new areas and applications. The balance of work between theory and practice will vary on project-basis, and a successful candidate should be proficient in both aspects. Excellent written and presentation skills in English are an advantage. About SAMPL: The lab focuses on sampling, modeling and processing of continuous-time and discrete-time signals with the aim of extracting as much information as possible using minimal resources to perform various tasks, including communication, radar, medical and optical imaging and biological inference. The lab also develops model-based methods for artificial intelligence (AI) that aid in obtaining increased information from fewer samples, and facilitates the transition from pure theoretical research to the development, design and implementation of prototype systems and clinical studies. Our approach can drastically reduce the sampling and processing rates well below the Nyquist rate, and greatly improve the resolution which can be obtained from a limited number of samples in time, space and frequency. It also paves the way to new technologies such as wireless ultrasound and joint radar and communication systems. The group works closely with several major hospitals in Israel and with research groups at MIT, Stanford, Duke, Princeton and more.
To submit your application, please send an updated CV with 3 letters of recommendation and a cover letter
Department of Computer Science and Applied Mathematics
MSc position
Masters students, interested in the areas of signal processing, machine learning, medical imaging, communications and radar processing:
More Information about MSc position
The department of mathematics and computer science at the Weizmann Institute invites students for a Masters, PhD or Postdoc position in the areas of signal processing and machine learning with applications in communications, radar, medical imaging and optical imaging. The selected candidate will work with Prof. Yonina Eldar at the SAMPL lab. In the area of medical imaging, the work will be performed in close collaboration with leading hospitals in Israel and abroad. Some of the topics will be in close collaboration with PIs at MIT, Stanford and the Broad Institute.
To submit your application, please send an updated CV with 2 letters of recommendation and a cover letter.
Department of Computer Science and Applied Mathematics
Postdoc position
The SAMPL Lab at the Weizmann Institute of Science offers a postdoctoral position within the project C'MON-QSENS! (Continuously Monitored Quantum Sensors: Smart Tools and Applications) funded by QuantERA EU program in Quantum Technologies.
More Information about Postdoc position
The appointment will be for a two years term, (possibly) renewable for a third year.
The successful candidate will work on theoretical and algorithmic aspects of Quantum Statistical Inference and Quantum Information, with particular focus on schemes that could be relevant for quantum sensors. Solid background on either real-time signal processing techniques, machine learning, quantum stochastic equations, sequential analysis and optimal control are very desirable.
John Calsamiglia Costa (Universitat Autonoma de Barcelona, SP) Jan Kolodynski (University of Warsaw, PL) Klaus Molmer (Aarhus University, DK) Witlef Wieczorek (Chalmers University of Technology, SE) Kasper Jensen (University of Nottingham, UK) Interested applicants should send a CV along with a short statement of purpose or presentation letter and arrange for two or three letters of recommendation to be sent using "C'MON-postdoc" as subject. Proposed start of appointment: Immediately.
Department of Biomolecular Sciences
MSc rotation
Available Rotations: 1st,2nd,3rd
Understanding how the transcription and translation processes control the cellular response to extra-cellular stimuli
More Information about MSc rotation
Regulation of gene expression at the transcriptional and translational levels is fundamental to all biological activities and is frequently altered in disease states. Our broad research interests are (i) to elucidate how the transcription and translation processes control the cellular response to enviromental stimuli; (ii) to reveal the connections between the transcription and translation processes and (iii) to develop tools to manipulate these processes for potential treatment of cancer, chronic inflammation and neurodegenrative diseases.
Department of Biomolecular Sciences
MSc rotation
Available Rotations: 1st,2nd,3rd
Understanding how the transcription and translation processes control the cellular response to extra-cellular stimuli
More Information about MSc rotation
Regulation of gene expression at the transcriptional and translational levels is fundamental to all biological activities and is frequently altered in disease states. Our broad research interests are (i) to elucidate how the transcription and translation processes control the cellular response to enviromental stimuli; (ii) to reveal the connections between the transcription and translation processes and (iii) to develop tools to manipulate these processes for potential treatment of cancer, chronic inflammation and neurodegenrative diseases.
Department of Biomolecular Sciences
MSc position
Understanding how the transcription and translation processes control the cellular response to extra-cellular stimuli
More Information about MSc position
Regulation of gene expression at the transcriptional and translational levels is fundamental to all biological activities and is frequently altered in disease states. Our broad research interests are (i) to elucidate how the transcription and translation processes control the cellular response to enviromental stimuli; (ii) to reveal the connections between the transcription and translation processes and (iii) to develop tools to manipulate these processes for potential treatment of cancer, chronic inflammation and neurodegenrative diseases.
Department of Biomolecular Sciences
PhD position
Understanding how the transcription and translation processes control the cellular response to extra-cellular stimuli
More Information about PhD position
Regulation of gene expression at the transcriptional and translational levels is fundamental to all biological activities and is frequently altered in disease states. Our broad research interests are (i) to elucidate how the transcription and translation processes control the cellular response to enviromental stimuli; (ii) to reveal the connections between the transcription and translation processes and (iii) to develop tools to manipulate these processes for potential treatment of cancer, chronic inflammation and neurodegenrative diseases.
Department of Biomolecular Sciences
Postdoc position
Understanding how the transcription and translation processes control the cellular response to extra-cellular stimuli
More Information about Postdoc position
Regulation of gene expression at the transcriptional and translational levels is fundamental to all biological activities and is frequently altered in disease states. Our broad research interests are (i) to elucidate how the transcription and translation processes control the cellular response to enviromental stimuli; (ii) to reveal the connections between the transcription and translation processes and (iii) to develop tools to manipulate these processes for potential treatment of cancer, chronic inflammation and neurodegenrative diseases.
Department of Chemical and Structural Biology
MSc rotation
Available Rotations: 1st,2nd,3rd
mechanism of an enzyme that catalyzes disulfide bond formation extracellularly to build the cell microenvironment
Department of Chemical and Structural Biology
MSc rotation
Available Rotations: 1st,2nd,3rd
Structural biology of extracellular matrix proteins-- combining X-ray crystallography, cross-linking/mass spectrometry, and electron microscopy
More Information about MSc rotation
Laminin is a major component of the extracellular matrix (ECM) and arose early in animal evolution. Due to its role in cell adhesion and migration, laminin is central to development and disease. Laminin is a heterotrimer with a total mass of up to 800 kD. Its three subunits (α, β, and γ) assemble into a distinctive cross-shaped structure, copies of which further self-assemble to form a network. Higher organisms contain a number of isotypes of each subunit, which produce, combinatorially, a rich family of related proteins with certain structural and functional distinctions. Many fundamental aspects of laminin structure are understood from rotary shadowing electron microscopy, recognizable amino acid sequence motifs (i.e., coiled-coil heptad repeats), and X-ray crystallography of laminin fragments. However, other conserved portions of laminin, namely the L4, LF, and Lβ knob domains, are still poorly understood, both structurally and functionally. The L4 and LF domains are embedded within the EGF-like repeats that make up the short arms of the laminin cross, whereas the Lβ knob is inserted into the coiled-coil that constitutes the long arm of the cross. Until we determine the structures and functions of these embedded domains, our understanding of laminin and its binding and signaling capabilities will remain incomplete. This research project offers a rotation student the opportunity to work with Ph.D. students in the lab to learn protein purification and X-ray crystallography, as applied to the structures of key segments of laminin. The rotation student would also have the opportunity to be introduced to novel techniques in electron microscopy. Overall, the lab aims to combine a variety of structural and cell biological approaches to advance our understanding of laminin and its relation to other ECM components and to cells.
Department of Computer Science and Applied Mathematics
MSc rotation
Available Rotations: 3rd
Virtual reality based project
More Information about MSc rotation
Virtual reality based project
We are looking for highly motivated students in Computer Science /Neuroscience with good coding skills to design and run virtual reality project based experiments. The work will be conducted in Prof. Tamar Flash laboratory for motor research control and robotics.
For more details please contact: Dr France Lerner France.Lerner@weizmann.ac.il 054733979 Ext 37333
Department of Computer Science and Applied Mathematics
MSc rotation
Available Rotations: 1st
ניסוי EEG ואוטיזם
More Information about MSc rotation
לסטודנטים לביולוגיה המחפשים רוטציה ראשונה -
בחודש הקרוב יוצא לדרך מחקר EEG בנבדקים עם אוטיזם במעבדת בקרת תנועה (פרופ' תמר פלש).
.מטרת המחקר הוא לבחון תפיסה של תנועה ביולוגית בנבדקים אלו
מחקרים קודמים ביססו את ההערכה כי באוטיזם אחוז גבוה של הפרעות קואורדינציה וכמו כן יכולת מופחתת לתפישה חזותית בהתבוננות בתנועה של בני אדם - תנועה ביולוגית.
במחקר קודם במעבדה איפיינו - בהתבסס על חוקי תנועה הקיימים באוכלוסייה הכללית, את הפקת התנועה הייחודית לנבדקים עם אוטיזם.
מטרת המחקר הנוכחי היא לבחון בנבדקים אלו את התגובה המוחית לצפייה בתנועה ביולוגית.
לפרטים נוספים:
שלומית בן עמי,
מעבדה לבקרת תנועה
benamishlomit@gmail.com
או בפנייה ישירות לפרופ' תמר פלש
Department of Molecular Chemistry and Materials Science
PhD position
Several positions available involving multidisciplinary projects studying structure & function of electrode and solid electrolyte materials by novel solid state NMR techniques and the underlying spin physics. Flexible starting date.
More Information about PhD position
Our group studies how the function of solid materials depend on their composition and structure as well as their interfacial chemistry. We use and develop new diagnostic tools based on magnetic resonance techniques such as solid state NMR and dynamic nuclear polarization (DNP), targeted at the investigation of surface and bulk phenomena in functional materials.
Current research projects include: (i) Developing new approaches for increasing the sensitivity of solid state NMR by polarization transfer from paramagnetic metal ions: this includes theoretical and experimental studies of the underlying spin physics such as the dependence of the polarization transfer process on the metal ion spin properties, the nuclear spin interactions and the electron-nuclear couplings. (ii) Mechanistic study of the functionality of native and artificial surface layers in electrode materials: gaining structural and chemical insight into the surface composition and its effect on ion transport properties across a solid-electrolyte interface. (iii) Elucidating the structural role of dopants on ionic conductivity of solid electrolytes.
Depending on the student's background and interest the projects can involve materials synthesis, device assembly and testing and development of new NMR approaches by theoretical analysis of the spin dynamics.
Department of Molecular Chemistry and Materials Science
MSc rotation
Available Rotations: 1st,2nd,3rd
Understanding interfacial phenomena in electrode materials for rechargeable batteries, development of novel nuclear magnetic resonance (NMR) techniques for probing functional materials
More Information about MSc rotation
Several diverse and multidisciplinary projects are available depending on the interest and background of potential students - (1) materials and characterization: materials synthesis, assembly of rechargeable battery cells, electrochemical tests and characterization by X-ray diffraction, electron microscopy, and solid state NMR. (2) magnetic resonance - development of new approaches for sensitivity enhancement in solid state NMR utilizing exogenous and endogenous radicals, theoretical analysis of the spin dynamics.
Department of Molecular Cell Biology
Postdoc position
Combination therapies for TNBC
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Triple negative breast cancer (TNBC) is a highly aggressive disease that affects young women and currently has no effective treatment. The goal of our studies is to identify new therapeutic strategies for this particular subtype of breast cancer. Synthetic lethality is a powerful approach to selectively eliminate vulnerable cancer cells, and thus can be exploited for cancer therapy. Many studies including our own indicate that synthetic lethality screens could be a promising approach to identify novel drug targets for TNBC. A postdoctoral position is available to establish a genome-wide synthetic lethal screen to identify potent combination therapies for TNBC subtypes.
Department of Molecular Cell Biology
Postdoc position
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Ferroptosis is a newly discovered cell death pathway driven by iron-dependent lipid peroxidation. We recently discovered new inducers of ferroptosis, and specific metabolic states that increase vulnerability to ferroptosis, and thus can be used for cancer therapy. We have multidisciplinary projects related to ferroptosis in TNBC, and we are currently looking for two talented and enthusiastic postdocs to join us.
Department of Molecular Cell Biology
Postdoc position
BRD4 as a therapeutic target for TNBC
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BRD4 (Bromodomain protein 4), a member of the BET (bromodomain and extra terminal domain) family, is an epigenetic reader that plays important roles in chromatin remodeling and transcriptional regulation. It is involved in cancer progression, metastasis and inflammatory diseases and is considered as promising therapeutic targets for different cancer subtypes, including TNBC. Targeting of BRD4 in TNBC and overcoming drug resistance are current questions that we address.
Department of Molecular Cell Biology
MSc rotation
Available Rotations: 3rd
Triple negative breast cancer: combination therapies and drug resistance.
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Triple negative breast cancer (TNBC) is a highly aggressive disease that affects young women and currently has no effective treatment. The goal of our studies is to identify new therapeutic strategies for this particular subtype of breast cancer. We are trying to identify therapeutic targets and design rational combination therapies that will overcome drug resistance mechanisms. We use advance molecular cell biology approaches, high throughput screen and animal models.
Department of Immunology
MSc rotation
Available Rotations: 2nd,3rd
PTM profiling: mapping the protein modification landscape in health and disease
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1. PTM profiling: mapping the protein modification landscape in health and disease
2. Decipher ubiquitin-dependent mechanisms of tumor-host interactions
3. Analyzing signaling dynamics in immune regulation
4. Studying intra-molecular interactions of post-translational modifications
Our group employs advanced high-throughput proteomic and genomic methods, cell biology, biochemistry and in-vivo models as well as bioinformatics to study the biology of protein modifications (PTMs) in health and disease. We are currently looking for enthusiastic, motivated and talented people, at all career stages, to join our team. To read more: http://yifatmerbl.wix.com/merbl-lab
Department of Molecular Genetics
MSc rotation
Available Rotations: 1st,2nd,3rd
Mechanisms of cell death, kinase cascades, translation control in stem cell differentiation, computational modeling the molecular network of cell death
Department of Molecular Genetics
MSc rotation
Available Rotations: 2nd,3rd
Developing image analysis tools for monitoring brain organoids.
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This project will involve a collaboration with Prof. Yonina Eldar to develop image analysis tools for fluorescent human brain organoids.
Department of Molecular Genetics
MSc rotation
Available Rotations: 1st,2nd,3rd
Cortical development in health and disease
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Our lab is focused on studying the molecular mechanisms involved in human brain development in health and in disease.
Department of Molecular Genetics
PhD position
Available Rotations: 3rd
Modeling of human brain development and evolution in health and disease
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We are seeking for students that will apply a multidisciplinary approach to study brain development during evolution and in health and disease.
Department of Molecular Genetics
Postdoc position
Multidisciplinary approaches to model human brain diseases
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We are using a multidisciplinary approach to model human brain diseases, using both mouse and human brain organoid model. We are seeking people with expertise in different areas which can be applied to this study.
Department of Neurobiology
PhD position
Ph.D. in visual neuroscience
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Massive work was done to decipher the neural code of the visual information at the retina level. How do retinal targets integrate and process the retinal output is still an unsolved question.
The aim of the project is to reveal how visual information is processed along the main visual pathway. For that, advanced in vivo imaging and electrophysiology techniques will be used in combination with retinal manipulations using pharmacogenetics and other methods.
Computational/engineering background and programming experience are preferable.
Experience with electrophysiology/two-photon imaging is an advantage.
Good social skills and a sense of humor are a must.
Interested candidates with proven academic record are requested to send their CV and contact details of 3 referees to michal.rivlin@weizmann.ac.il
Department of Neurobiology
Postdoc position
Postdoc in visual neuroscience
More Information about Postdoc position
Massive work was done to decipher the neural code of the visual information at the retina level. How do retinal targets integrate and process the retinal output is still an unsolved question.
The aim of the project is to reveal how visual information is processed along the main visual pathway. For that, advanced in vivo imaging and electrophysiology techniques will be used in combination with retinal manipulations using pharmacogenetics and other methods.
Computational/engineering background and programming experience are preferable.
Experience with electrophysiology/two-photon imaging is an advantage.
Good social skills and a sense of humor are a must.
Interested candidates with proven academic record are requested to send their CV and contact details of 3 referees to michal.rivlin@weizmann.ac.il
Department of Neurobiology
MSc rotation
Available Rotations: 1st,2nd,3rd
Visual processing in neuronal circuits in the retina in health and disease.
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The neuronal activity in multiple brain areas significantly changes in pathological states. We use a variety of advanced imaging and electrophysiology techniques to reveal changes in retinal neuronal activity under different pathological states. Our goal is to facilitate diagnosis of diseases at their early stage.
Department of Immunology
MSc rotation
Available Rotations: 1st,2nd,3rd
Molecular mechanisms regulating lymphocytes' survival in health and disease
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1. The molecular mechanisms regulating B cell survival in health and disease.
In B cells, as in every other tissue, the survival/apoptosis balance is essential for homoeostasis. A vast number of resting cells must be maintained to preserve a diverse B cell repertoire. Long-term B cell persistence in the periphery is dependent on survival signals that are transduced by cell surface receptors. Conversely, resistance to apoptosis, leading to enhanced survival, is associated with initiation and progression of B cell malignancies. Our study focuses on molecules that regulate B cell survival. These molecules have been also associated with tumor progression and metastasis. We are currently analyzing the survival pathways induced in CLL cells derived from patients in various stages. These findings could pave for novel therapeutic strategies aimed at blocking this survival pathway.
2. Regulation of peripheral lymphocytesֲ’ targeting to the LN and sites of inflammation in health and disease.
The majority of lymphocytes are capable of tissue selective trafficking (homing), recognizing organ-specific adhesion molecules on specialized endothelial cells. Previous studies focused on the specific recruitment of leukocytes to the lymph nodes (LN) or to sites of inflammation. However, little is known about the molecular mechanisms that negatively control or prevent homing of cells to these sites. Our studies focus on the pathways that restrict homing of specific subsets of immune cells, and thereby fine tune the immune response at specific lymphoid and peripheral tissues. Impaired homing of lymphocytes to peripheral lymph nodes results in attenuated progression of inflammation in various inflammatory models, including asthma, arthritis, inflammatory bowl disease (IBD) and experimental autoimmune encephalomyelitis (EAE). We are currently analyzing the additional pathways that are involved in this homing regulation.
Department of Chemical and Structural Biology
MSc rotation
Available Rotations: 1st,2nd,3rd
Structural and mechanistic characterization of the human protein disaggregation network
Department of Chemical and Structural Biology
MSc rotation
Available Rotations: 1st,2nd,3rd
NMR studies of transient chaperone-substrate interactions
Department of Chemical and Structural Biology
MSc rotation
Available Rotations: 1st,2nd,3rd
A combined biomedical/structural research aimed at understanding the mode of transfer of 4 phospho panthoteneic acid (P-Pant) from CoA onto acyl carrier protein and domains (ACP), key protein complexes in Mycobacterium tuberculosis causing the disease.
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To find a better cure for tuberculosis we conduct a combined biomedical/structural research aimed at understanding the mode of transfer of 4 phospho panthoteneic acid (P-Pant) from CoA onto acyl carrier protein and domains (ACP), key protein complexes in Mycobacterium tuberculosis causing the disease.
We look for M.Sc. students with a possible continuation towards a Ph.D. degree.
The work will be conducted in the department of Structural biology, Weizmann Institute, as a collaboration between Prof. Zippi Shakked and Dr. Oren Zimhony from the Infectious disease unit, Kaplan Medical Center affiliated to the Hebrew University and Hadassah.
For details please contact:
Prof. Zippi Shakked : email: zippi.shakked@weizmann.ac.il
and
Dr. Oren Zimhony: email: oren_z@clalit.org.il
and/or oren_zimhony@hotmail.com
Department of Chemical and Structural Biology
PhD position
The Shalev-Benami lab is looking for a highly motivated PhD candidate for a project involving the cryo-EM characterization of cell-cell communication in the CNS
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The Shalev-Benami lab is looking for a highly motivated PhD candidate for a project involving the cryo-EM characterization of cell-cell communication in the CNS. The ideal candidate will have solid background in biochemistry or structural biology.
Department of Biomolecular Sciences
MSc position
For a challenging and exciting project focusing on the regulation of the 20S proteasome we are seeking for a motivated MSc student. The study combines biochemical tools, native mass spectrometry and cell biology approaches.
Department of Biomolecular Sciences
PhD position
For a challenging and exciting project combining biology, chemistry and physics we are seeking for a motivated PhD student. The project involves the development of a new technology for bio-molecular analysis. This is a joint study of Ron Naaman's and Michal Sharon's lb.
More Information about PhD position
For a challenging and exciting project combining biology, chemistry and physics we are seeking for a motivated PhD student. The project involves the development of a new technology for bio-molecular analysis. This is a joint study of Ron Naaman's and Michal Sharon's lb.
Department of Biomolecular Sciences
PhD position
For a challenging and exciting project combining biology, chemistry and physics we are seeking for a motivated PhD student. The project involves the development of a new technology for bio-molecular analysis. This is a joint study of Ron Naaman's and Michal Sharon's lb.
Department of Biomolecular Sciences
PhD position
Developing a computational approach to assign mass spectrometry data - a theoretical project.
Department of Biomolecular Sciences
Postdoc position
Developing a computational approach to assign mass spectrometry data - a theoretical project.
Department of Biomolecular Sciences
MSc position
Developing a computational approach to assign mass spectrometry data - a theoretical project.
Department of Biomolecular Sciences
MSc rotation
Available Rotations: 1st,2nd,3rd
Studying large protein complexes involved in the protein degradation pathway using a novel mass spectrometry approach.
Department of Biomolecular Sciences
MSc rotation
Available Rotations: 2nd,3rd
Studying the structure function relationship of protein complexes involved the protein degradation pathway
Department of Biological Regulation
Postdoc position
The objective of this study is to better understand the state and severity of infection during pregnancy and its effect on fetal development and neonatal outcome.
Department of Biological Regulation
MSc position
More Information about MSc position
The objective of this study is to better understand the state and severity of infection during pregnancy and its effect on fetal development and neonatal outcome.
Department of Biological Regulation
PhD position
ECM crosslinking in pathology and physiology
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Development and utilisation of probes for analysis of ECM reactions that modulate tissue stiffness and fibrosis in degeneration and tissue regeneration. Development of probes for MRI and multimodal imaging of ECM cross linking.
Department of Biological Regulation
Postdoc position
Multimodal imaging of vascular morphogenesis in embryo implantation
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Development of novel imaging tools to reveal mechanisms and principles controlling early maternal fetal interaction during the early stages of pregnancy. Background in advanced imaging and/or molecular biology is an advantage.
Department of Biological Regulation
MSc rotation
Available Rotations: 1st,2nd,3rd
MRI and optical imaging of angiogenesis: reproduction, development and cancer.
Department of Biological Regulation
MSc rotation
Available Rotations: 3rd
A new lab seeks excellent and motivated students who are interested in chromatin and Epigenetics in the context of cancer and development, working with novel and exciting technologies
Department of Biological Regulation
MSc rotation
Available Rotations: 1st,2nd,3rd
The rotation will be focused on aspects of tissue remodeling - from molecular imaging to drug design
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Thinking outside the cell.
While most biological research centers on what goes on inside the cell, we look at what goes on outside the cell. Our lab focuses on the cell microenvironment which includes the extracellular matrix; a collection of extracellular molecules secreted by cells that provides structural and biochemical support to the surrounding cells (ECM) and multifunctional neighboring cells. We have found that ECM enzymes, which can induce morphological changes in the matrix, affect cellular programming. This provides us with significant opportunities to influence cellular programming and interfere in disease processes that affect intimate cellular communications at the very near microenvironment of cancer and inflammatory cells. Our lab focuses on the cell microenvironment which includes the extracellular matrix; a collection of extra-cellular molecules secreted by cells that provides structural and biochemical support to the surrounding cells(ECM) and multifunctional neighboring cells. We have found that ECM enzymes, which can induce morphological changes in the matrix, affect cellular programming. This provides us with significant opportunities to influence cellular programming and interfere in disease processes that affect intimate cellular communications at the very near microenvironment of cancer and inflammatory cells.
Department of Molecular Cell Biology
MSc rotation
Available Rotations: 2nd,3rd
The rotation project involves computational prediction of neo-antigens presented by tumor cells to T-cells. The project integrates computational analyses of various large-scale data, including RNAseq, Whole-genome sequencing, and proteomics data.
Department of Molecular Cell Biology
MSc rotation
Available Rotations: 1st,2nd,3rd
High-throughput, whole exome, whole genome sequencing and systems biology tools will be performed to decipher the genetic landscape in melanoma. Followup functional analysis of mutated genes using cell knockout technologies will be conducted.
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Our lab combines genomic tools, systems biology tools, advanced somatic cell knockout and knock-in techniques and various comprehensive functional approaches to study melanoma genetic mutations. Our studies link basic biology, computational biology and clinical studies. Trainees will learn sophisticated technologies such as high-throughput sequencing, whole exome sequencing, somatic cell knockouts and expression and proteomic analyses. Training will also include interaction with other laboratories and core facilities, such as DNA microarray analysis, genomic analysis and cell sorting. Candidates who wish to join the group may contact me at: Yardena.samuels@weizmann.ac.il
Department of Neurobiology
MSc rotation
Available Rotations: 1st,2nd,3rd
Elucidating the molecular machinery underlying the development of sexually dimorphic neuronal circuits
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How do genes shape neural circuits and animal behaviors? How does a neuronal circuit that controls a sexually dimorphic behavior develop? We aim to understand how sexual dimorphic wiring patterns in the brain develop, from patterning of synapses, to the behavior of the whole organism. Our lab uniquely addresses these questions by using the powerful genetic toolbox of the nematode Caenorhabditis elegans as an in vivo model system. We use diverse cutting-edge techniques such as synapse labeling, neuronal imaging, high-resolution live-imaging microscopy, optogenetics and behavior analysis.
Department of Earth and Planetary Sciences
MSc rotation
Available Rotations: 1st,2nd,3rd
We are recruiting enthusiastic students interested in atmospheric dynamics. We study weather systems, transport processes and extreme events by numerical modelling and diagnostic analysis of big data.
Department of Biomolecular Sciences
MSc rotation
Available Rotations: 1st,2nd,3rd
Transcriptional reprogramming and stress responses in the tumor microenvironment
Department of Neurobiology
MSc rotation
Available Rotations: 2nd,3rd
Imaging the human brain: ultra-high field MRI and new biomarkers for brain function
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The study of Magnetic Resonance Imaging (MRI) and of functional MRI (fMRI) is a prime example of contemporary multidisciplinary science; where Physics, Chemistry, Biology and Engineering are combined. The study combines on one hand - physics background for development of new MRI techniques, on another - Neurobiology background to perform actual human volunteer studies. Our lab research focuses on ultra-high field MRI aiming to better understand the human brain function. To do so, we are looking for new biomarkers and contrast methods, as well as new methods of acquisitions. Our lab interests include changes in electrical conductivity (a new type of contrast), specifically within the brain, which aim to provide a new, more direct, measurement method of the neuronal activation, as well as metabolic spectroscopic imaging that can shed light into the above topics. These topics go hand-in-hand with our study of fast and high-resolution imaging acquisitions, as well as research of new artificial materials for MRI which allow to effectively zoom-in as with a magnifying lens into the brain.
Department of Molecular Chemistry and Materials Science
MSc rotation
Available Rotations: 1st,2nd,3rd
Developing and applying advanced many-body computational approaches to study excited-state phenomena in materials of complex structure, and to understand underlying interaction processes and their relation to materials structure and design.
Department of Biomolecular Sciences
Postdoc position
PhD and Post-Doc positions
More Information about Postdoc position
OPEN PhD and Post-Doc positions:
Applicants with a strong research background at the intersection of molecular biology, biochemistry, imaging and/or biophysics are encouraged to apply. Experience in microbiology, molecular genetics (including CRISPR/Cas9), advanced imaging platforms (including image analysis) or advanced protein chemistry is advantageous.
This is a full-time position available from September 2020 for a period of two years with a possibility of a further extension subject to funding availability.
Candidate should send a cover letter and CV (includes a publication list) to Dr. Neta Regev-Rudzki.
For any informal inquiries please contact us by email at
neta.regev-rudzki@weizmann.ac.il
Department of Biomolecular Sciences
Postdoc position
Malaria laboratory, Weizmann Institute.
We are seeking highly motivated, independent, committed and curious researchers to join our team as Post-Doc. The projects center on the cellular biology of the malaria parasite, parasite-host interaction and the field of cell-cell communication.
More Information about Postdoc position
Applicants with a strong research background at the intersection of molecular biology, biochemistry, imaging and/or biophysics are encouraged to apply. Experience in microbiology, molecular genetics (including CRISPR/Cas9), advanced imaging platforms (including image analysis) or advanced protein chemistry is advantageous.
This is a full-time position available from October 2020 for a period of two years with a possibility of a further extension subject to funding availability.
Candidate should send a cover letter and CV (includes a publication list) to Dr. Neta Regev-Rudzki.
For any informal inquiries please contact us by email at
neta.regev-rudzki@weizmann.ac.il
Department of Biomolecular Sciences
MSc rotation
Available Rotations: 2nd,3rd
Malaria laboratory, Weizmann institute
We are seeking for highly motivated, committed and curious students.
More Information about MSc rotation
Malaria laboratory, Weizmann Institute
We are seeking for highly motivated, committed and curious students to join our team as rotation students. The projects center on different fascinating aspects of the cellular biology of the malaria parasite.
Applicants with a strong background at the interfaces of molecular biology and/or biophysics are encouraged to apply. The chosen applicant will peruse wide spread of molecular biology technics, tissue-culture, microscopy, bioinformatics and more.
Candidate should send a cover letter and CV (includes a publication list) to Dr. Neta Regev-Rudzki.
