2018 research activities
Overview
The areas of research in the Department of Organic Chemistry include synthetic and mechanistic organic and organometallic chemistry, novel reactions for organic synthesis, bond activation by metal complexes, polymeric reagents and catalysis. Bioorganic chemistry includes the studies of plant antiviral agents, the molecular mechanism of action of rhodopsin, artificial ion carriers and molecular sensors. Biological chemistry includes studies on structure,function, and mode of action of biologically active peptides and proteins; thermophilic enzymes; enzymes involved in DNA repair, DNA and RNA processing; studies of ordered, compact states of nucleic acids; and biomedical applications of EPR and NMR. Computational chemistry deals with the prediction of molecular properties by first principles (ab initio) and semiempirical quantum mechanical calculations..
ScientistsShow details
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Prof. Mario D. Bachi
Organic synthesis through free radical reactions.Synthesis of Yingzhaosu A and related antimalarial drug candidates.Stereocontrol through Sulfur-Mediated Temporary Intramolecularization of Reactions.
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Prof. Yigal Burstein
Thermophilic enzymesIsolation, characterization and cloning of enzymes from extremophilic microorganisms.Structure, function and thermal stability relationship studies of extremophilic enzymes.Crystalization and determination of the three-dimensional structures of extremophilic enzymes.
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Prof. Matityahu Fridkin
Chemical-Biological and Clinical studies on novel drugs, primarily of peptidic nature,related to therapy of infectious ,inflamatory and neoplastic diseases.Collaboration with: Y. Koch I. Gozes (TAU ) I. Offek (TAU ) R. Catane (TEL-HASHOMER )Anticancer, Antibacterial AntiinflammatoryNovel synthetic and analytical methdologies are being developed.Solid-phase synthesisClassical solution chemistryCombinatorial technologiesStudies include: drug design, pro-drugs, long-acting drugs and drug delivery.Collaboration with: Y. ShechterNovel iron chelatores as potential drugs for neurodegenarative diseasesCollaboration with: M. Youdim ( Technio9n )small-moleculesamino acids and peptides
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Dr. Nir London
Discovery and design of specific covalent inhibitorsCovalent personalized medicine for cancerComputational ligand/drug discovery
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Prof. Gershom (Jan) Martin
Computational Quantum ChemistryCollaboration with: D. Milstein, M. van der Boom, R. Neumann, M. A. Iron, L. KronikHigh-accuracy ab initio thermochemistry: method development and applications.Development of novel, more universal, density functionalsApplication of density functional methods to organometallic systems, with special reference to homogenous catalysis.Ab initio prediction of rotation-vibration spectra beyond the harmonic approximation.Intermolecular interactions
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Prof. David Milstein
Organometallic chemistry and catalysisBond activation by electron-rich transition metal complexes.Rational design of homogeneous catalysis and synthetic methodology based on transition metal complexes.Impact of molecular order on catalysis and reactivity.Generation and stabilization of elusive (potentially biologically active) molecules
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Prof. Boris Rybtchinski
Organic self-assembly: nanoreactors and nanocapsulesSolar fuels: photoinduced water splitting for hydrogen productionArtificial photosynthesis: light-harvesting materials for solar energy conversion
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Prof. Abraham Shanzer
Supramolecular chemistryBiomimetic ion binders, diagnostic tools in imaging technologies (fluorescent probes) and potential therapeutic agents. Synthesis, using classical and combinatorial chemistry methods and evaluation.Synthesis and properties of molecular based devices; molecular sensors, switches and logical gates for application in nanotechnology.Surface bound functional assemblies.
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