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פברואר 01, 2010
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Date:29חמישידצמבר 2011הרצאה
Immunology Special Guest Seminar: An AhR Nuclear Translocator (ARNT/Hif1β) axis coordinates the glycolytic switch in effector T cells
More information שעה 12:30 - 14:00מיקום בניין וולפסון למחקר ביולוגימרצה Ella Rozenzweig
Cantrell Laboratory) College of Life Sciences University of Dundee Scotland, UKמארגן המחלקה לאימונולוגיה מערכתיתצרו קשר -
Date:29חמישידצמבר 2011הרצאה
Chemical Physics Special Guest Seminar
More information שעה 14:00 - 15:30כותרת "Single File Dynamics"מיקום בניין פרלמן למדעי הכימיהמרצה Dr. Ophir Flomenbom
Flomenbom-BPS Ltd, Israelמארגן המחלקה לפיזיקה כימית וביולוגיתצרו קשר תקציר Show full text abstract about The basic single file process is the diffusion of N (N &...» The basic single file process is the diffusion of N (N → ∞) identical Brownian hard spheres in a quasi-one-dimensional channel of length L (L → ∞), such that the spheres do not jump one on top of the other, and the average particle's density is approximately fixed. The most known statistical properties in this process are that the mean square displacement (MSD) of a particle in the file follows, MSD~t1/2 and its probability density function (PDF) is a Gaussian in position with a variance, MSD.
I’LL focus in the talk on three new variants in file dynamics and address the following questions:
(*) First, the question about the origin of the unique scaling, MSD~t1/2, in simple files, is addressed using scaling law analysis and a new approach for full mathematical computations in normal files.
(*) The MSD is derived in normal files with particles’ density that is not fixed and with particles that are not identical, yet, the diffusion coefficients of the particles are distributed according to a probability density function. Results in these files follow:
In files with a density law that is not fixed, but decays as a power law with an exponent a with the distance from the origin, the particle in the origin has a MSD that scales like, MSD~t[1+a]/2, with a Gaussian PDF [1].
When, in addition, the particles' diffusion coefficients are distributed like a power law with exponent γ (around the origin), the MSD follows, MSD~t[1-γ]/[2/ (1+a) -γ], with a Gaussian PDF [2].
(*) Files with anomalous basic dynamics, both renewal ones and those that are not renewal are solved. Results in these files follow:
In anomalous files that are renewal, namely, when all particles attempt a jump together, yet, with jumping times taken from a distribution that decays as a power law with an exponent, −1 − α, ,the MSD scales like the MSD of the corresponding normal file, in the power of α [3].
In anomalous files of independent particles, the MSD is very slow and scales like, MSD~log2(t). Even more exciting, the particles form clusters in such files, defining a dynamical phase transition. This depends on the anomaly power α: the percentage of particles in clusters ξ follows, ξ= [4].
I’ll also talk about applications of file dynamics in several fields in applied chemistry and biophysics. These include: (a) the dynamics of molecules in channels, (b) the passage of molecules along 1d objects, (c) conductance in nano-wires, etc. The talk should interest both mathematical and applied chemists, physicists and biophysicists.
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Date:29חמישידצמבר 2011הרצאה
Climate Change and the "Tragedy of the Commons"
More information שעה 14:00 - 14:00מיקום בניין פרלמן למדעי הכימיהמרצה Prof. Micha Tomkiewicz
Dept. of Physics, Brooklyn College of CUNYמארגן המחלקה לכימיה מולקולרית ולמדע חומריםצרו קשר תקציר Show full text abstract about The talk will critically examine Climate Change from the Per...» The talk will critically examine Climate Change from the Perspectives of Garret Harding’s classical paper “The Tragedy of the Commons (Science – 1968)”. Webster’s definition of a tragedy is “a series drama typically describing a conflict between the protagonist and a superior force and having a sorrowful or disastrous conclusion that elicits pity or terror”. We are trying to develop instruments that are designed to prevent tragedy through the educational system. These instruments include a book that was just published titled “Climate Change: The Fork at the End of Now” that was written to serve as a textbook for the general public; development of a multiplayer electronic learning system, built on social/scientific simulations and fed by relevant and timely databases that require students to make choices and examine the consequences of these choices; and a documentary film that documents energy transition in the Sunderban region of India from hunter-gatherer to electrifying modern. -
Date:29חמישידצמבר 2011הרצאה
Life Science Lectures
More information שעה 15:00 - 15:00כותרת New Insights into Synaptic Dynamics of the Mammalian Sensory Systemמיקום אולם ע"ש דולפי ולולה אבנרמרצה Prof. Ilan Lampl
Department of Neurobiology Weizmann Institute of Scienceמארגן הפקולטה לביוכימיהצרו קשר -
Date:01ראשוןינואר 2012הרצאה
To be announced
More information שעה 13:00 - 13:00מיקום בניין ארתור ורושל בלפר למחקר ביורפואימרצה Ilya Soifer
Naama Barkai's group, Dept. of Molecular Genetics, WISמארגן המחלקה לגנטיקה מולקולריתצרו קשר -
Date:01ראשוןינואר 2012הרצאה
TBA
More information שעה 13:00 - 14:30מיקום מעבדה על-שם דני נ. היינמןמרצה Paolo Mazzali
INAF-Padovaמארגן מרכז לאסטרופיסיקה עש נלה וליאון בנוזיוצרו קשר -
Date:02שניינואר 2012הרצאה
Condensed Matter Seminar
More information שעה כל היוםמיקום בניין הפיזיקה ע"ש עדנה וק.ב. וייסמןמרצה Professor Kathryn Moler מארגן המחלקה לפיזיקה של חומר מעובהצרו קשר תקציר Show full text abstract about LaAlO3 (LAO) and SrTiO3 (STO) are both nonmagnetic band insu...» LaAlO3 (LAO) and SrTiO3 (STO) are both nonmagnetic band insulators, yet previous experimental and theoretical work has indicated the existence of a conducting (even superconducting) state at the interface, and suggested the possibility of ferromagnetism. We use scanning SQUID microscopy to image the magnetic behavior on micron length scales. We find three types of magnetic behaviors: weak, inhomogeneous diamagnetism consistent with superconductivity below 100 mK; a low-temperature 1/T-like paramagnetic response suggestive of a fairly uniform density of isolated spins; and ferromagnetic patches that are stable up to at least 60 Kelvin. The variety of details in reports of magnetism, including our observation of a landscape (rather than a homogeneous phase), support the exciting possibility that multiple states are important in this engineered interface. I will also discuss our recent unpublished results on the ferromagnetism's dependence on various parameters and sample conditions and on the superconductivity in which we image the landscape of superfluid density while tuning the critical temperature with gate voltage. -
Date:02שניינואר 2012הרצאה
Bioinformatics Workshop: RNA-Seq - The Use of Short Read Illumina Data for Transcriptome Annotation and Quantification
More information שעה 09:30 - 12:00מיקום בניין ע"ש משפחת הרי לויןמרצה Dr. Dena Leshkowitz
Bioinformatics Unit, Weizmann Institute of Scienceדף בית צרו קשר תקציר Show full text abstract about RNA-Seq is a powerful technology for analyzing transcriptome...» RNA-Seq is a powerful technology for analyzing transcriptomes. This workshop will start with an hour lecture on the various computational approaches and tools to analyze the data, including:
Read mapping
Transcriptome reconstruction
Expression quantification
Detecting differential genes and transcripts
A hands-on session will follow the lecture. In this session we will practice RNA-Seq workflows provided in Galaxy (Tophat, cufflinks and cuffdiff) and the Partek Genomics Suite software. -
Date:02שניינואר 2012הרצאה
Missing Heritability: New algorithmic and statistical approaches
More information שעה 10:00 - 10:00מיקום בניין ארתור ורושל בלפר למחקר ביורפואימרצה OR ZUK
Broad Instituteמארגן מרכז עש משפחת קאהן לחקר ביולוגיה של מערכות בתאי אדםצרו קשר תקציר Show full text abstract about The completion of the human genome project set a stepping st...» The completion of the human genome project set a stepping stone in building catalogs of common human genetic variation. These catalogs, in turn, enabled the search for associations between common variants and complex human traits and diseases, by performing Genome-Wide Association Studies (GWAS). GWAS have been successful in discovering thousands of statistically significant, reproducible, genotype-phenotype associations. However, the discovered variants (genotypes) explain only a small fraction of the phenotypic variance in the population for most human traits. In contrast, the heritability, defined as the proportion of phenotypic variance explained by all genetic factors, was estimated to be much larger for those same traits using indirect population-based estimators. This gap is referred to as ‘missing heritability’.
Mathematically, heritability is defined by considering a function F mapping a set of (Boolean) variables, (x1,.., xn) representing genotypes, and additional environmental or ‘noise’ variables ε, to a single (real or discrete) variable z, representing phenotype. We use the variance decomposition of F, separating the linear term, corresponding to additive (narrow-sense) heritability, and higher-order terms, representing genetic-interactions (epistasis), to explore several explanations for the ‘missing heritability’ mystery. We show that genetic interactions can significantly bias upwards current population-based heritability estimators, creating a false impression of ‘missing heritability’. We offer a solution to this problem by providing a novel consistent estimator based on unrelated individuals. We also use the Wright-Fisher process from population genetic theory to develop and apply a novel power correction method for inferring the relative contributions of rare and common variants to heritability. Finally, we propose a novel algorithm for estimating the different variance components (beyond additive) of heritability from GWAS data.
I will discuss the statistical methods and algorithms used. No prior biological knowledge is needed.
Based on joint works with Eric Lander, Eliana Hechter, Shamil Sunyaev and David Golan -
Date:02שניינואר 2012הרצאה
Using Individual Human Genomes to Illuminate the Mysteries of Early Human History
More information שעה 11:00 - 11:00מרצה Ilan Gronau
Cornell Universityמארגן הפקולטה למתמטיקה ומדעי המחשבצרו קשר -
Date:02שניינואר 2012הרצאה
"Dynamics of meristem maturation and the evolution of tomato inflorescence architecture"
More information שעה 11:15 - 11:15מיקום בניין אולמן למדעי החייםמרצה Dr. Zachary B. Lippman
Watson School of the Biological Sciences Cold Spring Harbor Laboratory, USAמארגן המחלקה למדעי הצמח והסביבהצרו קשר -
Date:02שניינואר 2012הרצאה
“Imaging a Landscape of Ferromagnetism, Paramagnetism, and Diamagnetism in LAO/STO Interfaces”‬
More information שעה 13:00 - 13:00מרצה Kathryn Moler
Stanford Universityמארגן המחלקה לפיזיקה של חומר מעובהצרו קשר תקציר Show full text abstract about LaAlO3 (LAO) and SrTiO3 (STO) are both nonmagnetic band insu...» LaAlO3 (LAO) and SrTiO3 (STO) are both nonmagnetic band insulators, yet previous experimental and theoretical work has indicated the existence of a conducting (even superconducting) state at the interface, and suggested the possibility of ferromagnetism. We use scanning SQUID microscopy to image the magnetic behavior on micron length scales. We find three types of magnetic behaviors: weak, inhomogeneous diamagnetism consistent with superconductivity below 100 mK; a low-temperature 1/T-like paramagnetic response suggestive of a fairly uniform density of isolated spins; and ferromagnetic patches that are stable up to at least 60 Kelvin. The variety of details in reports of magnetism, including our observation of a landscape (rather than a homogeneous phase), support the exciting possibility that multiple states are important in this engineered interface. I will also discuss our recent unpublished results on the ferromagnetism's dependence on various parameters and sample conditions and on the superconductivity in which we image the landscape of superfluid density while tuning the critical temperature with gate voltage. -
Date:02שניינואר 2012הרצאה
Good p53, bad p53
More information שעה 14:00 - 14:00מיקום בניין ע"ש מקס ולילאן קנדיוטימרצה Prof. Moshe Oren
Dept. Molecular Cell Biology Weizmann Instituteמארגן המחלקה לאימונולוגיה ורגנרציה ביולוגיתצרו קשר -
Date:02שניינואר 2012הרצאה
The Sliding Scale Conjecture From Intersecting Curves
More information שעה 14:30 - 14:30מיקום בניין יעקב זיסקינדמרצה Dana Moshkovitz
MITמארגן הפקולטה למתמטיקה ומדעי המחשבצרו קשר -
Date:02שניינואר 2012הרצאה
"The charge radius of the proton, a five sigma discrepancy?"
More information שעה 14:45 - 15:45מיקום בניין הפיזיקה ע"ש עדנה וק.ב. וייסמןמרצה Gil Paz
Wayne State Universityמארגן המחלקה לפיזיקה של חלקיקים ואסטרופיזיקהצרו קשר תקציר Show full text abstract about The charge radius of the proton is a basic non-perturbative ...» The charge radius of the proton is a basic non-perturbative parameter.
Recently, it was extracted for the first time from the Lamb shift in muonic hydrogen. For a long time it was anticipated that such a measurement would reduce the error by an order of magnitude compared to measurements from electron- proton scattering and regular hydrogen spectroscopy. While this goal was achieved, the value of the proton's charge radius that was obtained was, very surprisingly, five standard deviations away from the world average.
The extraction of the charge radius from the Lamb shift in muonic hydrogen depends on a theoretical input. Together with Richard J. Hill, we are studying the hadronic uncertainty in the theoretical prediction using the tool of an effective field theory, namely NRQED. In the talk I will describe the results of this study. I will also describe a previous study of the model-independent extraction of the charge radius from electron-proton scattering We have shown that previous extractions, spanning a period of over 40 years, have underestimated their error sometimes by a factor of two or more.
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Date:02שניינואר 2012הרצאה
Quantum Money from Hidden Subspaces
More information שעה 16:00 - 16:00מרצה Scott Aaronson
MITמארגן הפקולטה למתמטיקה ומדעי המחשב -
Date:02שניינואר 2012הרצאה
"Direct Photons in Heavy Ion Collisions"
More information שעה 16:15 - 17:15מיקום בניין הפיזיקה ע"ש עדנה וק.ב. וייסמןמרצה Zvi Citron
Weizmann Instituteמארגן המחלקה לפיזיקה של חלקיקים ואסטרופיזיקהצרו קשר תקציר Show full text abstract about Direct photons are a key probe for understanding the hot den...» Direct photons are a key probe for understanding the hot dense matter created in heavy ion collisions. The signature result of heavy ion experiments thus far, is the dramatic modification of the production of strongly interacting particles in the hot and dense medium. Since the photon does not undergo any strong force interactions, it emerges from the medium unmodified and is a clean probe which can be contrasted to measured jets and strongly interacting particles. In particular, photon-jet correlations have been referred to as a golden channel in heavy ion collisions. In a photon-jet event the unmodified photon allows us a direct insight into the modification of the opposite side jet. The results from RHIC and LHC will be discussed. -
Date:02שניינואר 2012הרצאה
מפגשים בחזית המדע
More information שעה 19:15 - 21:00מיקום מכון דוידסון לחינוך מדעימארגן יחידת שוהם במכון דוידסוןדף בית צרו קשר -
Date:03שלישיינואר 2012כנסים
Mini-Symposium-Windows into the Mind:New Approaches to Brain and Cognition
More information שעה כל היוםמיקום בניין ארתור ורושל בלפר למחקר ביורפואייושב ראש Naomi Mosesדף בית צרו קשר -
Date:03שלישיינואר 2012הרצאה
" Paradoxical role of DNA methylation in activation of the FoxA2 gene promoter: inhibiting the repressor"
More information שעה 10:00 - 10:30מיקום בניין וולפסון למחקר ביולוגימרצה Keren Bahar
Department of Biological Chemistry, Weizmann Instituteמארגן המחלקה למדעים ביומולקולרייםצרו קשר
