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February 18, 2016
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Date:24TuesdayMay 2016Lecture
Experience-induced transcriptional networks that regulate the function of cortical circuits
More information Time 12:30 - 12:30Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Ivo Spiegel
Department of Neurobiology, WISOrganizer Department of Brain SciencesContact Abstract Show full text abstract about Inhibitory neurons are critically important for the adaptati...» Inhibitory neurons are critically important for the adaptation of neural circuits to sensory experience, but the molecular mechanisms by which experience controls the connectivity between different types of inhibitory neurons to regulate cortical plasticity are largely unknown. In this talk, I will present studies demonstrating that sensory experience induces in cortical vasoactive intestinal peptide (VIP)-expressing neurons a gene program that is markedly distinct from that induced in excitatory neurons and other subtypes of inhibitory neuron. I will show that is Igf1 one of several activity-regulated genes that are specific to VIP neurons, that IGF1 functions cell-autonomously in VIP neurons to increase inhibitory synaptic input onto these neurons and that VIP neuron-derived IGF1 regulates visual acuity in an experience-dependent manner, likely by promoting the inhibition of disinhibitory neurons and affecting inhibition onto cortical pyramidal neurons. I will discuss how our findings support a model by which experience-induced transcriptional networks regulate the synaptic connectivity of each type of neuron according to a circuit-wide homeostatic logic and I will propose that the analysis of the genomic mechanisms regulating these transcriptional networks will allow us to evaluate the extent to which cell-type-specific homeostatic mechanisms contribute to the function of cortical circuits. -
Date:24TuesdayMay 2016Lecture
How SAGA reads, writes and erases the histone code
More information Time 14:00 - 14:00Location Helen and Milton A. Kimmelman BuildingLecturer Prof. Cynthia Wolberger
Department of Biophysics and Biophysical Chemistry Johns Hopkins University School of MedicineOrganizer Department of Chemical and Structural BiologyContact -
Date:24TuesdayMay 2016Cultural Events
The Israel Camerata Jerusalem "Thinking Music" Eternal Recurrence
More information Time 16:30 - 18:00Location Michael Sela AuditoriumContact -
Date:25WednesdayMay 2016Lecture
Metabolic approaches to the Microbiome
More information Time 10:00 - 12:00Title Gut microbiota, chronic inflammation, and metabolic syndromeLocation Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Prof. Andrew Gewirtz, Prof. Yitzhak Mizrahi, Maayan Levy Organizer Department of Molecular GeneticsContact -
Date:25WednesdayMay 2016Lecture
Next Joint Particle Seminar - May 25 2016
More information Time 11:00 - 11:00Location Technion (Aquarium Room)Lecturer Yotam Soreq
MITOrganizer Department of Particle Physics and AstrophysicsHomepage Contact Abstract Show full text abstract about We propose an inclusive search for dark photons A' at t...» We propose an inclusive search for dark photons A' at the LHCb experiment based on both prompt and displaced di-muon resonances.
Because the couplings of the dark photon are inherited from the photon via kinetic mixing, the dark photon A' -> mu+mu- rate can be directly inferred from the off-shell photon gamma* -> mu+mu- rate, making this a fully data-driven search. For Run 3 of the LHC, we estimate that LHCb will have sensitivity to large regions of the unexplored dark-photon parameter space, especially in the 210-520 MeV and 10-40 GeV mass ranges. This search leverages the excellent invariant-mass and vertex resolution of LHCb, along with its unique particle-identification and real-time data-analysis capabilities.
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Date:25WednesdayMay 2016Lecture
Protection mechanisms of cancer prevention - lessons from the heart
More information Time 12:00 - 13:00Location Gerhard M.J. Schmidt Lecture HallLecturer Dr. Rachel Sarig
Department of Molecular Cell BiologyOrganizer Department of Life Sciences Core FacilitiesContact -
Date:25WednesdayMay 2016Lecture
Systems Biology Approach to the Mammalian Cell Cycle
More information Time 13:00 - 13:00Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Prof. Itamar Simon
Department of Microbiology and Molecular Genetics, Hebrew University Medical School Hadassah Ein Kerem, JerusalemOrganizer Department of Molecular GeneticsContact -
Date:25WednesdayMay 2016Lecture
TBA
More information Time 13:30 - 13:30Location Technion (Aquarium Room)Lecturer Alex Kagan
CincinnatiOrganizer Department of Particle Physics and AstrophysicsHomepage Contact -
Date:25WednesdayMay 2016Lecture
Sexually dimorphic neuronal connectivity established by sex-specific synapse pruning in C. elegans
More information Time 14:00 - 15:00Location Raoul and Graziella de Picciotto Building for Scientific and Technical SupportLecturer Prof. Meital Oren-Suissa
Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NYOrganizer Department of Immunology and Regenerative BiologyContact -
Date:26ThursdayMay 2016Lecture
Magnetic Resonance Seminar
More information Time 09:30 - 09:30Title Magnetic Molecular Beams - a non-conventional approach for hyper sensitive NMRLocation Gerhard M.J. Schmidt Lecture HallLecturer Prof. Gil Alexandrowicz
Schulich Faculty of Chemistry, TechnionOrganizer Department of Chemical and Biological PhysicsContact -
Date:26ThursdayMay 2016Colloquia
Exploring Flatland
More information Time 11:15 - 12:30Location Edna and K.B. Weissman Building of Physical SciencesLecturer Andre Geim
ManchesterOrganizer Faculty of PhysicsContact Abstract Show full text abstract about Following the advent of graphene, many other one-atom or one...» Following the advent of graphene, many other one-atom or one-molecule thick crystals have been isolated and investigated. These two-dimensional crystals have become one of the hottest topics in materials science and condensed matter physics. Furthermore, isolated atomic planes can now be reassembled back into three-dimensional structures and crystals made layer by layer in a designer sequence. I will provide a brief, lowbrow introduction to graphene, trying to explain why this material has attracted so much attention, and then overview our progress in making new assemblies from available atomic planes in order to illustrate how rich in phenomena and application this research field is. -
Date:26ThursdayMay 2016Lecture
Single-molecule views of eukaryotic DNA mismatch repair
More information Time 14:00 - 14:00Location Helen and Milton A. Kimmelman BuildingLecturer Prof. Ilya Finkelstein
Department of Molecular Biosciences & ICMB University of Texas at AustinOrganizer Department of Chemical and Structural BiologyContact -
Date:27FridayMay 2016Cultural Events
Nathan's Friends - Argentine tango
More information Time 20:00 - 20:00Location Michael Sela AuditoriumContact -
Date:28SaturdayMay 2016Cultural Events
"Set el chbayeb Ima" - Iraqi show
More information Time 20:30 - 22:00Location Michael Sela AuditoriumContact -
Date:29SundayMay 201610FridayJune 2016Conference
Cosmological Probes of Fundamental Physics
More information Time All dayLocation Edna and K.B. Weissman Building of Physical SciencesChairperson Kfir BlumContact -
Date:29SundayMay 2016Lecture
G-INCPM-Special Seminar - Yael Malkinson Weiss, MD PhD, Executive Director Business Development, Ultragenyx Pharmaceutical, Novato CA - "Developing therapies for rare genetic diseases: weighing traditional versus novel therapeutic modalities"
More information Time 11:00 - 12:30Location Nancy and Stephen Grand Israel National Center for Personalized MedicineLecturer Yael Malkinson Weiss, MD PhD
Executive Director Business Development, Ultragenyx Pharmaceutical, Novato CAOrganizer Department of Biomolecular SciencesContact Abstract Show full text abstract about Developing therapies for the treatment of rare genetic disea...» Developing therapies for the treatment of rare genetic disease is frequently perceived to be simpler and with a lower risk than that associated with larger indications. This perception stems from the fact that many of these are monogenic, with predictable genetic effects and clear mechanisms, thus it should be straightforward to replace the defective protein. Since the diseases are usually severe the benefit is large, and in many cases, the rarer the disease, the smaller the clinical trials that are required for registration are.
However, there are over 7,000 genetic diseases with an even larger number of genes affected. The initial approach of protein replacement therapies can be successful but is limited to a relatively small diseases in which the defective proteins are localized in a subset of cellular organelles to which therapeutic proteins will naturally target (lysosome for example). Most of the diseases treatable with traditional protein replacement are becoming very crowded for how small the treatable patient population is. Thus - other solutions need to be considered for the thousands of diseases for which direct proteins replacement is not a viable approach.
Ultragenyx is a biotech company focused on development of therapies for rare genetic diseases. The company’s approach to building its pipeline and deciding how and when to include traditional (protein replacement therapies, small molecules) or new (nucleic acid based therapies) therapeutic modalities will be presented and examples will be discussed.
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Date:29SundayMay 2016Lecture
The ins and outs of subaerial lithotrophic biofilm in arid and hyper-arid environments
More information Time 11:00 - 11:00Location Sussman Family Building for Environmental SciencesLecturer Nimrod Wieler
Department of Environmental Hydrology & Microbiology Ben-Gurion University of the NegevOrganizer Department of Earth and Planetary SciencesContact Abstract Show full text abstract about Rock surfaces support microbial communities that may be invo...» Rock surfaces support microbial communities that may be involved in weathering processes. In arid and hyper-arid environments microbes dominate rock surfaces and were linked to weathering because the scarcity of water excludes classical mechanisms that erode rocks. We studied subaerial biofilms coating arid rocks, focusing on sedimentary rocks that feature comparable weathering morphologies but different lithologies. We hypothesized that weathering is fashioned by salt erosion and mediated by biofilms that play dual roles: stabilizing the rock surfaces by coating, and enhancing salt crystallization by preventing rapid desiccation (thus mitigating and facilitating erosion processes, respectively). We used a combination of microbial and geological techniques to characterize the rocks morphologies and their subaerial biofilms. Deep sequencing and microscopy analyses suggest that bacterial diversity is low, dominated by Proteobacteria, Cyanobacteria and Actinobacteria. Together these phyla formed laminar biofilms that secrete extracellular polymeric substances to aggregate microfabrics and mitigate desiccation, reducing water loss by over 40%. The biofilm was detected only in rocks exposed to the atmosphere, present distinct architecture and burrowed up to 9 mm beneath the surface, protected by sedimentary deposits. A closer inspection revealed that the composition of the biofilm was tightly linked to dust bacterial communities but distinct from soil communities. Moreover, the biofilm composition changed according to the rock location rather than its’ lithology, suggesting that microclimate (dew, relative humidity and radiation) play an important role in arid weathering. Our results contradict common dogmas that considered biofilms as degrading agents and propose their role as mitigators of geomorphic processes.
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Date:29SundayMay 2016Lecture
A systematic view on Influenza induced host shut-off
More information Time 13:00 - 13:00Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Julie Tai
Noam Stern-Ginossar's group, Dept. of Molecular Genetics, WISOrganizer Department of Molecular GeneticsContact -
Date:29SundayMay 2016Lecture
The Simple Physics Behind Energy Use
More information Time 13:00 - 13:00Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Peter Rez
Department of Physics, Arizona State University, USAOrganizer Weizmann School of ScienceContact -
Date:29SundayMay 2016Lecture
Quantitative investigation of birdsong: from learning to performance
More information Time 13:00 - 13:00Location Dannie N. Heineman LaboratoryLecturer Prof. Ofer Tchernichovski
Department of Psychology Hunter College, NYCOrganizer Clore Center for Biological PhysicsContact Abstract Show full text abstract about • Music maintains a characteristic balance between repetitio...» • Music maintains a characteristic balance between repetition and novelty. I will present evidence for a similar balance in singing performances of free-living Australian pied butcherbirds.
• While acquiring motor skills, such as courtship songs and dances, animals must match their performance to a desired target. However, because both the structure and the temporal position of individual gestures are adjustable, the number of possible motor transformations increases exponentially with sequence length, and searching for the optimal transformation quickly becomes computationally intractable. We show how zebra finches cope with the computational complexity of song learning.
