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February 01, 2010

  • Date:06MondayJune 2011

    "From Sensing to Logic to Therapy: Towards Unimolecular Theranostics"

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    Time
    11:00 - 11:00
    Title
    Department of Organic Chemistry - a special departmental seminar
    Location
    Helen and Milton A. Kimmelman Building
    LecturerProf. Engin Umut Akkaya
    Department of Chemistry & UNAM-Institute of Materials Science and Nanotechnology, Bilkent University, Turkey
    Organizer
    Department of Molecular Chemistry and Materials Science
    Contact
    AbstractShow full text abstract about Photodynamic therapy (PDT) is a non-invasive methodology whi...»
    Photodynamic therapy (PDT) is a non-invasive methodology which show promise in the treatment of various cancers and other problems such as macular degeneration. The current practice of PDT is essentially built around porphyrin derivatives and their biological precursors; however, it is also widely acknowledged that they are not ideal photosensitizers for this purpose. As a consequence, development of novel sensitizers for PDT is an active field of research. While exploring potential applications of a versatile group of chromophores known as Bodipy dyes, five years ago, we found out that these compounds can be transformed into sensitizers with good PDT potential.[1] Our later work focused on the modulation of photodynamic effect by making use of unique opportunities offered by “Bodipy chemistry”. One approach was to marry molecular logic gate idea[2,3] with singlet oxygen generation in order to achieve autonomous control of PDT action. Proof of principle for this regulation was reported two years ago.[4] In the last few years, supported by computational studies, we targeted rational design of novel sensitizers and chemical activation these sensitizers through energy transfer which would eliminate the need for external light sources for excitation. Our most recent motivation is bringing together sensing and therapeutic action on a single molecule; i.e., (uni)molecular theranostics. These results will be presented in relation our final goals.





    REFERENCES

    [1] Atilgan, S.; Dost, Z.; Dogan, A. L.; Guc, Akkaya, E.U. Chem. Commun. 2006, 4398-4400.
    [2] Coskun, A.; Deniz, E.; Akkaya, E.U. Org. Lett., 2005, 7, 5187-5189.
    [3] Bozdemir, O.A.; Guliyev, R.; Buyukcakir, O.; Selcuk, S.; Kolemen, S.; Gulseren, G.; Nalbantoglu, T.; Boyaci, H.; Akkaya, E.U.; J. Am. Chem. Soc. 2010, 132, 8029-8036.
    [4] Ozlem, S.; Akkaya, E.U. J. Am. Chem. Soc. 2009, 131, 48-49.

    Lecture
  • Date:06MondayJune 2011

    Image Classification with Invariant Representations

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    Time
    13:00 - 13:00
    Location
    Ziskind Bldg.
    LecturerStephane Mallat
    CMAP, Ecole Polytechnique
    Organizer
    Faculty of Mathematics and Computer Science
    Lecture
  • Date:06MondayJune 2011

    Determinant and Permanent

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    Time
    14:30 - 14:30
    Location
    Ziskind Bldg.
    LecturerAvi Wigderson
    Institute for Advanced Study
    Organizer
    Faculty of Mathematics and Computer Science
    Lecture
  • Date:06MondayJune 2011

    Meetings at the Frontiers of Science

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    Time
    19:15 - 19:15
    Organizer
    Science for All Unit
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    Lecture
  • Date:09ThursdayJune 2011

    TBA

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    Time
    11:15 - 12:30
    Location
    Edna and K.B. Weissman Building of Physical Sciences
    LecturerEhud Behar
    Technion
    Organizer
    Faculty of Physics
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    Lecture
  • Date:09ThursdayJune 2011

    X-Ray Absorption: Where What We Do Not See Matters

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    Time
    11:15 - 12:30
    Location
    Edna and K.B. Weissman Building of Physical Sciences
    LecturerEhud Behar
    Technion
    Organizer
    Faculty of Physics
    Contact
    AbstractShow full text abstract about The talk will explain various measurements of X-ray absorpti...»
    The talk will explain various measurements of X-ray absorption of astrophysical sources and the immense challenge to physically characterize the intervening matter.
    Only 10% of the baryons of the local Universe reside in galaxies, while 90% are conjectured to occupy the intergalactic medium in a form that makes it impossible to detect their electromagnetic emission.
    It will be shown how recent measurements of photo-electric absorption of the farthest known X-ray point sources, namely gamma-ray bursts and quasars, can account for the long sought baryons.
    Since X-ray absorption requires heavy elements (Z > 5), massive galactic winds are invoked to explain how these elements reached intergalactic space.
    The utilization of high-resolution atomic spectroscopy for estimating the mass flow in galactic winds emanating from around supermassive black holes will be demonstrated.
    Colloquia
  • Date:09ThursdayJune 2011

    Functional Imaging of Nanowires

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    Time
    15:00 - 15:00
    Location
    Perlman Chemical Sciences Building
    LecturerProf. Lincoln J. Lauhon
    Department of Materials Science and Engineering, Northwestern University, Evanston, IL
    Organizer
    Department of Molecular Chemistry and Materials Science
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    Lecture
  • Date:10FridayJune 2011

    Vascular club

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    Time
    10:00 - 12:30
    Location
    Max and Lillian Candiotty Building
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    Lecture
  • Date:12SundayJune 2011

    Semi-Supervised Learning in Gigantic Image Collection

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    Time
    11:00 - 11:00
    Location
    Ziskind Bldg.
    LecturerYair Weiss
    The Hebrew University of Jerusalem
    Organizer
    Faculty of Mathematics and Computer Science
    Lecture
  • Date:12SundayJune 2011

    "Pressure Solution and Stylolites in Carbonate Rocks"

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    Time
    11:00 - 11:00
    LecturerLeehee Laronne
    Environmental Sciences and Energy Research Dept. Weizmann Institute of Science
    Organizer
    Department of Earth and Planetary Sciences
    Contact
    Lecture
  • Date:12SundayJune 2011

    Journal club - A special discussion on PTF11eon.

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    Time
    12:30 - 14:00
    Title
    PTF11eon is the new SN on M51, discovered ~10 days ago by PTF and amateur astronomers simultaneously, (more or less).
    Location
    Dannie N. Heineman Laboratory
    LecturerProf. Avishay Gal-Yam
    Organizer
    Nella and Leon Benoziyo Center for Astrophysics
    Contact
    Lecture
  • Date:12SundayJune 2011

    Light matter interaction: Observable phenomena which can not be predicted by the standard formalism of quantum mechanics.

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    Time
    12:30 - 12:30
    Location
    Gerhard M.J. Schmidt Lecture Hall
    LecturerProfessor Nimrod Moiseyev
    Organizer
    Department of Chemical and Biological Physics
    Contact
    AbstractShow full text abstract about The non-hermitian formalism of quantum mechanics enables one...»
    The non-hermitian formalism of quantum mechanics enables one to solve problems which are extremely hard to solve and often even impossible to solve within the framework of the standard formalism of quantum mechanics.
    It this talk I will focus on a situation where in non-hermitian quantum
    mechanics two eigenvalues and their corresponding eigenfunctions are
    degenerated eigenvalues and states, respectively. We will discuss the effect of
    this "accidental" situation (which cannot happen in the standard formalism of
    quantum mechanics) on different type of observable phenomena.

    We will show how there are observable phenomena that can be predicted by the
    non-hermiitian formalism of quantum mechanics in light matter interactions.
    Either in propagation of light in waveguides or when atoms or molecules or
    nanostructures interact with laser fields.

    References to the CROSSING RULE in non-hermitian QM
    -----------------------------------------------------
    NM and S. Friedland, "The Association of Resonance States with the Incomplete
    Spectrum of Finite Complex-Scaled Hamiltonian Matrices." Phys. Rev. A, 22,
    618-623 (1980).

    E. Narevicius and NM, "Fingerprints of broad overlapping resonances in the e+H2
    cross section." Phys. Rev. Lett., 81, No. 11 (1998);

    E. Narevicius and NM, "Trapping of an electron due to molecular vibrations."
    Phys. Rev. Lett., 84, 1681 (2000).

    E. Narevicius, P. Serra and NM, "Critical phenomena associated with
    self-orthogonality in non_Hermitian quantum mechanics." Europhys. Lett., 62,
    789-794 (2003).

    S. Klaiman, U. Gunther, and NM, "Visualization of Branch Points in PT-Symmetric
    Waveguides, Phys. Rev. Lett. 101, 080402 (2008)

    O. Peleg, M. Segev, G. Bartal, D. N. Christodoulides, and NM, "NonlinearWaves
    in SubwavelengthWaveguide Arrays: Evanescent Bands and the "Phoenix Soliton
    Phys. Rev. Lett. 102, 163902 (2009).

    O. Peleg, Y. Plotnik, NM, O. Cohen, and M. Segev, "Self-trapped leaky waves and
    their interactions",
    Phys. Rev A80, 041801(R) 2009.

    R. Lefebvre, O. Atabek, M. Sindelka, and NM, "Resonance Coalescence in
    Molecular Photodissociation", Phys. Rev. Lett. 103, 123003, (2009).

    B. Alfassi, O. Peleg, NM, and M. Segev
    "Diverging Rabi Oscillations in Subwavelength Photonic Lattices"
    Phys. Rev. Lett. 106, 073901 (2011)

    NM, "Non-Hermitian Quantum Mechanics", Cambridge University Press, 2011.



    Lecture
  • Date:12SundayJune 2011

    The long and winding road: from NDEL1 to PPT1

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    Time
    13:00 - 13:00
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    LecturerMichal Segal
    Orly Reiner's group, Dept. of Molecular Genetics, WIS
    Organizer
    Department of Molecular Genetics
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    Lecture
  • Date:12SundayJune 2011

    Effective temperature of active systems

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    Time
    13:15 - 13:15
    Title
    Clore Physics-Biology Meetings
    Location
    Drory Auditorium
    LecturerProf. Nir Gov
    Dept. Chemical Physics
    Organizer
    Clore Center for Biological Physics
    Contact
    Lecture
  • Date:13MondayJune 2011

    From Biogenic Silica to Silica Bio-Hybrids - G.M.J. Schmidt Memorial Lecture

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    Time
    10:30 - 12:30
    Location
    Gerhard M.J. Schmidt Lecture Hall
    LecturerProf. Jacques Livage
    College de France, Paris
    Organizer
    Faculty of Chemistry
    Contact
    AbstractShow full text abstract about Micro-algaes such as diatoms are building silica shells in o...»
    Micro-algaes such as diatoms are building silica shells in order to protect themselves
    against predators. These biogenic glasses are made under ambiant conditions from the very
    small amount of silica dissolved in water. They exhibit an incredible variety of sophisticated
    architectures that are genetically controlled. They even behave as photonic crystals in order to
    control the behavior of sunlight.
    Following this example, the so-called 'sol-gel process' was developped in order to built
    nanostructured silica materials via the polycondensation of molecular precursors. The mild
    conditions associated with this process, allow the immobilization of biological species. These
    bio-hybrids open new possibilities in the field of biotechnologies. Enzymes, antibodies and
    even whole cells can be trapped within silica gels. They retain their bioactivity and can be
    used for many biological and medical applications : biosensors, bioreactors or drug release
    Many examples can now be found in the litterature, but one of the main challenge remains the
    viability of trapped cells within porous oxide matrices. As suggested by diatoms, life should
    be possible inside a silica cage ! This lecture presents an overview of most recent biological
    applications of the sol-gel process.
    Lecture
  • Date:13MondayJune 2011

    Existence of Klyachko models for GL(n,R) and GL(n,C)

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    Time
    11:00 - 11:00
    Location
    Ziskind Bldg.
    LecturerSiddhartha Sahi
    Rutgers
    Organizer
    Faculty of Mathematics and Computer Science
    Lecture
  • Date:13MondayJune 2011

    Regulation of terminal diferrentiation by Calpains and Myc

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    Time
    14:00 - 14:00
    Location
    Max and Lillian Candiotty Building
    LecturerDr.Maralice Conacci-Sorrell
    Fred Hutchinson Cancer Research Center, Seattle, WA. USA
    Organizer
    Department of Immunology and Regenerative Biology
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    Lecture
  • Date:13MondayJune 2011

    Decision related activity and top-down modulations in primate V1

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    Time
    14:00 - 14:00
    Location
    Gerhard M.J. Schmidt Lecture Hall
    LecturerProf. Eyal Seidemann
    Center for Perceptual Systems University of Texas at Austin
    Organizer
    Department of Brain Sciences
    Contact
    AbstractShow full text abstract about What are the sources of trial-to-trial variability in neural...»
    What are the sources of trial-to-trial variability in neural responses in early sensory cortical areas and how does this variability affect perceptual decisions? In this talk I will describe results from two studies that aim to address these questions. In the first study, we examined co-variations between behavioral choices of monkeys performing a threshold visual detection task and neural population responses recorded simultaneously from their V1. We found that fluctuations in V1 responses to the same visual stimulus are correlated with fluctuations in perceptual decisions. Our results provide insight regarding the decoding mechanisms that mediate behavior based on V1 responses and suggest that most choice-related variability is already present in V1. Top-down modulations from higher visual cortical areas are one potential source for these decision related signals in V1. The goal of the second study was to characterize two forms of top-down effects in V1: modulations by spatial uncertainty and by stimulus relevance. We found that V1 responses are unaffected by spatial uncertainty, suggesting that target sensitivity is not a limited resource that can be improved by focal attention in V1. Conversely, V1 responses were significantly modulated by stimulus relevance. These modulations are likely to contribute to spatial gating of task-irrelevant information. However, the spatial and temporal characteristics of this top-down signal suggest that it is not a major source of choice-related variability in V1. Our results are therefore consistent with a predominantly bottom-up source of decision related activity in V1.
    Lecture
  • Date:13MondayJune 2011

    Sublinear optimization for machine learning

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    Time
    14:30 - 14:30
    Location
    Ziskind Bldg.
    LecturerElad Hazan
    Technion
    Organizer
    Faculty of Mathematics and Computer Science
    Lecture
  • Date:14TuesdayJune 2011

    "How EFF-1 and AFF-1 Fuse Plasma Membranes and Sculpt Cells"

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    Time
    10:00 - 10:00
    Location
    Wolfson Building for Biological Research
    LecturerProf. Benjamin Podbilewicz
    Department of Biology Technion, Haifa
    Organizer
    Department of Biomolecular Sciences
    Contact
    Lecture

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