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January 01, 2015
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Date:20MondayDecember 2021Colloquia
From cell circuits to collective cell behaviour
More information Time 11:00 - 12:15Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Leah Edelstein-Keshet
Department of Mathematics, University of British Columbia, CanadaOrganizer Faculty of ChemistryHomepage Contact Abstract Show full text abstract about In order for our body to heal and repair injury, cell sheets...» In order for our body to heal and repair injury, cell sheets must move together to seal a gap. To overcome infection, white blood cells need to track down and destroy pathogens. Such processes can only work if cells can "sense" their environment and "decide" to move in the right direction, or else, to coordinate with neighbouring cells. This requires tight control of adhesion between cells, as well as the speed and direction of cell migration. In this talk, I will describe mathematical and computational research on cell migration, both in normal and abnormal (cancer) cells. I will focus mainly on recent "multi-scale" modeling, where we combine our understanding of the "molecular machinery" inside cells, with information about how cells interact with one another. We use this approach to investigate the behaviour of groups of cells. Combining mathematics and computational methods, we can get some insights on cell organization in development and in wound healing, as well as what could go wrong in disease such as cancer. -
Date:21TuesdayDecember 2021Lecture
To be announced
More information Time 10:00 - 10:00Location Nella and Leon Benoziyo Building for Biological SciencesLecturer Vaishnavi Dandavate
Dept. of Biomolecular Sciences - WISOrganizer Department of Biomolecular SciencesContact -
Date:21TuesdayDecember 2021Lecture
Student Seminar
More information Time 11:00 - 12:00Title A spatiotemporally resolved single cell atlas of the Plasmodium liver stageLocation Wolfson Building for Biological ResearchLecturer Amichay Afriat Organizer Department of Molecular Cell BiologyContact Abstract Show full text abstract about Malaria infection involves an obligatory, yet clinically sil...» Malaria infection involves an obligatory, yet clinically silent liver stage. Hepatocytes operate in repeating units termed lobules, exhibiting heterogeneous gene expression patterns along the lobule axis, but the effects of hepatocyte zonation on parasite development have not been molecularly explored. In our work, we combine single-cell RNA sequencing and single-molecule transcript imaging to characterize the host’s and parasite’s temporal expression programs in a zonally-controlled manner for the rodent malaria parasite Plasmodium berghei ANKA. We identify differences in parasite gene expression in distinct zones, and a sub-population of periportally-biased hepatocytes that harbor abortive infections associated with parasitophorous vacuole breakdown. These ‘abortive hepatocytes’ up-regulate immune recruitment and key signaling programs. They exhibit reduced levels of Plasmodium transcripts, perturbed parasite mRNA localization, and may give rise to progressively lower abundance of periportal infections. Our study provides a resource for understanding the liver stage of Plasmodium infection at high spatial resolution and highlights heterogeneous behavior of both the parasite and the host hepatocyte. -
Date:21TuesdayDecember 2021Lecture
Special Guest Seminar
More information Time 11:30 - 12:30Title How a plastidial retrograde signaling metabolite reprograms plant adaptive-responses and developmental networksLocation Benoziyo Bldg. for Biological Sciences Auditorium - Floor 1Lecturer Prof. Katayoon (Katie) Dehesh
Institute of Integrative Genome Biology and Department of Botany and Plant Sciences UC Riverside, USAOrganizer Department of Plant and Environmental SciencesContact -
Date:21TuesdayDecember 2021Lecture
Zoom seminar: The role of noncanonical hippocampal circuits in memory
More information Time 12:30 - 13:30Lecturer Prof. Thomas McHugh
Laboratory for Circuit and Behavioral Physiology RIKEN Center for Brain Science, JapanOrganizer Department of Brain SciencesContact Abstract Show full text abstract about The human hippocampus plays a crucial role in episodic memor...» The human hippocampus plays a crucial role in episodic memory; the who, what, where memories that define our lives. In the rodent, well-defined anatomy and physiology make the structure an ideal model system; amenable to circuit manipulations and observations designed to test hypotheses concerning how memories are formed and used. Here I will present our recent work in mice which combines anatomical characterization, genetic interventions and in vivo recording to address how noncononical inputs and outputs influence information flow in the hippocampus. I will first introduce our study identifying a novelty signaling hub in the hypothalamus – the supramammillary nucleus (SuM). Unique about this region is that it not only responds broadly to novel stimuli, but segregates and selectively routes different types of information to discrete cortical targets, the dentate gyrus (DG) and CA2 fields of the hippocampus, for the modulation of mnemonic processing. Next, I will describe ongoing work focused on how CA2’s output impacts both local and distal circuits, including our identification and characterization of a novel descending glutamatergic projection from CA2 pyramidal cells to PV+ neurons in the MS that can regulate cholinergic tone and hippocampal memory.
Zoom link:
https://weizmann.zoom.us/j/95406893197?pwd=REt5L1g3SmprMUhrK3dpUDJVeHlrZz09
Meeting ID: 954 0689 3197
Password: 750421 -
Date:21TuesdayDecember 2021Lecture
Ubiquitin-proteasome System Contribution to Hypoxia-induced Mitochondria Quality Control
More information Time 14:00 - 15:00Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Michael Glickman
Faculty of Biology, TechnionOrganizer Department of Chemical and Structural BiologyContact -
Date:22WednesdayDecember 2021Lecture
Quantitative Tools for Neuroscience Questions
More information Time 12:30 - 13:30Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Dr. Ari Pakman
Department of Statistics & the Center for Theoretical Neuroscience, Columbia UniversityOrganizer Department of Brain SciencesContact Abstract Show full text abstract about As bigger neuroscience datasets are generated with novel obs...» As bigger neuroscience datasets are generated with novel observation modalities, so grows the need for computational tools to answer basic questions. What different types of neurons exist in a population? How to sort out neurons from their electric activity? How do neurons process information? I will present statistical, machine learning and information-theoretic tools that address such questions. In particular, I will discuss new solutions to the problem of classifying neuron types using genetic markers, amortizing spike-sorting in modern multi-electrode arrays and disentangling the simultaneous presence of synergy and redundancy in neural information processing circuits.
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Date:22WednesdayDecember 2021Lecture
M.Sc thesis: "Computational approach to excited state dynamics at the interfaces of layered transition-metal dichalcogenide heterostructures"
More information Time 15:00 - 16:00Location The David Lopatie Hall of Graduate StudiesLecturer Amir Kleiner Organizer Department of Molecular Chemistry and Materials ScienceContact Abstract Show full text abstract about Single layers of transition metal dichalcogenides are semico...» Single layers of transition metal dichalcogenides are semiconducting 2D materials which present unique electronic, excitonic and spin properties. Heterostructures composed of these materials show highly intriguing excited-state phenomena, along with a large degree of atomistic and structural tunability stemming from the underlying quantum selection rules dominating these phenomena. A predictive understanding of the effect of structural complexity on the nature of excited-state properties and interaction dynamics is crucial in order to design efficient devices for various applications, within the fields of photovoltaics, photocatalytics, optoelectronics, spintronics, and material-based quantum computing. In this research, we propose a study of the electronic and excitonic properties in heterostructures based on layered transition metal dichalcogenides and the role of structural complexities in their time-resolved relaxation mechanisms. For this, we will analyze decay processes induced by excitonic interactions with lattice vibrations, as well as other excitons and charged particles in the crystals. We will utilize predictive, Green’s-function based ab-initio methods implemented through advanced software and apply highly advanced computations using high-performance computing clusters worldwide. We will develop computational models based on these predictive approaches and on our findings to study the underlying mechanisms dominating the involved excitation processes and the light-matter interactions leading to them. Our research will be constantly driven and validated by collaborations with relevant experimental research. -
Date:23ThursdayDecember 2021Lecture
Hybrid seminar: "NMR structural virology”
More information Time 09:30 - 10:30Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Amir Goldbourt, Ana Naamat
School of Chemistry, TAUOrganizer Clore Institute for High-Field Magnetic Resonance Imaging and SpectroscopyContact Abstract Show full text abstract about @ Schmidt Lecture Hall, + Zoom link: https://weizmann.zoom.u...» @ Schmidt Lecture Hall, + Zoom link: https://weizmann.zoom.us/j/93943963455?pwd=Um9ab2NBQXhhWTRqSnBOYU1sWmVYdz09
passcode: 061594
A major effort in our group is dedicated to studying intact viral systems using primarily solid-state NMR techniques. They allow us to study structure and dynamics of viral capsids, to look into their pre-mature forms, and to assess the information content that NMR can provide on full-length intact RNA and DNA. We will discuss the structures of M13 and IKe filamentous phages, CSA recoupling techniques to study their dynamics, and properties of the gVp-ssDNA complex, the form of the virus inside the bacterial cell just prior to assembly. We will also discussed means to detect hydrogen bonds in full-length RNA and in particular demonstrate a new technique to obtain 15N-15N correlations that shortens the long mixing times required to achieve such spectra. With this technique, we also find a new resonance transfer condition that we entitle half-rotational resonance.
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Date:23ThursdayDecember 2021Lecture
Humans, climate and brain size correlation for the Quaternary Extinctions of Mammals
More information Time 11:30 - 12:30Location Nella and Leon Benoziyo Building for Biological SciencesLecturer Jacob Dembitzer
University of Naples Federico IIOrganizer Scientific Archeology UnitHomepage Contact -
Date:23ThursdayDecember 2021Lecture
At the crossroads of science, engineering, and medicine: Improving cancer diagnosis
More information Time 14:00 - 15:00Location Max and Lillian Candiotty BuildingLecturer Prof. Yonina Eldar & Keren Peri-Hanania, MD
Department of Computer Science and Applied Mathematics • Faculty of Mathematics and Computer ScienceOrganizer Dwek Institute for Cancer Therapy ResearchContact -
Date:26SundayDecember 2021Lecture
The impact of friction on the stability of ice sheets
More information Time 11:00 - 11:00Location https://weizmann.zoom.us/j/7621438333?pwd=c0lpdlQzYSthellXWG9rZnM0ZDRFZz09Lecturer Roiy Sayag Organizer Department of Earth and Planetary SciencesContact Abstract Show full text abstract about Ice sheets can dramatically impact the state of climate. Thi...» Ice sheets can dramatically impact the state of climate. This is due to their capacity to modify the planetary energy balance through variations in the ice cover and mass. A major question is how rapidly could such modification occur and to what extent ? This question can be addressed by investigating phenomena that involve relatively large mass flux of ice into the ocean, such as ice calving and rifting, ice streams, and melting. Many of these processes involve interactions between the ice sheet and the underlying bedrock or ocean. We model ice sheets as buoyancy-driven flows of nonlinear (non Newtonian) fluid and explore the resulted flow dynamics and stability due to different friction conditions along the base of the ice. I will show results from scaled laboratory experiments and theoretical modelling of several flows under different friction conditions that evolve patterns reminiscent to those that emerge in glacier ice flows. Specifically, the basal friction that we consider ranges from no-slip conditions, in which radially symmetric flows are stable, to free-slip conditions, in which such flows are unstable, developing patterns reminiscent to ice rifts and ice bergs. Under mixed conditions of friction, an initially radially symmetric flow can be either stable, or develop patterns reminiscent to ice streams. Our insights may have implications to predicting ice flow on Earth and possibly on other planetary objects.
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Date:26SundayDecember 2021Lecture
ZOOM seminar: Sleep-related memory consolidation in humans: beyond single, isolated memories
More information Time 12:30 - 13:30Lecturer Dr. Eitan Schechtman
Northwestern University, Evanston, IllinoisOrganizer Department of Brain SciencesContact Abstract Show full text abstract about Sleep is critical for the stabilization of memories. This pr...» Sleep is critical for the stabilization of memories. This process is thought to be supported by the reactivation of memories, thereby strengthening the neural infrastructure supporting them. Theoretical accounts of this consolidation process focus on the process through which memories are independently strengthened, but in natural settings individual memories never exist in a vacuum. In this talk, I will present a series of studies exploring the extent of memory reactivation during sleep in humans, how interactions between memories impact the consolidation process, and the role of encoding context in memory processing during sleep. The main technique used to explore memory reactivation in these studies is targeted memory reactivation, a behavioral manipulation that can selectively bias consolidation during sleep. The results demonstrate that multiple semantically related memories can be simultaneously consolidated during sleep. Additionally, they show that memory reactivation during sleep may involve contextual reinstatement, thereby impacting multiple contextually linked memories. These data suggest that reactivation during sleep is not limited to single memory items, and can occur at the network or brain-state level. Relatedly, we show that reactivating a suppression state during sleep can be used to selectively weaken memories. Taken together, these results inform our current understanding regarding memory consolidation processes and open new avenues for translatable research to alleviate memory-related symptoms in patients suffering from psychiatric disorders. -
Date:26SundayDecember 2021Lecture
Non-Newtonian Gravity and Neutrality of Matter Searches with Levitated Test Masses
More information Time 12:30 - 12:30Location : https://weizmann.zoom.us/j/97240339317?pwd=SlMxZGVUZ0J6d0svUlpqV2p3NjlpUT09Lecturer Dr. Nadav Priel
Stanford, USAOrganizer Department of Particle Physics and AstrophysicsContact Abstract Show full text abstract about The universal law of gravitation has undergone stringent tes...» The universal law of gravitation has undergone stringent tests for many
decades over a signicant range of length scales, from atomic to planetary. Of
particular interest is the short distance regime, where modications to Newto-
nian gravity may arise from axion-like particles or extra dimensions. We have
constructed an ultra-sensitive force sensor based on optically-levitated micro-
spheres with a force sensitivity of 10 -
Date:26SundayDecember 2021Lecture
Guest seminar with Vered Shacham-Silverberg
More information Time 14:00 - 15:00Title New hPSC-derived esophageal cultures for the study of development and diseaseLocation Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Dr. Vered Shacham-Silverberg
Cincinnati Children’s Hospital Medical Center, USAOrganizer Department of Molecular GeneticsContact -
Date:27MondayDecember 2021Lecture
Ph.D thesis: (Zoom)- "Electro(chemo)mechanical properties of non-stoichiometric oxides
More information Time 10:00 - 11:00Lecturer Evgenyi Makagon, Ana Naamat Organizer Department of Molecular Chemistry and Materials ScienceContact Abstract Show full text abstract about Zoom Link: https://weizmann.zoom.us/j/91582672181?pwd=WFR1N...» Zoom Link: https://weizmann.zoom.us/j/91582672181?pwd=WFR1NVhKZGtra2w1WG9CcGFLSGU0Zz09
Non-stoichiometric oxides are a group of materials that are extremely popular in the energy storage and conversion industry. Their functionality relies heavily on point defects and their various properties show significant dependency on point defect type and concentration. This work deals with three such properties: mechanical, electromechanical and electro-chemo-mechanical while looking into two case study materials:
1. Acceptor-doped proton conducting BaZrO3, a promising electrolyte for protonic ceramic fuel cells as it combines high bulk proton conductivity with good chemical stability. The protonic conductivity is achieved by dissociative water incorporation into oxygen vacancies formed by acceptor dopants on Zr4+ sites. Doping was found to cause linear decrease in elastic modulus with increasing dopant concentration while the size of the dopant was proved to be a key factor. Water incorporation into the vacancies decreases the moduli even further. An unexpectedly large strain electrostriction coefficient of ≈ 5·10-16 m2/V2 was observed which makes BaZrO3 the first non-classical electrostrictor with a perovskite structure. The electromechanical response was observed to follow elastic moduli trend with respect to dopant size, giving a clear indication that electrostrictive response is related to point defect induced lattice distortions.
2. Acceptor doped oxygen conducting CeO2. The first known all solid-state electro-chemo-mechanical actuators operating at room temperature were demonstrated. These devices are based on nanocrystalline (Ti-oxide/Ce0.8Gd0.2O1.9) and (V-oxide/Ce0.8Gd0.2O1.9) composite layers. Under applied bias these composites undergo an electrochemical reaction generating change in specific volume and, thereby, mechanical work. The nanocrystalline composites are the key part of these devices and they are specifically designed to provide the fastest oxygen ion diffusion coefficient observed in a solid at room temperature. This achievement paves a way to a new field of studies: all solid-state chemotronics.
The findings presented in this work link together three properties of non-stoichiometric ion conducting oxides: elastic deformation, electromechanical response and solid-state electrochemistry.
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Date:28TuesdayDecember 2021Lecture
Faculty Seminar
More information Time 11:15 - 12:15Title Approximating the Arboricity in Sublinear TimeOrganizer Faculty of Mathematics and Computer ScienceContact -
Date:28TuesdayDecember 2021Lecture
Root exudation as functional trait involved in plant nutrition-use strategy classification and in shaping plant microbiota diversity and function
More information Time 11:30 - 12:30Title Zoom Guest SeminarLocation https://weizmann.zoom.us/j/93885750016?pwd=blVnQ2phWDdlWTJ3UlVteVlYL1BkQT09 Meeting ID: 938 8575 0016 Password: 365291Lecturer Prof. Feth el Zahar Haichar
Biosciences Department, Institut National des Sciences Appliquées de LyonOrganizer Department of Plant and Environmental SciencesContact Abstract Show full text abstract about Plants adopt a variety of life history strategies to succeed...» Plants adopt a variety of life history strategies to succeed in the Earth’s diverse environments. Using functional traits which are defined as “morphological, biochemical, physiological, or phonological” characteristics measurable at the individual level, plants are classified according to their species’ adaptative strategies, more than their taxonomy, from fast growing plant species to slower-growing conservative species. These different strategies probably influence the input and output of carbon (C)- resources, from the assimilation of carbon by photosynthesis to its release in the rhizosphere soil via root exudation. However, while root exudation was known to mediate plant-microbe interactions in the rhizosphere, it was not used as functional trait until recently. In addition, no study analyzed the impact of plant nutritional strategy via root exudation quality and quantity on rhizosphere microbial activities and diversity. Here, we (i) assess whether root exudate levels are useful plant functional traits in the classification of plant nutrient-use strategies and (ii) determine using stable isotope probing (SIP) approach the impact of root exudates quality and quantity on active microbiota diversity and activity. For this purpose, six grass species distributed along a gradient of plant nutrient resource strategies, from conservative species, characterized by low nitrogen (N) uptake, a long lifespans and low root exudation level, to exploitative species, characterized by high rates of photosynthesis, rapid rates of N uptake were used. We show, for the first time, that root exudation rate can be used as a key functional trait in plant ecology studies and plant strategy classification. In addition, measurement of microbial activities revealed an increase in denitrification and respiration activities for microbial communities colonizing the root adhering soil of exploitative species. This increase of microbial activities results probably from a higher exudation rate and more diverse metabolites by exploitative plant species. Furthermore, our results demonstrate that plant nutrient resource strategies have a role in shaping active microbiota. We present evidence demonstrating that plant nutrient use strategies shape active microbiota involved in root exudate assimilation and soil organic matter degradation via root exudation. -
Date:28TuesdayDecember 2021Lecture
ZOOM seminar - Dissecting retinal and brain circuits transmitting light intensity signals and regulating mood
More information Time 12:30 - 12:30Lecturer Dr. Shai Sabbah
Dept of Medical Neurobiology The Hebrew University of JerusalemOrganizer Department of Brain SciencesContact Abstract Show full text abstract about Environmental light intensity affects the nervous system and...» Environmental light intensity affects the nervous system and is a powerful modulator of behavior. Light-intensity-dependent activity is observed in a subset of retinal output cells, which innervate a newly discovered nucleus of the dorsal thalamus, that in turn projects to the prefrontal cortex and striatum. Silencing the transmission along this pathway has been shown to affect mood. I will describe the retinal networks responsible for the transmission of light intensity signals, and show new results demonstrating the capacity for light-intensity encoding in diverse brain regions.
Zoom Seminar
Zoom Link:
https://weizmann.zoom.us/j/95406893197?pwd=REt5L1g3SmprMUhrK3dpUDJVeHlrZz09
Meeting ID: 954 0689 3197
Password: 750421
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Date:28TuesdayDecember 2021Academic Events
Scientific Council meeting
More information Time 14:00 - 16:00Contact
