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Prof. Dan Shahar
Physics of electron's spinQuantum phase transitions: General transport studies and mesoscopics of the metal-insulator, superconductor-insulator and other transitions.Scanning tunneling experiments at ultra-low temperaturesFractional and integer quantum Hall effect and related phenomena.Experiments on materials at ultra low-temperatures.
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Prof. Idit Shachar
Analyze the pathway regulateing the survival cascades in Chronic lymphocytic leukemiaCollaboration with: Dr Michal Haran, Kaplan Medical centerFollow the mechanisms controlling homing of immune cells in health and disease.Determine the mechanisms regulating peripheral B cell maturation and survival in health and disease.
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Prof. Michael Sela
An aptamer strategy to target oncogenic signaling in ErbB2 carrying human tumors.Collaboration with: G. Mahlknecht , Y. Yarden G. MahlknechtSynergy of antibodies towards decreasing pancreatic cancer.Collaboration with: R. Maron, B. Schechter, Y. YardenTowards vaccination: Generation of peptide mimotopes specific for anti ErbB-2 monoclonal antibodies.Collaboration with: E. Witsch, Y. YardenMechanism of action of Copolymer 1 (Copaxone), a therapeutic vaccine against multiple sclerosis.Collaboration with: R. ArnonEffective synergism by anti ErbB-2 mAb combinations comprising one mAb against the dimerization site of ErbB-2.Collaboration with: Y. YardenMonoclonal antibodies (mAbs) to ErbB-1 and ErbB-2 receptors and their role in potential anti-tumor strategy.Collaboration with: B. Schechter, Y. YardenSynergistic effects of combinations of mAb against distinct epitopes on EGFR/ErbB-1 and ErbB-2 receptors: accelerated receptor aggregation, down regulation and inhibition of tumor growth.Collaboration with: B. Schechter, Y. Yarden
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Prof. Rony Seger
The nuclear translocation of signaling protein as a drug target for cancer and inflammationThe nuclear translocation of ERKThe nuclear translocation of JNK and p38Develop peptide inhibitors of the nuclear translocation of ERK/JNK/p38 for the cure of cancer and inflammationDevelopment of small molecular weight inhibitors of the nuclear translocation of ERK for the cure of cancerThe subcellular localisation of AKTThe mechanisms and roles of MEK nuclear translocationERK1c in the regulation of Golgi fragmentationThe mechanisms of golgi translocation of ERK1cSubstrates of ERK1c in the GolgiMechanism of ERK1c-regulated Golgi architecture
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Prof. Menahem Segal
Electrical activity in small hippocampal networksCollaboration with: Dominik FrecheIntracellular calcium and structural/functional plasticity in cultured neurons.Collaboration with: Dr. Eduard Korkotian, Professor Michael FrotscherActivity maintains survival of neurons in cultureCollaboration with: Eldi Schonfeld-DadoHippocampal structure and function during stressCollaboration with: Dr. Gayane Grigoryan, Prof. Gal Richter-Levin
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Prof. Michal Schwartz
The cross-talk between the immune and nervous systems autoimmunity as a mechanism of tissue repair: Molecular, cellular, physiological and behavioral aspects.Immunological aspects of neuronal loss in neurodegenerative and mental disorders (Alzheimers, ALS, Huntingdon, Glaucoma).Spinal cord injury and repairDevelopment of vaccination for neurodegenerative disorders.Neurogenesis (stem cells) and inflammation in the CNS.
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Prof. Oren Schuldiner
A genetic dissection of developmental axon regenerationMolecular mechanisms of neuronal remodeling during development: Developmental axon pruning in DrosophilaThe role of cell-cell interaction in regulating developmental axon pruningThe role of intracellular signaling in regulating developmental axon pruningThe role of trafficking in regulating developmental axon pruningGlia and their effect on neuronal growth and remodeling
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Prof. Maya Schuldiner
Uncovering tethers, functions and regulators of membrane contact sites in yeastMitochondria-Peroxisome contact sitesPeroxisome-Plasma membrane contact sitesLipid Droplet-Mitochondria contact sitesThe proteome of contact sitesTargeting and translocation to OrganellesUncovering a role for the Ssh1, alternative, translocon in yeast Targeting of membrane proteins to peroxisomesDeciphering targeting of proteins to mitochondriaTargeting of membrane proteins to peroxisomesUncovering new peroxisomal proteins and their functionsCollaboration with: Dr. Einat ZalckvarMetabolite transport across the peroxisome membranePeroxisome contact sitesPeroxisome quality controlPeroxisome targetingNovel methodologies for systematic exploration of yeast organelle protein functionsCreation of versatile yeast librariesHigh throughput electron microscopy techniquesTranslocation sensors
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