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February 18, 2016

  • Date:04TuesdayJune 2024

    Or Amar’s Thesis Defense

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    Time
    09:30 - 09:30
    Title
    Discovery of enzymes for degrading anthropogenic materials using knowledge graph embedding
    Location
    Benoziyo Room 290
    Organizer
    Department of Plant and Environmental Sciences
    Contact
    Lecture
  • Date:04TuesdayJune 2024

    Lineage tracing in the pancreas reveal the pancreatic ductal adenocarcinoma cell of origin

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    Time
    10:00 - 11:00
    Location
    Nella and Leon Benoziyo Building for Biological Sciences
    LecturerDr. Gabriela Koifman
    Department of Biomolecular Sciences
    Organizer
    Department of Biomolecular Sciences
    Contact
    AbstractShow full text abstract about Pancreatic ductal adenocarcinoma (PDAC) is one of the deadli...»
    Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers with a five-year survival rate of ˜12.5% and is the fourth leading cause of cancer-related death in the western world, estimated to become the second leading cause of cancer related death by the year 2030. PDAC is characterized by a high metastatic burden leading to poor patient outcome. This capability to induce metastatic growth has been ascribed to specific sub-clones within tumours. Intra tumour heterogeneity in PDAC is also exemplified by the coexistence of a tumour hierarchy consisting of phenotypically different sub-populations that harbour unique proliferative, tumourigenic and chemoresistant capacities. Understanding PDAC hierarchies might be a crucial step to identify the cells of origin of PDAC, which will provide an important avenue that will allow deeper understanding of the disease and the development of more effective treatments for PDA patients. Given the ductal morphology of PDAC, ductal cells have for long been the main candidates as tumour initiating cells. However, more recent studies seemed to suggest that PDAC originate from non-ductal, endocrine or acinar cells, transdifferentiating into a ductal-like morphology. Recently, by utilizing commonly used genetic mouse model, we were able to identify a subpopulation of cells within the acinar cell population that is responsible for tumour initiation and serves as the cell of origin of PDAC in this mouse model. we have identified the gene signature of PDAC acinar cell of origin that consist of proliferation and stem cell associated gene signatures. This characterization might lead to the identification of early disease biomarkers and new therapeutic approaches to target the disease and improve the outcome PDAC patients.
    Lecture
  • Date:04TuesdayJune 2024

    Blood flow perturbations and its impact on brain structure and function: from microstrokes to heartbeats

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    Time
    12:30 - 13:30
    Location
    Gerhard M.J. Schmidt Lecture Hall
    LecturerProf. Pablo Blinder
    Dept of Neurobiology, Tel Aviv University
    Organizer
    Department of Brain Sciences
    Contact
    Lecture
  • Date:04TuesdayJune 2024

    The Clore Center for Biological Physics

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    Time
    13:15 - 14:30
    Title
    Flexoelectricity versus Electrostatics in Polar Nematic Liquid Crystals
    Location
    Nella and Leon Benoziyo Physics Library
    LecturerProf. Jonathan Selinger
    Kent State University
    Organizer
    Clore Center for Biological Physics
    Contact
    AbstractShow full text abstract about In the most common phase of liquid crystals, called the ne...»

    In the most common phase of liquid crystals, called the nematic phase, molecules are aligned up or down along some axis, so that the net electrostatic polarization is zero. Recent experiments have found a new class of liquid crystals, called ferroelectric nematic, in which molecules align predominantly in one direction along the axis, leading to a nonzero polarization. From the perspective of statistical mechanics, the ferroelectric nematic phase has two special features. First, it has flexoelectricity, meaning that the polarization induces a splay of the molecular orientation. Second, the energy includes an electrostatic interaction, which favors a domain structure. In this talk, we discuss the competition between those two effects to control the phase behavior.
    FOR THE LATEST UPDATES AND CONTENT ON SOFT MATTER AND BIOLOGICAL PHYSICS AT THE WEIZMANN, VISIT OUR WEBSITE: https://www.biosoftweizmann.com/
    Lecture
  • Date:04TuesdayJune 2024

    Synthetic Biology Platforms to Study Biological Systems and for Biomedical Applications

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    Time
    14:00 - 15:00
    Location
    Gerhard M.J. Schmidt Lecture Hall
    LecturerDr. Lior Nissim
    The Faculty of Medicine Hebrew University
    Organizer
    Department of Chemical and Structural Biology
    Contact
    Lecture
  • Date:05WednesdayJune 2024

    Memory consolidation and generalization during sleep

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    Time
    10:00 - 11:00
    Location
    Nella and Leon Benoziyo Building for Brain Research
    LecturerElla Bar-Student Seminar-PhD Thesis Defense
    Prof. Rony Paz Lab & Prof. Yuval Nir, Tel Aviv University
    Organizer
    Department of Brain Sciences
    Contact
    AbstractShow full text abstract about During sleep, our memories are reactivated and consolidated ...»
    During sleep, our memories are reactivated and consolidated in an active process that significantly influences our memory and decision-making. In this talk, I will present two studies about sleep-memory consolidation. The first study investigated sleep memory consolidation's local versus global properties within the brain. By exploiting the unique functional neuroanatomy of olfactory system, we were able to manipulate sleep oscillations and enhance memories locally within a single hemisphere during sleep. These findings underscore the local nature of sleep memory consolidation, which can be selectively manipulated within the brain, thereby creating an important link between theories of local sleep and learning. The second research explored the relationship between generalization processes and sleep, acknowledging that overgeneralization of negative stimuli and disruptions in sleep quality contribute to anxiety and PTSD disorders. Specifically, we studied participants' responses to stimuli associated with positive, negative, or neutral outcomes. Our findings revealed significant correlations between brain activity, as detected by fMRI, during the association of a stimulus with an outcome and the perceptual generalization of these stimuli. While activity in limbic brain areas was correlated with immediate negative stimulus generalization, we observed that the activation in these areas predicted recovery and positively related generalization following sleep. Moreover, we identified specific sleep oscillations correlated with this recovery generalization using high-density EEG recordings. These results highlight the crucial role of sleep in both generalization processes and the restoration of balanced responses to stimuli. Understanding these mechanisms can offer valuable insights into developing therapeutic strategies for anxiety and PTSD.
    Lecture
  • Date:05WednesdayJune 2024

    Tubular Morphogenesis in a dish

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    Time
    10:00 - 11:00
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    LecturerDr. Eyal Karzburn
    Department of Molecular Genetics, WIS
    Contact
    Lecture
  • Date:05WednesdayJune 2024

    Machine Learning and Statistics Seminar

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    Time
    11:15 - 12:15
    Title
    Harnessing Literature for Boosting Scientific and Clinical Predictive Models
    Location
    Jacob Ziskind Building
    LecturerTom Hope
    HUJI
    Organizer
    Department of Computer Science and Applied Mathematics
    Contact
    AbstractShow full text abstract about The explosion of scholarly knowledge presents tremendous opp...»
    The explosion of scholarly knowledge presents tremendous opportunities for accelerating research across the sciences. In this talk, I will present recent work toward helping researchers and clinicians make use of knowledge embedded in the literature. I will focus on methods that use information in the literature for training predictive models and generating scientific hypotheses. This includes models that predict (1) clinical outcomes of hospital patients, (2) new links in biomedical knowledge graphs, and (3) hypotheses in computer science research.

    Bio: Tom Hope is an assistant professor at The Hebrew University of Jerusalem's School of Computer Science and Engineering, and a research scientist at The Allen Institute for AI (AI2). Tom was awarded the Azrieli Early Career Faculty Fellowship which is given to eight scientists across all fields of study. Prior to that he was a postdoctoral researcher at AI2 and the University of Washington (UW). His work has received four best paper awards, appeared in top AI, NLP and HCI venues, and received coverage from Nature and Science. https://www.cs.huji.ac.il/~tomhope/
    Lecture
  • Date:05WednesdayJune 2024

    ESR1 mutations: From Discovery to Clinical Practice

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    Time
    14:00 - 15:00
    Location
    Max and Lillian Candiotty Building
    LecturerDr. Rinath Jeselsohn
    Dana Farber Cancer Institute, Harvard Medical School
    Organizer
    Dwek Institute for Cancer Therapy Research
    Contact
    Lecture
  • Date:06ThursdayJune 2024

    Molecular Neuroscience Trainees day 2024

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    Time
    08:30 - 16:00
    Location
    Dolfi and Lola Ebner Auditorium
    Organizer
    Department of Molecular Neuroscience
    Contact
    Lecture
  • Date:06ThursdayJune 2024

    Targeted Metabolic Analysis – Using an Out of the Box Approach

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    Time
    09:00 - 10:00
    Location
    Max and Lillian Candiotty Building
    LecturerDr. Alexander Brandis
    Targeted Metabolomics Unit
    Organizer
    Department of Life Sciences Core Facilities
    Contact
    Lecture
  • Date:06ThursdayJune 2024

    Physics Colloquium

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    Time
    11:15 - 12:30
    Title
    Emergent Quantum Phenomena in Crystalline Multilayer Graphene
    Location
    Edna and K.B. Weissman Building of Physical Sciences
    LecturerProf. Long Ju
    MIT
    Organizer
    Department of Condensed Matter Physics
    Contact
    AbstractShow full text abstract about Condensed matter physics has witnessed emergent quantum phen...»
    Condensed matter physics has witnessed emergent quantum phenomena driven by electron correlation and topology. Such phenomena have been mostly observed in conventional crystalline materials where flat electronic bands are available. In recent years, moiré superlattices built upon two-dimensional (2D) materials emerged as a new platform to engineer and study electron correlation and topology. In this talk, I will introduce a family of synthetic quantum materials, based on crystalline multilayer graphene, as a new platform to engineer and study emergent phenomena driven by many-body interactions. This system hosts flat-bands in highly ordered conventional crystalline materials and dresses them with proximity effects enabled by rich structures in 2D van der Waals heterostructures. As a result, a rich spectrum of emergent phenomena including correlated insulators, spin/valley-polarized metals, integer and fractional quantum anomalous Hall effects, as well as superconductivities have been observed in our experiments. I will also discuss the implications of these observations for topological quantum computation.
    References:
    [1] Han, T., Lu, Z., Scuri, G. et al. Nat. Nanotechnol. 19, 181–187 (2024). [2] Han, T., Lu, Z., Scuri, G. et al. Nature 623, 41–47 (2023). [3] Han, T., Lu, Z., Yao, Y. et al. Science 384,647-651(2024). [4] Lu, Z., Han, T., Yao, Y. et al. Nature 626, 759–764 (2024). [5] Yang, J., Chen, G., Han, T. et al. Science, 375(6586), pp.1295-1299. (2022)

    Colloquia
  • Date:06ThursdayJune 2024

    Vision and AI

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    Time
    12:15 - 13:15
    Title
    LIPVOICER: Generating Speech From Silent Videos Guided By Lip-Reading
    Location
    Jacob Ziskind Building
    LecturerSharon Ganot
    Bar-Ilan University
    Organizer
    Department of Computer Science and Applied Mathematics
    Contact
    AbstractShow full text abstract about Lip-to-speech involves generating a natural-sounding speech ...»
    Lip-to-speech involves generating a natural-sounding speech synchronized with a soundless video of a person talking. Despite recent advances, current methods still cannot produce high-quality speech with high levels of intelligibility for challenging and realistic datasets. This talk presents LipVoicer, a novel method that generates high-quality speech, even for in-the-wild and rich datasets, by incorporating the text modality. Given a silent video, we first predict the spoken text using a pre-trained lip-reading network. We then condition a diffusion model on the video and use the extracted text through a classifier-guidance mechanism where a pre-trained automatic speech recognition (ASR) serves as the classifier. We demonstrate the effectiveness of LipVoicer through human evaluation, which shows that it produces more natural and synchronized speech signals than competing methods (demo page: https://lipvoicer.github.io). The presented LipVoicer is a joint work of Yochai Yemini, Aviv Shamsian, Lior Bracha, Sharon Gannot, and Ethan Fetaya.

    Bio:

    Sharon Gannot obtained his Ph.D. in electrical engineering from Tel-Aviv University, Israel, in 2000. He is a full professor in the Faculty of Engineering at Bar-Ilan University, Israel. He serves as a senior area chair for IEEE Transactions on Audio, Speech, and Language Processing, a member of the senior editorial board of IEEE Signal Processing Magazine, a member of the editorial board of IEEE SPS Education Center, and the chair of the IEEE Signal Processing Society Data Science Initiative. Previously, he was chair of the IEEE Audio and Acoustic Signal Processing Technical Committee in 2017–2018. He has also held other roles, such as the general co-chair of the 2010 International Workshop on Acoustic Signal Enhancement and the 2013 IEEE Workshop on Applications of Signal Processing to Audio and Acoustics. He is the general co-chair of Interspeech 2024, which will be held in September in Greece. His research interests include statistical signal processing and machine learning in the audio processing domain. The methods he develops utilize multi-microphone and multi-modal information. Applications include speech enhancement, noise reduction, speaker separation and diarization, dereverberation, speaker localization, and tracking. Sharon Gannot is the recipient of the 2022 European Association for Signal Processing Group Technical Achievement Award and a Fellow of the IEEE.

     

     
    Lecture
  • Date:06ThursdayJune 2024

    Geometric Functional Analysis and Probability Seminar

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    Time
    13:30 - 14:30
    Title
    Charge fluctuations in the hierarchical Coulomb gas
    Location
    Jacob Ziskind Building
    LecturerAlon Nishry
    TAU
    Organizer
    Department of Mathematics
    Contact
    AbstractShow full text abstract about The two-dimensional One-Component Plasma (OCP) is a Coulomb ...»
    The two-dimensional One-Component Plasma (OCP) is a Coulomb system (a point process) that consists of identical, electrically charged particles embedded in a uniform background of the opposite charge, interacting through a logarithmic potential, and kept at a fixed temperature. In the 90s, Jancovici, Lebowitz and Manificat discovered a law for the probabilities of observing large charge fluctuations in the OCP. Mathematically, this law has been fully proved only for one very special value of the temperature (corresponding to the Ginibre random matrix ensemble).

    A few years ago, Chatterjee introduced a hierarchical version of the OCP, inspired by Dyson's hierarchical model of the Ising ferromagnet. We show that the JLM law holds for the hierarchical Coulomb model at any finite positive temperature.

    Based on a joint work with Oren Yakir.
    Lecture
  • Date:06ThursdayJune 2024

    Insights from germline and somatic replication repair deficiency on cancer initiation and immunotherapy

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    Time
    14:00 - 15:00
    Location
    Max and Lillian Candiotty Building
    LecturerProf. Uri Tabori
    Head, Neuroonconcology program Division of Haematology/Oncology The Hospital for Sick Children Toronto, ON, Canada
    Organizer
    Dwek Institute for Cancer Therapy Research
    Contact
    Lecture
  • Date:09SundayJune 2024

    Special Guest Seminar

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    Time
    10:00 - 11:00
    Title
    Combined multimodal single-synapse profiling of synaptic activity, multiprotein composition, and translation
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    LecturerDr. Reuven (Beny) Falkovich
    MIT Department of Biological Engineering
    Organizer
    Department of Molecular Neuroscience
    Contact
    AbstractShow full text abstract about The analog computation at the chemical synapse that underlie...»
    The analog computation at the chemical synapse that underlies cognition depends on a highly compartmentalized, tightly regulated, and complex network of interactions between synaptic activity and hundreds of proteins and the mechanisms that regulate them. For a top-down study of how the network operates in concert, I present a modular, versatile approach for combined imaging of multiprotein composition, activation states, ion and neurotransmitter fluxes, and mRNA translation across the same individual synapses. I will show how this approach extends to other subcellular systems such as mitochondria. I will discuss the use of Bayesian network inference to extract biological insight from high-dimensional, multimodal synapse distributions. Finally, I will present applications of this approach to identify convergent molecular phenotypes across autism and schizophrenia-associated genes, and for an in-depth study of the complex synaptic response to genetic and chemical perturbations of GluN2A.
    Lecture
  • Date:10MondayJune 2024

    AI (R)Evolution in (Quantum) Chemistry and Physics

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    Time
    11:00 - 12:15
    Title
    Annual Pearlman Lecture
    Location
    Gerhard M.J. Schmidt Lecture Hall
    LecturerProf. Alexandre Tkatchenko
    Theoretical Chemical Physics, University of Luxembourg
    Organizer
    Department of Molecular Chemistry and Materials Science
    Homepage
    Contact
    Colloquia
  • Date:10MondayJune 2024

    Midrasha on Groups Seminar

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    Time
    11:15 - 13:00
    Title
    Understanding infinitely presented groups using markings and applications to Hilbert–Schmidt stability
    Location
    Jacob Ziskind Building
    LecturerAlon Dogon
    Weizmann
    Organizer
    Department of Mathematics
    Contact
    AbstractShow full text abstract about In this talk I will present a useful construction introduced...»
    In this talk I will present a useful construction introduced by Kassabov and Pak, called diagonal products. They arise naturally in the study of the space of marked groups, that is, the normal subgroups of a free group with the Chabauty topology. It turns out that diagonal products are extremely rich, and proved to be a useful tool for providing a full spectrum of various growth functions for groups. This includes answers to questions such as "How fast do Følner sets grow in an amenable group" and "How fast do residual chains grow in residually finite groups" etc. We will elaborate on a joint work with Arie Levit and Itamar Vigdorovich, where we give a general classification result for characters (á la Thoma) of many diagonal products. As a result, we deduce that there are uncountably many Hilbert–Schmidt stable groups, which are as unstable as one wants.
    Lecture
  • Date:10MondayJune 2024

    Midrasha on Groups Seminar

    More information
    Time
    11:15 - 13:00
    Title
    Understanding infinitely presented groups using markings and applications to Hilbert–Schmidt stability
    Location
    Jacob Ziskind Building
    LecturerAlon Dogon
    Weizmann
    Organizer
    Department of Mathematics
    Contact
    AbstractShow full text abstract about In this talk I will present a useful construction introduced...»
    In this talk I will present a useful construction introduced by Kassabov and Pak, called diagonal products. They arise naturally in the study of the space of marked groups, that is, the normal subgroups of a free group with the Chabauty topology. It turns out that diagonal products are extremely rich, and proved to be a useful tool for providing a full spectrum of various growth functions for groups. This includes answers to questions such as "How fast do Følner sets grow in an amenable group" and "How fast do residual chains grow in residually finite groups" etc. We will elaborate on a joint work with Arie Levit and Itamar Vigdorovich, where we give a general classification result for characters (á la Thoma) of many diagonal products. As a result, we deduce that there are uncountably many Hilbert–Schmidt stable groups, which are as unstable as one wants.
    Lecture
  • Date:10MondayJune 2024

    Foundations of Computer Science Seminar

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    Time
    11:15 - 12:15
    Title
    Fast and Cheap Asynchronous Construction of Small $k$-Dominating Sets
    Location
    Jacob Ziskind Building
    LecturerYuval Emek
    Technion
    Organizer
    Department of Computer Science and Applied Mathematics
    Contact
    AbstractShow full text abstract about A $k$-dominating set ($k$-DS) is a node subset of distance a...»
    A $k$-dominating set ($k$-DS) is a node subset of distance at most $k$ from any node in the graph.
    The task of constructing a small (i.e., existentially optimal) $k$-DS was suggested by Kutten and Peleg (Journal of Algorithms, 1998) as a useful primitive for distributed graph algorithms and received considerable attention ever since.
    In the current paper, we advance the state-of-the-art of distributed small $k$-DS construction by presenting a randomized asynchronous CONGEST KT1 algorithm for this task that runs in $ ilde{O}( k^{2} )$ time and sends $ ilde{O}( n k )$ messages whp.
    When $k leq polylog( n )$, we obtain the first asynchronous algorithm for a non-trivial distributed task whose communication cost is near-linear (in $n$).

    The talk will be self contained.
    Lecture

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