2021 research activities

Head Prof. Milko van der Boom

Picture of Prof. Milko van der Boom

Prof. Milko van der Boom

Office +972-8-934-2515


The areas of research in the Department of Organic Chemistry include synthetic and mechanistic organic and organometallic chemistry, novel reactions for organic synthesis, bond activation by metal complexes, polymeric reagents and catalysis. Bioorganic chemistry includes the studies of plant antiviral agents, the molecular mechanism of action of rhodopsin, artificial ion carriers and molecular sensors. Biological chemistry includes studies on structure,function, and mode of action of biologically active peptides and proteins; thermophilic enzymes; enzymes involved in DNA repair, DNA and RNA processing; studies of ordered, compact states of nucleic acids; and biomedical applications of EPR and NMR. Computational chemistry deals with the prediction of molecular properties by first principles (ab initio) and semiempirical quantum mechanical calculations..

ScientistsShow details

  • Picture of Prof. Mario D. Bachi

    Prof. Mario D. Bachi

    Organic synthesis through free radical reactions.
    Synthesis of Yingzhaosu A and related antimalarial drug candidates.
    Stereocontrol through Sulfur-Mediated Temporary Intramolecularization of Reactions.
  • Picture of Prof. Yigal Burstein

    Prof. Yigal Burstein

    Thermophilic enzymes
    Isolation, characterization and cloning of enzymes from extremophilic microorganisms.
    Structure, function and thermal stability relationship studies of extremophilic enzymes.
    Crystalization and determination of the three-dimensional structures of extremophilic enzymes.

  • Picture of Prof. Matityahu Fridkin

    Prof. Matityahu Fridkin

    Chemical-Biological and Clinical studies on novel drugs, primarily of peptidic nature,related to therapy of infectious ,inflamatory and neoplastic diseases.
    Collaboration with:  Y. Koch I. Gozes (TAU ) I. Offek (TAU ) R. Catane (TEL-HASHOMER )
    Anticancer, Antibacterial Antiinflammatory
    Novel synthetic and analytical methdologies are being developed.
    Solid-phase synthesis
    Classical solution chemistry
    Combinatorial technologies
    Studies include: drug design, pro-drugs, long-acting drugs and drug delivery.
    Collaboration with:  Y. Shechter
    Novel iron chelatores as potential drugs for neurodegenarative diseases
    Collaboration with:  M. Youdim ( Technio9n )
    amino acids and peptides

  • Picture of Dr. Nir London

    Dr. Nir London

    Discovery and design of specific covalent inhibitors
    Covalent personalized medicine for cancer
    Computational ligand/drug discovery

  • Picture of Prof. Gershom (Jan) Martin

    Prof. Gershom (Jan) Martin

    Computational Quantum Chemistry
    Collaboration with:  D. Milstein, M. van der Boom, R. Neumann, M. A. Iron, L. Kronik
    High-accuracy ab initio thermochemistry: method development and applications.
    Development of novel, more universal, density functionals
    Application of density functional methods to organometallic systems, with special reference to homogenous catalysis.
    Ab initio prediction of rotation-vibration spectra beyond the harmonic approximation.
    Intermolecular interactions

  • Picture of Prof. David Milstein

    Prof. David Milstein

    Organometallic chemistry and catalysis
    Bond activation by electron-rich transition metal complexes.
    Rational design of homogeneous catalysis and synthetic methodology based on transition metal complexes.
    Impact of molecular order on catalysis and reactivity.
    Generation and stabilization of elusive (potentially biologically active) molecules

  • Picture of Prof. Boris Rybtchinski

    Prof. Boris Rybtchinski

    Organic self-assembly: nanoreactors and nanocapsules
    Solar fuels: photoinduced water splitting for hydrogen production
    Artificial photosynthesis: light-harvesting materials for solar energy conversion

  • Picture of Prof. Abraham Shanzer

    Prof. Abraham Shanzer

    Supramolecular chemistry
    Biomimetic ion binders, diagnostic tools in imaging technologies (fluorescent probes) and potential therapeutic agents. Synthesis, using classical and combinatorial chemistry methods and evaluation.
    Synthesis and properties of molecular based devices; molecular sensors, switches and logical gates for application in nanotechnology.
    Surface bound functional assemblies.