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February 01, 2010

  • Date:29ThursdayDecember 2011

    Immunology Special Guest Seminar: An AhR Nuclear Translocator (ARNT/Hif1β) axis coordinates the glycolytic switch in effector T cells

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    Time
    12:30 - 14:00
    Location
    Wolfson Building for Biological Research
    LecturerElla Rozenzweig
    Cantrell Laboratory) College of Life Sciences University of Dundee Scotland, UK
    Organizer
    Department of Systems Immunology
    Contact
    Lecture
  • Date:29ThursdayDecember 2011

    Chemical Physics Special Guest Seminar

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    Time
    14:00 - 15:30
    Title
    "Single File Dynamics"
    Location
    Perlman Chemical Sciences Building
    LecturerDr. Ophir Flomenbom
    Flomenbom-BPS Ltd, Israel
    Organizer
    Department of Chemical and Biological Physics
    Contact
    AbstractShow full text abstract about The basic single file process is the diffusion of N (N &...»
    The basic single file process is the diffusion of N (N → ∞) identical Brownian hard spheres in a quasi-one-dimensional channel of length L (L → ∞), such that the spheres do not jump one on top of the other, and the average particle's density is approximately fixed. The most known statistical properties in this process are that the mean square displacement (MSD) of a particle in the file follows, MSD~t1/2 and its probability density function (PDF) is a Gaussian in position with a variance, MSD.

    I’LL focus in the talk on three new variants in file dynamics and address the following questions:
    (*) First, the question about the origin of the unique scaling, MSD~t1/2, in simple files, is addressed using scaling law analysis and a new approach for full mathematical computations in normal files.
    (*) The MSD is derived in normal files with particles’ density that is not fixed and with particles that are not identical, yet, the diffusion coefficients of the particles are distributed according to a probability density function. Results in these files follow:
    In files with a density law that is not fixed, but decays as a power law with an exponent a with the distance from the origin, the particle in the origin has a MSD that scales like, MSD~t[1+a]/2, with a Gaussian PDF [1].
    When, in addition, the particles' diffusion coefficients are distributed like a power law with exponent γ (around the origin), the MSD follows, MSD~t[1-γ]/[2/ (1+a) -γ], with a Gaussian PDF [2].

    (*) Files with anomalous basic dynamics, both renewal ones and those that are not renewal are solved. Results in these files follow:
    In anomalous files that are renewal, namely, when all particles attempt a jump together, yet, with jumping times taken from a distribution that decays as a power law with an exponent, −1 − α, ,the MSD scales like the MSD of the corresponding normal file, in the power of α [3].
    In anomalous files of independent particles, the MSD is very slow and scales like, MSD~log2(t). Even more exciting, the particles form clusters in such files, defining a dynamical phase transition. This depends on the anomaly power α: the percentage of particles in clusters ξ follows, ξ= [4].

    I’ll also talk about applications of file dynamics in several fields in applied chemistry and biophysics. These include: (a) the dynamics of molecules in channels, (b) the passage of molecules along 1d objects, (c) conductance in nano-wires, etc. The talk should interest both mathematical and applied chemists, physicists and biophysicists.
    Lecture
  • Date:29ThursdayDecember 2011

    Climate Change and the "Tragedy of the Commons"

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    Time
    14:00 - 14:00
    Location
    Perlman Chemical Sciences Building
    LecturerProf. Micha Tomkiewicz
    Dept. of Physics, Brooklyn College of CUNY
    Organizer
    Department of Molecular Chemistry and Materials Science
    Contact
    AbstractShow full text abstract about The talk will critically examine Climate Change from the Per...»
    The talk will critically examine Climate Change from the Perspectives of Garret Harding’s classical paper “The Tragedy of the Commons (Science – 1968)”. Webster’s definition of a tragedy is “a series drama typically describing a conflict between the protagonist and a superior force and having a sorrowful or disastrous conclusion that elicits pity or terror”. We are trying to develop instruments that are designed to prevent tragedy through the educational system. These instruments include a book that was just published titled “Climate Change: The Fork at the End of Now” that was written to serve as a textbook for the general public; development of a multiplayer electronic learning system, built on social/scientific simulations and fed by relevant and timely databases that require students to make choices and examine the consequences of these choices; and a documentary film that documents energy transition in the Sunderban region of India from hunter-gatherer to electrifying modern.
    Lecture
  • Date:29ThursdayDecember 2011

    Life Science Lectures

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    Time
    15:00 - 15:00
    Title
    New Insights into Synaptic Dynamics of the Mammalian Sensory System
    Location
    Dolfi and Lola Ebner Auditorium
    LecturerProf. Ilan Lampl
    Department of Neurobiology Weizmann Institute of Science
    Organizer
    Faculty of Biochemistry
    Contact
    Lecture
  • Date:01SundayJanuary 2012

    To be announced

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    Time
    13:00 - 13:00
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    LecturerIlya Soifer
    Naama Barkai's group, Dept. of Molecular Genetics, WIS
    Organizer
    Department of Molecular Genetics
    Contact
    Lecture
  • Date:01SundayJanuary 2012

    TBA

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    Time
    13:00 - 14:30
    Location
    Dannie N. Heineman Laboratory
    LecturerPaolo Mazzali
    INAF-Padova
    Organizer
    Nella and Leon Benoziyo Center for Astrophysics
    Contact
    Lecture
  • Date:02MondayJanuary 2012

    Condensed Matter Seminar

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    Time
    All day
    Location
    Edna and K.B. Weissman Building of Physical Sciences
    LecturerProfessor Kathryn Moler
    Organizer
    Department of Condensed Matter Physics
    Contact
    AbstractShow full text abstract about LaAlO3 (LAO) and SrTiO3 (STO) are both nonmagnetic band insu...»
    LaAlO3 (LAO) and SrTiO3 (STO) are both nonmagnetic band insulators, yet previous experimental and theoretical work has indicated the existence of a conducting (even superconducting) state at the interface, and suggested the possibility of ferromagnetism. We use scanning SQUID microscopy to image the magnetic behavior on micron length scales. We find three types of magnetic behaviors: weak, inhomogeneous diamagnetism consistent with superconductivity below 100 mK; a low-temperature 1/T-like paramagnetic response suggestive of a fairly uniform density of isolated spins; and ferromagnetic patches that are stable up to at least 60 Kelvin. The variety of details in reports of magnetism, including our observation of a landscape (rather than a homogeneous phase), support the exciting possibility that multiple states are important in this engineered interface. I will also discuss our recent unpublished results on the ferromagnetism's dependence on various parameters and sample conditions and on the superconductivity in which we image the landscape of superfluid density while tuning the critical temperature with gate voltage.
    Lecture
  • Date:02MondayJanuary 2012

    Bioinformatics Workshop: RNA-Seq - The Use of Short Read Illumina Data for Transcriptome Annotation and Quantification

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    Time
    09:30 - 12:00
    Location
    Harry Levine Family Building
    LecturerDr. Dena Leshkowitz
    Bioinformatics Unit, Weizmann Institute of Science
    Homepage
    Contact
    AbstractShow full text abstract about RNA-Seq is a powerful technology for analyzing transcriptome...»
    RNA-Seq is a powerful technology for analyzing transcriptomes. This workshop will start with an hour lecture on the various computational approaches and tools to analyze the data, including:

    Read mapping
    Transcriptome reconstruction
    Expression quantification
    Detecting differential genes and transcripts
    A hands-on session will follow the lecture. In this session we will practice RNA-Seq workflows provided in Galaxy (Tophat, cufflinks and cuffdiff) and the Partek Genomics Suite software.
    Lecture
  • Date:02MondayJanuary 2012

    Missing Heritability: New algorithmic and statistical approaches

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    Time
    10:00 - 10:00
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    LecturerOR ZUK
    Broad Institute
    Organizer
    The Kahn Family Research Center for Systems Biology of the Human Cell
    Contact
    AbstractShow full text abstract about The completion of the human genome project set a stepping st...»
    The completion of the human genome project set a stepping stone in building catalogs of common human genetic variation. These catalogs, in turn, enabled the search for associations between common variants and complex human traits and diseases, by performing Genome-Wide Association Studies (GWAS). GWAS have been successful in discovering thousands of statistically significant, reproducible, genotype-phenotype associations. However, the discovered variants (genotypes) explain only a small fraction of the phenotypic variance in the population for most human traits. In contrast, the heritability, defined as the proportion of phenotypic variance explained by all genetic factors, was estimated to be much larger for those same traits using indirect population-based estimators. This gap is referred to as ‘missing heritability’.
    Mathematically, heritability is defined by considering a function F mapping a set of (Boolean) variables, (x1,.., xn) representing genotypes, and additional environmental or ‘noise’ variables ε, to a single (real or discrete) variable z, representing phenotype. We use the variance decomposition of F, separating the linear term, corresponding to additive (narrow-sense) heritability, and higher-order terms, representing genetic-interactions (epistasis), to explore several explanations for the ‘missing heritability’ mystery. We show that genetic interactions can significantly bias upwards current population-based heritability estimators, creating a false impression of ‘missing heritability’. We offer a solution to this problem by providing a novel consistent estimator based on unrelated individuals. We also use the Wright-Fisher process from population genetic theory to develop and apply a novel power correction method for inferring the relative contributions of rare and common variants to heritability. Finally, we propose a novel algorithm for estimating the different variance components (beyond additive) of heritability from GWAS data.
    I will discuss the statistical methods and algorithms used. No prior biological knowledge is needed.
    Based on joint works with Eric Lander, Eliana Hechter, Shamil Sunyaev and David Golan
    Lecture
  • Date:02MondayJanuary 2012

    Using Individual Human Genomes to Illuminate the Mysteries of Early Human History

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    Time
    11:00 - 11:00
    LecturerIlan Gronau
    Cornell University
    Organizer
    Faculty of Mathematics and Computer Science
    Contact
    Lecture
  • Date:02MondayJanuary 2012

    "Dynamics of meristem maturation and the evolution of tomato inflorescence architecture"

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    Time
    11:15 - 11:15
    Location
    Ullmann Building of Life Sciences
    LecturerDr. Zachary B. Lippman
    Watson School of the Biological Sciences Cold Spring Harbor Laboratory, USA
    Organizer
    Department of Plant and Environmental Sciences
    Contact
    Lecture
  • Date:02MondayJanuary 2012

    “Imaging a Landscape of Ferromagnetism, Paramagnetism, and Diamagnetism in LAO/STO Interfaces”‬

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    Time
    13:00 - 13:00
    LecturerKathryn Moler
    Stanford University
    Organizer
    Department of Condensed Matter Physics
    Contact
    AbstractShow full text abstract about LaAlO3 (LAO) and SrTiO3 (STO) are both nonmagnetic band insu...»
    LaAlO3 (LAO) and SrTiO3 (STO) are both nonmagnetic band insulators, yet previous experimental and theoretical work has indicated the existence of a conducting (even superconducting) state at the interface, and suggested the possibility of ferromagnetism. We use scanning SQUID microscopy to image the magnetic behavior on micron length scales. We find three types of magnetic behaviors: weak, inhomogeneous diamagnetism consistent with superconductivity below 100 mK; a low-temperature 1/T-like paramagnetic response suggestive of a fairly uniform density of isolated spins; and ferromagnetic patches that are stable up to at least 60 Kelvin. The variety of details in reports of magnetism, including our observation of a landscape (rather than a homogeneous phase), support the exciting possibility that multiple states are important in this engineered interface. I will also discuss our recent unpublished results on the ferromagnetism's dependence on various parameters and sample conditions and on the superconductivity in which we image the landscape of superfluid density while tuning the critical temperature with gate voltage.
    Lecture
  • Date:02MondayJanuary 2012

    Good p53, bad p53

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    Time
    14:00 - 14:00
    Location
    Max and Lillian Candiotty Building
    LecturerProf. Moshe Oren
    Dept. Molecular Cell Biology Weizmann Institute
    Organizer
    Department of Immunology and Regenerative Biology
    Contact
    Lecture
  • Date:02MondayJanuary 2012

    The Sliding Scale Conjecture From Intersecting Curves

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    Time
    14:30 - 14:30
    Location
    Jacob Ziskind Building
    LecturerDana Moshkovitz
    MIT
    Organizer
    Faculty of Mathematics and Computer Science
    Contact
    Lecture
  • Date:02MondayJanuary 2012

    "The charge radius of the proton, a five sigma discrepancy?"

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    Time
    14:45 - 15:45
    Location
    Edna and K.B. Weissman Building of Physical Sciences
    LecturerGil Paz
    Wayne State University
    Organizer
    Department of Particle Physics and Astrophysics
    Contact
    AbstractShow full text abstract about The charge radius of the proton is a basic non-perturbative ...»
    The charge radius of the proton is a basic non-perturbative parameter.
    Recently, it was extracted for the first time from the Lamb shift in muonic hydrogen. For a long time it was anticipated that such a measurement would reduce the error by an order of magnitude compared to measurements from electron- proton scattering and regular hydrogen spectroscopy. While this goal was achieved, the value of the proton's charge radius that was obtained was, very surprisingly, five standard deviations away from the world average.

    The extraction of the charge radius from the Lamb shift in muonic hydrogen depends on a theoretical input. Together with Richard J. Hill, we are studying the hadronic uncertainty in the theoretical prediction using the tool of an effective field theory, namely NRQED. In the talk I will describe the results of this study. I will also describe a previous study of the model-independent extraction of the charge radius from electron-proton scattering We have shown that previous extractions, spanning a period of over 40 years, have underestimated their error sometimes by a factor of two or more.
    Lecture
  • Date:02MondayJanuary 2012

    Quantum Money from Hidden Subspaces

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    Time
    16:00 - 16:00
    LecturerScott Aaronson
    MIT
    Organizer
    Faculty of Mathematics and Computer Science
    Lecture
  • Date:02MondayJanuary 2012

    "Direct Photons in Heavy Ion Collisions"

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    Time
    16:15 - 17:15
    Location
    Edna and K.B. Weissman Building of Physical Sciences
    LecturerZvi Citron
    Weizmann Institute
    Organizer
    Department of Particle Physics and Astrophysics
    Contact
    AbstractShow full text abstract about Direct photons are a key probe for understanding the hot den...»
    Direct photons are a key probe for understanding the hot dense matter created in heavy ion collisions. The signature result of heavy ion experiments thus far, is the dramatic modification of the production of strongly interacting particles in the hot and dense medium. Since the photon does not undergo any strong force interactions, it emerges from the medium unmodified and is a clean probe which can be contrasted to measured jets and strongly interacting particles. In particular, photon-jet correlations have been referred to as a golden channel in heavy ion collisions. In a photon-jet event the unmodified photon allows us a direct insight into the modification of the opposite side jet. The results from RHIC and LHC will be discussed.
    Lecture
  • Date:02MondayJanuary 2012

    מפגשים בחזית המדע

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    Time
    19:15 - 21:00
    Location
    Davidson Institute of Science Education
    Organizer
    Science for All Unit
    Homepage
    Contact
    Lecture
  • Date:03TuesdayJanuary 2012

    Mini-Symposium-Windows into the Mind:New Approaches to Brain and Cognition

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    Time
    All day
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    Chairperson
    Naomi Moses
    Homepage
    Contact
    Conference
  • Date:03TuesdayJanuary 2012

    " Paradoxical role of DNA methylation in activation of the FoxA2 gene promoter: inhibiting the repressor"

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    Time
    10:00 - 10:30
    Location
    Wolfson Building for Biological Research
    LecturerKeren Bahar
    Department of Biological Chemistry, Weizmann Institute
    Organizer
    Department of Biomolecular Sciences
    Contact
    Lecture

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