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November 02, 2015
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Date:14ThursdayNovember 2024Lecture
PhD Thesis Defense - Hila Tishler (Prof. Ayelet Erez Lab)
More information Time 11:30 - 11:30Title Enhancing the Sensitivity of Triple Negative Breast Cancers to JAK-STAT Inhibitors by Targeting Arginine AvailabilityLocation Ullmann Building of Life SciencesLecturer Dr. Hila Tishler Organizer Department of Molecular Cell BiologyContact -
Date:14ThursdayNovember 2024Lecture
Revisiting the Neoantigen Approach to Cancer Immunotherapy
More information Time 14:00 - 15:00Location Max and Lillian Candiotty BuildingLecturer Prof. Yardena Samuels
Knell Family Professorial Chair Director, the EKARD Institute for Cancer Diagnosis Research President Elect, European Association for Cancer Research Department of Molecular Cell Biology The Weizmann Institute of ScienceOrganizer Moross Integrated Cancer Center (MICC)Contact -
Date:14ThursdayNovember 2024Lecture
An unconventional journey from, almost, obvious questions to new ideas in exocytosis
More information Time 15:00 - 16:00Location Nella and Leon Benoziyo Building for Biological SciencesLecturer Prof. Ori Avinoam
Dept. of Biomolecular Sciences-WISOrganizer Department of Biomolecular SciencesContact Abstract Show full text abstract about A wide range of vertebrate secretory glands, such as the exo...» A wide range of vertebrate secretory glands, such as the exocrine pancreas and lung goblet cells, package their cargoes in large vesicles (LSVs). The diameter of these vesicles ranges from 1 to 10 µm, roughly the size of a yeast cell. The membrane surface area and internal volume of these vesicles are orders of magnitude greater than those of conventional vesicles (30–500 nm in diameter), posing formidable challenges for vesicle biogenesis, trafficking, fusion, content release, and the maintenance of apical membrane homeostasis. By asking how cells compensate for the significant membrane load introduced by LSVs at the cell surface, our work uncovered an entirely overlooked mode of exocytosis and revealed key components of the intricate molecular mechanisms underlying LSV fusion and exocytosis in exocrine tissues.
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Date:17SundayNovember 2024Conference
Andi
More information Time 08:00 - 08:00Location The David Lopatie Conference CentreChairperson Avraham Yaron -
Date:17SundayNovember 2024Lecture
The Clore Center for Biological Physics
More information Time 13:15 - 14:30Title Yet Another Approach to Loschmidt's ParadoxLocation Nella and Leon Benoziyo Physics LibraryLecturer Dr. Lev Melnikovsky
Department of Molecular Chemistry and Materials ScienceOrganizer Clore Center for Biological PhysicsContact -
Date:18MondayNovember 2024Colloquia
2024 G.M.J. SCHMIDT MEMORIAL LECTURE - Prof. Sason S. Shaik
More information Time 11:00 - 12:15Title Oriented Electric Field - A Universal CatalystLocation Gerhard M.J. Schmidt Lecture HallLecturer Prof. Sason S. Shaik
Department of Chemistry, HUJIOrganizer Department of Molecular Chemistry and Materials ScienceHomepage Contact Abstract Show full text abstract about This talk tells my outlook on the development of electric-fi...» This talk tells my outlook on the development of electric-field-mediated-chemistry/biochemistry and predicts a vision of its future state.1 The talk discusses applications of oriented electric-fields (OEFs) to chemical and biochemical reactions e.g., Diels Alder reactions, and reactions of the enzyme Cytochrome P450. As shall be demonstrated, the orientation of the OEF controls reaction-rate (acceleration/inhibition), chemo-selectivity, enantio-selectivity, and solvent effect. This will be followed by showing relevant experimental verifications of the impact of OEF on structure and reactivity.
Subsequently, the talk will outline other ways of generating OEFs, e.g. by use of; pH-switchable charges, ionic additives, water droplets, and so on. I shall further describe the application of static vs. oscillating OEFs to decompose peptide plaques (e.g., Amyloid Plaques in Alzheimer’s disease).
The second part of the talk consists of conceptual principles for understanding and predicting OEF effects, e.g., the “reaction-axis rule”, the capability of OEFs to act as tweezers that orient reactants and accelerate their reaction, etc. Finally, I shall discuss the prospects of up-scaling applications of various OEF-sources to Molar concentrations. The talk ends with the vision that, in the forthcoming years, OEF usage will change chemical education, if not also the art of making new molecules. -
Date:18MondayNovember 2024Lecture
Midrasha on Groups Seminar
More information Time 11:15 - 13:00Title Subgroup Tests and the Aldous-Lyons conjectureLocation Jacob Ziskind BuildingLecturer Michael Chapman
NYUOrganizer Department of MathematicsContact Abstract Show full text abstract about A common theme in mathematics is that limits of finite objec...» A common theme in mathematics is that limits of finite objects are well behaved. This allows one to prove many theorems about finitely approximable objects, while leaving the general case open — examples for this are Gottschalk's conjecture, Kaplansky's direct finiteness conjecture, and many more. When the topology of the space is somewhat coarse, it becomes very hard to decide whether every object is approximable by finite ones, or whether there exist non-approximable objects. Some of the more famous problems in various fields of mathematics can be framed this way -
Date:18MondayNovember 2024Lecture
Foundations of Computer Science Seminar
More information Time 11:15 - 12:15Title Subgroup Tests and the Aldous--Lyons conjectureLocation Jacob Ziskind BuildingLecturer Michael Chapman
NYUOrganizer Department of Computer Science and Applied MathematicsContact Abstract Show full text abstract about A common theme in mathematics is that limits of finite objec...» A common theme in mathematics is that limits of finite objects are well behaved. This allows one to prove many theorems about finitely approximable objects, while leaving the general case open --- examples for this are Gottschalk's conjecture, Kaplansky's direct finiteness conjecture, and many more. When the topology of the space is somewhat coarse, it becomes very hard to decide whether every object is approximable by finite ones, or whether there exist non-approximable objects. Some of the more famous problems in various fields of mathematics can be framed this way -
Date:18MondayNovember 2024Lecture
Midrasha on Groups Seminar
More information Time 14:15 - 16:00Title Subgroup Tests and Tailored Non-local GamesLocation Jacob Ziskind BuildingLecturer Michael Chapman
NYUOrganizer Department of MathematicsContact Abstract Show full text abstract about In the previous talk we defined Subgroup Tests and the inter...» In the previous talk we defined Subgroup Tests and the interactive proof system induced by them. In addition, we showed that if the Aldous--Lyons conjecture was true, then this interactive proof system contains only decidable languages. In this talk, we describe why the Halting Problem can be decided in our interactive proof system, which in turn refutes the Aldous--Lyons conjecture. This is done in two steps: The first relates Subgroup Test to a new subclass of non-local games which we term Tailored Games. The second shows that the techniques of MIP*=RE can be refined so that all the games in it are tailored, or in acronym fashion, that Tailored-MIP*=RE.
This talk is based on a joint work with Lewis Bowen, Alex Lubotzky and Thomas vidick.
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Date:20WednesdayNovember 2024Lecture
Special Guest Seminar
More information Time 10:00 - 11:00Title A formalism for Arithmetic Quantum Field TheoryLocation Jacob Ziskind BuildingLecturer Nadav Gropper
University of Haifa and UPennOrganizer Department of MathematicsContact Abstract Show full text abstract about Arithmetic Topology, first pioneered by Mazur in 1963, draws...» Arithmetic Topology, first pioneered by Mazur in 1963, draws analogies between number theory and low dimensional topology, primes and knots, and surface and p-adic fields.
On one hand, quantum field theory can be expressed in terms of the geometry and topology of low-dimensional manifolds, on the level of states (via the Atiyah-Segal) and on the level of observables (via the Beilinson–Drinfeld). Thus, as first proposed by Minhyong Kim (in his Arithmetic Chern-Simons Theory), one can try and find arithmetic versions of quantum field theoretic ideas.
In the talk, I will introduce a new general framework for (d 1)-dimensional arithmetic TQFT.
I will explain the classification of such TQFTS for the (1 1)-dimensional case, in terms of Frobenius algebras with some extra structure, this enables us to study pro-p cobordisms and TQFTs for p-adic fields and surfaces at the same time.
If time permits, I will outline how we use the above to compute a Dijkgraaf-Witten like invariants for G, a finite p-group, to get formulas for counting covers of Surfaces/p-adic fields with Galois group G (these formulas are similar to the ones given by Mednykh for surfaces using TQFTs, and by Masakazu Yamagishi using a more algebraic approach).
The talk is based on joint work with Oren Ben-Bassat.
No prior knowledge of Topological Quantum Field Theory or Arithmetic Topology will be assumed.
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Date:20WednesdayNovember 2024Lecture
Lecture on Alon Ohel and Other Hostages
More information Time 11:00 - 12:00Location Dolfi and Lola Ebner AuditoriumOrganizer Department of Molecular GeneticsContact -
Date:20WednesdayNovember 2024Lecture
Machine Learning and Statistics Seminar
More information Time 11:15 - 12:15Title Strategic Classification: Learning With Data That 'Behaves'Location Jacob Ziskind BuildingLecturer Nir Rosenfeld
TechnionOrganizer Department of Computer Science and Applied MathematicsContact Abstract Show full text abstract about The growing success of machine learning across a wide range ...» The growing success of machine learning across a wide range of domains and applications has made it appealing to be used also as a tool for informing decisions about humans. But humans are not your conventional input: they have goals, beliefs, and aspirations, and take action to promote their own self-interests. Given that standard learning methods are not designed to handle inputs that "behave", it is natural to ask: how should we design learning systems when we know they will be deployed and used in social environments?
As a starting point, I will present the problem of strategic classification, in which users can modify their features (at a cost) in response to a learned classifier in order to obtain favorable predictions. I will then describe some of our work in this field, demonstrating how even mild forms of strategic behavior can dramatically transform the learning problem, and the role game theory can play in addressing some of the new challenges that arise. Finally, I will argue for strategic classification as a framework that can be useful for formally reasoning about learning under user behavior in general, and which holds potential for weaving more elaborate forms of economic modeling into the learning pipeline.
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Date:20WednesdayNovember 2024Lecture
Spotlight on Science - Dr. Ronen Gabizon (Department of Chemical and Structural Biology)
More information Time 12:30 - 14:00Location Gerhard M.J. Schmidt Lecture HallLecturer Dr. Ronen Gabizon
Department of Chemical and Structural BiologyContact Abstract Show full text abstract about Designing novel drugs can be tricky. The accumulated knowled...» Designing novel drugs can be tricky. The accumulated knowledge on the cause and progress is key in the development. Often there is a key protein or receptor that plays a key role. One strategy is to find a molecule that will strongly bind to its target and inhibit its activity.
In the Nir London Lab, we focus on a unique class of drugs called covalent drugs. These molecules act by forming a stable, covalent bond with their target protein. One important, recent example (not from our lab) is Paxlovid, an antiviral covalent drug against SARS-Cov-2 that inhibits an enzyme crucial for its replication. In this talk, I will describe the computational and experimental approaches we use to design and characterize novel covalent drugs and present two projects in which we combined covalent chemistry with two other emerging drug classes: targeted degraders and peptides. -
Date:20WednesdayNovember 2024Lecture
spotlight on science
More information Time 12:30 - 14:00Title TBALocation Gerhard M.J. Schmidt Lecture HallContact -
Date:20WednesdayNovember 2024Lecture
ABC CHATS: Michal Tsur - Remepy
More information Time 14:00 - 15:30Title From startup to a public company - an open conversationLocation George and Esther Sagan Students' Residence HallLecturer Dr. Michal Tsur
co-founder and co-CEO of RemepyContact -
Date:21ThursdayNovember 2024Lecture
Vision and AI
More information Time 12:15 - 13:15Title Why unsupervised "object centric learning" may not make sense and what can we do about it?Lecturer Daniel Zoran
Google DeepMindOrganizer Department of Computer Science and Applied MathematicsContact Abstract Show full text abstract about Objects play an important role in vision. Much of human visi...» Objects play an important role in vision. Much of human vision is centered around objects and there is evidence we develop a basic understanding of what objects are from a very young age.
Learning about objects without supervision has been a focus of much research in recent years. Many models have been suggested with different structures, assumptions and inductive biases
and while impressive progress has been achieved in some limited domains we have yet to obtain a general system that can learn about objects unsupervised from real-world data.
In this talk I argue that there is a fundamental mismatch between some of the assumptions made by most "object centric" models and real-world data, and that this mismatch prevents such models from learning
meaningful representations at scale - ultimately making the problem setting ill-posed. Following that I will present some of our current work which attempts to address some of these issues.
Bio: Daniel Zoran is a research scientist at Google DeepMind in London working on problems in computer vision, attention and visual representation learning.
He completed his PhD under the supervision of Prof. Yair Weiss at the Hebrew University of Jerusalem and was a postdoc at Bill Freeman's group at MIT.
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Date:21ThursdayNovember 2024Lecture
Towards enhancing immunotherapy - Insights from functional genomics.
More information Time 14:00 - 15:00Location Max and Lillian Candiotty BuildingLecturer Prof. Daniel Peeper
Department of Molecular Oncology & Immunology at the Netherlands Cancer Institute (NKI), Amsterdam, NetherlandsOrganizer Moross Integrated Cancer Center (MICC)Contact -
Date:24SundayNovember 2024Lecture
Location matters - a spatial view of cellular interactions
More information Time 09:00 - 10:00Title The Department of Molecular Cell Biology and the Department of Immunology & Regenerative Biology Guest SeminarLocation Wolfson Building for Biological ResearchLecturer Dr. Michal Polonsky
California Institute of Technology (Caltech)Organizer Department of Molecular Cell BiologyContact -
Date:24SundayNovember 2024Lecture
2024 SPECIAL CLORE SEMINAR
More information Time 13:15 - 14:30Title this year's nobel prizes explainedLocation The David Lopatie Conference CentreLecturer Prof. Eran Hornstein, Prof. Eytan Domany, Prof. Sarel-Jacob Fleishman Organizer Clore Center for Biological PhysicsContact Abstract Show full text abstract about Physiology or Medicine Victor Ambros and Gary Ruvkun discov...» Physiology or Medicine
Victor Ambros and Gary Ruvkun discovered microRNA, a new class of tiny RNA molecules that play a crucial role in gene regulation. Their groundbreaking discovery in the small worm C. elegans revealed a completely new principle of gene regulation. This turned out to be essential for multicellular organisms, including humans. MicroRNAs are proving to be fundamentally important for how organisms develop and function.
Physics
John Hopfield introduced a spin model that can store and reconstruct information. Geoffrey Hinton built on Hopfield’s idea to invent the Boltzmann Machine, that is able to learn from examples to reconstruct a set of desired patterns. He also popularized and improved Backpropagation of Errors, a method actually used in today’s advanced AI technology (e.g. Deep Learning).
Chemistry
The Nobel Prize in Chemistry 2024 is about proteins, life’s ingenious chemical tools. David Baker has succeeded with the almost impossible feat of building entirely new kinds of proteins. Demis Hassabis and John Jumper have developed an AI model to solve a 50-year-old problem: predicting proteins’ complex structures. These discoveries hold enormous potential.
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Date:28ThursdayNovember 2024Colloquia
Physics - Colloquium
More information Time 11:15 - 12:30Title Erasure detection with superconducting qubitsLocation Edna and K.B. Weissman Building of Physical SciencesLecturer Prof. Alex Retzker
Hebrew University of JerusalemOrganizer Department of Physics of Complex SystemsContact
