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April 27, 2017

  • Date:09ThursdayNovember 2017

    “Targeted metabolic analysis: present and perspectives”

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    Time
    09:00 - 10:00
    Location
    Max and Lillian Candiotty Building
    LecturerDr. Alexander Brandis
    Department of Life Sciences Core Facilities
    Organizer
    Department of Life Sciences Core Facilities
    Contact
    Lecture
  • Date:09ThursdayNovember 2017

    Search for new physics at the intensity frontier

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    Time
    11:15 - 12:15
    Location
    Edna and K.B. Weissman Building of Physical Sciences
    LecturerTBA
    Organizer
    Faculty of Physics
    Contact
    AbstractShow full text abstract about With the discovery at the LHC of the Higgs boson, the main m...»
    With the discovery at the LHC of the Higgs boson, the main missing block of the Standard Model is now in place. An additional LHC result of great importance is that a large new territory has been explored and no unambiguous signal of New Physics has been found.
    However some new particles or interactions are required to explain a number of observed phenomena in particle physics, astrophysics, and cosmology as the neutrino masses, the baryon asymmetry of the universe, the Dark Matter and the cosmological inflation.
    So far the experimental efforts have been concentrated on the discovery of new particles with masses at or above the EW scale with sizable couplings with SM particles. Another viable possibility, largely unexplored, is that these new particles are below the EW scale and have not been detected because they interact very feebly with the SM particles.
    I will review the current status of the search for these new particles with masses in the MeV-GeV region at beam dump experiments currently running or proposed at CERN.
    Colloquia
  • Date:12SundayNovember 2017

    CARMENES: Searching for habitable planets around red stars

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    Time
    11:00 - 11:00
    Location
    Sussman Family Building for Environmental Sciences
    LecturerStefan Dreizler
    University of Göttingen Institute of Astrophysics
    Organizer
    Department of Earth and Planetary Sciences
    Contact
    Lecture
  • Date:13MondayNovember 2017

    Life Science Colloquium

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    Time
    11:00 - 12:00
    Title
    The Secret Life of FGF21
    Location
    Dolfi and Lola Ebner Auditorium
    LecturerProf. David Mangelsdorf
    The University of Texas Southwestern Medical Center
    Contact
    Colloquia
  • Date:13MondayNovember 2017

    Shorter pulses and lower average laser power reduce photodamage during two-photon imaging of microdomain Ca2+ transients in fine astrocyte processes.

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    Time
    11:00 - 12:00
    Location
    Nella and Leon Benoziyo Building for Biological Sciences
    LecturerDr. Martin Oheim
    CNRS Saint-Pères Paris Institute for Neurosciences (SPPIN), University Paris Descartes
    Organizer
    Department of Biomolecular Sciences
    Contact
    Lecture
  • Date:13MondayNovember 2017

    Shorter pulses and lower average laser power reduce photodamage during two-photon imaging of microdomain Ca2+ transients in fine astrocyte processes.

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    Time
    11:00 - 12:00
    Location
    Nella and Leon Benoziyo Building for Biological Sciences
    LecturerDr. Martin Oheim
    CNRS Saint-Pères Paris Institute for Neurosciences (SPPIN), University Paris Descartes
    Organizer
    Department of Biomolecular Sciences
    Contact
    Lecture
  • Date:13MondayNovember 2017

    Epigenetic strategies to overcome chemoresistance and to radiosensitize cancers

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    Time
    14:00 - 15:00
    Title
    Special Guest Seminar
    Location
    Max and Lillian Candiotty Building
    LecturerProf. Elizabeth Martinez
    Department of Pharmacology, Hamon Center for Therapeutic Oncology, Research, UT Southwestern Medical Center, Dallas, USA
    Organizer
    Department of Immunology and Regenerative Biology
    Contact
    Lecture
  • Date:13MondayNovember 2017

    Wicked problem at Kruger National Park - Elephant conservation, loss of tall trees and bush encroachment

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    Time
    14:00 - 14:00
    Location
    Nella and Leon Benoziyo Building for Biological Sciences
    LecturerDr. Izak Smit
    South African National Parks & University of the Witwatersrand, South Africa
    Organizer
    Department of Plant and Environmental Sciences
    Contact
    Lecture
  • Date:14TuesdayNovember 2017

    Epistasis, pleiotropy, the ruggedness of fitness landscape, and the Predictability of RNA virus evolution

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    Time
    10:00 - 11:00
    Location
    Arthur and Rochelle Belfer Building for Biomedical Research
    LecturerProf. Santiago Elena
    Institute for Molecular and Cellular Plant Biology (CSIC), Valencia, Spain
    Organizer
    Azrieli Institute for Systems Biology
    Contact
    Lecture
  • Date:14TuesdayNovember 2017

    The Fellowships of the Rings: evolution and biosynthesis of circular peptides

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    Time
    10:00 - 11:00
    Location
    Nella and Leon Benoziyo Building for Biological Sciences
    LecturerDr. Joshua Mylne
    School of Molecular Sciences, The University of Western Australia
    Organizer
    Department of Biomolecular Sciences
    Contact
    Lecture
  • Date:14TuesdayNovember 2017

    Reactivity and applications of novel triazolate-based MOFs with open metal sites

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    Time
    11:00 - 12:30
    Location
    Helen and Milton A. Kimmelman Building
    LecturerDr. Yuri Tulchinsky
    Organizer
    Department of Molecular Chemistry and Materials Science
    Contact
    Lecture
  • Date:14TuesdayNovember 2017

    Chemical signals from microalgae that shape communities and structure the marine environment

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    Time
    11:30 - 11:30
    Location
    Nella and Leon Benoziyo Building for Biological Sciences
    LecturerProf. Georg Pohnert
    Institute for Inorganic and Analytical Chemistry Bioorganic Analytics, Friedrich-Schiller-Universitat Jena, Germany
    Organizer
    Department of Plant and Environmental Sciences
    Contact
    AbstractShow full text abstract about Unicellular algae have established efficient means to intera...»
    Unicellular algae have established efficient means to interact with other organisms in their environment. Especially chemical signals play an important role in this context. Algal exudates as well as intracellular metabolites can, for instance, influence feeding activity of herbivores and algal / algal interactions. But also communication of algae with the surrounding microbial community is mediated by such chemical signals. Knowledge about the nature of these signal molecules opens up possibilities to investigate their mode of action, the regulation of interactions, and even to manipulate communities. This talk highlights that efficient chemical signaling is often a highly dynamic process that can be switched on and off upon demand. Indeed, surveys based on elaborate mass spectrometric methods confirm that algae exhibit a high plasticity of metabolite production during their development and in interaction situations. This regulation opens up new avenues for the identification of signals and mechanisms of chemically mediated interactions. Using a combination of comparative metabolomics and ecological investigations even dilute signal molecules can be elucidated. In addition, microscopic gradients of metabolites are visualized and mimicked to illustrate how chemical information can structure the otherwise homogeneous aqueous environment of microbes. Overall this talk will introduce novel concepts in marine chemical ecology.
    Lecture
  • Date:14TuesdayNovember 2017

    "Binding without folding: Extreme disorder and dynamics in a high-affinity protein complex "

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    Time
    14:00 - 15:00
    Location
    Helen and Milton A. Kimmelman Building
    LecturerProf. Benjamin Schuler, Miri Nakar
    University of Zurich
    Organizer
    Department of Chemical and Structural Biology
    Contact
    AbstractShow full text abstract about Molecular communication in biology is mediated by protein in...»
    Molecular communication in biology is mediated by protein interactions. According to the current paradigm, the specificity and affinity required for these interactions are encoded in the precise complementarity of binding interfaces. Even proteins that are disordered under physiological conditions or that contain large unstructured regions commonly interact with well-structured binding sites on other biomolecules. We recently discovered the existence of an unexpected interaction mechanism: The two intrinsically disordered human proteins histone H1 and its nuclear chaperone prothymosin α associate in a one-to-one complex with picomolar affinity, but they fully retain their structural disorder, long-range flexibility, and highly dynamic character. Based on the close integration of single-molecule experiments, NMR, and molecular simulations, we obtain a detailed picture of this complex and show that the interaction can be explained by the large opposite net charge of the two proteins without requiring defined binding sites or interactions between specific individual residues
    Lecture
  • Date:15WednesdayNovember 2017

    Chemical and Biological Physics Dept Guest Seminar

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    Time
    10:00 - 10:00
    Title
    Feynman path integral approach to tunnelling time
    Location
    Gerhard M.J. Schmidt Lecture Hall
    LecturerDr Alexandra Landsman
    Max Planck Institute for the Physics of Complex Systems, Germany
    Organizer
    Department of Chemical and Biological Physics
    Contact
    AbstractShow full text abstract about The tunnelling time problem is almost as old as quantum mech...»
    The tunnelling time problem is almost as old as quantum mechanics itself and is a highly debated subject. Time is not a quantum observable, and therefore many conflicting theories have been developed over the decades. Here we present the Feynman path integral (FPI) approach to tunnelling time, and show how it can be used to calculate tunnelling time probability amplitudes. The FPI approach also sheds new light on four best-known definitions of tunnelling times (Buttiker- Landauer, Pollak-Miller, Eisenbud-Wigner, and Larmor), which although derived using very different physical models, can also be represented as different averages using FPI tunnelling time probability amplitudes. Relation between the FPI approach, other tunnelling time definitions and the theory of weak measurement is also reviewed.
    Lecture
  • Date:15WednesdayNovember 2017

    G-INCPM Special Seminar - Prof. Amnon Peled, CEO-CSO, Biokine Therapeutics Ltd., Ness-Ziona - "Development of HTS for Novel Chemokine Antagonists"

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    Time
    11:00 - 12:30
    Location
    Nancy and Stephen Grand Israel National Center for Personalized Medicine
    LecturerProf. Amnon Peled
    CEO-CSO, Biokine Therapeutics Ltd.
    Organizer
    Department of Biomolecular Sciences
    Contact
    AbstractShow full text abstract about Chemokines and their receptors play critical roles in the pr...»
    Chemokines and their receptors play critical roles in the progression of autoimmunity and inflammation and cancer. Typically, multiple chemokines are involved in the development of these pathologies. Indeed, targeting single chemokines or chemokine receptors has failed to achieve significant clinical benefits in treating autoimmunity and inflammation. In our work, promiscuous chemokine binding peptides that could bind and inhibit multiple inflammatory chemokines, such as CCL20, CCL2, CCL5, and CXCL9/10/11, were selected from phage display libraries. These peptides were cloned into human mutated immunoglobulin Fc-protein fusions (peptibodies). These peptibodies showed a significant inhibition of disease progression in a variety of animal models for autoimmunity, inflammation and cancer. Based on our peptibodies we develop HTP screening system which allow us the identification of novel anti chemokines small molecules.

    Lecture
  • Date:15WednesdayNovember 2017

    Precision searches for new physics using optically levitated microspheres"

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    Time
    11:00 - 11:00
    Location
    Edna and K.B. Weissman Building of Physical Sciences
    LecturerDavid Moore
    YALE UNIV
    Organizer
    Department of Particle Physics and Astrophysics
    Contact
    AbstractShow full text abstract about High-sensitivity searches for ``fifth forces'' can...»
    High-sensitivity searches for ``fifth forces'' can test a variety of models of new physics that produce new weakly coupled or short range (
    Lecture
  • Date:15WednesdayNovember 2017

    “Searching for BSM physics with highly charged ions”

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    Time
    13:00 - 13:00
    Location
    Edna and K.B. Weissman Building of Physical Sciences
    LecturerMarianna Safronova
    UNIV OF DELWARE
    Organizer
    Department of Particle Physics and Astrophysics
    Contact
    AbstractShow full text abstract about The modern theories directed toward unifying gravitation wit...»
    The modern theories directed toward unifying gravitation with the three other fundamental interactions suggest variation of the fundamental constants. While the energy scale of such physics beyond the Standard Model is much higher than that currently attainable by particle accelerators the variation of the fundamental constants may nevertheless be detectable via precision measurements at low energies. I will give an overview of various searches for new physics with atomic clocks and focus on proposals for future experiments with highly charged ions. Proposal for tests of Lorentz symmetry with Yb+ and highly charged ions are also presented.
    Lecture
  • Date:15WednesdayNovember 2017

    Chemical and Biological Physics Dept Guest Seminar

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    Time
    15:00 - 15:00
    Title
    ħ’s sign-reversal for spin-0 particle↔antiparticle transformation: anti-gravity and elimination of CPT-invariance
    Location
    Perlman Chemical Sciences Building
    LecturerProf Alexander E. Kaplan
    Dept. Chemical and Biological Physics, Weizmann Institute and Dept. Electr. and Comp. Eng., Johns Hopkins University, Baltimore
    Organizer
    Department of Chemical and Biological Physics
    Contact
    AbstractShow full text abstract about While revisiting Klein-Gordon relativistic quantum equation ...»
    While revisiting Klein-Gordon relativistic quantum equation for spin-0 particles, we predicted that ħ reverses its sign for negative energies. We formulated a universal symmetry rule, whereby all the parameters that couple particles to external fields reverse their sign along with ħ at a particle↔antiparticle transformation. This in particular implies anti-gravitation between matter and antimatter.
    Our results suggest that the ħ-conjugation principle and related invariance may replace CPT-invariance in general relativistic quantum mechanics.
    Lecture
  • Date:16ThursdayNovember 2017

    Theory and modeling of correlated ionic and electronic motions in hybrid organic-inorganic perovskites

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    Time
    11:00 - 12:00
    Location
    Perlman Chemical Sciences Building
    LecturerProf. Andrew Rappe
    Dept. of Chemistry, Pennsylvania
    Organizer
    Department of Molecular Chemistry and Materials Science
    Contact
    AbstractShow full text abstract about The perovskite crystal structure hosts a wealth of intriguin...»
    The perovskite crystal structure hosts a wealth of intriguing properties, and the renaissance of interest in halide (and hybrid organic-inorganic) perovskites (HOIPs) has further broadened the palette of exciting physical phenomena. Breakthroughs in HOIP synthesis, characterization, and solar cell design have led to remarkable increases in reported photovoltaic efficiency.

    However, the observed long carrier lifetime and PV performance have eluded comprehensive physical justification. The hybrid perovskites serve as an enigmatic crossroads of physics. Concepts from crystalline band theory, molecular physics, liquids, and phase transitions have been applied with some success, but the observations of HOIPs make it clear that none of these conceptual frameworks completely fits. In this talk, recent theoretical progress in understanding HOIPs will be reviewed and integrated with experimental findings. The large amplitude motions of HOIPs will be highlighted, including ionic diffusion, anharmonic phonons, and dynamic incipient order on various length and time scales. The intricate relationships between correlated structural fluctuations, polar order, and excited charge carrier dynamics will also be discussed.
    Lecture
  • Date:16ThursdayNovember 2017

    Small-Scale, Highly Precise Tests of the Standard Model and Its Symmetries

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    Time
    11:15 - 12:15
    Location
    Edna and K.B. Weissman Building of Physical Sciences
    LecturerProf. Gerald Gabrielse
    Harvard
    Organizer
    Faculty of Physics
    Contact
    AbstractShow full text abstract about The Standard Model of particle physics is the great success ...»
    The Standard Model of particle physics is the great success and the great frustration of modern physics. It is very surprising that the Standard Model can successfully predict what is measured to up to a part in 10^{12}, and yet be completely unable to explain either why a universe could survive the big bang or why it should be made of matter rather than antimatter. Low energy experiments play a crucial role in testing the Standard Model. The most precise prediction of the Standard Model, for example, was tested with one suspended electron used to make make the most accurate measurement of a property of an elementary particle. The symmetries of the Standard Model can be directly tested by comparing particles and antiparticles. Searches for physics beyond the Standard Model at energy scales at and above LHC energies are carried out by searching for an electric dipole moment of an electron in a polar molecule.
    Colloquia

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