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April 30, 2015
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Date:25ThursdayJanuary 2018Cultural Events
The Israel Camerata Jerusalem
More information Time 20:00 - 20:00Title Lalo, Saint-Saens and HaydnLocation Michael Sela AuditoriumContact -
Date:27SaturdayJanuary 2018Cultural Events
Maestro ALEXANDER VASILIEV - Fashion historian
More information Time 19:00 - 19:00Title "secrets of Fashionable House"Location Michael Sela AuditoriumContact -
Date:28SundayJanuary 2018Lecture
A Martian Origin for the Mars Trojan Asteroids
More information Time 11:00 - 11:00Location Sussman Family Building for Environmental SciencesLecturer Dr. David Polishook
Department of Earth and Planetary SciencesOrganizer Department of Earth and Planetary SciencesContact -
Date:28SundayJanuary 2018Lecture
Personalized Nanomedicines: Principles for using nanotechnology in cancer research
More information Time 11:00 - 12:00Location Perlman Chemical Sciences BuildingLecturer Prof. Avi Schroeder
Dept. Chemical Engineering, TechnionOrganizer Department of Molecular Chemistry and Materials ScienceContact Abstract Show full text abstract about Medicine is taking its first steps towards patient-specifi...»
Medicine is taking its first steps towards patient-specific care. Nanoparticles have many potential benefits for treating cancer, including the ability to transport complex molecular cargoes including siRNA and protein, as well as targeting to specific cell populations.
The talk will address principles for engineering drug-loaded nanoparticles that can be remotely triggered to release their payload in disease sites. The evolution of such nanoparticles into programmed nano robots, unique particles that have an internal capacity to synthesize protein drugs, and their promise for treating cancer, will be discussed.
Our research is aimed at tailoring treatments to address each person’s individualized needs and unique disease presentation. Specifically, we developed barcoded nanoparticles that target sites of cancer where they perform a programmed therapeutic task. These systems utilize molecular-machines to improve efficacy and reduce side effects.
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Date:28SundayJanuary 2018Lecture
Molecular Genetics Departmental Seminars 2017-2018
More information Time 13:00 - 13:00Title "Metabolic enzyme coupling of Malate Dehydrogenases is enabled by piggybacking to peroxisomes".Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Shiran Maskit Organizer Department of Molecular GeneticsContact -
Date:28SundayJanuary 2018Lecture
Design and characterization of light-gated proteins for the investigation of medial prefrontal cortex function
More information Time 14:30 - 14:30Location Gerhard M.J. Schmidt Lecture HallLecturer Mathias Mahn (PhD Defense Thesis)
Ofer Yizhar Lab, Dept of Neurobiology, WISOrganizer Department of Brain SciencesContact Abstract Show full text abstract about Reversible modulation of neuronal activity is a powerful app...» Reversible modulation of neuronal activity is a powerful approach for isolating the roles of specific neuronal populations in circuit dynamics and behavior. Optogenetics enables such experiments, through excitation and inhibition of defined cells within neural circuits. However, in contrast to optogenetic excitation, for which a limited number of optogenetic tools can serve to all but a few experimental needs, tools used for inhibition of neuronal activity still impose stringent constraints on the experimental paradigm. During the seminar I will present data showing that the optimal approach for optogenetic silencing differs between subcellular neuronal compartments, characterize current tools for axonal inhibition and introduce a set of soma-targeted naturally-occurring anion-conducting channelrhodopsins as the potential next generation of inhibitory optogenetic tools for somatodendritic silencing approaches in neuroscience. -
Date:29MondayJanuary 2018Lecture
Ultimate Dark Matter detector
More information Time 10:00 - 10:00Location Edna and K.B. Weissman Building of Physical SciencesLecturer Andrzej K. Drukier
OKC, University of StockholmOrganizer Department of Particle Physics and AstrophysicsContact Abstract Show full text abstract about We disclose an implementation of RT-bolometers which compris...» We disclose an implementation of RT-bolometers which comprise high chemical-energy materials, e.g. explosive or catalase, H2O2}-system, that can be operated at temperature between 4oC and room temperature (RT). Energy deposited by the incident weakly interacting particle to the nuclei can trigger a local release of chemical energy;. The energy release in such a `nano-explosion’ indicates that a coherent scattering event has taken place and allows for the localization of this event;
For DM detection {catalase, H2O2}-system is preferred, and there are many catalases, which have maximum activity at temperatures from about 10oC to about 90oC. This permits to optimize enzymatic reactions and influences the read-out design. {catalase, H2O2}-system works because the range of recoiling nuclei is so short that most of the energy is transferred in a single “voxel” called “vertex”, leading to a large local temperature increase.
When neutrino or WIMPs scatter on nuclei, the majority of the recoil nucleus energy is transferred to the lattice, which leads to the creation of ballistic phonons which rapidly thermalize, i.e. increase the temperature in vertex. For 5 GeV/c2 < MDM < 15 GeV/c2 the energy of the recoiling nuclei is 0.5-2.0 keV and all this energy is deposited within a few nm. Thus, the dE/dx = O(0.1 keV/nm) is deposited in the vertex. The energy deposition is much smaller in the case of single charged, relativistic particles and corresponds to dE/dx < 1 eV/nm for single charged particles. These permits background rejection.
We developed a very efficient read-out for such detectors. The expected detector cost is low, ca. $50,000 per ton. The deployment will be deep underwater, say at Marina Trench at depth of 11 km. Optionally, such a detector can be used as a “spaghetti detector” and placed in very deep bore-holes down to 20 km water equivalent.
Similar detectors can be used for Emission Geo-Neutrino Tomography aka Neutrino Geology. -
Date:29MondayJanuary 2018Lecture
Organization of temporal gene expression: from promoter cycles to circadian clocks
More information Time 13:30 - 13:30Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Dr. Felix Naef
The Institute of Bioengineering School of Life Sciences Ecole Polytechnique Federale de Lausanne (EPFL)Organizer Department of Molecular Cell BiologyContact -
Date:30TuesdayJanuary 2018Conference
A special symposium in honor of Prof. Ruhama Even
More information Time 08:00 - 08:00Location The David Lopatie Conference CentreChairperson Ronnie Karsenty -
Date:30TuesdayJanuary 2018Lecture
Noncoding RNA in Health and Disease
More information Time 10:00 - 11:00Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Prof. Nikolaus Rajewsky
Scientific Director, Berlin Institute for Medical Systems Biology, Max Delbrück Center, BerlinOrganizer Azrieli Institute for Systems BiologyContact -
Date:30TuesdayJanuary 2018Lecture
Uncovering the mechanisms underlying individuality
More information Time 10:00 - 11:00Location Nella and Leon Benoziyo Building for Biological SciencesLecturer Dr. Shay Stern
The Rockefeller University, NYOrganizer Department of Biomolecular SciencesContact Abstract Show full text abstract about Individuals within the same population may show stereotyped ...» Individuals within the same population may show stereotyped behaviors, but also unique behaviors that distinguish them from each other, a property called individuality. While individuality in behavior is widespread across species, including humans, the underlying mechanisms that generate individual-to-individual behavioral variation remain largely unknown. In my talk, I will present a newly developed imaging system for studying long-term individuality in C. elegans by monitoring the behavior of multiple individual animals across development, from egg hatching to adulthood, spanning a full generation time. I will show that while C. elegans animals have reproducible patterns of long-term behaviors, individuals within isogenic populations show consistent behavioral biases that persist across development and distinguish them from one another. I will further describe the conserved signaling pathways I uncovered that function to regulate long-term behavior, as well as to increase or decrease the degree of individuality across the population. These studies open a new window for dissecting mechanisms that generate and shape behavioral individuality across developmental timescales.
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Date:30TuesdayJanuary 2018Lecture
Joint Structural Biological and Magnetic Resonance Seminar
More information Time 14:30 - 14:30Title Solid-State NMR Studies of the Structure and Dynamics of an Influenza Membrane Protein for Proton Transport and Membrane ScissionLocation Gerhard M.J. Schmidt Lecture HallLecturer Prof. Mei Hong
Massachusetts Institute of TechnologyOrganizer Department of Chemical and Biological PhysicsContact Abstract Show full text abstract about Membrane proteins carry out a myriad of biological functions...» Membrane proteins carry out a myriad of biological functions such as ion conduction, substrate transport, and signaling. Solid-state NMR spectroscopy allows us to obtain exquisite atomic-level information of the structures and structural changes that underlie these functions. In this talk, I will present our investigations of the structure and dynamics of a multifunctional influenza virus membrane protein, matrix protein 2 (M2), which conducts protons and causes membrane scission. 13C, 15N, and 1H chemical shifts provided detailed information about pH-dependent conformational changes and equilibria between the open and closed states of the proton channel. Motionally averaged NMR spectra revealed microsecond-timescale dynamics of the proton-selective histidine and the gating tryptophan of the channel, while 2D exchange NMR spectra revealed millisecond-timescale dynamics of the entire tetrameric complex. Hydrogen bonding between water and the proton-selective histidine and proton exchange dynamics have been directly observed in 15N NMR spectra, giving insight into the atomic processes of proton transfer through the hydrated channel. In the second function, the M2 protein interacts with membrane cholesterol to cause scission of the emerging virus particle from the host cell in the final step of virus budding. By measuring 13C-19F distances between cholesterol and the protein, we determined the first cholesterol-binding site structure of a membrane protein in lipid bilayers. The structure gave unexpected insight into how M2 is attracted to the neck of the budding virus to cause membrane scission. Such intermolecular binding studies are crucially enabled by long-range distance constraints. We are exploring 19F-19F dipolar coupling measurements that probe distances up to 2 nm, to determine protein structures and protein-ligand interactions. -
Date:31WednesdayJanuary 2018Cultural Events
Russian Classic hits
More information Time 20:00 - 20:00Location Michael Sela AuditoriumContact -
Date:01ThursdayFebruary 2018Conference
Annual meeting of the Israeli Biophysical Society
More information Time 08:00 - 08:00Location The David Lopatie Conference CentreChairperson Nir GovOrganizer Department of Chemical and Biological PhysicsHomepage -
Date:01ThursdayFebruary 2018Lecture
“A fast track for DNA manipulation”
More information Time 09:00 - 10:00Location Max and Lillian Candiotty BuildingLecturer Dr. Yoav Peleg
Structural Proteomics Unit (SPU)Organizer Department of Life Sciences Core FacilitiesContact -
Date:01ThursdayFebruary 2018Lecture
Magnetic Resonance Seminar
More information Time 09:30 - 09:30Title MRI/NMR detection of critical electrochemical device parametersLocation Gerhard M.J. Schmidt Lecture HallLecturer Prof. Alexej Jerschow
New York UniversityOrganizer Department of Chemical and Biological PhysicsContact Abstract Show full text abstract about Batteries are drivers of alternative energy solutions and th...» Batteries are drivers of alternative energy solutions and the electric vehicle market, and are central to portable electronic devices. In this talk I will describe our work on the development of techniques for assessment of Li-ion batteries, supercapacitors, and battery materials via magnetic resonance imaging (MRI). The goal of these studies is to analyze the devices and energy storage mechanisms in situ during charging or discharging conditions by imaging changes in both the electrolyte and the electrodes in a noninvasive fashion. In situ NMR/MRI have proven to be powerful tools to probe the structure of Li-ion batteries. These techniques have the potential to monitor dynamics and visually monitor changes in functioning electrochemical systems in real time. The operation of some energy storage devices where only the electrolyte is involved in the electrochemical process (such as supercapacitors) can only be studied in situ, as the electrolyte concentration gradients will relax as a potential is removed from the cell. I will discuss how the rf field is perturbed by the presence of conducting materials in the probe, how susceptibility shifts can be used for assessing the morphology of microstructure buildup on electrodes, how the location and concentration of both cations and anions can be followed separately. I will also discuss the opportunities for indirectly monitoring SEI layer properties and Li-dendrite growth mechanisms. Recent results on MRI of commercial-type cells, and the determination of state of charge and health will also be presented. This last development is of importance for analyzing, for example, cell-phone cells nondestructively, and may hence be of value for assessing the state of these devices under various conditions. -
Date:01ThursdayFebruary 2018Colloquia
Physics Young PIS Colloquium
More information Time 11:15 - 12:30Location Edna and K.B. Weissman Building of Physical SciencesLecturer Ranny Budnik, Prof. Oren Raz, Prof. Binghai Yan
WISOrganizer Faculty of PhysicsContact Abstract Show full text abstract about Ranny Budnik "Exploring the dark side with bright, pur...» Ranny Budnik
"Exploring the dark side with bright, pure crystals“
Dark matter surrounds us and passes through us, yet it has not been discovered, after over a decade of intense efforts. However, many "windows" to dark matter parameter space remain closed, and opening them has become a leading target for the particle cosmology community. I will go quickly through the basics of dark matter, detection methods and recent results, and present an effort we are pursuing in our lab at the Weizmann Institute, to develop a new type of detector, able to detect low mass dark matter, using rare defects in pure crystals.
Oren Raz
"Anomalous thermal relaxation: from your kitchen to trapped ions“
Take a cold system, and couple it to a hot environment. Evidently, the system will heat up. Surprisingly, many aspects of this common process are poorly understood. Examples range from the anomalous heating rate in trapped ions, where the observed heating rate is commonly three orders of magnitude higher than naively expected, to a "thermal overshoot" where the system's temperature, during the relaxation process, becomes higher than the environment's temperature.
Binghai Yan
“The history and new understanding of surface states”
"A story about the electronic state on the surface, from the Shockley state to the topological state."
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Date:01ThursdayFebruary 2018Lecture
When Lymphocytes
More information Time 14:00 - 15:00Title Cancer Research ClubLocation Max and Lillian Candiotty BuildingLecturer Prof. Eli Pikarsky
Faculty of Medicine, The Hebrew University of JerusalemOrganizer Department of Immunology and Regenerative BiologyContact Abstract Show full text abstract about Inflammation usually entails a diffuse influx of immune cell...» Inflammation usually entails a diffuse influx of immune cells, scattered throughout the inflamed
tissue. However, it can also form complex structures that histologically resemble lymphoid organs,
referred to as ectopic lymphoid-like structures (ELSs). Using a mouse model forming hepatic
ELSs we revealed that they can form protumorigenic immune niches, which foster growth of
Hepatocellular carcinoma (HCC) progenitors. We are currently investigating the mechanisms that
drive HCC formation in ELSs, as well as mechanisms that turn the ELS from an anti-tumor immune
micro-organ into a protumorigenic one. -
Date:04SundayFebruary 201809FridayFebruary 2018Conference
Emerging Concepts in Mitochondria Biology
More information Time 08:00 - 08:00Chairperson Atan GrossHomepage -
Date:04SundayFebruary 2018Lecture
Recent advances in finding the water waves' breaking criterion
More information Time 11:00 - 11:00Location Sussman Family Building for Environmental SciencesLecturer Dan Liberzon
TechnionOrganizer Department of Earth and Planetary SciencesContact
