Pages
February 01, 2010
-
Date:06MondayJune 2011Lecture
"From Sensing to Logic to Therapy: Towards Unimolecular Theranostics"
More information Time 11:00 - 11:00Title Department of Organic Chemistry - a special departmental seminarLocation Helen and Milton A. Kimmelman BuildingLecturer Prof. Engin Umut Akkaya
Department of Chemistry & UNAM-Institute of Materials Science and Nanotechnology, Bilkent University, TurkeyOrganizer Department of Molecular Chemistry and Materials ScienceContact Abstract Show full text abstract about Photodynamic therapy (PDT) is a non-invasive methodology whi...» Photodynamic therapy (PDT) is a non-invasive methodology which show promise in the treatment of various cancers and other problems such as macular degeneration. The current practice of PDT is essentially built around porphyrin derivatives and their biological precursors; however, it is also widely acknowledged that they are not ideal photosensitizers for this purpose. As a consequence, development of novel sensitizers for PDT is an active field of research. While exploring potential applications of a versatile group of chromophores known as Bodipy dyes, five years ago, we found out that these compounds can be transformed into sensitizers with good PDT potential.[1] Our later work focused on the modulation of photodynamic effect by making use of unique opportunities offered by “Bodipy chemistry”. One approach was to marry molecular logic gate idea[2,3] with singlet oxygen generation in order to achieve autonomous control of PDT action. Proof of principle for this regulation was reported two years ago.[4] In the last few years, supported by computational studies, we targeted rational design of novel sensitizers and chemical activation these sensitizers through energy transfer which would eliminate the need for external light sources for excitation. Our most recent motivation is bringing together sensing and therapeutic action on a single molecule; i.e., (uni)molecular theranostics. These results will be presented in relation our final goals.
REFERENCES
[1] Atilgan, S.; Dost, Z.; Dogan, A. L.; Guc, Akkaya, E.U. Chem. Commun. 2006, 4398-4400.
[2] Coskun, A.; Deniz, E.; Akkaya, E.U. Org. Lett., 2005, 7, 5187-5189.
[3] Bozdemir, O.A.; Guliyev, R.; Buyukcakir, O.; Selcuk, S.; Kolemen, S.; Gulseren, G.; Nalbantoglu, T.; Boyaci, H.; Akkaya, E.U.; J. Am. Chem. Soc. 2010, 132, 8029-8036.
[4] Ozlem, S.; Akkaya, E.U. J. Am. Chem. Soc. 2009, 131, 48-49.
-
Date:06MondayJune 2011Lecture
Image Classification with Invariant Representations
More information Time 13:00 - 13:00Location Ziskind Bldg.Lecturer Stephane Mallat
CMAP, Ecole PolytechniqueOrganizer Faculty of Mathematics and Computer Science -
Date:06MondayJune 2011Lecture
Determinant and Permanent
More information Time 14:30 - 14:30Location Ziskind Bldg.Lecturer Avi Wigderson
Institute for Advanced StudyOrganizer Faculty of Mathematics and Computer Science -
Date:06MondayJune 2011Lecture
Meetings at the Frontiers of Science
More information Time 19:15 - 19:15Organizer Science for All UnitHomepage Contact -
Date:09ThursdayJune 2011Lecture
TBA
More information Time 11:15 - 12:30Location Edna and K.B. Weissman Building of Physical SciencesLecturer Ehud Behar
TechnionOrganizer Faculty of PhysicsContact -
Date:09ThursdayJune 2011Colloquia
X-Ray Absorption: Where What We Do Not See Matters
More information Time 11:15 - 12:30Location Edna and K.B. Weissman Building of Physical SciencesLecturer Ehud Behar
TechnionOrganizer Faculty of PhysicsContact Abstract Show full text abstract about The talk will explain various measurements of X-ray absorpti...» The talk will explain various measurements of X-ray absorption of astrophysical sources and the immense challenge to physically characterize the intervening matter.
Only 10% of the baryons of the local Universe reside in galaxies, while 90% are conjectured to occupy the intergalactic medium in a form that makes it impossible to detect their electromagnetic emission.
It will be shown how recent measurements of photo-electric absorption of the farthest known X-ray point sources, namely gamma-ray bursts and quasars, can account for the long sought baryons.
Since X-ray absorption requires heavy elements (Z > 5), massive galactic winds are invoked to explain how these elements reached intergalactic space.
The utilization of high-resolution atomic spectroscopy for estimating the mass flow in galactic winds emanating from around supermassive black holes will be demonstrated.
-
Date:09ThursdayJune 2011Lecture
Functional Imaging of Nanowires
More information Time 15:00 - 15:00Location Perlman Chemical Sciences BuildingLecturer Prof. Lincoln J. Lauhon
Department of Materials Science and Engineering, Northwestern University, Evanston, ILOrganizer Department of Molecular Chemistry and Materials ScienceContact -
Date:10FridayJune 2011Lecture
Vascular club
More information Time 10:00 - 12:30Location Max and Lillian Candiotty BuildingContact -
Date:12SundayJune 2011Lecture
Semi-Supervised Learning in Gigantic Image Collection
More information Time 11:00 - 11:00Location Ziskind Bldg.Lecturer Yair Weiss
The Hebrew University of JerusalemOrganizer Faculty of Mathematics and Computer Science -
Date:12SundayJune 2011Lecture
"Pressure Solution and Stylolites in Carbonate Rocks"
More information Time 11:00 - 11:00Lecturer Leehee Laronne
Environmental Sciences and Energy Research Dept. Weizmann Institute of ScienceOrganizer Department of Earth and Planetary SciencesContact -
Date:12SundayJune 2011Lecture
Journal club - A special discussion on PTF11eon.
More information Time 12:30 - 14:00Title PTF11eon is the new SN on M51, discovered ~10 days ago by PTF and amateur astronomers simultaneously, (more or less).Location Dannie N. Heineman LaboratoryLecturer Prof. Avishay Gal-Yam Organizer Nella and Leon Benoziyo Center for AstrophysicsContact -
Date:12SundayJune 2011Lecture
Light matter interaction: Observable phenomena which can not be predicted by the standard formalism of quantum mechanics.
More information Time 12:30 - 12:30Location Gerhard M.J. Schmidt Lecture HallLecturer Professor Nimrod Moiseyev Organizer Department of Chemical and Biological PhysicsContact Abstract Show full text abstract about The non-hermitian formalism of quantum mechanics enables one...» The non-hermitian formalism of quantum mechanics enables one to solve problems which are extremely hard to solve and often even impossible to solve within the framework of the standard formalism of quantum mechanics.
It this talk I will focus on a situation where in non-hermitian quantum
mechanics two eigenvalues and their corresponding eigenfunctions are
degenerated eigenvalues and states, respectively. We will discuss the effect of
this "accidental" situation (which cannot happen in the standard formalism of
quantum mechanics) on different type of observable phenomena.
We will show how there are observable phenomena that can be predicted by the
non-hermiitian formalism of quantum mechanics in light matter interactions.
Either in propagation of light in waveguides or when atoms or molecules or
nanostructures interact with laser fields.
References to the CROSSING RULE in non-hermitian QM
-----------------------------------------------------
NM and S. Friedland, "The Association of Resonance States with the Incomplete
Spectrum of Finite Complex-Scaled Hamiltonian Matrices." Phys. Rev. A, 22,
618-623 (1980).
E. Narevicius and NM, "Fingerprints of broad overlapping resonances in the e+H2
cross section." Phys. Rev. Lett., 81, No. 11 (1998);
E. Narevicius and NM, "Trapping of an electron due to molecular vibrations."
Phys. Rev. Lett., 84, 1681 (2000).
E. Narevicius, P. Serra and NM, "Critical phenomena associated with
self-orthogonality in non_Hermitian quantum mechanics." Europhys. Lett., 62,
789-794 (2003).
S. Klaiman, U. Gunther, and NM, "Visualization of Branch Points in PT-Symmetric
Waveguides, Phys. Rev. Lett. 101, 080402 (2008)
O. Peleg, M. Segev, G. Bartal, D. N. Christodoulides, and NM, "NonlinearWaves
in SubwavelengthWaveguide Arrays: Evanescent Bands and the "Phoenix Soliton
Phys. Rev. Lett. 102, 163902 (2009).
O. Peleg, Y. Plotnik, NM, O. Cohen, and M. Segev, "Self-trapped leaky waves and
their interactions",
Phys. Rev A80, 041801(R) 2009.
R. Lefebvre, O. Atabek, M. Sindelka, and NM, "Resonance Coalescence in
Molecular Photodissociation", Phys. Rev. Lett. 103, 123003, (2009).
B. Alfassi, O. Peleg, NM, and M. Segev
"Diverging Rabi Oscillations in Subwavelength Photonic Lattices"
Phys. Rev. Lett. 106, 073901 (2011)
NM, "Non-Hermitian Quantum Mechanics", Cambridge University Press, 2011.
-
Date:12SundayJune 2011Lecture
The long and winding road: from NDEL1 to PPT1
More information Time 13:00 - 13:00Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Michal Segal
Orly Reiner's group, Dept. of Molecular Genetics, WISOrganizer Department of Molecular GeneticsContact -
Date:12SundayJune 2011Lecture
Effective temperature of active systems
More information Time 13:15 - 13:15Title Clore Physics-Biology MeetingsLocation Drory AuditoriumLecturer Prof. Nir Gov
Dept. Chemical PhysicsOrganizer Clore Center for Biological PhysicsContact -
Date:13MondayJune 2011Lecture
From Biogenic Silica to Silica Bio-Hybrids - G.M.J. Schmidt Memorial Lecture
More information Time 10:30 - 12:30Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Jacques Livage
College de France, ParisOrganizer Faculty of ChemistryContact Abstract Show full text abstract about Micro-algaes such as diatoms are building silica shells in o...» Micro-algaes such as diatoms are building silica shells in order to protect themselves
against predators. These biogenic glasses are made under ambiant conditions from the very
small amount of silica dissolved in water. They exhibit an incredible variety of sophisticated
architectures that are genetically controlled. They even behave as photonic crystals in order to
control the behavior of sunlight.
Following this example, the so-called 'sol-gel process' was developped in order to built
nanostructured silica materials via the polycondensation of molecular precursors. The mild
conditions associated with this process, allow the immobilization of biological species. These
bio-hybrids open new possibilities in the field of biotechnologies. Enzymes, antibodies and
even whole cells can be trapped within silica gels. They retain their bioactivity and can be
used for many biological and medical applications : biosensors, bioreactors or drug release
Many examples can now be found in the litterature, but one of the main challenge remains the
viability of trapped cells within porous oxide matrices. As suggested by diatoms, life should
be possible inside a silica cage ! This lecture presents an overview of most recent biological
applications of the sol-gel process. -
Date:13MondayJune 2011Lecture
Existence of Klyachko models for GL(n,R) and GL(n,C)
More information Time 11:00 - 11:00Location Ziskind Bldg.Lecturer Siddhartha Sahi
RutgersOrganizer Faculty of Mathematics and Computer Science -
Date:13MondayJune 2011Lecture
Regulation of terminal diferrentiation by Calpains and Myc
More information Time 14:00 - 14:00Location Max and Lillian Candiotty BuildingLecturer Dr.Maralice Conacci-Sorrell
Fred Hutchinson Cancer Research Center, Seattle, WA. USAOrganizer Department of Immunology and Regenerative BiologyContact -
Date:13MondayJune 2011Lecture
Decision related activity and top-down modulations in primate V1
More information Time 14:00 - 14:00Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Eyal Seidemann
Center for Perceptual Systems University of Texas at AustinOrganizer Department of Brain SciencesContact Abstract Show full text abstract about What are the sources of trial-to-trial variability in neural...» What are the sources of trial-to-trial variability in neural responses in early sensory cortical areas and how does this variability affect perceptual decisions? In this talk I will describe results from two studies that aim to address these questions. In the first study, we examined co-variations between behavioral choices of monkeys performing a threshold visual detection task and neural population responses recorded simultaneously from their V1. We found that fluctuations in V1 responses to the same visual stimulus are correlated with fluctuations in perceptual decisions. Our results provide insight regarding the decoding mechanisms that mediate behavior based on V1 responses and suggest that most choice-related variability is already present in V1. Top-down modulations from higher visual cortical areas are one potential source for these decision related signals in V1. The goal of the second study was to characterize two forms of top-down effects in V1: modulations by spatial uncertainty and by stimulus relevance. We found that V1 responses are unaffected by spatial uncertainty, suggesting that target sensitivity is not a limited resource that can be improved by focal attention in V1. Conversely, V1 responses were significantly modulated by stimulus relevance. These modulations are likely to contribute to spatial gating of task-irrelevant information. However, the spatial and temporal characteristics of this top-down signal suggest that it is not a major source of choice-related variability in V1. Our results are therefore consistent with a predominantly bottom-up source of decision related activity in V1. -
Date:13MondayJune 2011Lecture
Sublinear optimization for machine learning
More information Time 14:30 - 14:30Location Ziskind Bldg.Lecturer Elad Hazan
TechnionOrganizer Faculty of Mathematics and Computer Science -
Date:14TuesdayJune 2011Lecture
"How EFF-1 and AFF-1 Fuse Plasma Membranes and Sculpt Cells"
More information Time 10:00 - 10:00Location Wolfson Building for Biological ResearchLecturer Prof. Benjamin Podbilewicz
Department of Biology Technion, HaifaOrganizer Department of Biomolecular SciencesContact
