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January 01, 2013

  • Date:01MondayJanuary 2018

    "Chiral Single-Walled Carbon Nanotubes – New Platforms for Spintronics"

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    Time
    11:00 - 12:15
    Location
    Gerhard M.J. Schmidt Lecture Hall
    LecturerProf. Michael J. Therien
    Duke University
    Organizer
    Faculty of Chemistry
    Contact
    Colloquia
  • Date:01MondayJanuary 2018

    Chemical and Biological Physics Dept Guest Seminar

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    Time
    14:00 - 14:00
    Title
    Swimmer-microrheology
    Location
    Perlman Chemical Sciences Building
    LecturerProf. Shigeyuki Komura
    Tokyo Metropolitan University
    Organizer
    Department of Chemical and Biological Physics
    Contact
    AbstractShow full text abstract about We discuss the locomotion of a three-sphere microswimmer in ...»
    We discuss the locomotion of a three-sphere microswimmer in a viscoelastic medium and propose a new type of active microrheology.‎ We derive a relation that connects the average swimming velocity and the frequency-dependent viscosity of the surrounding medium.‎
    ‎In this relation, the viscous contribution can exist only when the time-reversal symmetry is broken, whereas the elastic contribution is present only when the structural symmetry of the swimmer is ‎broken.‎ Purcell's scallop theorem breaks down for a three-sphere swimmer in a viscoelastic medium
    Lecture
  • Date:02TuesdayJanuary 201804ThursdayJanuary 2018

    2018 JUSTEN PASSWELL MEMORIAL SYMPOSIUM

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    Time
    08:00 - 08:00
    Location
    The David Lopatie Conference Centre
    Chairperson
    Ofer Yizhar
    Homepage
    Conference
  • Date:02TuesdayJanuary 2018

    Fixing the nitrogen gap - plant strategies of symbiotic dinitrogen fixation across biomes

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    Time
    11:30 - 11:30
    Location
    Nella and Leon Benoziyo Building for Biological Sciences
    LecturerDr. Efrat Sheffer
    The Robert H. Smith Institute of Plant Sciences and Genetics in Agriculture, The Robert H. Smith Faculty of Agriculture, Food and Environment at Rehovot, The Hebrew University of Jerusalem
    Organizer
    Department of Plant and Environmental Sciences
    Homepage
    Contact
    Lecture
  • Date:02TuesdayJanuary 2018

    Various approaches to online inference - human behavior and theoretical models

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    Time
    12:30 - 12:30
    Location
    Gerhard M.J. Schmidt Lecture Hall
    LecturerDr. Rava Azeredo da Silveira
    Ecole Normale Superieure, Paris, France
    Organizer
    Department of Brain Sciences
    Contact
    AbstractShow full text abstract about In natural settings, we make decisions based on streams of p...»
    In natural settings, we make decisions based on streams of partial and noisy information. Arguably, we summarize the perceived information into a probabilistic model of the world, which we can exploit to make decisions. This talk will explore such ‘mental models’ in the context of idealized tasks that can be carried out in the laboratory and modeled quantitatively. The starting point of the talk will be a sequential inference task that probes inference in changing environments, in humans. I will describe the task and an experimental finding, namely, that humans make use of fine differences in temporal statistics when making inferences. While our observations agrees qualitatively with an optimal inference model, the data exhibit biases. What is more, human responses, unlike those of the optimal model, are variable, and this behavioral variability is itself modulated during the inference task. In order to uncover the putative algorithmic framework employed by humans, I will go on to examine a family of models that break away from the optimal model in diverse ways. This investigation will suggest a picture in which humans carry out inference using noisy mental representations. More specifically, rather than representing a whole probability function, human subjects may manipulate probabilities using a (possibly modest) number of samples. The approach just outlined illustrates a range of possible computational structures of sub-optimal inference, but it lacks the appeal of a normative framework. If time permits, I will discuss recent ideas on a normative approach to human inference subject to internal ‘costs’ or ‘drives’, which can explain various biases. While different in its formulation, this approach shares conceptual commonalities with the rational inattention theory and other constrained optimization frameworks in cognitive science.
    Lecture
  • Date:03WednesdayJanuary 2018

    Cancer Immunotherapy: successes and challenges

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    Time
    08:00 - 08:00
    Location
    Dolfi and Lola Ebner Auditorium
    Chairperson
    Dina Preise
    Organizer
    Moross Integrated Cancer Center (MICC)
    Homepage
    Conference
  • Date:03WednesdayJanuary 2018

    Reconstructing temperature and composition histories of sedimentary basins using carbonate clumped-isotope thermometry

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    Time
    10:00 - 10:00
    Location
    Sussman Family Building for Environmental Sciences
    LecturerUri Ryb
    Division of Geological and Planetary Sciences California Institute of Technology
    Organizer
    Department of Earth and Planetary Sciences
    Contact
    AbstractShow full text abstract about Sedimentary basins are commonly viewed as archives of ancien...»
    Sedimentary basins are commonly viewed as archives of ancient depositional environments and geochemical signals measured in these basins are frequently interpreted as proxies for ancient Earth-surface environments. However, in the course of the sedimentary basins life-cycle, sedimentary rocks can undergo alteration in diagenetic, epigenetic and metamorphic environments. When put in the correct context, these altered geochemical records are valuable sources of information that reflect the complex thermal, compositional, and deformational histories experienced by the sedimentary rocks. Additionally these measurements can serve as key observations in the study of the interactions among the Earth’s surface and internal processes.
    In the talk, I will demonstrate how carbonate clumped isotope thermometry (a relatively new temperature-proxy) can be used to study the thermal history of the Colorado Plateau (southwestern N. America), and constrain the oxygen isotope composition of the Phanerozoic Ocean. Clumped and single isotope compositions of calcite and dolomite minerals collected from the Paleozoic sedimentary sequence at the Grand Canyon are consistent with isotopic alteration through open-system recrystallization and/or solid-state isotopic reordering at elevated burial temperatures. By comparing these values with modeled predictions of isotopic signal alteration, we constrain the peak burial temperatures and thermal gradient, and infer the total overburden and exhumation above the top Paleozoic datum at the Colorado Plateau. We also use our data to back-calculate the oxygen isotope composition of dolomite parental water and our results indicate that the oxygen isotope composition of seawater has remained stable throughout the Phanerozoic. This stability suggests that the fluxes of globally averaged oxygen isotope exchange, associated with weathering and hydrothermal alteration reactions, have remained proportional through time. This observation is consistent with the hypothesis that a steady-state balance exists between seafloor hydrothermal activity and surface weathering.
    Lecture
  • Date:03WednesdayJanuary 2018

    G-INCPM Special Seminar - Dr. Yifat Merbl, Dept. of Immunology, Weizmann - "A Ubiquitin-Dependent Mechanism of Proteostasis Control"

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    Time
    14:00 - 15:15
    Location
    Nancy and Stephen Grand Israel National Center for Personalized Medicine
    LecturerProf. Yifat Merbl
    Dept. of Immunology, Weizmann
    Organizer
    Department of Biomolecular Sciences
    Contact
    AbstractShow full text abstract about Primary focus has been given to the endoplasmic reticulum (E...»
    Primary focus has been given to the endoplasmic reticulum (ER) in the context of quality control of misfolded or aberrant proteins. Although passage from the ER through the Golgi is mandatory for endomembrane and secreted proteins, the Golgi has mainly been studied in the context of its role as a packaging and sorting organelle, and as a site of protein glycomodification. Here I will describe the discovery of a Golgi ApparatusRelated Degradation (GARD) quality control mechanism, which constitutes a novel and important checkpoint in the secretory pathway. Our findings may have significant implications on proteostasis regulation in health and disease.
    Lecture
  • Date:04ThursdayJanuary 2018

    “To see beyond the dot: recent advances in Imaging Flow Cytometry”

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    Time
    09:00 - 10:00
    Location
    Max and Lillian Candiotty Building
    LecturerDr. Ziv Porat
    Flow Cytometry unit
    Organizer
    Department of Life Sciences Core Facilities
    Contact
    Lecture
  • Date:04ThursdayJanuary 2018

    Statistical physics of active particles

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    Time
    11:15 - 12:30
    Location
    Edna and K.B. Weissman Building of Physical Sciences
    LecturerJulien Tailleur
    Université Paris Diderot
    Organizer
    Faculty of Physics
    Contact
    AbstractShow full text abstract about Active matter describes a large class of systems in which in...»
    Active matter describes a large class of systems in which individual units are able to dissipate energy stored in the environment to generate self-propelling forces. These systems, driven out of thermal equilibrium at the microscopic scale, can be found in Nature or synthesized in the lab. From bacteria and molecular motors to bird flocks and fisch schools, through self-phoretic janus colloids or Quincke rollers, they display a wide range of phenomenologies without counterparts in equilibrium systems. In this colloquium, I will review recent progresses in the field of active matter and show how non-equilibrium statistical mechanics accounts for the emerging properties of active materials. In particular, I will discuss the anomalous mechanical properties of active systems, showing that their mechanical pressures generically do not satisfy equations of state. I will also discuss their collective behaviours, from the transition to collective motion to the so-called motility induced phase separation through which a liquid-gas phase coexistence can emerge in the absence of attractive forces.
    Colloquia
  • Date:04ThursdayJanuary 2018

    Pelletron meeting (by invitation only)

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    Time
    16:00 - 18:00
    Contact
    Lecture
  • Date:07SundayJanuary 2018

    Aqueous Nanoscale Systems

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    Time
    11:00 - 12:00
    Location
    Perlman Chemical Sciences Building
    LecturerProf. Sylvie Roke
    Ecole Polytechnique Federale de Lausanne (EPFL), Switzerland
    Organizer
    Department of Molecular Chemistry and Materials Science
    Contact
    AbstractShow full text abstract about Water is the most important liquid for life as well as f...»
    Water is the most important liquid for life as well as for the environment. In liquid water there is a hydrogen bonding network that originates from the interactions of H atoms with neighboring O atoms from other water molecules. This network reorganizes itself on the femtosecond (10-15 s) time scale and leads to transient liquid structuring on the nanoscale. Because of its complexity, the relationship between the unique properties of water and its molecular structure have not been solved. Techniques that can provide femtosecond structural information over multiple length scales can help. To do so, we developed nonlinear light scattering and imaging tools to access molecular structural information of aqueous solutions and interfaces. With these methods we have found nanoscale ordering in dilute salt solutions, and probe the structure of aqueous nanoscopic interfaces relevant for biology: lipid droplets, liposomes and water droplets. The optical properties of water can also be used to determine the electrical potential (voltage) of interfaces. This unique readout is useful for chemistry, neurology and device characterization. In this presentation I will give an overview of the field and our findings.

    Lecture
  • Date:07SundayJanuary 2018

    Health impacts avoided by reducing air pollution

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    Time
    11:00 - 11:00
    Location
    Sussman Family Building for Environmental Sciences
    LecturerJos Lelieveld
    Max Planck Institute for Chemistry, Germany
    Organizer
    Department of Earth and Planetary Sciences
    Contact
    AbstractShow full text abstract about The Global Burden of Disease relates premature mortality to ...»
    The Global Burden of Disease relates premature mortality to a range of causes, including air pollution by ozone and fine particulate matter (PM2.5). Quantifying the role of air pollution has been a challenge, in part due to uncertainty about human exposure to air pollution worldwide. We present results from a global atmospheric chemistry model, combined with population data, country-level health statistics and pollution exposure response functions. We calculate that outdoor air pollution, mostly by PM2.5, leads to about 4.5 million premature deaths/year worldwide, predominantly in Asia (75%). This is three times the rate by HIV/AIDS and malaria together. Contrary to the common view that traffic, industry and power generation are dominant sources, we show that residential energy use (e.g. heating, cooking) is the largest category worldwide due to its prevalence in India and China. Strong control measures are needed to substantially lower morbidity and mortality from air pollution. Clean air is a human right, being fundamental to many sustainable development goals of the United Nations.
    Lecture
  • Date:07SundayJanuary 2018

    Molecular Genetics Departmental Seminar

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    Time
    13:15 - 13:15
    Title
    “Measurements of myonuclear dynamics in intact Drosophila larvae”
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    LecturerDr. Dana Lorber
    Organizer
    Department of Molecular Genetics
    Contact
    Lecture
  • Date:07SundayJanuary 2018

    Neuro-immuno-metabolism - the sympathetic macrophage connection

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    Time
    15:00 - 16:00
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    LecturerProf. Steffen Jung
    Department of Immunology Weizmann Institute of Science
    Contact
    Lecture
  • Date:08MondayJanuary 2018

    Reconstructing the amount and distribution of rainfall in the Levant during past arid intervals

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    Time
    10:00 - 10:00
    Location
    Sussman Family Building for Environmental Sciences
    LecturerDr. Yael Kiro
    Geochemistry Lamont-Doherty Earth Observatory
    Organizer
    Department of Earth and Planetary Sciences
    Contact
    AbstractShow full text abstract about The present climate in the Levant is highly variable and su...»
    The present climate in the Levant is highly variable and suffers from periodic droughts. There is a strong meridional gradient in precipitation and evaporation and influence from both tropical and northern hemisphere climates. The ICDP Dead Sea Deep Drilling Project cores allow for the first time reconstruction of past climate during the warmest and driest periods in the region. We focus here on the Holocene and Marine Isotope Stage (MIS) 5e intervals. These contain thick layers of halite, reflecting the driest periods over the past 220 ky. The fast sedimentation rate (up to several cm per year) allows identification of climatic changes at high temporal resolution. From salt and major element (Mg, Cl and Na) balances in pore waters and fluid inclusions, we have quantified the average runoff, which was 30-50% of the present-day (pre-1964 diversion of the Jordan River) during that time, reaching 20% during the most arid intervals, lasting decades to centuries. 234U/238U activity ratios in authigenic minerals (aragonite, gypsum and halite), which reflect the water sources around the Dead Sea watershed, show drastic shifts in the lake’s hydrology during the driest times, both during MIS 5e and the Holocene. 234U/238U activity ratio decreased during the driest periods from the typical value of ~1.5 to ~1.1, indicating a shift from the typical Mediterranean (northern/western) influence toward tropical (southern/ eastern) influence. Combining the ICDP core record with other climate records and with NCAR climate model (CCSM3) runs of the last interglacial (130, 125 and 120 ka) highlights the temporal variability due to changes in the orbital forcings between 125 ka (peak summer insolation) and 120 ka. While 125 ka, which is salt-free in the core, is characterized by summer and winter precipitation, 120 ka, which is reflected by the thickest salt accumulation, is characterized by dry winters, increases in fall season precipitation and scarce but intense rainfall flooding events.
    Lecture
  • Date:08MondayJanuary 2018

    "Probing Spatiotemporal Dynamics in all States of Matter"

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    Time
    11:00 - 12:15
    Location
    Gerhard M.J. Schmidt Lecture Hall
    LecturerProf. Tobias Brixner
    University of Wuerzburg
    Organizer
    Faculty of Chemistry
    Contact
    Colloquia
  • Date:08MondayJanuary 2018

    3D Bioprinting of Vascularized Tissues

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    Time
    14:00 - 14:00
    Location
    Wolfson Building for Biological Research
    LecturerDr. Mark Skylar-Scott
    Harvard University
    Organizer
    Department of Molecular Cell Biology
    Contact
    AbstractShow full text abstract about While tissue engineering can generate thin grafts, its abili...»
    While tissue engineering can generate thin grafts, its ability to recapitulate the structure and function of bulk tissues and organs has been fundamentally limited, in large-part by the absence of a readily perfusable vasculature. Absent a blood supply, any metabolically demanding tissue thicker than a few hundred microns will undergo rapid core necrosis due to the lack of oxygen and nutrients. 3D bioprinting has recently enabled the construction of complex, heterogeneous tissues with embedded vascular networks, which, when connected to pumps can enable large-scale tissues to remain viable. In this talk, I will highlight two recent advances in 3D bioprinting that can manufacture vasculature networks from the micron scale to the centimeter scale. The first method uses multimaterial bioprinting to manufacture stem-cell laden vascularized tissues that are > 1 cm thick. The second method uses multi-photon photolithography to manufacture, with laser-precision, complex 3D capillary networks at the micron-scale.
    Lecture
  • Date:09TuesdayJanuary 2018

    Single cell analysis of rare events in cancer

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    Time
    10:00 - 11:00
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    LecturerProf. Arjun Raj
    University of Pennsylvania, Department of Bioengineering
    Organizer
    Azrieli Institute for Systems Biology
    Contact
    Lecture
  • Date:09TuesdayJanuary 2018

    From human genetics to a new mechanism underlying type 2 diabetes.

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    Time
    10:00 - 10:30
    Location
    Nella and Leon Benoziyo Building for Biological Sciences
    LecturerDr. Eitan Hoch
    Broad Institute of MIT and Harvard, Cambridge, MA
    Organizer
    Department of Biomolecular Sciences
    Contact
    AbstractShow full text abstract about Solute Carriers (SLCs) account for approximately 2% of known...»
    Solute Carriers (SLCs) account for approximately 2% of known human coding genes, and play diverse roles in human physiology. Despite ~100 SLCs being implicated in human disease, they also remain one of the most under-studied groups of genes in human biology.
    Genetic variants in one such uncharacterized SLC, namely SLC16A11, were recently identified as one of the largest genetic risk signals for type 2 diabetes (T2D).
    I will describe the functional follow-up to the genetic discovery of SLC16A11, which led to the identification of two distinct molecular mechanisms that link SLC16A11 dysfunction to disease.
    This work suggests that SLC16A11 is a promising therapeutic target for T2D.

    Solute Carriers (SLCs) account for approximately 2% of known human coding genes, and play diverse roles in human physiology. Despite ~100 SLCs being implicated in human disease, they also remain one of the most under-studied groups of genes in human biology.
    Genetic variants in one such uncharacterized SLC, namely SLC16A11, were recently identified as one of the largest genetic risk signals for type 2 diabetes (T2D).
    I will describe the functional follow-up to the genetic discovery of SLC16A11, which led to the identification of two distinct molecular mechanisms that link SLC16A11 dysfunction to disease.
    This work suggests that SLC16A11 is a promising therapeutic target for T2D.

    Solute Carriers (SLCs) account for approximately 2% of known human coding genes, and play diverse roles in human physiology. Despite ~100 SLCs being implicated in human disease, they also remain one of the most under-studied groups of genes in human biology.
    Genetic variants in one such uncharacterized SLC, namely SLC16A11, were recently identified as one of the largest genetic risk signals for type 2 diabetes (T2D).
    I will describe the functional follow-up to the genetic discovery of SLC16A11, which led to the identification of two distinct molecular mechanisms that link SLC16A11 dysfunction to disease.
    This work suggests that SLC16A11 is a promising therapeutic target for T2D.
    Lecture

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