Pathological mechanism in the CNS of various multiple sclerosis animal models.

Neuroprotection, neurogenesis and remyelination – consequences of Glatiramer Acetate treatment in EAE.

Mechanism of action of Copolymer 1 (Copaxone®), a therapeutic vaccine against multiple sclerosis.

Involvement of peptides in animal models of Alzheimer disease and its amelioration

Teaching the foundations of computer science to young students

Fundamental ideas in computer science: Identifying the core ideas of the discipline, examining their teaching and learning processes

Research on cognitive characteristics of non academically oriented math students.

Design of curriculum materials as a research based activity

Long-term design of a new curriculum for grades 10, 11 and 12 for non-academically oriented students.

Caspases without death and death without caspases in Drosophila development

Paternal mitochondrial formation and elimination after fertilization in Drosophila

Developing a systems-level framework to characterize signal integration at the single cell level.

Defining the role of perception and integration of complex stimuli in determining cellular fate.

Analyzing multi-ligand information processing in the BMP/TGFβ pathway and its effect on mesenchymal stem cell differentiation.

Studying signal processing capabilities of additional pathways (e.g. JAK/STAT, Wnt, FGF)

The structure of the membrane proximal extra-cellular region of HIV-1 gp41 and its role in viral fusion

The structure of the V3 loop of the HIV-1 envelope protein gp120 and its interactions with chemokines receptors

NMR structure of alpha Interferon complex with its receptor

The interactions of scorpion toxins with sodium channels and the structures of the channels extra-cellular loops

Plasticity of gene expression during differenatiation in the gonads.

Crosstalk amond signals that control apoptosis.

Carcinogenesis in endocrine glands.

Genomics and Systems Biology of the Immune System.

Decoding the mammalian transcriptional Regulatory Code in health and disease.

Combining theoretical and experimental methods to discover design principles of biological circuits

Systems level analysis of gene regulation networks, with E. coli as a model system.

Systems Immunology

Evolution

Integrin and chemokine signals for leukocyte diapedesis, differentiation and killing

Leukocyte-type specific roles of ICAM-1 and ICAM-2 in leukocyte emigration across the pulmonary vasculature

Role of lymph node ICAMs in lymphocyte priming and differentiation

Trafficking cues for leukocyte emigration and function in lung and skin infections

Mechanical properties of nuclei in solid tumors: implications in cell barrier crossing, survival and metastasis

Breast cancer killing in primary tumors and inside the lung vasculature: regulation by tumor cell ICAM-1

The role of antigens on lung metastatic lesions in the recruitment and killing capacity of circulating CTLs and TILs