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פברואר 18, 2016

  • Date:24שלישימאי 2016

    Experience-induced transcriptional networks that regulate the function of cortical circuits

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    שעה
    12:30 - 12:30
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצהProf. Ivo Spiegel
    Department of Neurobiology, WIS
    מארגן
    המחלקה למדעי המוח
    צרו קשר
    תקצירShow full text abstract about Inhibitory neurons are critically important for the adaptati...»
    Inhibitory neurons are critically important for the adaptation of neural circuits to sensory experience, but the molecular mechanisms by which experience controls the connectivity between different types of inhibitory neurons to regulate cortical plasticity are largely unknown. In this talk, I will present studies demonstrating that sensory experience induces in cortical vasoactive intestinal peptide (VIP)-expressing neurons a gene program that is markedly distinct from that induced in excitatory neurons and other subtypes of inhibitory neuron. I will show that is Igf1 one of several activity-regulated genes that are specific to VIP neurons, that IGF1 functions cell-autonomously in VIP neurons to increase inhibitory synaptic input onto these neurons and that VIP neuron-derived IGF1 regulates visual acuity in an experience-dependent manner, likely by promoting the inhibition of disinhibitory neurons and affecting inhibition onto cortical pyramidal neurons. I will discuss how our findings support a model by which experience-induced transcriptional networks regulate the synaptic connectivity of each type of neuron according to a circuit-wide homeostatic logic and I will propose that the analysis of the genomic mechanisms regulating these transcriptional networks will allow us to evaluate the extent to which cell-type-specific homeostatic mechanisms contribute to the function of cortical circuits.
    הרצאה
  • Date:24שלישימאי 2016

    How SAGA reads, writes and erases the histone code

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    שעה
    14:00 - 14:00
    מיקום
    בניין הלן ומילטון קימלמן
    מרצהProf. Cynthia Wolberger
    Department of Biophysics and Biophysical Chemistry Johns Hopkins University School of Medicine
    מארגן
    המחלקה לביולוגיה מבנית וכימית
    צרו קשר
    הרצאה
  • Date:24שלישימאי 2016

    הקאמרטה הישראלית ירושלים "חושבים מוסיקה" השיבה הנצחית

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    שעה
    16:30 - 18:00
    מיקום
    אודיטוריום מיכאל סלע
    צרו קשר
    אירועי תרבות
  • Date:25רביעימאי 2016

    Metabolic approaches to the Microbiome

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    שעה
    10:00 - 12:00
    כותרת
    Gut microbiota, chronic inflammation, and metabolic syndrome
    מיקום
    בניין ארתור ורושל בלפר למחקר ביורפואי
    מרצהProf. Andrew Gewirtz, Prof. Yitzhak Mizrahi, Maayan Levy
    מארגן
    המחלקה לגנטיקה מולקולרית
    צרו קשר
    הרצאה
  • Date:25רביעימאי 2016

    Next Joint Particle Seminar - May 25 2016

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    שעה
    11:00 - 11:00
    מיקום
    Technion (Aquarium Room)
    מרצהYotam Soreq
    MIT
    מארגן
    המחלקה לפיזיקה של חלקיקים ואסטרופיזיקה
    דף בית
    צרו קשר
    תקצירShow full text abstract about We propose an inclusive search for dark photons A' at t...»
    We propose an inclusive search for dark photons A' at the LHCb experiment based on both prompt and displaced di-muon resonances.
    Because the couplings of the dark photon are inherited from the photon via kinetic mixing, the dark photon A' -> mu+mu- rate can be directly inferred from the off-shell photon gamma* -> mu+mu- rate, making this a fully data-driven search. For Run 3 of the LHC, we estimate that LHCb will have sensitivity to large regions of the unexplored dark-photon parameter space, especially in the 210-520 MeV and 10-40 GeV mass ranges. This search leverages the excellent invariant-mass and vertex resolution of LHCb, along with its unique particle-identification and real-time data-analysis capabilities.
    הרצאה
  • Date:25רביעימאי 2016

    Protection mechanisms of cancer prevention - lessons from the heart

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    שעה
    12:00 - 13:00
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצהDr. Rachel Sarig
    Department of Molecular Cell Biology
    מארגן
    המחלקה לתשתיות מחקר מדעי החיים
    צרו קשר
    הרצאה
  • Date:25רביעימאי 2016

    Systems Biology Approach to the Mammalian Cell Cycle

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    שעה
    13:00 - 13:00
    מיקום
    בניין ארתור ורושל בלפר למחקר ביורפואי
    מרצהProf. Itamar Simon
    Department of Microbiology and Molecular Genetics, Hebrew University Medical School Hadassah Ein Kerem, Jerusalem
    מארגן
    המחלקה לגנטיקה מולקולרית
    צרו קשר
    הרצאה
  • Date:25רביעימאי 2016

    TBA

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    שעה
    13:30 - 13:30
    מיקום
    Technion (Aquarium Room)
    מרצהAlex Kagan
    Cincinnati
    מארגן
    המחלקה לפיזיקה של חלקיקים ואסטרופיזיקה
    דף בית
    צרו קשר
    הרצאה
  • Date:25רביעימאי 2016

    Sexually dimorphic neuronal connectivity established by sex-specific synapse pruning in C. elegans

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    שעה
    14:00 - 15:00
    מיקום
    בניין תשתיות ושירותי מחקר על-שם ראול וגרציאלה דה פיצ'וטו
    מרצהProf. Meital Oren-Suissa
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY
    מארגן
    המחלקה לאימונולוגיה ורגנרציה ביולוגית
    צרו קשר
    הרצאה
  • Date:26חמישימאי 2016

    Magnetic Resonance Seminar

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    שעה
    09:30 - 09:30
    כותרת
    Magnetic Molecular Beams - a non-conventional approach for hyper sensitive NMR
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצהProf. Gil Alexandrowicz
    Schulich Faculty of Chemistry, Technion
    מארגן
    המחלקה לפיזיקה כימית וביולוגית
    צרו קשר
    הרצאה
  • Date:26חמישימאי 2016

    Exploring Flatland

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    שעה
    11:15 - 12:30
    מיקום
    בניין הפיזיקה ע"ש עדנה וק.ב. וייסמן
    מרצהAndre Geim
    Manchester
    מארגן
    הפקולטה לפיזיקה
    צרו קשר
    תקצירShow full text abstract about Following the advent of graphene, many other one-atom or one...»
    Following the advent of graphene, many other one-atom or one-molecule thick crystals have been isolated and investigated. These two-dimensional crystals have become one of the hottest topics in materials science and condensed matter physics. Furthermore, isolated atomic planes can now be reassembled back into three-dimensional structures and crystals made layer by layer in a designer sequence. I will provide a brief, lowbrow introduction to graphene, trying to explain why this material has attracted so much attention, and then overview our progress in making new assemblies from available atomic planes in order to illustrate how rich in phenomena and application this research field is.
    סימפוזיונים
  • Date:26חמישימאי 2016

    Single-molecule views of eukaryotic DNA mismatch repair

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    שעה
    14:00 - 14:00
    מיקום
    בניין הלן ומילטון קימלמן
    מרצהProf. Ilya Finkelstein
    Department of Molecular Biosciences & ICMB University of Texas at Austin
    מארגן
    המחלקה לביולוגיה מבנית וכימית
    צרו קשר
    הרצאה
  • Date:27שישימאי 2016

    החברים של נתן - טנגו ארגנטינאי

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    שעה
    20:00 - 20:00
    מיקום
    אודיטוריום מיכאל סלע
    צרו קשר
    אירועי תרבות
  • Date:28שבתמאי 2016

    סת אל חבייב אמא - מופע עירקי

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    שעה
    20:30 - 22:00
    מיקום
    אודיטוריום מיכאל סלע
    צרו קשר
    אירועי תרבות
  • Date:29ראשוןמאי 201610שישייוני 2016

    Cosmological Probes of Fundamental Physics

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    שעה
    כל היום
    מיקום
    בניין הפיזיקה ע"ש עדנה וק.ב. וייסמן
    יושב ראש
    Kfir Blum
    צרו קשר
    כנסים
  • Date:29ראשוןמאי 2016

    G-INCPM-Special Seminar - Yael Malkinson Weiss, MD PhD, Executive Director Business Development, Ultragenyx Pharmaceutical, Novato CA - "Developing therapies for rare genetic diseases: weighing traditional versus novel therapeutic modalities"

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    שעה
    11:00 - 12:30
    מיקום
    המרכז הישראלי הלאומי לרפואה מותאמת אישית על-שם ננסי וסטיבן גרנד
    מרצהYael Malkinson Weiss, MD PhD
    Executive Director Business Development, Ultragenyx Pharmaceutical, Novato CA
    מארגן
    המחלקה למדעים ביומולקולריים
    צרו קשר
    תקצירShow full text abstract about Developing therapies for the treatment of rare genetic disea...»
    Developing therapies for the treatment of rare genetic disease is frequently perceived to be simpler and with a lower risk than that associated with larger indications. This perception stems from the fact that many of these are monogenic, with predictable genetic effects and clear mechanisms, thus it should be straightforward to replace the defective protein. Since the diseases are usually severe the benefit is large, and in many cases, the rarer the disease, the smaller the clinical trials that are required for registration are.
    However, there are over 7,000 genetic diseases with an even larger number of genes affected. The initial approach of protein replacement therapies can be successful but is limited to a relatively small diseases in which the defective proteins are localized in a subset of cellular organelles to which therapeutic proteins will naturally target (lysosome for example). Most of the diseases treatable with traditional protein replacement are becoming very crowded for how small the treatable patient population is. Thus - other solutions need to be considered for the thousands of diseases for which direct proteins replacement is not a viable approach.
    Ultragenyx is a biotech company focused on development of therapies for rare genetic diseases. The company’s approach to building its pipeline and deciding how and when to include traditional (protein replacement therapies, small molecules) or new (nucleic acid based therapies) therapeutic modalities will be presented and examples will be discussed.

    הרצאה
  • Date:29ראשוןמאי 2016

    The ins and outs of subaerial lithotrophic biofilm in arid and hyper-arid environments

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    שעה
    11:00 - 11:00
    מיקום
    בניין משפחת זוסמן
    מרצהNimrod Wieler
    Department of Environmental Hydrology & Microbiology Ben-Gurion University of the Negev
    מארגן
    המחלקה למדעי כדור הארץ וכוכבי הלכת
    צרו קשר
    תקצירShow full text abstract about Rock surfaces support microbial communities that may be invo...»
    Rock surfaces support microbial communities that may be involved in weathering processes. In arid and hyper-arid environments microbes dominate rock surfaces and were linked to weathering because the scarcity of water excludes classical mechanisms that erode rocks. We studied subaerial biofilms coating arid rocks, focusing on sedimentary rocks that feature comparable weathering morphologies but different lithologies. We hypothesized that weathering is fashioned by salt erosion and mediated by biofilms that play dual roles: stabilizing the rock surfaces by coating, and enhancing salt crystallization by preventing rapid desiccation (thus mitigating and facilitating erosion processes, respectively). We used a combination of microbial and geological techniques to characterize the rocks morphologies and their subaerial biofilms. Deep sequencing and microscopy analyses suggest that bacterial diversity is low, dominated by Proteobacteria, Cyanobacteria and Actinobacteria. Together these phyla formed laminar biofilms that secrete extracellular polymeric substances to aggregate microfabrics and mitigate desiccation, reducing water loss by over 40%. The biofilm was detected only in rocks exposed to the atmosphere, present distinct architecture and burrowed up to 9 mm beneath the surface, protected by sedimentary deposits. A closer inspection revealed that the composition of the biofilm was tightly linked to dust bacterial communities but distinct from soil communities. Moreover, the biofilm composition changed according to the rock location rather than its’ lithology, suggesting that microclimate (dew, relative humidity and radiation) play an important role in arid weathering. Our results contradict common dogmas that considered biofilms as degrading agents and propose their role as mitigators of geomorphic processes.
    הרצאה
  • Date:29ראשוןמאי 2016

    A systematic view on Influenza induced host shut-off

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    שעה
    13:00 - 13:00
    מיקום
    בניין ארתור ורושל בלפר למחקר ביורפואי
    מרצהJulie Tai
    Noam Stern-Ginossar's group, Dept. of Molecular Genetics, WIS
    מארגן
    המחלקה לגנטיקה מולקולרית
    צרו קשר
    הרצאה
  • Date:29ראשוןמאי 2016

    The Simple Physics Behind Energy Use

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    שעה
    13:00 - 13:00
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצהProf. Peter Rez
    Department of Physics, Arizona State University, USA
    מארגן
    בית הספר למחקר - מכון ויצמן למדע
    צרו קשר
    הרצאה
  • Date:29ראשוןמאי 2016

    Quantitative investigation of birdsong: from learning to performance

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    שעה
    13:00 - 13:00
    מיקום
    מעבדה על-שם דני נ. היינמן
    מרצהProf. Ofer Tchernichovski
    Department of Psychology Hunter College, NYC
    מארגן
    מרכז לפיזיקה ביולוגית עש קלור
    צרו קשר
    תקצירShow full text abstract about • Music maintains a characteristic balance between repetitio...»
    • Music maintains a characteristic balance between repetition and novelty. I will present evidence for a similar balance in singing performances of free-living Australian pied butcherbirds.
    • While acquiring motor skills, such as courtship songs and dances, animals must match their performance to a desired target. However, because both the structure and the temporal position of individual gestures are adjustable, the number of possible motor transformations increases exponentially with sequence length, and searching for the optimal transformation quickly becomes computationally intractable. We show how zebra finches cope with the computational complexity of song learning.
    הרצאה

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