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April 27, 2017
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Date:09ThursdayNovember 2017Lecture
“Targeted metabolic analysis: present and perspectives”
More information Time 09:00 - 10:00Location Max and Lillian Candiotty BuildingLecturer Dr. Alexander Brandis
Department of Life Sciences Core FacilitiesOrganizer Department of Life Sciences Core FacilitiesContact -
Date:09ThursdayNovember 2017Colloquia
Search for new physics at the intensity frontier
More information Time 11:15 - 12:15Location Edna and K.B. Weissman Building of Physical SciencesLecturer TBA Organizer Faculty of PhysicsContact Abstract Show full text abstract about With the discovery at the LHC of the Higgs boson, the main m...» With the discovery at the LHC of the Higgs boson, the main missing block of the Standard Model is now in place. An additional LHC result of great importance is that a large new territory has been explored and no unambiguous signal of New Physics has been found.
However some new particles or interactions are required to explain a number of observed phenomena in particle physics, astrophysics, and cosmology as the neutrino masses, the baryon asymmetry of the universe, the Dark Matter and the cosmological inflation.
So far the experimental efforts have been concentrated on the discovery of new particles with masses at or above the EW scale with sizable couplings with SM particles. Another viable possibility, largely unexplored, is that these new particles are below the EW scale and have not been detected because they interact very feebly with the SM particles.
I will review the current status of the search for these new particles with masses in the MeV-GeV region at beam dump experiments currently running or proposed at CERN.
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Date:12SundayNovember 2017Lecture
CARMENES: Searching for habitable planets around red stars
More information Time 11:00 - 11:00Location Sussman Family Building for Environmental SciencesLecturer Stefan Dreizler
University of Göttingen Institute of AstrophysicsOrganizer Department of Earth and Planetary SciencesContact -
Date:13MondayNovember 2017Colloquia
Life Science Colloquium
More information Time 11:00 - 12:00Title The Secret Life of FGF21Location Dolfi and Lola Ebner AuditoriumLecturer Prof. David Mangelsdorf
The University of Texas Southwestern Medical CenterContact -
Date:13MondayNovember 2017Lecture
Shorter pulses and lower average laser power reduce photodamage during two-photon imaging of microdomain Ca2+ transients in fine astrocyte processes.
More information Time 11:00 - 12:00Location Nella and Leon Benoziyo Building for Biological SciencesLecturer Dr. Martin Oheim
CNRS Saint-Pères Paris Institute for Neurosciences (SPPIN), University Paris DescartesOrganizer Department of Biomolecular SciencesContact -
Date:13MondayNovember 2017Lecture
Shorter pulses and lower average laser power reduce photodamage during two-photon imaging of microdomain Ca2+ transients in fine astrocyte processes.
More information Time 11:00 - 12:00Location Nella and Leon Benoziyo Building for Biological SciencesLecturer Dr. Martin Oheim
CNRS Saint-Pères Paris Institute for Neurosciences (SPPIN), University Paris DescartesOrganizer Department of Biomolecular SciencesContact -
Date:13MondayNovember 2017Lecture
Epigenetic strategies to overcome chemoresistance and to radiosensitize cancers
More information Time 14:00 - 15:00Title Special Guest SeminarLocation Max and Lillian Candiotty BuildingLecturer Prof. Elizabeth Martinez
Department of Pharmacology, Hamon Center for Therapeutic Oncology, Research, UT Southwestern Medical Center, Dallas, USAOrganizer Department of Immunology and Regenerative BiologyContact -
Date:13MondayNovember 2017Lecture
Wicked problem at Kruger National Park - Elephant conservation, loss of tall trees and bush encroachment
More information Time 14:00 - 14:00Location Nella and Leon Benoziyo Building for Biological SciencesLecturer Dr. Izak Smit
South African National Parks & University of the Witwatersrand, South AfricaOrganizer Department of Plant and Environmental SciencesContact -
Date:14TuesdayNovember 2017Lecture
Epistasis, pleiotropy, the ruggedness of fitness landscape, and the Predictability of RNA virus evolution
More information Time 10:00 - 11:00Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Prof. Santiago Elena
Institute for Molecular and Cellular Plant Biology (CSIC), Valencia, SpainOrganizer Azrieli Institute for Systems BiologyContact -
Date:14TuesdayNovember 2017Lecture
The Fellowships of the Rings: evolution and biosynthesis of circular peptides
More information Time 10:00 - 11:00Location Nella and Leon Benoziyo Building for Biological SciencesLecturer Dr. Joshua Mylne
School of Molecular Sciences, The University of Western AustraliaOrganizer Department of Biomolecular SciencesContact -
Date:14TuesdayNovember 2017Lecture
Reactivity and applications of novel triazolate-based MOFs with open metal sites
More information Time 11:00 - 12:30Location Helen and Milton A. Kimmelman BuildingLecturer Dr. Yuri Tulchinsky Organizer Department of Molecular Chemistry and Materials ScienceContact -
Date:14TuesdayNovember 2017Lecture
Chemical signals from microalgae that shape communities and structure the marine environment
More information Time 11:30 - 11:30Location Nella and Leon Benoziyo Building for Biological SciencesLecturer Prof. Georg Pohnert
Institute for Inorganic and Analytical Chemistry Bioorganic Analytics, Friedrich-Schiller-Universitat Jena, GermanyOrganizer Department of Plant and Environmental SciencesContact Abstract Show full text abstract about Unicellular algae have established efficient means to intera...» Unicellular algae have established efficient means to interact with other organisms in their environment. Especially chemical signals play an important role in this context. Algal exudates as well as intracellular metabolites can, for instance, influence feeding activity of herbivores and algal / algal interactions. But also communication of algae with the surrounding microbial community is mediated by such chemical signals. Knowledge about the nature of these signal molecules opens up possibilities to investigate their mode of action, the regulation of interactions, and even to manipulate communities. This talk highlights that efficient chemical signaling is often a highly dynamic process that can be switched on and off upon demand. Indeed, surveys based on elaborate mass spectrometric methods confirm that algae exhibit a high plasticity of metabolite production during their development and in interaction situations. This regulation opens up new avenues for the identification of signals and mechanisms of chemically mediated interactions. Using a combination of comparative metabolomics and ecological investigations even dilute signal molecules can be elucidated. In addition, microscopic gradients of metabolites are visualized and mimicked to illustrate how chemical information can structure the otherwise homogeneous aqueous environment of microbes. Overall this talk will introduce novel concepts in marine chemical ecology. -
Date:14TuesdayNovember 2017Lecture
"Binding without folding: Extreme disorder and dynamics in a high-affinity protein complex "
More information Time 14:00 - 15:00Location Helen and Milton A. Kimmelman BuildingLecturer Prof. Benjamin Schuler, Miri Nakar
University of ZurichOrganizer Department of Chemical and Structural BiologyContact Abstract Show full text abstract about Molecular communication in biology is mediated by protein in...» Molecular communication in biology is mediated by protein interactions. According to the current paradigm, the specificity and affinity required for these interactions are encoded in the precise complementarity of binding interfaces. Even proteins that are disordered under physiological conditions or that contain large unstructured regions commonly interact with well-structured binding sites on other biomolecules. We recently discovered the existence of an unexpected interaction mechanism: The two intrinsically disordered human proteins histone H1 and its nuclear chaperone prothymosin α associate in a one-to-one complex with picomolar affinity, but they fully retain their structural disorder, long-range flexibility, and highly dynamic character. Based on the close integration of single-molecule experiments, NMR, and molecular simulations, we obtain a detailed picture of this complex and show that the interaction can be explained by the large opposite net charge of the two proteins without requiring defined binding sites or interactions between specific individual residues -
Date:15WednesdayNovember 2017Lecture
Chemical and Biological Physics Dept Guest Seminar
More information Time 10:00 - 10:00Title Feynman path integral approach to tunnelling timeLocation Gerhard M.J. Schmidt Lecture HallLecturer Dr Alexandra Landsman
Max Planck Institute for the Physics of Complex Systems, GermanyOrganizer Department of Chemical and Biological PhysicsContact Abstract Show full text abstract about The tunnelling time problem is almost as old as quantum mech...» The tunnelling time problem is almost as old as quantum mechanics itself and is a highly debated subject. Time is not a quantum observable, and therefore many conflicting theories have been developed over the decades. Here we present the Feynman path integral (FPI) approach to tunnelling time, and show how it can be used to calculate tunnelling time probability amplitudes. The FPI approach also sheds new light on four best-known definitions of tunnelling times (Buttiker- Landauer, Pollak-Miller, Eisenbud-Wigner, and Larmor), which although derived using very different physical models, can also be represented as different averages using FPI tunnelling time probability amplitudes. Relation between the FPI approach, other tunnelling time definitions and the theory of weak measurement is also reviewed. -
Date:15WednesdayNovember 2017Lecture
G-INCPM Special Seminar - Prof. Amnon Peled, CEO-CSO, Biokine Therapeutics Ltd., Ness-Ziona - "Development of HTS for Novel Chemokine Antagonists"
More information Time 11:00 - 12:30Location Nancy and Stephen Grand Israel National Center for Personalized MedicineLecturer Prof. Amnon Peled
CEO-CSO, Biokine Therapeutics Ltd.Organizer Department of Biomolecular SciencesContact Abstract Show full text abstract about Chemokines and their receptors play critical roles in the pr...» Chemokines and their receptors play critical roles in the progression of autoimmunity and inflammation and cancer. Typically, multiple chemokines are involved in the development of these pathologies. Indeed, targeting single chemokines or chemokine receptors has failed to achieve significant clinical benefits in treating autoimmunity and inflammation. In our work, promiscuous chemokine binding peptides that could bind and inhibit multiple inflammatory chemokines, such as CCL20, CCL2, CCL5, and CXCL9/10/11, were selected from phage display libraries. These peptides were cloned into human mutated immunoglobulin Fc-protein fusions (peptibodies). These peptibodies showed a significant inhibition of disease progression in a variety of animal models for autoimmunity, inflammation and cancer. Based on our peptibodies we develop HTP screening system which allow us the identification of novel anti chemokines small molecules.
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Date:15WednesdayNovember 2017Lecture
Precision searches for new physics using optically levitated microspheres"
More information Time 11:00 - 11:00Location Edna and K.B. Weissman Building of Physical SciencesLecturer David Moore
YALE UNIVOrganizer Department of Particle Physics and AstrophysicsContact Abstract Show full text abstract about High-sensitivity searches for ``fifth forces'' can...» High-sensitivity searches for ``fifth forces'' can test a variety of models of new physics that produce new weakly coupled or short range ( -
Date:15WednesdayNovember 2017Lecture
“Searching for BSM physics with highly charged ions”
More information Time 13:00 - 13:00Location Edna and K.B. Weissman Building of Physical SciencesLecturer Marianna Safronova
UNIV OF DELWAREOrganizer Department of Particle Physics and AstrophysicsContact Abstract Show full text abstract about The modern theories directed toward unifying gravitation wit...» The modern theories directed toward unifying gravitation with the three other fundamental interactions suggest variation of the fundamental constants. While the energy scale of such physics beyond the Standard Model is much higher than that currently attainable by particle accelerators the variation of the fundamental constants may nevertheless be detectable via precision measurements at low energies. I will give an overview of various searches for new physics with atomic clocks and focus on proposals for future experiments with highly charged ions. Proposal for tests of Lorentz symmetry with Yb+ and highly charged ions are also presented. -
Date:15WednesdayNovember 2017Lecture
Chemical and Biological Physics Dept Guest Seminar
More information Time 15:00 - 15:00Title ħ’s sign-reversal for spin-0 particle↔antiparticle transformation: anti-gravity and elimination of CPT-invarianceLocation Perlman Chemical Sciences BuildingLecturer Prof Alexander E. Kaplan
Dept. Chemical and Biological Physics, Weizmann Institute and Dept. Electr. and Comp. Eng., Johns Hopkins University, BaltimoreOrganizer Department of Chemical and Biological PhysicsContact Abstract Show full text abstract about While revisiting Klein-Gordon relativistic quantum equation ...» While revisiting Klein-Gordon relativistic quantum equation for spin-0 particles, we predicted that ħ reverses its sign for negative energies. We formulated a universal symmetry rule, whereby all the parameters that couple particles to external fields reverse their sign along with ħ at a particle↔antiparticle transformation. This in particular implies anti-gravitation between matter and antimatter.
Our results suggest that the ħ-conjugation principle and related invariance may replace CPT-invariance in general relativistic quantum mechanics.
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Date:16ThursdayNovember 2017Lecture
Theory and modeling of correlated ionic and electronic motions in hybrid organic-inorganic perovskites
More information Time 11:00 - 12:00Location Perlman Chemical Sciences BuildingLecturer Prof. Andrew Rappe
Dept. of Chemistry, PennsylvaniaOrganizer Department of Molecular Chemistry and Materials ScienceContact Abstract Show full text abstract about The perovskite crystal structure hosts a wealth of intriguin...» The perovskite crystal structure hosts a wealth of intriguing properties, and the renaissance of interest in halide (and hybrid organic-inorganic) perovskites (HOIPs) has further broadened the palette of exciting physical phenomena. Breakthroughs in HOIP synthesis, characterization, and solar cell design have led to remarkable increases in reported photovoltaic efficiency.
However, the observed long carrier lifetime and PV performance have eluded comprehensive physical justification. The hybrid perovskites serve as an enigmatic crossroads of physics. Concepts from crystalline band theory, molecular physics, liquids, and phase transitions have been applied with some success, but the observations of HOIPs make it clear that none of these conceptual frameworks completely fits. In this talk, recent theoretical progress in understanding HOIPs will be reviewed and integrated with experimental findings. The large amplitude motions of HOIPs will be highlighted, including ionic diffusion, anharmonic phonons, and dynamic incipient order on various length and time scales. The intricate relationships between correlated structural fluctuations, polar order, and excited charge carrier dynamics will also be discussed.
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Date:16ThursdayNovember 2017Colloquia
Small-Scale, Highly Precise Tests of the Standard Model and Its Symmetries
More information Time 11:15 - 12:15Location Edna and K.B. Weissman Building of Physical SciencesLecturer Prof. Gerald Gabrielse
HarvardOrganizer Faculty of PhysicsContact Abstract Show full text abstract about The Standard Model of particle physics is the great success ...» The Standard Model of particle physics is the great success and the great frustration of modern physics. It is very surprising that the Standard Model can successfully predict what is measured to up to a part in 10^{12}, and yet be completely unable to explain either why a universe could survive the big bang or why it should be made of matter rather than antimatter. Low energy experiments play a crucial role in testing the Standard Model. The most precise prediction of the Standard Model, for example, was tested with one suspended electron used to make make the most accurate measurement of a property of an elementary particle. The symmetries of the Standard Model can be directly tested by comparing particles and antiparticles. Searches for physics beyond the Standard Model at energy scales at and above LHC energies are carried out by searching for an electric dipole moment of an electron in a polar molecule.
