Head
Prof. Deborah Fass
Prof. Deborah Fass
Head
Prof. Deborah Fass
Office +972-8-934-3214
Email deborah.fass@weizmann.ac.il
Overview
All biological systems function thanks to the structure and assembly of macromolecules. Therefore, determination of the molecular structures and structure-function relationships of biological materials such as proteins, DNA, RNA, and lipid membranes provides great insights into biological mechanisms. Much of the research in structural biology at the Weizmann Institute is carried out in the Faculty of Chemistry, using a diverse set of cutting-edge research tools and methods. Investigators in the Structural Biology Department rely on the primary techniques for experimental structure determination, namely X-ray crystallography, NMR, and electron microscopy, but they also employ a variety of other specialized and emerging spectroscopic methods combined with creative molecular engineering to explore macromolecular structures, energetics, and dynamics. Experimental strategies are complemented by computational and theoretical approaches. Among the specific subjects of research in the department are ribosomes, protein chaperones, viruses, extracellular matrices, and biominerals. Processes being investigated include protein aggregation in cells, conformational dynamics of enzymes, formation of skeletal tissues, cell penetration by viruses, DNA recognition by proteins, and protein folding. Efforts are also directed towards the design of potential drugs. The wide variety of research activities in the department are based on a shared appreciation for the physical and chemical foundations of biological activities.
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Prof. Yehiel Zick
Mode of action of galectin-8, a mammalian lectin
The molecular basis of Insulin Resistance: a Phosphorylation based Uncoupling of Insulin Signalling
The insulin receptor as a model system for transmembrane signaling: Mode of interaction of the insulin receptor with its downstream effector molecules.
Mammalian lectins as regulators of cell adhesion, cell growth, and apoptosis.
Receptor trafficking: Regulation of endocytosis and recycling of the insulin receptor.
Role of Galectin-8 in bone remodeling
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Prof. Elazar Zelzer
the roles of the VEGF pathway in different steps during skeletal development.
Studying the role of mechanical load on embryonic bone development
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Prof. Ofer Zeitouni
Applications in nonlinear filtering, Communication and Information theory
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Prof. Ada Yonath
Antibiotics targeting ribosomes
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Prof. Yosef Yomdin
High Order Data Representation, Nonlinear Model Approximation. Taylor Models, High-Order Numerical methods
Semialgebraic Complexity of functions, Signals Acquisition via non-linear model approximation
Collaboration with:
D. Batenkov, G. Goldman, Y. Salman, V. Golubyatnikov
Analytic Theory of Differential Equations, Generalized Moments, Compositions
Collaboration with:
M. Briskin, F. Pakovich, N. Roytvarf
Zeroez distribution in Families of Analytic Functions
Collaboration with:
M. Briskin, G. Comte
Model-based image analysis, representation, compression. Model-based search, capturing, and animation
Collaboration with:
G. Dinkin
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Dr. Ofer Yizhar
* Functional analysis of neural circuit changes associated with psychiatric disease
* Development of novel optogenetic methods for light-based control of neural activity in vitro and in vivo
* Synaptic organization and function in cortical networks
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Prof. Edit Yerushalmi
Development implementation and evaluation of a 2-year interdisciplinary program for high school chemistry and physics students on
Collaboration with:
A. Hofstein, S. Livne, Y. Roth, R. Blonder, A. Yarden, S. Safran, B. Eylon, B. Geiger
Instructional strategies intended to develop reflective problem solving skills in high school physics students
Collaboration with:
C. Singh, E. Cohen, E. Bagno, B. Eylon
Study of the effects of self-diagnosis tasks on learning from physics problem solving.
Development, implementation and evaluation of web-based test preparation modules aimed at organizing students knowledge and developing awareness of common misconceptions (Mechanics, Electricity and Magnetism).
Development, implementation and research of long-term professional development frameworks for physics high school teachers
Collaboration with:
R. Safadi, E. Bagno, A. Rozen
Workshops for Arab high school physics teachers intended to develop reflective problem solving skills in their students through alternative assessment activities. Workshop approach: Collaborative inquiry into students' self diagnostic activities.
Models for collaborative action research workshops for high school physics teachers.
Long-term didactical courses introducing pre-service teachers to current research in physics education and its implications to the learning/teaching process.
University physics faculty perceptions of learning and teaching problem solving.
Collaboration with:
C. Henderson, K. Heller, P. Heller, V. Quo, E. Cohen
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Prof. Ephraim Yavin
Signal transduction and protein kinase C isozymes in brain of normal and growth-retarded fetuses.
Free radicals and lipid modulators in the developing and aging brain.
Novel genes during oxidative stress in utero and role of docosahexaenoic acid.
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Prof. Avraham Yaron
Signaling mechanisms of axonal guidance cues
Mechanisms of axonal degeneration
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