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Prof. Alex Tsafriri
Molecular regulation of ovulatory changes in mammals.Collaboration with: Helena Ashkenazi, Shmulik Motola, Xiumei Cao, Malka Popliker, Seymour Pomerantz, Marco Conti, StanfordThe roles of gonadotropins and EGF-like factors in triggering ovulation.The resumption of meiosis and its regulation.Ovulation as a tissue remodeling process.The development and demise of ovarian follicles <I>in vivo</I> and <I>in vitro</I>: the role of apoptosis.Collaboration with: Atan Gross, KerenYacobi
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Prof. Yoram Shechter
Mechanism of insulin action: Post-binding events in insulin actionPost-receptor agents mimicking insulin.Effect of vanadium <I>in vivo</I> and <I>in vitro</I>.Role of protein tyrosine kinases and protein phosphotyrosine phosphatases in insulin effects.Inhibitors of tyrosine kinases.Chemical modifications of peptides and protein drugs.Novel technologies to prolong life time of peptide and protein drugs.
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Prof. Matityahu Fridkin
Chemical-Biological and Clinical studies on novel drugs, primarily of peptidic nature,related to therapy of infectious ,inflamatory and neoplastic diseases.Collaboration with: Y. Koch I. Gozes (TAU ) I. Offek (TAU ) R. Catane (TEL-HASHOMER )Anticancer, Antibacterial AntiinflammatoryNovel synthetic and analytical methdologies are being developed.Solid-phase synthesisClassical solution chemistryCombinatorial technologiesStudies include: drug design, pro-drugs, long-acting drugs and drug delivery.Collaboration with: Y. ShechterNovel iron chelatores as potential drugs for neurodegenarative diseasesCollaboration with: M. Youdim ( Technio9n )small-moleculesamino acids and peptides
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Prof. Eytan Domany
Computational Physics: equilibrium and non-equilibrium statistical mechanics of spin glassesCollaboration with: A. P. Young (UCSC)Development of tools and algorithms for large scale data analysis. Bioinformatics.Analysis of high-throughput biological data (in particular, gene expression data)Collaboration with: Several research groups at Weizmann, in the USA and in Europe; see below.Controlled experiments on cell lines and mice (with D. Givol, V. Rotter, Y. Groner, L. Sachs; D. Gazit (Hadassa))Development of antigen chips, applications for autoimmune diseases (with I. Cohen)Studies human cancer samples; leukemia (with E. Canaani; G. Rechavi S. Izraeli (Sheba))Colorectal cancer; (with D. Notterman (UMDNJ), F. Barany (Cornell), P. Paty (MSK), A. Levine (Princeton))Prostate cancer; (with Z. Eshhar, A. Orr (TA Sourasky));Glioblastoma; (with M. Hegi, R. Stupp (CHUV))Breast and cervical cancer (with J-P Thiery, F. Radvanyi, X. Sastre, C. Rosty (Inst Curie))
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Prof. Yoseph Imry
Mesoscopic physics: persistent currents, classical and quantum fluctuations, quantum interference effects on transport, decoheherce.Collaboration with: see below.Effects of interaction on localization and on single-electron resonances. Many-electron effects and phase-shifts. Dephasing of Quantum interference in mesoscopics. Quantum noise and its detection. Effects of quantum fluctuations on nanosuperconductors.Collaboration with: Y. Levinson, A. Aharony and E. Entin-Wohlman (TAU and BGU), Y. Ovadyahu and A. schiller (HU), P. Silvestrov (Leiden), M. Schechter and P, Stamp (UBC).
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Prof. Amiram Grinvald
The Interactions between evoked and on-going activity and their potential functional role in cortical processing.Collaboration with: D. Omer, M. TsodyksThe space-time dynamics of cortical activity as revealed by population activity (EEG, LFP and real-time optical imaging) coupled with single-unit and intracellular recordings.Collaboration with: D. Omer, L. Rom M. TsodyksCortical correlates of attention in behaving monkeys.Collaboration with: D. Omer, L. RomThe functional architecture underlying visual perception.Collaboration with: D. Omer, L. Rom,The dynamics of cortical representations in the visual cortex.Collaboration with: S. Naaman
