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December 01, 2014
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Date:05SundayNovember 2023Lecture
TBA
More information Time 11:00 - 11:00Location Sussman Family Building for Environmental SciencesLecturer Paul O'Gorman Organizer Department of Earth and Planetary SciencesContact -
Date:13MondayNovember 2023Lecture
PhD Thesis Defense - Alon Bar (Prof. Uri Alon Lab)
More information Time 12:00 - 14:00Title Design principles of long-term control in physiological circuitsLocation Wolfson Building for Biological ResearchLecturer Alon Bar (Prof. Uri Alon Lab) Organizer Department of Molecular Cell BiologyContact -
Date:15WednesdayNovember 2023Lecture
Synthetic Ex Utero Embryogenesis: from Naive Stem Cells to Complete Embryo Models
More information Time 10:00 - 11:00Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Prof. Jacob (Yaqub) Hanna
Dept of Molecular Genetics WISContact -
Date:19SundayNovember 2023Lecture
cancelled
More information Time 11:00 - 12:00Location Sussman Family Building for Environmental SciencesLecturer Erwin Zehe Organizer Department of Earth and Planetary SciencesContact -
Date:23ThursdayNovember 2023Lecture
Seminar for PhD thesis defense
More information Time 11:00 - 12:00Title “Interactions between bacteria and their viruses”Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Avigail Stokar Avihail Organizer Department of Molecular GeneticsContact -
Date:23ThursdayNovember 2023Lecture
Dissecting the role of peripheral immunity in Alzheimer’s Disease pathogenesis and disease course
More information Time 11:30 - 12:30Title Student Seminar PhD Thesis Defense ZOOMLecturer Tommaso Croese PhD Defense
Advisor: Prof. Michal Schwartz Dept of Brain Sciences WISOrganizer Department of Brain SciencesContact Abstract Show full text abstract about Recent research has increasingly focused on the intricate in...» Recent research has increasingly focused on the intricate interactions between the brain and the immune system, a critical line of inquiry for understanding neurological disorders like Alzheimer's Disease (AD). AD, once defined primarily by amyloid-β and tau aggregations, is now being explored for its complex interplay with immune processes, offering a deeper understanding of its development.
This study delves into the dynamic relationship between the brain and the immune system, utilizing human samples from individuals predisposed to AD and various preclinical models. Our findings reveal that both environmental and genetic risk factors for AD significantly influence immune phenotypes and functions, which in turn impact disease progression.
Further, we discovered that disrupting brain-spleen communication alters myeloid cell fate and cognitive performance in 5xFAD mice. These insights demonstrate the profound and reciprocal influence between the brain and the immune system. They underscore the importance of these interactions in understanding not only AD but also a wider array of neurological conditions, suggesting that this interplay is crucial for comprehending the complexities of such diseases.
Zoom Link: https://weizmann.zoom.us/j/5420322495?pwd=ZmhUR0kxWTB6aDh0bklBNFlzV1JNdz09
Meeting ID: 542 032 2495
Password: 862769
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Date:26SundayNovember 2023Lecture
Cancelled
More information Time 11:00 - 11:00Location Sussman Family Building for Environmental SciencesLecturer Jianmin Chen Organizer Department of Earth and Planetary SciencesContact -
Date:30ThursdayNovember 2023Colloquia
Physics Hybrid Colloquium
More information Time 11:15 - 12:30Title The Large Array Survey TelescopeLocation Edna and K.B. Weissman Building of Physical SciencesLecturer Prof. Eran Ofek
Weizmann Institute of ScienceOrganizer Department of Particle Physics and AstrophysicsContact Abstract Show full text abstract about We are building a new ground-based observatory in Neot Smada...» We are building a new ground-based observatory in Neot Smadar, located in the south of the Negev desert.
One of the telescopes hosted at this site is the Large Array Survey Telescope (LAST). LAST is a cost-effective survey telescope capable of quickly
scanning the sky and studying the dynamic sky, from solar system objects to explosions at cosmological distances.
I will describe the Neot Smadar site, the LAST system, and some of the science cases for which LAST was built.
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Date:04MondayDecember 2023Lecture
Faculty Seminar
More information Time 16:00 - 17:00Title Identifying underlying geometry to denoise and analyze (high-dimensional) dataLecturer Shira Faigenbaum-Golovin
Duke UniversityOrganizer Department of Computer Science and Applied MathematicsContact Abstract Show full text abstract about In many applications that involve large volumes of data (whe...» In many applications that involve large volumes of data (whether low- or high-dimensional), identifying and exploiting the underlying geometry is an essential ingredient -
Date:06WednesdayDecember 2023Lecture
Special guest seminar
More information Time All dayLecturer Prof. Or Gozani Organizer Department of Immunology and Regenerative BiologyContact -
Date:06WednesdayDecember 2023Lecture
Seminar for PhD thesis defense
More information Time 10:00 - 10:00Title Mutational Analysis and Downregulation of EIF 4 G 2 Protein Expression in Cancer and its Significance in Shaping Patient Outcomes in Endometrial CancerLocation Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Sarit Meril Organizer Department of Molecular GeneticsContact -
Date:06WednesdayDecember 2023Lecture
Context-Dependent Dynamic Coordination of Head and Eye Movements During Visual Orienting
More information Time 14:00 - 15:00Lecturer Ofer Karp-PhD Defense seminar
Dept of Brain Sciences Advisor: Prof. Ehud AhissarOrganizer Department of Brain SciencesContact Abstract Show full text abstract about The orienting response, described by Pavlov as the “what is ...» The orienting response, described by Pavlov as the “what is it?” reflex, aims to describe an individual's reaction to unexpected stimuli in their environment. Many experimental results show that in such an event, the quickest motor response is of a saccadic eye movement, and if the head is free to move, a head-shift follows the eye to meet the event. Studying orienting in different tasks and contexts have uncovered several variations in head-eye coordination, including modulations of the number of saccades during a single orienting motion and modulations of the relative timing between head and eye movements.
In this presentation, I will present my attempt at understanding and modeling the brain-environment loops underlying the visual orienting response. For this aim I have designed and constructed a virtual reality (VR) setting that allows head and eye real-time tracking during visual tasks in different contexts. I will show that, with head-free viewing, the classic eye-leading, fast saccadic gaze-shift response is typical for cases of external visual stimuli. In contrast, multi-saccadic, head-leading gaze-shifts are typical for cases in which the subject orients towards an internal reference position, with no external visual que, regardless of the angle. I demonstrate that the kinematics of the first saccadic eye movement is different between the two conditions, suggesting different motor control mechanisms. My results suggest that the context of orienting, whether it is exogenous (targeting an external stimulus) or endogenous (targeting an internal reference point) affects the balance between the two mechanisms. A comparison of the orienting responses towards visual versus auditory stimuli suggests different modalities (such as auditory and proprioceptive) are treated as endogenous by the visual control system. Based on these results, I suggest a competitive multiple-closed-loop dynamic model of gaze orienting. Simulations of the model show it can replicate the empirical kinematics and statistics.
My results suggest that the traditional view of the mechanism underlying gaze orienting response should be revisited to take into account the source of the response as well as the subjective context of orienting. I propose that the closed-loop model for orienting presented here can address this aspect. If accepted, this model can facilitate the diagnosis and treatment of several oculomotor impairments.
Zoom: https://weizmann.zoom.us/j/98466393859?pwd=blJkSDUyWkR0L2FhQUFueS9FY2lwZz09
Id: 98466393859
passcode: 059130 -
Date:07ThursdayDecember 2023Lecture
Spatial Biology by Imaging Mass Cytometry
More information Time 09:00 - 10:00Location ZOOMLecturer Dr. Sean Pawlowski (Ionpath) & Dr. Tomer-Meir Salame (LSCF)
Mass Cytometry UnitOrganizer Department of Life Sciences Core FacilitiesHomepage Contact -
Date:12TuesdayDecember 2023Lecture
Open Day at SAMPL Lab
More information Time 15:00 - 16:30Location Ullmann Building of Life SciencesLecturer Modeling Processing and Learning Lab., Prof. Yonina Eldar Organizer Department of MathematicsHomepage Contact -
Date:19TuesdayDecember 2023Lecture
From Randomness to Function: de novo Proteins as a Source of Molecular and Cellular Innovation
More information Time 11:00 - 12:00Location Nella and Leon Benoziyo Building for Biological SciencesLecturer Dr. Idan Frumkin
Life Sciences, Massachusetts Institute of Technology (MIT), USAOrganizer Department of Biomolecular SciencesContact Abstract Show full text abstract about How do novel genes emerge? While new genes often evolve from...» How do novel genes emerge? While new genes often evolve from older ones, novelty can also originate from random sequences in a process termed "de novo gene birth". The functions of such de novo genes and how they integrate into complex cellular systems are poorly understood. By screening a library of 100 million random proteins with no sequence similarity to existing proteins, we identified thousands of functional proteins promoting E. coli survival against a toxin or a bacterial virus. Using genetic and biochemical tools, we characterized selected random proteins and revealed they integrate into pre-existing cellular pathways to mitigate cellular threats. Our work provides a mechanistic basis for understanding how de novo gene birth can yield functional proteins that effectively benefit cells evolving under stress.
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Date:20WednesdayDecember 2023Lecture
"Shedding light on the dark matter of viral proteomes to advance our understanding of antiviral immunity"
More information Time 10:00 - 12:00Location Nella and Leon Benoziyo Building for Biological SciencesLecturer Dr. Shira Weingarten-Gabbay
Broad Institute of MIT and HarvardOrganizer Department of Molecular Cell BiologyContact -
Date:21ThursdayDecember 2023Lecture
Geometric Functional Analysis and Probability Seminar
More information Time 13:30 - 14:30Title Gaps of Fourier Quasicrystals and Lee-Yang PolynomialsLocation Jacob Ziskind BuildingLecturer Lior Alon
MITOrganizer Department of MathematicsContact Abstract Show full text abstract about The concept of "quasi-periodic" sets, functions, a...» The concept of "quasi-periodic" sets, functions, and measures is
prevalent in diverse mathematical fields such as Mathematical Physics,
Fourier Analysis, and Number Theory. The Poisson summation formula provides a “Fourier characterization” for discrete periodic sets, saying that the Fourier transform of the counting measure of a discrete periodic set is also a counting measure of a discrete periodic set. Fourier Quasicrystals (FQ) generalize this notion of periodicity: a counting measure of a discrete set is called a Fourier quasicrystal (FQ) if its Fourier transform is also a discrete atomic measure, together with some growth condition.
Recently Kurasov and Sarnak provided a method for construction of one-dimensional counting measures which are FQ (motivated by quantum graphs) using the torus zero sets of multivariate Lee-Yang polynomials. In this talk, I will show that the Kurasov-Sarnak construction generates all FQ counting measures in 1D.
A discrete set on the real line is fully described by the gaps between consecutive points. A discrete periodic set has finitely many gaps. We show that a non-periodic FQ has uncountably many gaps, with a well-defined gap distribution. This distribution is given explicitly in terms of an ergodic dynamical system induced from irrational flow on the torus.
The talk is aimed at a broad audience, no prior knowledge in the field is assumed.
Based on joint works with Alex Cohen and Cynthia Vinzant.
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Date:26TuesdayDecember 2023Lecture
The structure of protein complexes underlies co-translational assembly
More information Time 14:00 - 15:00Location Gerhard M.J. Schmidt Lecture HallOrganizer Department of Chemical and Structural BiologyContact -
Date:27WednesdayDecember 2023Lecture
Membrane dynamics during giant vesicle secretion
More information Time 10:00 - 11:00Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Prof. Benny Shilo
Dept of Molecular GeneticsContact -
Date:27WednesdayDecember 2023Lecture
Foundations of Computer Science Seminar
More information Time 11:15 - 12:15Title Explicit Codes for Poly-Size Circuits and Functions that are Hard to Sample on Low Entropy DistributionsLocation Jacob Ziskind BuildingLecturer Jad Silbak
Northeastern UniversityOrganizer Department of Computer Science and Applied MathematicsContact Abstract Show full text abstract about Guruswami and Smith (J. ACM 2016) considered codes for chann...» Guruswami and Smith (J. ACM 2016) considered codes for channels that are computationally bounded which modify at most a p-fraction of the bits of the codeword. This class of channels is significantly stronger than Shannon’s binary symmetric channel which flips each bit independently with probability p, but weaker than Hamming’s channels which may flip any p-fraction of bits and are computationally unbounded.
Recently, there has been a growing body of work that aims to construct codes against channels that are computationally bounded (e.g., bounded memory channels, channels that are poly-size circuits). In this work, we consider bounded size channels and construct codes that:
- Achieve an optimal rate of 1-H(p) (matching the rate of binary symmetric channels, and beating the rate of Hamming channels).
- Are explicit, assuming E does not have a size 2^Ω(n) nondeterministic circuits.
Achieving these codes implies circuit lower bounds (and therefore explicit constructions need to be based on hardness assumptions). This result builds on the recent result by Shaltiel and Silbak (FOCS 2022) that gave a randomized Monte-Carlo construction, rather than explicit codes.
A key component in our codes (that we believe to be of independent interest) is a new complexity theoretic notion of hard to sample functions (HTS).
Loosely speaking, a function f is HTS for circuits of size n^c, if for every randomized circuit A of size n^c that samples a distribution (X,Y) such that X has sufficiently large min-entropy, it holds that Pr[Y=f(X)] is small.
This notion is inspired by a related notion introduced by Viola (SICOMP 2012) in which X is the uniform distribution and is similar in flavor to the definition of multi-collision-resistant hash functions. Building on classical works on “hardness amplification” (and using many additional tools and ideas from pseudorandomness) we construct HTS functions under hardness assumptions.
This is a joint work with Ronen Shaltiel.