Pages

פברואר 01, 2010

  • Date:06שנייוני 2011

    "From Sensing to Logic to Therapy: Towards Unimolecular Theranostics"

    More information
    שעה
    11:00 - 11:00
    כותרת
    Department of Organic Chemistry - a special departmental seminar
    מיקום
    בניין הלן ומילטון קימלמן
    מרצהProf. Engin Umut Akkaya
    Department of Chemistry & UNAM-Institute of Materials Science and Nanotechnology, Bilkent University, Turkey
    מארגן
    המחלקה לכימיה מולקולרית ולמדע חומרים
    צרו קשר
    תקצירShow full text abstract about Photodynamic therapy (PDT) is a non-invasive methodology whi...»
    Photodynamic therapy (PDT) is a non-invasive methodology which show promise in the treatment of various cancers and other problems such as macular degeneration. The current practice of PDT is essentially built around porphyrin derivatives and their biological precursors; however, it is also widely acknowledged that they are not ideal photosensitizers for this purpose. As a consequence, development of novel sensitizers for PDT is an active field of research. While exploring potential applications of a versatile group of chromophores known as Bodipy dyes, five years ago, we found out that these compounds can be transformed into sensitizers with good PDT potential.[1] Our later work focused on the modulation of photodynamic effect by making use of unique opportunities offered by “Bodipy chemistry”. One approach was to marry molecular logic gate idea[2,3] with singlet oxygen generation in order to achieve autonomous control of PDT action. Proof of principle for this regulation was reported two years ago.[4] In the last few years, supported by computational studies, we targeted rational design of novel sensitizers and chemical activation these sensitizers through energy transfer which would eliminate the need for external light sources for excitation. Our most recent motivation is bringing together sensing and therapeutic action on a single molecule; i.e., (uni)molecular theranostics. These results will be presented in relation our final goals.





    REFERENCES

    [1] Atilgan, S.; Dost, Z.; Dogan, A. L.; Guc, Akkaya, E.U. Chem. Commun. 2006, 4398-4400.
    [2] Coskun, A.; Deniz, E.; Akkaya, E.U. Org. Lett., 2005, 7, 5187-5189.
    [3] Bozdemir, O.A.; Guliyev, R.; Buyukcakir, O.; Selcuk, S.; Kolemen, S.; Gulseren, G.; Nalbantoglu, T.; Boyaci, H.; Akkaya, E.U.; J. Am. Chem. Soc. 2010, 132, 8029-8036.
    [4] Ozlem, S.; Akkaya, E.U. J. Am. Chem. Soc. 2009, 131, 48-49.

    הרצאה
  • Date:06שנייוני 2011

    Image Classification with Invariant Representations

    More information
    שעה
    13:00 - 13:00
    מיקום
    Ziskind Bldg.
    מרצהStephane Mallat
    CMAP, Ecole Polytechnique
    מארגן
    הפקולטה למתמטיקה ומדעי המחשב
    הרצאה
  • Date:06שנייוני 2011

    Determinant and Permanent

    More information
    שעה
    14:30 - 14:30
    מיקום
    Ziskind Bldg.
    מרצהAvi Wigderson
    Institute for Advanced Study
    מארגן
    הפקולטה למתמטיקה ומדעי המחשב
    הרצאה
  • Date:06שנייוני 2011

    מפגשים בחזית המדע

    More information
    שעה
    19:15 - 19:15
    מארגן
    יחידת שוהם במכון דוידסון
    דף בית
    צרו קשר
    הרצאה
  • Date:09חמישייוני 2011

    TBA

    More information
    שעה
    11:15 - 12:30
    מיקום
    בניין הפיזיקה ע"ש עדנה וק.ב. וייסמן
    מרצהEhud Behar
    Technion
    מארגן
    הפקולטה לפיזיקה
    צרו קשר
    הרצאה
  • Date:09חמישייוני 2011

    X-Ray Absorption: Where What We Do Not See Matters

    More information
    שעה
    11:15 - 12:30
    מיקום
    בניין הפיזיקה ע"ש עדנה וק.ב. וייסמן
    מרצהEhud Behar
    Technion
    מארגן
    הפקולטה לפיזיקה
    צרו קשר
    תקצירShow full text abstract about The talk will explain various measurements of X-ray absorpti...»
    The talk will explain various measurements of X-ray absorption of astrophysical sources and the immense challenge to physically characterize the intervening matter.
    Only 10% of the baryons of the local Universe reside in galaxies, while 90% are conjectured to occupy the intergalactic medium in a form that makes it impossible to detect their electromagnetic emission.
    It will be shown how recent measurements of photo-electric absorption of the farthest known X-ray point sources, namely gamma-ray bursts and quasars, can account for the long sought baryons.
    Since X-ray absorption requires heavy elements (Z > 5), massive galactic winds are invoked to explain how these elements reached intergalactic space.
    The utilization of high-resolution atomic spectroscopy for estimating the mass flow in galactic winds emanating from around supermassive black holes will be demonstrated.
    סימפוזיונים
  • Date:09חמישייוני 2011

    Functional Imaging of Nanowires

    More information
    שעה
    15:00 - 15:00
    מיקום
    בניין פרלמן למדעי הכימיה
    מרצהProf. Lincoln J. Lauhon
    Department of Materials Science and Engineering, Northwestern University, Evanston, IL
    מארגן
    המחלקה לכימיה מולקולרית ולמדע חומרים
    צרו קשר
    הרצאה
  • Date:10שישייוני 2011

    Vascular club

    More information
    שעה
    10:00 - 12:30
    מיקום
    בניין ע"ש מקס ולילאן קנדיוטי
    צרו קשר
    הרצאה
  • Date:12ראשוןיוני 2011

    Semi-Supervised Learning in Gigantic Image Collection

    More information
    שעה
    11:00 - 11:00
    מיקום
    Ziskind Bldg.
    מרצהYair Weiss
    The Hebrew University of Jerusalem
    מארגן
    הפקולטה למתמטיקה ומדעי המחשב
    הרצאה
  • Date:12ראשוןיוני 2011

    "Pressure Solution and Stylolites in Carbonate Rocks"

    More information
    שעה
    11:00 - 11:00
    מרצהLeehee Laronne
    Environmental Sciences and Energy Research Dept. Weizmann Institute of Science
    מארגן
    המחלקה למדעי כדור הארץ וכוכבי הלכת
    צרו קשר
    הרצאה
  • Date:12ראשוןיוני 2011

    Journal club - A special discussion on PTF11eon.

    More information
    שעה
    12:30 - 14:00
    כותרת
    PTF11eon is the new SN on M51, discovered ~10 days ago by PTF and amateur astronomers simultaneously, (more or less).
    מיקום
    מעבדה על-שם דני נ. היינמן
    מרצהProf. Avishay Gal-Yam
    מארגן
    מרכז לאסטרופיזיקה עש נלה וליאון בנוזיו
    צרו קשר
    הרצאה
  • Date:12ראשוןיוני 2011

    Light matter interaction: Observable phenomena which can not be predicted by the standard formalism of quantum mechanics.

    More information
    שעה
    12:30 - 12:30
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצהProfessor Nimrod Moiseyev
    מארגן
    המחלקה לפיזיקה כימית וביולוגית
    צרו קשר
    תקצירShow full text abstract about The non-hermitian formalism of quantum mechanics enables one...»
    The non-hermitian formalism of quantum mechanics enables one to solve problems which are extremely hard to solve and often even impossible to solve within the framework of the standard formalism of quantum mechanics.
    It this talk I will focus on a situation where in non-hermitian quantum
    mechanics two eigenvalues and their corresponding eigenfunctions are
    degenerated eigenvalues and states, respectively. We will discuss the effect of
    this "accidental" situation (which cannot happen in the standard formalism of
    quantum mechanics) on different type of observable phenomena.

    We will show how there are observable phenomena that can be predicted by the
    non-hermiitian formalism of quantum mechanics in light matter interactions.
    Either in propagation of light in waveguides or when atoms or molecules or
    nanostructures interact with laser fields.

    References to the CROSSING RULE in non-hermitian QM
    -----------------------------------------------------
    NM and S. Friedland, "The Association of Resonance States with the Incomplete
    Spectrum of Finite Complex-Scaled Hamiltonian Matrices." Phys. Rev. A, 22,
    618-623 (1980).

    E. Narevicius and NM, "Fingerprints of broad overlapping resonances in the e+H2
    cross section." Phys. Rev. Lett., 81, No. 11 (1998);

    E. Narevicius and NM, "Trapping of an electron due to molecular vibrations."
    Phys. Rev. Lett., 84, 1681 (2000).

    E. Narevicius, P. Serra and NM, "Critical phenomena associated with
    self-orthogonality in non_Hermitian quantum mechanics." Europhys. Lett., 62,
    789-794 (2003).

    S. Klaiman, U. Gunther, and NM, "Visualization of Branch Points in PT-Symmetric
    Waveguides, Phys. Rev. Lett. 101, 080402 (2008)

    O. Peleg, M. Segev, G. Bartal, D. N. Christodoulides, and NM, "NonlinearWaves
    in SubwavelengthWaveguide Arrays: Evanescent Bands and the "Phoenix Soliton
    Phys. Rev. Lett. 102, 163902 (2009).

    O. Peleg, Y. Plotnik, NM, O. Cohen, and M. Segev, "Self-trapped leaky waves and
    their interactions",
    Phys. Rev A80, 041801(R) 2009.

    R. Lefebvre, O. Atabek, M. Sindelka, and NM, "Resonance Coalescence in
    Molecular Photodissociation", Phys. Rev. Lett. 103, 123003, (2009).

    B. Alfassi, O. Peleg, NM, and M. Segev
    "Diverging Rabi Oscillations in Subwavelength Photonic Lattices"
    Phys. Rev. Lett. 106, 073901 (2011)

    NM, "Non-Hermitian Quantum Mechanics", Cambridge University Press, 2011.



    הרצאה
  • Date:12ראשוןיוני 2011

    The long and winding road: from NDEL1 to PPT1

    More information
    שעה
    13:00 - 13:00
    מיקום
    בניין ארתור ורושל בלפר למחקר ביורפואי
    מרצהMichal Segal
    Orly Reiner's group, Dept. of Molecular Genetics, WIS
    מארגן
    המחלקה לגנטיקה מולקולרית
    צרו קשר
    הרצאה
  • Date:12ראשוןיוני 2011

    Effective temperature of active systems

    More information
    שעה
    13:15 - 13:15
    כותרת
    Clore Physics-Biology Meetings
    מיקום
    Drory Auditorium
    מרצהProf. Nir Gov
    Dept. Chemical Physics
    מארגן
    מרכז לפיזיקה ביולוגית עש קלור
    צרו קשר
    הרצאה
  • Date:13שנייוני 2011

    From Biogenic Silica to Silica Bio-Hybrids - G.M.J. Schmidt Memorial Lecture

    More information
    שעה
    10:30 - 12:30
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצהProf. Jacques Livage
    College de France, Paris
    מארגן
    הפקולטה לכימיה
    צרו קשר
    תקצירShow full text abstract about Micro-algaes such as diatoms are building silica shells in o...»
    Micro-algaes such as diatoms are building silica shells in order to protect themselves
    against predators. These biogenic glasses are made under ambiant conditions from the very
    small amount of silica dissolved in water. They exhibit an incredible variety of sophisticated
    architectures that are genetically controlled. They even behave as photonic crystals in order to
    control the behavior of sunlight.
    Following this example, the so-called 'sol-gel process' was developped in order to built
    nanostructured silica materials via the polycondensation of molecular precursors. The mild
    conditions associated with this process, allow the immobilization of biological species. These
    bio-hybrids open new possibilities in the field of biotechnologies. Enzymes, antibodies and
    even whole cells can be trapped within silica gels. They retain their bioactivity and can be
    used for many biological and medical applications : biosensors, bioreactors or drug release
    Many examples can now be found in the litterature, but one of the main challenge remains the
    viability of trapped cells within porous oxide matrices. As suggested by diatoms, life should
    be possible inside a silica cage ! This lecture presents an overview of most recent biological
    applications of the sol-gel process.
    הרצאה
  • Date:13שנייוני 2011

    Existence of Klyachko models for GL(n,R) and GL(n,C)

    More information
    שעה
    11:00 - 11:00
    מיקום
    Ziskind Bldg.
    מרצהSiddhartha Sahi
    Rutgers
    מארגן
    הפקולטה למתמטיקה ומדעי המחשב
    הרצאה
  • Date:13שנייוני 2011

    Regulation of terminal diferrentiation by Calpains and Myc

    More information
    שעה
    14:00 - 14:00
    מיקום
    בניין ע"ש מקס ולילאן קנדיוטי
    מרצהDr.Maralice Conacci-Sorrell
    Fred Hutchinson Cancer Research Center, Seattle, WA. USA
    מארגן
    המחלקה לאימונולוגיה ורגנרציה ביולוגית
    צרו קשר
    הרצאה
  • Date:13שנייוני 2011

    Decision related activity and top-down modulations in primate V1

    More information
    שעה
    14:00 - 14:00
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצהProf. Eyal Seidemann
    Center for Perceptual Systems University of Texas at Austin
    מארגן
    המחלקה למדעי המוח
    צרו קשר
    תקצירShow full text abstract about What are the sources of trial-to-trial variability in neural...»
    What are the sources of trial-to-trial variability in neural responses in early sensory cortical areas and how does this variability affect perceptual decisions? In this talk I will describe results from two studies that aim to address these questions. In the first study, we examined co-variations between behavioral choices of monkeys performing a threshold visual detection task and neural population responses recorded simultaneously from their V1. We found that fluctuations in V1 responses to the same visual stimulus are correlated with fluctuations in perceptual decisions. Our results provide insight regarding the decoding mechanisms that mediate behavior based on V1 responses and suggest that most choice-related variability is already present in V1. Top-down modulations from higher visual cortical areas are one potential source for these decision related signals in V1. The goal of the second study was to characterize two forms of top-down effects in V1: modulations by spatial uncertainty and by stimulus relevance. We found that V1 responses are unaffected by spatial uncertainty, suggesting that target sensitivity is not a limited resource that can be improved by focal attention in V1. Conversely, V1 responses were significantly modulated by stimulus relevance. These modulations are likely to contribute to spatial gating of task-irrelevant information. However, the spatial and temporal characteristics of this top-down signal suggest that it is not a major source of choice-related variability in V1. Our results are therefore consistent with a predominantly bottom-up source of decision related activity in V1.
    הרצאה
  • Date:13שנייוני 2011

    Sublinear optimization for machine learning

    More information
    שעה
    14:30 - 14:30
    מיקום
    Ziskind Bldg.
    מרצהElad Hazan
    Technion
    מארגן
    הפקולטה למתמטיקה ומדעי המחשב
    הרצאה
  • Date:14שלישייוני 2011

    "How EFF-1 and AFF-1 Fuse Plasma Membranes and Sculpt Cells"

    More information
    שעה
    10:00 - 10:00
    מיקום
    בניין וולפסון למחקר ביולוגי
    מרצהProf. Benjamin Podbilewicz
    Department of Biology Technion, Haifa
    מארגן
    המחלקה למדעים ביומולקולריים
    צרו קשר
    הרצאה

Pages