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September 24, 2015

  • Date:24ThursdayDecember 2015

    Kendrew lecture: "Sir John Kendrew, Whose Vision Lead to the Birth of Computational Biology"

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    Time
    11:00 - 12:30
    Location
    Dolfi and Lola Ebner Auditorium
    Organizer
    Faculty of Chemistry
    Contact
    Colloquia
  • Date:24ThursdayDecember 2015

    Physical computation in animal collectives

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    Time
    11:15 - 12:30
    Location
    Edna and K.B. Weissman Building of Physical Sciences
    LecturerIain Couzin
    Max Planck, Konstanz
    Organizer
    Faculty of Physics
    Contact
    AbstractShow full text abstract about Understanding how social influence shapes biological process...»
    Understanding how social influence shapes biological processes is a central challenge in con-temporary science, essential for achieving progress in a variety of fields ranging from the or-ganization and evolution of coordinated collective action among cells, or animals, to the dy-namics of information exchange in human societies. Using an integrated experimental and theoretical approach I will address how, and why, animals exhibit highly-coordinated collective behavior. I will demonstrate new imaging technology that allows us to reconstruct (automatcally) the dynamic, time-varying networks that correspond to the visual cues employed by organisms when making movement decisions [1]. Sensory networks are shown to provide a much more accurate representation of how social influence propagates in groups, and their analysis allows us to identify, for any instant in time, the most socially-influential individuals within groups, and to predict the magnitude of complex behavioral cascades before they actually occur [2]. I will also investigate the coupling between spatial and information dynamics in groups and reveal that emergent problem solving is the predominant mechanism by which mobile groups sense, and respond to complex environmental gradients [3]. Evolutionary modeling demonstrates such ‘physical computation’ readily evolves within populations of selfish organisms, and allowing individuals to compute collectively the spatial distribution of rsources and to allocate themselves effectively among distinct, and distant, resource patches,
    Without requiring information about the number, location or size of patches [4].
    Finally I will reveal the critical role uninformed, or unbiased, individuals play in effecting fast and democratic consensus decision-making in collectives [5-7], and will test these predictions with experiments involving schooling fish [6] and wild baboons [8].

    1) Strandburg-Peshkin, A., Twomey, C.R., Bode, N.W., Kao, A.B., Katz, Y., Ioannou, C.C., Rosenthal, S.B., Torney, C.J., Wu, H., Levin, S.A. & Couzin, I.D. (2013) Visual sensory networks and effective information transfer in animal groups, Current Biology 23(17), R709-711.
    2) Rosenthal, S.B., Twomey, C.R., Hartnett, A.T., Wu, H.S. & Couzin, I.D. (2015) Revealing the hidden networks of interaction in mobile animal groups allows prediction of complex behavioral contagion, PNAS 112(15), 4690-4695.
    3) Berdahl, A., Torney, C.J., Ioannou, C.C., Faria, J. & Couzin, I.D. (2013) Emergent sensing of complex environments by mobile animal groups, Science 339(6119) 574-576.
    4) Hein, A. M., Rosenthal, S.B., Hagstron, G.I., Berdahl, A., Torney, C.J. & Couzin, I.D. (2015) The evolution of distribued sensing and collective computation in animal populations, eLife, in press.
    5) Couzin, I.D., Krause, J., Franks, N.R. & Levin, S.A. (2005) Effective leadership and decision making in animal groups on the move. Nature 433, 513-516.
    6) Couzin, I.D., Ioannou, C.C., Demirel, G., Gross, T., Torney, C.J., Hartnett, A., Conradt, L., Levin, S.A. & Leonard, N.E. (2011) Uninformed individuals promote democratic consensus in animal groups. Science 334(6062) 1578-1580.
    7) Hartnett, A.T., Schertzer, E., Levin, S.A. & Couzin, I.D. (2015) The role of heterogeneous preference and local nonlinearity in consensus decision-making, Physical Review Letters.
    8) Strandburg-Peshkin, A., Farine, D.R., Couzin, I.D. & Crofoot, M.C. (2015) Shared decision-making drives collective movement in wild baboons. Science 348(6241), 1358-1361.

    Lecture
  • Date:24ThursdayDecember 2015

    CEACAM1 in metastatic melanoma

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    Time
    14:00 - 15:00
    Title
    Guest Seminar
    Location
    Wolfson Building for Biological Research
    LecturerProf. Gal Markel, MD PhD
    Chief Scientist, The Ella Lemelbaum Institute of Melanoma Sheba Medical Center Associate Professor, Clinical Microbiology and Immunology Sackler School of Medicine, Tel Aviv University
    Organizer
    Department of Systems Immunology
    Contact
    Lecture
  • Date:24ThursdayDecember 2015

    Life Science Lecture

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    Time
    15:00 - 16:00
    Title
    Avraham Yaron
    Location
    Dolfi and Lola Ebner Auditorium
    LecturerProf. Avraham Yaron
    Contact
    Lecture
  • Date:24ThursdayDecember 2015

    Pelletron Lecture Series - by invitation

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    Time
    16:00 - 17:45
    Location
    Pelletron
    Contact
    Lecture
  • Date:27SundayDecember 2015

    Dry air intrusions: climatology and their relevance for strong surface winds in the Euro-Mediterranean region

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    Time
    11:00 - 11:00
    Location
    Sussman Family Building for Environmental Sciences
    LecturerProf. Shira Raveh-Rubin
    ETH Zurich
    Organizer
    Department of Earth and Planetary Sciences
    Contact
    AbstractShow full text abstract about Dry air intrusions (DAIs) are large-scale descending airstre...»
    Dry air intrusions (DAIs) are large-scale descending airstreams. A DAI is typically referred to as a coherent airstream in the cold sector of an extratropical cyclone. Emerging evidence suggests that DAIs are linked to severe surface wind gusts. However, there is yet no strict Lagrangian definition of DAIs, and so their climatological frequency, physical characteristics as well as their seasonal and spatial distributions are unknown. Furthermore, it is unclear how many of the DAIs occur together with a cyclone, and the dynamical interaction between DAIs and strong surface winds is not fully understood.
    Here, we suggest a Lagrangian definition for DAI air parcels, namely a minimum pressure increase along a trajectory of 400 hPa in 48 hours. Based on this criterion, the open questions are addressed by: (i) a novel global Lagrangian climatology for the ECMWF ERA-Interim reanalysis dataset for the years 1979-2014; (ii) examples for the interaction between DAIs and strong surface winds, shown with composite analysis and with a case study of a high-impact cyclone, using a mesoscale regional model simulation.
    We find that DAIs occur predominantly in winter, with higher occurrence frequency in the northern hemisphere. DAIs coherently descend from the upper troposphere (its stratospheric origin is small), to the mid- and low levels, where they mix with their environment and diverge. Different physical characteristics typify DAIs in the different regions and seasons, and when occurring together with a cyclone. Finally, we demonstrate the different mechanisms by which DAIs can destabilize the boundary layer and facilitate the formation of strong surface winds.
    Lecture
  • Date:27SundayDecember 2015

    To be announced

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    Time
    13:00 - 13:00
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    LecturerGal Ofir
    Rotem Sorek's group, Dept. of Molecular Genetics
    Organizer
    Department of Molecular Genetics
    Contact
    Lecture
  • Date:27SundayDecember 2015

    Single molecule approaches for studying gene expression in intact mammalian tissues

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    Time
    14:30 - 15:30
    Location
    Camelia Botnar Building
    LecturerProf. Shalev Itzkovitz
    Department of Molecular Cell Biology
    Organizer
    Department of Life Sciences Core Facilities
    Contact
    Lecture
  • Date:27SundayDecember 2015

    The role of microRNAs in regulating the central stress response and their involvement in stress-induced psychopathologies

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    Time
    15:00 - 15:00
    Location
    Gerhard M.J. Schmidt Lecture Hall
    LecturerNaama Volk (PhD Defense Thesis)
    Alon Chen Lab, Dept of Neurobiology, WIS
    Organizer
    Department of Brain Sciences
    Contact
    AbstractShow full text abstract about microRNAs (miRNAs) are important post transcriptional regula...»
    microRNAs (miRNAs) are important post transcriptional regulators of the mRNA levels of key gene products in distinct cell types. The main focus of my PhD thesis was to mechanistically explore the emerging role of specific miRNAs in the complex regulation of the central stress response and to study their possible involvement in stress-induced psychiatric disorders. In this lecture, I will describe three related projects, demonstrating the identification and function of three stress-linked miRNAs and their involvement in stress response regulation and stress-induced psychopathologies in both preclinical models and human patients.
    Lecture
  • Date:28MondayDecember 2015

    17th Mini-Workshop in Applied and Computational Mathematics

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    Time
    09:00 - 17:30
    Location
    Jacob Ziskind Building
    Organizer
    Faculty of Mathematics and Computer Science
    Homepage
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    Lecture
  • Date:28MondayDecember 2015

    Metabolic dynamics in microbial systems and ecosystems

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    Time
    09:15 - 09:15
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    Organizer
    Department of Systems Immunology
    Contact
    Lecture
  • Date:28MondayDecember 2015

    Life Sciences Colloquium

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    Time
    11:00 - 12:00
    Title
    Modeling Cancer in the Mouse
    Location
    Dolfi and Lola Ebner Auditorium
    LecturerProf. Tyler Jacks
    MIT, Cambridge, USA
    Contact
    Colloquia
  • Date:28MondayDecember 2015

    Population networks : the promised land of wet computing

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    Time
    13:15 - 13:15
    Location
    Edna and K.B. Weissman Building of Physical Sciences
    LecturerDr. Renaud Renault
    Institut Curie and Institut Pierre-Gilles de Gennes (IPGG)
    Organizer
    Clore Center for Biological Physics
    Contact
    AbstractShow full text abstract about Neurons grown in vitro are in theory amenable to generate an...»
    Neurons grown in vitro are in theory amenable to generate and process information as they normally do inside brains, enabling many ground-breaking applications including glucose-powered neural implants to repair cerebral functions, in vitro models for cognitive studies, and even new kinds of artificial intelligence. However, there is currently no consensus about how to harness the capabilities of neurons in culture or how to build robust and efficient neuronal devices.

    Based on the properties of cultured networks that are both resilient and experimentally accessible on the one hand, and the theoretical framework of Frank Rosenblatt’s perceptron on the other hand, we propose a new architecture for neuronal devices that can bypass many limitations of previous realizations. Our devices are divided into several neuronal populations by the mean of compartmented microchips, individually acting as cohesive « switch-like » units. Between the compartments, axon tunnels of various geometries have been developed to precisely control the directions and strengths of the connections between units, thus defining the initial computational abilities of our devices.

    The capacity of perceptrons to learn new computations on the fly by adjusting the strength of the connections between their units can also be implemented in such neuronal devices by exploiting synaptic plasticity, the natural ability of living neurons to change the strength of their connections when subjected to specific stimulations. Communication and learning are currently being investigated inside such devices, through a fully optical interface based on optogenetics and calcium imaging that can furthermore be implemented with off-the-shelf components.

    These recent theoretical and technological developments lay a solid foundation for the study of communication, computation, plasticity and learning inside living neuronal devices, and their implementation in living neuronal computers and their applications.
    Lecture
  • Date:28MondayDecember 2015

    Emergent thermal dynamics in Darwinian evolution

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    Time
    14:15 - 14:15
    Location
    Edna and K.B. Weissman Building of Physical Sciences
    LecturerGuy Bunin
    MIT
    Organizer
    Department of Physics of Complex Systems
    Contact
    AbstractShow full text abstract about In the past years, the dynamics of a finite population under...»
    In the past years, the dynamics of a finite population undergoing mutations and selection have been mapped to those of a single system in contact with a heat bath. Here we argue that such thermal dynamics will hold much more generally when growth rate increases slowly, as will eventually happen in systems with rugged fitness landscapes. Many non-trivial suggestions from the physics of glasses may be thus applied to evolutionary systems. We discuss two examples: experimental probes for rugged landscapes, and faster-than-Darwinian evolution.


    Lecture
  • Date:29TuesdayDecember 2015

    How interactions and environments modulate strategies of microbial growth

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    Time
    10:00 - 10:00
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    Organizer
    Department of Systems Immunology
    Contact
    Lecture
  • Date:29TuesdayDecember 2015

    3D SUPERSYMMETRIC VECTOR MODELS, ACCIDENTAL SYMMETRIES, AND THE CONFORMAL BOOTSTRAP

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    Time
    10:30 - 12:00
    Location
    Neve Shalom
    LecturerRan Yacoby
    Princeton
    Organizer
    Department of Particle Physics and Astrophysics
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    AbstractShow full text abstract about I will discuss a particular class of theories, which form a ...»
    I will discuss a particular class of theories, which form a certain supersymmetric generalization of three-dimensional O(N) vector models. By combining tools of the conformal bootstrap with results obtained through supersymmetric localization, I will argue that theories in this class exhibit a symmetry enhancement at the infrared fixed point. This example is interesting because the putative infrared theory with no symmetry enhancement does not exhibit any obvious inconsistencies at first sight. Once the correct infrared theories have been identified, I will present a detailed numerical bootstrap analysis showing features (or "kinks") at positions that very nearly coincide with our expectation for these models. Moreover, I will present general numerical bounds in dimensions 3
    Lecture
  • Date:29TuesdayDecember 2015

    Challenges and Solutions to Functional Nanoparticle Devices

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    Time
    11:00 - 12:00
    Location
    Gerhard M.J. Schmidt Lecture Hall
    LecturerProf. Richard Robinson
    Cornell University, NY
    Organizer
    Department of Molecular Chemistry and Materials Science
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    Lecture
  • Date:29TuesdayDecember 2015

    UNIVERSAL PROPERTIES OF CYLINDER PARTITION FUNCTIONS

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    Time
    12:00 - 12:00
    Location
    Neve Shalom
    LecturerLorenzo Di Pietro
    Weizmann Institute of Science
    Organizer
    Department of Particle Physics and Astrophysics
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    Contact
    AbstractShow full text abstract about We consider 4d N=1 superconformal theories on a cylinder. Th...»
    We consider 4d N=1 superconformal theories on a cylinder. The partition function on this geometry computes the superconformal index, and can be obtained via the path integral with time direction compactified on a circle and periodic conditions for fermions. We will use an effective field theory approach to derive formulas for the asymptotics of such partition functions in the limit of very large circle and of very small circle. These limits are completely fixed in terms of coefficients of the Weyl anomaly (a,c). We will explain why supersymmetry is a necessary condition in 4d to establish these higher dimensional analogues of classic results in 2d CFTs. Finally we will discuss the extension to 6d and some applications.
    Lecture
  • Date:29TuesdayDecember 2015

    Systemic spread of antiviral RNAi immunity in insects through extracellular vesicles

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    Time
    12:15 - 12:15
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    LecturerProf. Carla Saleh
    Institut Pasteur, Virology Department
    Organizer
    Department of Molecular Genetics
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    Lecture
  • Date:29TuesdayDecember 2015

    Understanding the roles of amygdala-prefrontal connections through targeted optogenetic perturbation

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    Time
    12:30 - 12:30
    Location
    Gerhard M.J. Schmidt Lecture Hall
    LecturerProf. Ofer Yizhar
    Department of Neurobiology, WIS
    Organizer
    Department of Brain Sciences
    Contact
    AbstractShow full text abstract about Fear-related disorders are thought to reflect strong and per...»
    Fear-related disorders are thought to reflect strong and persistent learned fear associations resulting from aberrant synaptic plasticity mechanisms. The basolateral amygdala (BLA) and the medial prefrontal cortex (mPFC) play a key role in the acquisition and extinction of fear memories. Strong reciprocal synaptic connections between these two regions are believed to play a role in the encoding of fear memories, but the contribution of these projection pathways to memory formation and maintenance remains elusive. We evaluated several optogenetic approaches for silencing presynaptic terminals. Surprisingly, we found that sustained activation of Arch, a light-gated proton pump that is commonly used for optogenetic silencing, paradoxically causes presynaptic calcium influx and neurotransmitter release. This increase in neurotransmission was mediated by presynaptic alkalization and calcium influx, and resulted in recruitment of local-circuit feed-forward inhibition, potentially confounding the interpretation of such experiments. We therefore established an optogenetic stimulation protocol that evokes long-term depression in BLA-mPFC synapses. Using this approach, we explored the role of the BLA-mPFC pathway in fear learning. We found that attenuation of synaptic strength in this pathway prior to fear conditioning leads to impaired learning. In mice that have already acquired the cued fear association, depotentiation of BLA-mPFC inputs prior to extinction training facilitated the extinction process. Our findings suggest a new role for the BLA-mPFC pathway not only in the in the acquisition but also the maintenance of learned associations and provide a framework for functional analysis of long-range projections.
    Lecture

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