Pages
April 30, 2015
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Date:11ThursdayJanuary 2018Lecture
The molecular mechanisms regulating CLL survival
More information Time 14:00 - 15:00Title Cancer Research ClubLocation Max and Lillian Candiotty BuildingLecturer Prof. Idit Shachar
Dept. of Immunology, WISOrganizer Department of Immunology and Regenerative BiologyContact Abstract Show full text abstract about Chronic lymphocytic leukemia (CLL) is the most common leukem...» Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world. The disease is characterized by decreased apoptosis and accumulation of mature B lymphocytes. We have previously shown that CD74 induces a downstream cascade that regulates CLL survival. Recently, we showed that CD74-intracellular domain interacts with the transcription factors RUNX and NF-B and binds to proximal and distal regulatory sites enriched for genes involved in apoptosis, immune response and cell migration. One of CD74 target genes is CD84. Our results demonstrate that CD84 mediates the interaction of CLL cells with their microenvironment inducing cell survival. In addition, activation of CD84 elevates PD-L1 expression on CLL cells and their microenvironment which interact with PD-1 expressed on T cells. Our results suggest CD84 blockade as a novel therapeutic strategy to reverse tumor-induced immune suppression. -
Date:11ThursdayJanuary 2018Lecture
SHIRAT HAMADA
More information Time 19:30 - 21:00Location Dolfi and Lola Ebner AuditoriumOrganizer Department of Systems ImmunologyContact -
Date:14SundayJanuary 201815MondayJanuary 2018Conference
When Light Meets Matter: Celebrating Yehiam Prior's first 70 years
More information Time 08:00 - 08:00Location The David Lopatie Conference CentreChairperson Ilya AverbukhHomepage -
Date:14SundayJanuary 2018Lecture
New insights on marine aerosol formation: First year preliminary results from the Tara Pacific expedition
More information Time 11:00 - 11:00Location Sussman Family Building for Environmental SciencesLecturer Michel Flores
Department of Earth and Planetary Sciences Weizmann Institute of ScienceOrganizer Department of Earth and Planetary SciencesContact -
Date:14SundayJanuary 2018Lecture
Water and the Hydrophobic Interaction at 10,000,000-fold Magnification
More information Time 11:00 - 12:00Location Perlman Chemical Sciences BuildingLecturer Prof. Uri Sivan
Dep. of Physics and the Russell Berrie Nanotechnology Institute – TechnionOrganizer Department of Molecular Chemistry and Materials ScienceContact Abstract Show full text abstract about The governing role of hydrophobic interactions in countless ...» The governing role of hydrophobic interactions in countless biological phenomena and technological systems, including protein folding, transmembrane proteins, cell membranes, detergents, paints, decontamination of pollute water, and more, has motivated extensive theoretical and experimental efforts aimed at deciphering the microscopic foundations of this interaction. Yet, after more than a century of extensive research a full predictive theory of this elusive phenomenon is still missing, largely due to the lack of suitable experimental techniques capable of probing the interface between hydrophobic surfaces and water at high enough resolution. In the talk, I will present our recent explorations of this interface using an ultra-high resolution atomic force microscope built in-house for the task and disclose compelling evidence that the hydrophobic interaction reflects a phase transition taking place in the medium when two hydrophobic surfaces approach each other to within a few nanometers. Along the way I'll demonstrate the sub-atomic resolution of our microscope and its value for the study of water structure near surfaces and biomolecules. -
Date:14SundayJanuary 2018Lecture
Biomarker research in major depression
More information Time 12:30 - 12:30Location Nella and Leon Benoziyo Building for Brain ResearchLecturer Prof. Hiroshi Kunugi, M.D., Ph.D
Director, Dept of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, TokyoOrganizer Department of Brain SciencesContact -
Date:14SundayJanuary 2018Lecture
Israel's Renewable Energy Scheme: current status, opportunities and challenges
More information Time 13:00 - 14:00Title SAERI - Sustainability And Energy Research Initiative Seminar SeriesLocation Gerhard M.J. Schmidt Lecture HallLecturer Mr. Honi Kabalo
Head of Renewable Energy Section in the Israeli Electricity Regulatory Authority (ERA)Organizer Weizmann School of ScienceContact -
Date:14SundayJanuary 2018Lecture
Molecular Genetics Departmental Seminars 2017-2018
More information Time 13:00 - 13:00Title "Evolution of splicing towards optimization of gene expression"Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Idan Frumkin Organizer Department of Molecular GeneticsContact -
Date:15MondayJanuary 2018Lecture
The barcode of life – using 600 species to improve cancer diagnostics and drug development
More information Time 14:00 - 15:00Title Special Guest SeminarLocation Max and Lillian Candiotty BuildingLecturer Dr. Yuval Tabach
Department of Developmental Biology and Cancer Research, The Institute For Medical Research-Israel-Canada The Hebrew University-Hadassah Medical School Jerusalem.Organizer Department of Immunology and Regenerative BiologyContact -
Date:16TuesdayJanuary 2018Conference
Minisymposium on Bioengineering Science and Technology
More information Time 08:00 - 08:00Location Gerhard M.J. Schmidt Lecture HallChairperson Samuel Safran -
Date:16TuesdayJanuary 2018Conference
Minisymposium on Bioengineering Science and Technology
More information Time 08:00 - 08:00Location Gerhard M.J. Schmidt Lecture HallChairperson Samuel Safran -
Date:16TuesdayJanuary 2018Conference
Windows to the Brain: Advances in Optical Imaging for Understanding Neural Circuit Function
More information Time 08:30 - 17:30Location The David Lopatie Conference CentreChairperson Yaniv ZivOrganizer Department of Brain Sciences -
Date:16TuesdayJanuary 2018Lecture
Frontiers in Systems Biology: Prof. Anshule Kundaje
More information Time 10:00 - 11:00Title Machine learning approaches to denoise, integrate, impute and decode functional genomic dataLocation Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Prof. Anshule Kundaje
Department of Genetics & Computer Science, Stanford University, USAOrganizer Department of Molecular GeneticsContact -
Date:16TuesdayJanuary 2018Lecture
Unique cellulosome system of (Pseudo)Bacteroides cellulosolvens unravels inimitable ways of biomass degradation.
More information Time 10:00 - 10:30Location Nella and Leon Benoziyo Building for Biological SciencesLecturer Olga Zhivin-Nissan
Members - Dept. of Biomolecular Sciences-WISOrganizer Department of Biomolecular SciencesContact Abstract Show full text abstract about Current global prosperity is based on fossil fuels that prov...» Current global prosperity is based on fossil fuels that provides energy required for our luxuriant way of life but are unsustainable. Biofuels, produced mainly from cellulosic plant-derived biomass, are the current practical alternative. The cellulolytic bacterium (Pseudo)Bacteroides cellulosolvens is a good candidate for biomass degradation towards improved biofuels production. Recently, we sequenced the B. cellulosolvens genome, and discovered that this bacterium produces the most intricate multi-enzyme cellulosome system known. Subsequent comprehensive bioinformatic analysis revealed an unprecedented number of cellulosome-related components, thus providing novel insight into the architecture, composition and function of the most intricate and extensive cellulosomal system known today.
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Date:16TuesdayJanuary 2018Lecture
"Tutorial lecture on cross-linking MS (XL-MS)"
More information Time 10:30 - 11:00Location Nella and Leon Benoziyo Building for Biological SciencesLecturer Dr. David Morgenstern
G-INCPM, Protein Profiling Unit - WISOrganizer Department of Biomolecular SciencesContact Abstract Show full text abstract about Mass spectrometry based proteomics became an enabling techno...» Mass spectrometry based proteomics became an enabling technology in the investigation of proteins and proteomes – from protein dynamics, through signaling, protein network interaction to structural determination. The combination of chemical crosslinking of proteins with mass spectrometry (XL-MS) opened up an opportunity to investigate protein-protein interactions within the framework of a whole proteome, even in-vivo, as well as provide a powerful tool for structure determination of proteins and protein complexes. In recent years, improvement in instrumentation and computing power led to improved accessibility of this technique to the non-expert researcher. However, XL-MS suffers from basic deficiencies due to intrinsic issues with sample preparation, data acquisition and analysis. In this tutorial we will discuss current hardware and software capabilities and limitations, and how experiment design can best utilize current capabilities for a successful experiment
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Date:16TuesdayJanuary 2018Conference
Minisymposium on Bioengineering Science and Technology
More information Time 11:00 - 16:00Location Gerhard M.J. Schmidt Lecture HallChairperson Samuel SafranHomepage -
Date:16TuesdayJanuary 2018Lecture
Bioinspired materials: from siliceous spicules in ancient ceramics to biological fabrication of cotton fibers with tailored properties
More information Time 11:30 - 11:30Location Nella and Leon Benoziyo Building for Biological SciencesOrganizer Department of Plant and Environmental SciencesContact -
Date:16TuesdayJanuary 2018Lecture
Prof. Rotem Sorek - Viruses that attack bacteria – friend or foe?
More information Time 12:00 - 12:00Title Viruses that attack bacteria – friend or foe?Location Dolfi and Lola Ebner AuditoriumLecturer Prof. Rotem Sorek Organizer Communications and Spokesperson DepartmentHomepage Contact -
Date:16TuesdayJanuary 2018Lecture
“Protein archeology: How proteins emerged and evolve?”
More information Time 14:00 - 15:00Location Helen and Milton A. Kimmelman BuildingLecturer Dr. Nir Ben-Tal
TAUOrganizer Department of Chemical and Structural BiologyContact -
Date:17WednesdayJanuary 2018Lecture
Electron ratchets: producing currents without a bias
More information Time 11:00 - 12:00Location Perlman Chemical Sciences BuildingLecturer Dr. Ofer Kedem
Center for Bio-inspired Energy Science (CBES), Northwestern UniversityOrganizer Department of Molecular Chemistry and Materials ScienceContact Abstract Show full text abstract about Biological motors, such as the myosin-actin system respons...»
Biological motors, such as the myosin-actin system responsible for muscle contraction, rectify Brownian motion using asymmetry and chemical energy. This type of rectification mechanism is called a ratchet, and has been implemented in artificial systems. Ratchets are non-equilibrium devices producing directed transport without an overall applied bias. Ratchets operate by breaking spatial and time-reversal symmetries through the application of a time-dependent potential with locally asymmetric features. In this talk, I will highlight some of our recent explorations of electron ratchets, using both experiment and theory. We find complex, unintuitive behaviors, with high sensitivity to structural and operating parameters, leading to effects such as current reversals. I will detail some promising features of a new experimental ratchet design, as well as a proposed photovoltaic device based on the ratchet principle.