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February 01, 2010
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Date:29ThursdayDecember 2011Lecture
Immunology Special Guest Seminar: An AhR Nuclear Translocator (ARNT/Hif1β) axis coordinates the glycolytic switch in effector T cells
More information Time 12:30 - 14:00Location Wolfson Building for Biological ResearchLecturer Ella Rozenzweig
Cantrell Laboratory) College of Life Sciences University of Dundee Scotland, UKOrganizer Department of Systems ImmunologyContact -
Date:29ThursdayDecember 2011Lecture
Chemical Physics Special Guest Seminar
More information Time 14:00 - 15:30Title "Single File Dynamics"Location Perlman Chemical Sciences BuildingLecturer Dr. Ophir Flomenbom
Flomenbom-BPS Ltd, IsraelOrganizer Department of Chemical and Biological PhysicsContact Abstract Show full text abstract about The basic single file process is the diffusion of N (N &...» The basic single file process is the diffusion of N (N → ∞) identical Brownian hard spheres in a quasi-one-dimensional channel of length L (L → ∞), such that the spheres do not jump one on top of the other, and the average particle's density is approximately fixed. The most known statistical properties in this process are that the mean square displacement (MSD) of a particle in the file follows, MSD~t1/2 and its probability density function (PDF) is a Gaussian in position with a variance, MSD.
I’LL focus in the talk on three new variants in file dynamics and address the following questions:
(*) First, the question about the origin of the unique scaling, MSD~t1/2, in simple files, is addressed using scaling law analysis and a new approach for full mathematical computations in normal files.
(*) The MSD is derived in normal files with particles’ density that is not fixed and with particles that are not identical, yet, the diffusion coefficients of the particles are distributed according to a probability density function. Results in these files follow:
In files with a density law that is not fixed, but decays as a power law with an exponent a with the distance from the origin, the particle in the origin has a MSD that scales like, MSD~t[1+a]/2, with a Gaussian PDF [1].
When, in addition, the particles' diffusion coefficients are distributed like a power law with exponent γ (around the origin), the MSD follows, MSD~t[1-γ]/[2/ (1+a) -γ], with a Gaussian PDF [2].
(*) Files with anomalous basic dynamics, both renewal ones and those that are not renewal are solved. Results in these files follow:
In anomalous files that are renewal, namely, when all particles attempt a jump together, yet, with jumping times taken from a distribution that decays as a power law with an exponent, −1 − α, ,the MSD scales like the MSD of the corresponding normal file, in the power of α [3].
In anomalous files of independent particles, the MSD is very slow and scales like, MSD~log2(t). Even more exciting, the particles form clusters in such files, defining a dynamical phase transition. This depends on the anomaly power α: the percentage of particles in clusters ξ follows, ξ= [4].
I’ll also talk about applications of file dynamics in several fields in applied chemistry and biophysics. These include: (a) the dynamics of molecules in channels, (b) the passage of molecules along 1d objects, (c) conductance in nano-wires, etc. The talk should interest both mathematical and applied chemists, physicists and biophysicists.
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Date:29ThursdayDecember 2011Lecture
Climate Change and the "Tragedy of the Commons"
More information Time 14:00 - 14:00Location Perlman Chemical Sciences BuildingLecturer Prof. Micha Tomkiewicz
Dept. of Physics, Brooklyn College of CUNYOrganizer Department of Molecular Chemistry and Materials ScienceContact Abstract Show full text abstract about The talk will critically examine Climate Change from the Per...» The talk will critically examine Climate Change from the Perspectives of Garret Harding’s classical paper “The Tragedy of the Commons (Science – 1968)”. Webster’s definition of a tragedy is “a series drama typically describing a conflict between the protagonist and a superior force and having a sorrowful or disastrous conclusion that elicits pity or terror”. We are trying to develop instruments that are designed to prevent tragedy through the educational system. These instruments include a book that was just published titled “Climate Change: The Fork at the End of Now” that was written to serve as a textbook for the general public; development of a multiplayer electronic learning system, built on social/scientific simulations and fed by relevant and timely databases that require students to make choices and examine the consequences of these choices; and a documentary film that documents energy transition in the Sunderban region of India from hunter-gatherer to electrifying modern. -
Date:29ThursdayDecember 2011Lecture
Life Science Lectures
More information Time 15:00 - 15:00Title New Insights into Synaptic Dynamics of the Mammalian Sensory SystemLocation Dolfi and Lola Ebner AuditoriumLecturer Prof. Ilan Lampl
Department of Neurobiology Weizmann Institute of ScienceOrganizer Faculty of BiochemistryContact -
Date:01SundayJanuary 2012Lecture
To be announced
More information Time 13:00 - 13:00Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Ilya Soifer
Naama Barkai's group, Dept. of Molecular Genetics, WISOrganizer Department of Molecular GeneticsContact -
Date:01SundayJanuary 2012Lecture
TBA
More information Time 13:00 - 14:30Location Dannie N. Heineman LaboratoryLecturer Paolo Mazzali
INAF-PadovaOrganizer Nella and Leon Benoziyo Center for AstrophysicsContact -
Date:02MondayJanuary 2012Lecture
Condensed Matter Seminar
More information Time All dayLocation Edna and K.B. Weissman Building of Physical SciencesLecturer Professor Kathryn Moler Organizer Department of Condensed Matter PhysicsContact Abstract Show full text abstract about LaAlO3 (LAO) and SrTiO3 (STO) are both nonmagnetic band insu...» LaAlO3 (LAO) and SrTiO3 (STO) are both nonmagnetic band insulators, yet previous experimental and theoretical work has indicated the existence of a conducting (even superconducting) state at the interface, and suggested the possibility of ferromagnetism. We use scanning SQUID microscopy to image the magnetic behavior on micron length scales. We find three types of magnetic behaviors: weak, inhomogeneous diamagnetism consistent with superconductivity below 100 mK; a low-temperature 1/T-like paramagnetic response suggestive of a fairly uniform density of isolated spins; and ferromagnetic patches that are stable up to at least 60 Kelvin. The variety of details in reports of magnetism, including our observation of a landscape (rather than a homogeneous phase), support the exciting possibility that multiple states are important in this engineered interface. I will also discuss our recent unpublished results on the ferromagnetism's dependence on various parameters and sample conditions and on the superconductivity in which we image the landscape of superfluid density while tuning the critical temperature with gate voltage. -
Date:02MondayJanuary 2012Lecture
Bioinformatics Workshop: RNA-Seq - The Use of Short Read Illumina Data for Transcriptome Annotation and Quantification
More information Time 09:30 - 12:00Location Harry Levine Family BuildingLecturer Dr. Dena Leshkowitz
Bioinformatics Unit, Weizmann Institute of ScienceHomepage Contact Abstract Show full text abstract about RNA-Seq is a powerful technology for analyzing transcriptome...» RNA-Seq is a powerful technology for analyzing transcriptomes. This workshop will start with an hour lecture on the various computational approaches and tools to analyze the data, including:
Read mapping
Transcriptome reconstruction
Expression quantification
Detecting differential genes and transcripts
A hands-on session will follow the lecture. In this session we will practice RNA-Seq workflows provided in Galaxy (Tophat, cufflinks and cuffdiff) and the Partek Genomics Suite software. -
Date:02MondayJanuary 2012Lecture
Missing Heritability: New algorithmic and statistical approaches
More information Time 10:00 - 10:00Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer OR ZUK
Broad InstituteOrganizer The Kahn Family Research Center for Systems Biology of the Human CellContact Abstract Show full text abstract about The completion of the human genome project set a stepping st...» The completion of the human genome project set a stepping stone in building catalogs of common human genetic variation. These catalogs, in turn, enabled the search for associations between common variants and complex human traits and diseases, by performing Genome-Wide Association Studies (GWAS). GWAS have been successful in discovering thousands of statistically significant, reproducible, genotype-phenotype associations. However, the discovered variants (genotypes) explain only a small fraction of the phenotypic variance in the population for most human traits. In contrast, the heritability, defined as the proportion of phenotypic variance explained by all genetic factors, was estimated to be much larger for those same traits using indirect population-based estimators. This gap is referred to as ‘missing heritability’.
Mathematically, heritability is defined by considering a function F mapping a set of (Boolean) variables, (x1,.., xn) representing genotypes, and additional environmental or ‘noise’ variables ε, to a single (real or discrete) variable z, representing phenotype. We use the variance decomposition of F, separating the linear term, corresponding to additive (narrow-sense) heritability, and higher-order terms, representing genetic-interactions (epistasis), to explore several explanations for the ‘missing heritability’ mystery. We show that genetic interactions can significantly bias upwards current population-based heritability estimators, creating a false impression of ‘missing heritability’. We offer a solution to this problem by providing a novel consistent estimator based on unrelated individuals. We also use the Wright-Fisher process from population genetic theory to develop and apply a novel power correction method for inferring the relative contributions of rare and common variants to heritability. Finally, we propose a novel algorithm for estimating the different variance components (beyond additive) of heritability from GWAS data.
I will discuss the statistical methods and algorithms used. No prior biological knowledge is needed.
Based on joint works with Eric Lander, Eliana Hechter, Shamil Sunyaev and David Golan -
Date:02MondayJanuary 2012Lecture
Using Individual Human Genomes to Illuminate the Mysteries of Early Human History
More information Time 11:00 - 11:00Lecturer Ilan Gronau
Cornell UniversityOrganizer Faculty of Mathematics and Computer ScienceContact -
Date:02MondayJanuary 2012Lecture
"Dynamics of meristem maturation and the evolution of tomato inflorescence architecture"
More information Time 11:15 - 11:15Location Ullmann Building of Life SciencesLecturer Dr. Zachary B. Lippman
Watson School of the Biological Sciences Cold Spring Harbor Laboratory, USAOrganizer Department of Plant and Environmental SciencesContact -
Date:02MondayJanuary 2012Lecture
“Imaging a Landscape of Ferromagnetism, Paramagnetism, and Diamagnetism in LAO/STO Interfaces”‬
More information Time 13:00 - 13:00Lecturer Kathryn Moler
Stanford UniversityOrganizer Department of Condensed Matter PhysicsContact Abstract Show full text abstract about LaAlO3 (LAO) and SrTiO3 (STO) are both nonmagnetic band insu...» LaAlO3 (LAO) and SrTiO3 (STO) are both nonmagnetic band insulators, yet previous experimental and theoretical work has indicated the existence of a conducting (even superconducting) state at the interface, and suggested the possibility of ferromagnetism. We use scanning SQUID microscopy to image the magnetic behavior on micron length scales. We find three types of magnetic behaviors: weak, inhomogeneous diamagnetism consistent with superconductivity below 100 mK; a low-temperature 1/T-like paramagnetic response suggestive of a fairly uniform density of isolated spins; and ferromagnetic patches that are stable up to at least 60 Kelvin. The variety of details in reports of magnetism, including our observation of a landscape (rather than a homogeneous phase), support the exciting possibility that multiple states are important in this engineered interface. I will also discuss our recent unpublished results on the ferromagnetism's dependence on various parameters and sample conditions and on the superconductivity in which we image the landscape of superfluid density while tuning the critical temperature with gate voltage. -
Date:02MondayJanuary 2012Lecture
Good p53, bad p53
More information Time 14:00 - 14:00Location Max and Lillian Candiotty BuildingLecturer Prof. Moshe Oren
Dept. Molecular Cell Biology Weizmann InstituteOrganizer Department of Immunology and Regenerative BiologyContact -
Date:02MondayJanuary 2012Lecture
The Sliding Scale Conjecture From Intersecting Curves
More information Time 14:30 - 14:30Location Jacob Ziskind BuildingLecturer Dana Moshkovitz
MITOrganizer Faculty of Mathematics and Computer ScienceContact -
Date:02MondayJanuary 2012Lecture
"The charge radius of the proton, a five sigma discrepancy?"
More information Time 14:45 - 15:45Location Edna and K.B. Weissman Building of Physical SciencesLecturer Gil Paz
Wayne State UniversityOrganizer Department of Particle Physics and AstrophysicsContact Abstract Show full text abstract about The charge radius of the proton is a basic non-perturbative ...» The charge radius of the proton is a basic non-perturbative parameter.
Recently, it was extracted for the first time from the Lamb shift in muonic hydrogen. For a long time it was anticipated that such a measurement would reduce the error by an order of magnitude compared to measurements from electron- proton scattering and regular hydrogen spectroscopy. While this goal was achieved, the value of the proton's charge radius that was obtained was, very surprisingly, five standard deviations away from the world average.
The extraction of the charge radius from the Lamb shift in muonic hydrogen depends on a theoretical input. Together with Richard J. Hill, we are studying the hadronic uncertainty in the theoretical prediction using the tool of an effective field theory, namely NRQED. In the talk I will describe the results of this study. I will also describe a previous study of the model-independent extraction of the charge radius from electron-proton scattering We have shown that previous extractions, spanning a period of over 40 years, have underestimated their error sometimes by a factor of two or more.
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Date:02MondayJanuary 2012Lecture
Quantum Money from Hidden Subspaces
More information Time 16:00 - 16:00Lecturer Scott Aaronson
MITOrganizer Faculty of Mathematics and Computer Science -
Date:02MondayJanuary 2012Lecture
"Direct Photons in Heavy Ion Collisions"
More information Time 16:15 - 17:15Location Edna and K.B. Weissman Building of Physical SciencesLecturer Zvi Citron
Weizmann InstituteOrganizer Department of Particle Physics and AstrophysicsContact Abstract Show full text abstract about Direct photons are a key probe for understanding the hot den...» Direct photons are a key probe for understanding the hot dense matter created in heavy ion collisions. The signature result of heavy ion experiments thus far, is the dramatic modification of the production of strongly interacting particles in the hot and dense medium. Since the photon does not undergo any strong force interactions, it emerges from the medium unmodified and is a clean probe which can be contrasted to measured jets and strongly interacting particles. In particular, photon-jet correlations have been referred to as a golden channel in heavy ion collisions. In a photon-jet event the unmodified photon allows us a direct insight into the modification of the opposite side jet. The results from RHIC and LHC will be discussed. -
Date:02MondayJanuary 2012Lecture
מפגשים בחזית המדע
More information Time 19:15 - 21:00Location Davidson Institute of Science EducationOrganizer Science for All UnitHomepage Contact -
Date:03TuesdayJanuary 2012Conference
Mini-Symposium-Windows into the Mind:New Approaches to Brain and Cognition
More information Time All dayLocation Arthur and Rochelle Belfer Building for Biomedical ResearchChairperson Naomi MosesHomepage Contact -
Date:03TuesdayJanuary 2012Lecture
" Paradoxical role of DNA methylation in activation of the FoxA2 gene promoter: inhibiting the repressor"
More information Time 10:00 - 10:30Location Wolfson Building for Biological ResearchLecturer Keren Bahar
Department of Biological Chemistry, Weizmann InstituteOrganizer Department of Biomolecular SciencesContact
