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Prof. Meir Wilchek
Study and application of molecular biorecognitionAvidin-biotin system: Studies of the strong binding using chemical, physical and biological methods; new applications of the system.Affinity chromatography: Studies to improve purification of protein by developing new carriers, new activation methods and new principles.Affinity therapy: Development of methods to couple drugs and toxins to biological carriers, such as antibodies, and their delivery to target cells.
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Prof. Stephen Weiner
Structure - mechanical function relations in mineralized tissues (bones and teeth) using Optical Metrology.Collaboration with: Ron Shahar, Hebrew University of JerusalemArchaeological science: revealing the microscopic archaeological recordCollaboration with: E. Boaretto,Biomineralization: mechanisms of mineral formation and growth in biology.Collaboration with: L. Addadi, Leeor Kronick, Dan Oron
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Prof. David Wallach
Regulation of cell death and tissue damage:Proteins involved in the signaling for the cell-killing (apoptotic and necrotic), immunoregulatory, and inflammatory functions of cytokines of the tumor necrosis factor (TNF) family, and in the regulation of these functions.In vivo models for the functions of the signaling mechanisms activated by ligands of the TNF family and for their pathological aberrations.Natural antagonists to ligands of the TNF family, for protection against the deleterious effects of these cytokines in autoimmune and infectious diseases.Regulation of the activity of the NF kappa B transcription factors.The caspases, their functions and mechanisms of activation.Molecular mechanisms for chronic inflammatory skin diseases.Contributions of aberrations in the function of signaling proteins activated by ligands of the TNF family to cancercancer-cells' survival factors
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Prof. Michael Walker
Selective gene expression in pancreatic beta cells:Role of specific transcription factors in expression of the insulin gene in pancreatic beta cells and in control of pancreatic development.Novel beta cell specific genes: isolation, characterization and use as potential tools in diagnosis and therapy of diabetes.
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Prof. Zvi Vogel
Molecular mechanisms of opiate addiction, tolerance and withdrawal.The cannabinoid ligands, their endogenous ligands and signal transduction.Collaboration with: Raphael MechoulamRegulation of microglial activation by cannabinoids: Possible role in neurodegenrative and neuroinflammatory diseases
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Prof. Assaf Vardi
The ecological and evolutionary role of programmed cell death in single-celled marine photosynthetic microorganismsThe role of infochemicals and their regulation of cell fate and cell-cell interactions in marine photosynthetic microorganismsSensing Environmental Stress and Acclimation Strategies in Marine AlgaeCell Signaling Pathways and their role in the Chemical Arms Race during Algal Host-Virus and Predator-Prey interactions
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Prof. Vladimir Usov
Physical processes in relativistic electron-positron plasma.Collaboration with: G.Z. MachabeliThe theory of nonthermal radiation from compact astronomical objects (pulsars, white dwarfs, gamma-ray bursters etc.).Collaboration with: A.K. Harding, D.B. Melrose, M. Milgrom, A.G. Muslimov, A.E. ShabadPhysical processes in very strong magnetic fields.Collaboration with: A.E. ShabadPhysical processes at the surface and astrophysical appearance of strange-quark-matter stars.Collaboration with: K.S. Cheng, T. Harko, M. Milgrom, F.WeberHydrodynamics and high-energy physics of colliding stellar winds in binary systems.Collaboration with: N.N. Pilyugin