2024 research activities

Head Prof. Milko van der Boom

Picture of Prof. Milko van der Boom
Head

Prof. Milko van der Boom

Office +972-8-934-2515

Overview

The areas of research in the Department of Organic Chemistry include synthetic and mechanistic organic and organometallic chemistry, novel reactions for organic synthesis, bond activation by metal complexes, polymeric reagents and catalysis. Bioorganic chemistry includes the studies of plant antiviral agents, the molecular mechanism of action of rhodopsin, artificial ion carriers and molecular sensors. Biological chemistry includes studies on structure,function, and mode of action of biologically active peptides and proteins; thermophilic enzymes; enzymes involved in DNA repair, DNA and RNA processing; studies of ordered, compact states of nucleic acids; and biomedical applications of EPR and NMR. Computational chemistry deals with the prediction of molecular properties by first principles (ab initio) and semiempirical quantum mechanical calculations..

ScientistsShow details

  • Picture of Prof. Mario D. Bachi

    Prof. Mario D. Bachi

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    Organic synthesis through free radical reactions.
    Synthesis of Yingzhaosu A and related antimalarial drug candidates.
    Stereocontrol through Sulfur-Mediated Temporary Intramolecularization of Reactions.

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  • Picture of Prof. Yigal Burstein

    Prof. Yigal Burstein

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    Thermophilic enzymes
    Collaboration with:  Moshe Peretz, Orly Dym, Linda Shimon
    Isolation, characterization and cloning of enzymes from extremophilic microorganisms.
    Structure, function and thermal stability relationship studies of extremophilic enzymes.
    Crystalization and determination of the three-dimensional structures of extremophilic enzymes.
    Fatty Acid Synthesis in Tuberculosis causing baceria
    Collaboration with:  Zippora Shakked, Oren Zimhony, Ron Diskin, Moshe Peretz, Shira Albeck, Yoav Pelleg, Orly Dym
    Structure of acyl carrier protein synthase (AcpS) from Mycobacterium tuberculosis (Mtb)
    Expression and enzymatic studies on recombinant, 4'-Phosphopantetheinylated, active M. tuberculosis fatty acid synthase I

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  • Picture of Prof. Matityahu Fridkin

    Prof. Matityahu Fridkin

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    Chemical-Biological and Clinical studies on novel drugs, primarily of peptidic nature,related to therapy of infectious ,inflamatory and neoplastic diseases.
    Collaboration with:  Y. Koch I. Gozes (TAU ) I. Offek (TAU ) R. Catane (TEL-HASHOMER )
    Anticancer, Antibacterial Antiinflammatory
    Novel synthetic and analytical methdologies are being developed.
    Solid-phase synthesis
    Classical solution chemistry
    Combinatorial technologies
    Studies include: drug design, pro-drugs, long-acting drugs and drug delivery.
    Collaboration with:  Y. Shechter
    Novel iron chelatores as potential drugs for neurodegenarative diseases
    Collaboration with:  M. Youdim ( Technio9n )
    small-molecules
    amino acids and peptides

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  • Picture of Dr. Nir London

    Dr. Nir London

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    Discovery and design of specific covalent inhibitors
    Covalent personalized medicine for cancer
    Computational ligand/drug discovery

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  • Picture of Prof. Gershom (Jan) Martin

    Prof. Gershom (Jan) Martin

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    Computational Quantum Chemistry
    Collaboration with:  D. Milstein, M. van der Boom, R. Neumann, M. A. Iron, L. Kronik, J. L. Sussman
    High-accuracy ab initio thermochemistry: method development and applications.
    Development of novel, more universal, density functionals, with particular emphasis on fifth-rung ("double hybrid") approaches
    Application of density functional methods to organometallic systems, with special reference to homogenous catalysis.
    Ab initio prediction of rotation-vibration spectra beyond the harmonic approximation.
    Intermolecular interactions
    Computational molecular biology (focusing on acetylcholinesterase and on COVID19)

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  • Picture of Prof. David Milstein

    Prof. David Milstein

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    Organometallic chemistry and green catalysis
    Bond activation by pincer-type complexes
    Rational design of green and sustainable catalysis and synthetic methodology based on pincer-type metal complexes
    Sustainable, green energy based on catalytic design
    Hydrogen Storage. Design and development of novel Liquid Organic Hydrogen Carriers (LOHCs)
    Metal-Ligand Cooperation
    Oxidation of organic compounds using water as formal oxidant with H2 liberation

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  • Picture of Prof. Ronny Neumann

    Prof. Ronny Neumann

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    Carbon Dioxide Reduction and Valorization
    Reduction of Molecular Nitrogen to Ammonia
    Activation of Molecular Oxygen
    Water as Oxygen Donor
    "Inorganic Enzymes" by Supramolecular Chemistry

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  • Picture of Prof. Boris Rybtchinski

    Prof. Boris Rybtchinski

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    Organic self-assembly: nanoreactors and nanocapsules
    Solar fuels: photoinduced water splitting for hydrogen production
    Artificial photosynthesis: light-harvesting materials for solar energy conversion

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  • Picture of Prof. Abraham Shanzer

    Prof. Abraham Shanzer

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    Supramolecular chemistry
    Biomimetic ion binders, diagnostic tools in imaging technologies (fluorescent probes) and potential therapeutic agents. Synthesis, using classical and combinatorial chemistry methods and evaluation.
    Synthesis and properties of molecular based devices; molecular sensors, switches and logical gates for application in nanotechnology.
    Surface bound functional assemblies.

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