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Prof. Rivka Dikstein
Transcription and translation control in health and diseaseCollaboration with: Yuki Yamaguchi, Idit Shachar, Nahum Sonenberg, Yuri Svitkin, Franck Martin, Katsura Asano, Igor Ulitsky, Michael Walker, Neta Regev-RudskyMechanism of rapid transcriptional induction of inflammatory genesLinks between mammalian transcription and mRNA translationDeveloping pharmacological tools to address fundamental questions in mRNA translation and for therapeutic purposesMechanism of start site selection in transcription and translation and its role in cancer and neurodegenerative diseases
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Prof. Nava Dekel
Molecular characterization of the ovulatory cascadeMechanisms involved in successful implantation.Regulation of the meiotic cell cycle: use of rodent oocytes as a model system.Cell-to-cell communication: regulation of expression, posttranslational modification, degradation and function of the gap junction proteins, Cx43 and Cx37.
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Prof. Hadassa Degani
Perfusion and angiogensis in lung cancer: The role of the bronchial and pulmonary vascular network using Fluorescence and magnetic resonance imaging methodsMolecular magnetic resonance imaging of the estrogen receptorCollaboration with: Professors David Milstein and Joel Sussman, Weizmann InstituteSynthesis of new, high affinity ligands of the estrogen receptor as probes for molecular imagingStructuaral studies (x-ray crystalography and NMR) of the estrogen receptor - targeted ligands complexFunctional activities and molecular imaging of the new targeted ligands in estrogen receptor positive huaman breast cancer cellsMechanisms of lymphatic metastasis in breast cancer; In vivo fluorescence and magnetic resonanc imagingAdvanced non invasive MRI methods for breast cancer detection and diagnosis ; clinical investigationsCollaboration with: Dr. Myra Shapiro, Meir medical Center3D Tracking of the mammary tree using diffusion tensor magnetic resonance imagingAdvanced methods for analysis of dynamic contrast enhanced MRI based on a combined model free and model based method.Hyperpolarized magnetic resonance spectroscopy and imaging of cancer metabolism; searching for novel metabolic markers of cancerCollaboration with: Professor Lucio Frydman, Weizmann InstituteRenal function through sodium grandients; Non-invasive, high resolution sodium MRI.Collaboration with: Dr. Edna Haran, Weizmann InstituteEstrogen regulation of angiogenesis and perfusion of breast cancer; from molecular mechanisms to functional MRI of the microvascular physiology
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Prof. Nir Davidson
Ultracold atomsQuantum degenerated atomic gasesCollaboration with: Roee OzeriQuantum nonlinear dynamics and chaosLaser physicsCollaboration with: Asher FriesemSlow and stored lightCollaboration with: Ofer FirstenbergAtomic optics and interferometryCollaboration with: Ofer Firstenberg
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Prof. Irun R. Cohen
Development and clinical applications of an antigen microarray device and informatics analyses aimed at diagnosis, prognosis, monitoring and management of autoimmune and other inflammatory diseases – the ImmunArray Ltd iCHIP (Israel and USA); now in clinical use.Treatment of inflammatory bowel disease, arthritis and other autoimmune conditions using DNA plasmids encoding human HSP90 or HSP70 – Alma Bio Therapeutics (France).Treatment of ALS using a synthetic peptide that inhibits apoptosis and fosters cell growth – Immunity Pharma Ltd. (Israel); entering clinical trials.
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Prof. David Cahen
Sustainable Materials- Solar EnergyCollaboration with: @WIS: G. Hodes, D. Oron, S. Cohen, L. Kronik, L Houben; A. Kahn (Princeton); Helmholtz Centre Berlin, HZB; M. Bär (Erlangen, HZB); H. Bolink (Valencia);P. Nayak (TIFR-H); S Avashti (IISc); H. Ishii (Chiba); P. Schultz, JF. Guillemoles (IPVF-CNRS); T. Kirchartz (Duisburg-Jülich).Self-healing materials & concepts; New optoelectronic materials; Halide Perovskites; Between hard and soft matter.BioelectronicsCollaboration with: @ WIS: M. Sheves, I. Pecht; A. Vilan. M. Tornow (TU-Munich); G. Vattya (Budapest); J. Blumberger (Imp. College); L. Zotti (Sevilla); JC Cuevas (Madrid); H. Chen (Zhejiang U);Proteins as solid-state electronic materials; Fundamentals of electronic charge transport in and across proteins; Biomolecular electronics; Between soft & hard matter.
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