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February 01, 2019
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Date:12SundayDecember 2021Lecture
Seminar for PhD thesis defense
More information Time 13:15 - 13:15Title “Defining molecular principles that distinguish the human naïve and primed pluripotent states”Location Zoom: https://weizmann.zoom.us/j/92323030132?pwd=blVMSks1b3dqUHdqbFZTeDBZUXZYZz09 Meeting ID: 923 2303 0132 Password: 487975Lecturer Tom Shani Organizer Department of Molecular GeneticsContact -
Date:13MondayDecember 2021Lecture
Foundations of Computer Science Seminar
More information Time 11:15 - 12:15Title New Diameter Reducing Shortcuts: Breaking the $O(sqrt{n})$ BarrierLocation Jacob Ziskind BuildingLecturer Prof. Merav Parter Organizer Faculty of Mathematics and Computer ScienceContact -
Date:14TuesdayDecember 2021Lecture
To be announced
More information Time 10:00 - 11:00Location Nella and Leon Benoziyo Building for Biological SciencesOrganizer Department of Biomolecular SciencesContact -
Date:14TuesdayDecember 2021Lecture
Membraneless Organelles and Wisdom of the Crowds: Novel Mechanisms Underlying Regulation in Bacteria
More information Time 11:30 - 12:30Location Nella and Leon Benoziyo Building for Biological SciencesLecturer Prof. Orna Amster-Choder
Dept. of Microbiology and Molecular Genomics, The Hebrew UniversityOrganizer Department of Plant and Environmental SciencesContact Abstract Show full text abstract about The poles of rod-shaped bacteria are emerging as a “microBra...» The poles of rod-shaped bacteria are emerging as a “microBrain”, serving as hubs for sensing and regulation. Not only do they contain specific proteins, but we have shown that they contain a unique RNA population, which includes most small regulatory RNAs (sRNA). Upon stress, most sRNAs massively accumulate at the poles with the RNA chaperone Hfq. We have recently provided a proof-of-concept for the existence of a polygenic plan for sRNA-mediated regulation, with the poles providing an arena for its implementation. In my talk, I will show that the mechanism underlying this plan is assembly of Hfq with polar condensates, which a new pole-localizer, TmaR, forms by liquid-liquid phase separation (LLPS). I will further show that this LLPS-driven membraneless polar organelle serves as a hub for regulating various bacterial survival strategies. -
Date:14TuesdayDecember 2021Lecture
Neuron-glia interactions in neurodevelopmental disorders: from basic research to a clinical trial
More information Time 12:30 - 12:30Location Gerhard M.J. Schmidt Lecture HallLecturer Dr. Boaz Barak
School of Psychological Sciences and Sagol School of Neuroscience, Tel Aviv UniversityOrganizer Department of Brain SciencesContact Abstract Show full text abstract about Neuron-glia interactions are key for proper myelination in t...» Neuron-glia interactions are key for proper myelination in the brain and for its functionality. To study neuron-glia interaction roles in brain development we focus on the genetic disorder Williams syndrome (WS). WS is a multisystemic neurodevelopmental disorder caused by a de-novo hemizygous deletion of ~26 genes from chromosome 7q11.23. We previously revealed surprising aberrations in myelination and brain development in a novel mouse model for the hypersociability phenotype associated with WS, as a result of a neuronal deletion of the transcription factor Gtf2i, which is one of the genes deleted in WS. In this talk, I will present our recent findings focused on altered white matter and brain development in WS, and discuss potential molecular and cellular explanations for the neurodevelopmental deficits in WS. Specifically, I will present evidence for mitochondrial dysfunction in neurons, and what are the microglial responses to the resultant myelination deficits. Furthermore, to study the implication of our studies from mouse models on human condition, I will show our new data on the altered epigenome of human frontal cortex tissue from WS compared to controls. Finally, I will present our approaches to develop new therapeutic approaches and will update on our clinical trial focused on ameliorating white matter deficits in WS.
Hybrid seminar
Zoom link:
https://weizmann.zoom.us/j/95406893197?pwd=REt5L1g3SmprMUhrK3dpUDJVeHlrZz09
Meeting ID: 954 0689 3197
Password: 750421
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Date:14TuesdayDecember 2021Lecture
From Molecules to Organs: Bayesian Metamodeling Across Representations and Scales
More information Time 14:00 - 15:00Location Gerhard M.J. Schmidt Lecture HallLecturer Dr. Barak Raveh
School of Computer Science and Engineering The Hebrew University of JerusalemOrganizer Department of Chemical and Structural BiologyContact -
Date:14TuesdayDecember 2021Lecture
Zoom: Embarking on a Thermal Journey in Low Dimensions with a 21st Century Thermometer: Graphene Nonlocal Noise
More information Time 15:00 - 16:00Lecturer Dr. Jonah Waissman
Dept. Physics and Applied Physics, Harvard UniversityOrganizer Department of Molecular Chemistry and Materials ScienceContact Abstract Show full text abstract about Zoom Link: https://weizmann.zoom.us/j/95894806650?pwd=c21JS...» Zoom Link: https://weizmann.zoom.us/j/95894806650?pwd=c21JSFRhcUZaalROaUlBWnh4T25yZz09
Low-dimensional materials, such as 2D monolayers, 1D nanowires, and 0D quantum dots and molecules, are rich with new phenomena. The reduced dimensionality, strong interactions, and topological effects lead to new emergent degrees of freedom of fundamental interest and promise for future applications, such as energy-efficient computation and quantum information. Thermal transport, which is sensitive to all energy-carrying degrees of freedom and their interactions, provides a discriminating probe to study these materials and identify their emergent excitations. However, thermal measurement in low dimensions is dominated by the lattice, requiring an approach to isolate the electronic contribution. In this talk, I will discuss how the measurement of nonlocal voltage fluctuations in a multiterminal device can reveal the electronic heat transported across a low-dimensional bridge. We use 2D graphene as an electronic noise thermometer, demonstrating quantitative electronic thermal conductance measurement over a wide temperature range in an array of dimensionalities: 2D graphene, 1D nanotubes, 0D localized electron chains, and 3D, microscale bulk materials. I will discuss ongoing work revealing electron hydrodynamics, interaction-mediated plasmon hopping, spin waves in a magnetic insulator, and a crossover from phonon to spin transport in a bulk spin liquid candidate material. -
Date:16ThursdayDecember 2021Lecture
AMOS special seminar
More information Time 11:00 - 12:00Title Engineering quantum processors and quantum networks atom-by-atomLocation Edna and K.B. Weissman Building of Physical SciencesLecturer Prof. Hannes Bernien
University of ChicagoOrganizer Crown Photonics CenterContact Abstract Show full text abstract about Reconfigurable arrays of neutral atoms are an exciting new p...» Reconfigurable arrays of neutral atoms are an exciting new platform to study quantum many-body phenomena and quantum information protocols. Their excellent coherence combined with programmable Rydberg interactions have led to intriguing observations such as quantum phase transitions, the discovery of quantum many-body scars, and the recent realization of a topological spin liquid phase. Here, I will introduce new methods for controlling and measuring atom arrays that open up new directions in quantum state control, quantum feedback, and many-body physics. First, I will introduce a dual species atomic array in which the second atomic species can be used to measure and control the primary species. This will lead to the possibility of performing quantum nondemolition measurements and new ways of engineering large, entangled states on these arrays. Furthermore, prospects of studying open systems with engineered environments will be discussed. An alternative, hybrid approach for engineering interactions and scaling these quantum systems is the coupling of atoms to nanophotonic structures in which photons mediate interactions between atoms. Such a system can function as the building block of a large-scale quantum network. In this context, I will present quantum network node architectures that are capable of long-distance entanglement distribution at telecom wavelengths. -
Date:16ThursdayDecember 2021Lecture
High-resolution study of Middle Palaeolithic deposits and formation processes at Tabun Cave, Israel: Guano-rich cave deposits and detailed stratigraphic appreciation of Layer C
More information Time 11:30 - 12:30Location Nella and Leon Benoziyo Building for Biological SciencesLecturer Dr. David Friesem
Department of Maritime Civilizations, School of Archaeology and Maritime Cultures, University of HaifaOrganizer Scientific Archeology UnitHomepage Contact -
Date:16ThursdayDecember 2021Lecture
Glial Metabolic Mechanisms Regulating Axonal Regeneration - Looking Beyond the Neurons
More information Time 14:00 - 15:00Location Max and Lillian Candiotty BuildingLecturer Prof. Oshri Avraham
Department of Neuroscience, Washington University School of MedicineOrganizer Department of Immunology and Regenerative BiologyContact -
Date:19SundayDecember 2021Lecture
Lessons from the past: Climate variability in the Levantine corridor during the Pliocene-Pleistocene transition
More information Time 11:00 - 11:00Location https://weizmann.zoom.us/j/7621438333?pwd=c0lpdlQzYSthellXWG9rZnM0ZDRFZz09Lecturer Nicolas Waldman Organizer Department of Earth and Planetary SciencesContact Abstract Show full text abstract about The study of past warm climates with high atmospheric CO2 co...» The study of past warm climates with high atmospheric CO2 concentrations provides important tools for understanding present trends and developing mitigation strategies for future scenarios. The Pliocene is the last long lasting warm interval characterized by similar global climate circulation patterns and continental settings as today. Reconstructing Pliocene climate change from well-dated geological archives provides valuable insights into the climate forcing and pathways that modulated the transfer of heat and humidity and disentangle regional impacts without anthropogenic influence. To address this challenge, the current presentation shows initial results from a comprehensive study that amalgamates high-resolution multi-proxy analyses from both marine and lacustrine records from the Levant region aiming to provide an important reference for future climate and environment change scenarios under high atmospheric CO2 concentrations. -
Date:19SundayDecember 2021Lecture
Joint DPPA and AMOS Seminar
More information Time 12:30 - 14:00Title Precision searches for new physics using optically levitated sensorsLocation Nella and Leon Benoziyo Physics LibraryLecturer Dr. Gadi Afek
Yale UniversityOrganizer Faculty of PhysicsContact Abstract Show full text abstract about In an attempt to provide further insight into one of the maj...» In an attempt to provide further insight into one of the major questions of physics beyond the standard model, highly sensitive optomechanical sensors are developed utilizing techniques from the field of atomic physics. These sensors are table-top experimental tools offering exquisite control of mechanical, rotational and electrical degrees of freedom of optically levitated ~fg-ng masses in vacuum, enabling unprecedented acceleration and force sensitivities.
I will present two recent searches, the first looking for recoils from passing DM particles and the second for deviations from charge neutrality and so-called "millicharged particles". For certain, well-motivated dark matter models, these searches exceed the sensitivity of even large-scale experiments, thereby offering a complementary approach. I will also discuss possible techniques enabling sensor sensitivity to dark matter in the low-mass regime, where large, existing detectors lack in sensitivity.
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Date:20MondayDecember 2021Colloquia
From cell circuits to collective cell behaviour
More information Time 11:00 - 12:15Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Leah Edelstein-Keshet
Department of Mathematics, University of British Columbia, CanadaOrganizer Faculty of ChemistryHomepage Contact Abstract Show full text abstract about In order for our body to heal and repair injury, cell sheets...» In order for our body to heal and repair injury, cell sheets must move together to seal a gap. To overcome infection, white blood cells need to track down and destroy pathogens. Such processes can only work if cells can "sense" their environment and "decide" to move in the right direction, or else, to coordinate with neighbouring cells. This requires tight control of adhesion between cells, as well as the speed and direction of cell migration. In this talk, I will describe mathematical and computational research on cell migration, both in normal and abnormal (cancer) cells. I will focus mainly on recent "multi-scale" modeling, where we combine our understanding of the "molecular machinery" inside cells, with information about how cells interact with one another. We use this approach to investigate the behaviour of groups of cells. Combining mathematics and computational methods, we can get some insights on cell organization in development and in wound healing, as well as what could go wrong in disease such as cancer. -
Date:21TuesdayDecember 2021Lecture
To be announced
More information Time 10:00 - 10:00Location Nella and Leon Benoziyo Building for Biological SciencesLecturer Vaishnavi Dandavate
Dept. of Biomolecular Sciences - WISOrganizer Department of Biomolecular SciencesContact -
Date:21TuesdayDecember 2021Lecture
Student Seminar
More information Time 11:00 - 12:00Title A spatiotemporally resolved single cell atlas of the Plasmodium liver stageLocation Wolfson Building for Biological ResearchLecturer Amichay Afriat Organizer Department of Molecular Cell BiologyContact Abstract Show full text abstract about Malaria infection involves an obligatory, yet clinically sil...» Malaria infection involves an obligatory, yet clinically silent liver stage. Hepatocytes operate in repeating units termed lobules, exhibiting heterogeneous gene expression patterns along the lobule axis, but the effects of hepatocyte zonation on parasite development have not been molecularly explored. In our work, we combine single-cell RNA sequencing and single-molecule transcript imaging to characterize the host’s and parasite’s temporal expression programs in a zonally-controlled manner for the rodent malaria parasite Plasmodium berghei ANKA. We identify differences in parasite gene expression in distinct zones, and a sub-population of periportally-biased hepatocytes that harbor abortive infections associated with parasitophorous vacuole breakdown. These ‘abortive hepatocytes’ up-regulate immune recruitment and key signaling programs. They exhibit reduced levels of Plasmodium transcripts, perturbed parasite mRNA localization, and may give rise to progressively lower abundance of periportal infections. Our study provides a resource for understanding the liver stage of Plasmodium infection at high spatial resolution and highlights heterogeneous behavior of both the parasite and the host hepatocyte. -
Date:21TuesdayDecember 2021Lecture
Special Guest Seminar
More information Time 11:30 - 12:30Title How a plastidial retrograde signaling metabolite reprograms plant adaptive-responses and developmental networksLocation Benoziyo Bldg. for Biological Sciences Auditorium - Floor 1Lecturer Prof. Katayoon (Katie) Dehesh
Institute of Integrative Genome Biology and Department of Botany and Plant Sciences UC Riverside, USAOrganizer Department of Plant and Environmental SciencesContact -
Date:21TuesdayDecember 2021Lecture
Zoom seminar: The role of noncanonical hippocampal circuits in memory
More information Time 12:30 - 13:30Lecturer Prof. Thomas McHugh
Laboratory for Circuit and Behavioral Physiology RIKEN Center for Brain Science, JapanOrganizer Department of Brain SciencesContact Abstract Show full text abstract about The human hippocampus plays a crucial role in episodic memor...» The human hippocampus plays a crucial role in episodic memory; the who, what, where memories that define our lives. In the rodent, well-defined anatomy and physiology make the structure an ideal model system; amenable to circuit manipulations and observations designed to test hypotheses concerning how memories are formed and used. Here I will present our recent work in mice which combines anatomical characterization, genetic interventions and in vivo recording to address how noncononical inputs and outputs influence information flow in the hippocampus. I will first introduce our study identifying a novelty signaling hub in the hypothalamus – the supramammillary nucleus (SuM). Unique about this region is that it not only responds broadly to novel stimuli, but segregates and selectively routes different types of information to discrete cortical targets, the dentate gyrus (DG) and CA2 fields of the hippocampus, for the modulation of mnemonic processing. Next, I will describe ongoing work focused on how CA2’s output impacts both local and distal circuits, including our identification and characterization of a novel descending glutamatergic projection from CA2 pyramidal cells to PV+ neurons in the MS that can regulate cholinergic tone and hippocampal memory.
Zoom link:
https://weizmann.zoom.us/j/95406893197?pwd=REt5L1g3SmprMUhrK3dpUDJVeHlrZz09
Meeting ID: 954 0689 3197
Password: 750421 -
Date:21TuesdayDecember 2021Lecture
Ubiquitin-proteasome System Contribution to Hypoxia-induced Mitochondria Quality Control
More information Time 14:00 - 15:00Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Michael Glickman
Faculty of Biology, TechnionOrganizer Department of Chemical and Structural BiologyContact -
Date:22WednesdayDecember 2021Lecture
Quantitative Tools for Neuroscience Questions
More information Time 12:30 - 13:30Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Dr. Ari Pakman
Department of Statistics & the Center for Theoretical Neuroscience, Columbia UniversityOrganizer Department of Brain SciencesContact Abstract Show full text abstract about As bigger neuroscience datasets are generated with novel obs...» As bigger neuroscience datasets are generated with novel observation modalities, so grows the need for computational tools to answer basic questions. What different types of neurons exist in a population? How to sort out neurons from their electric activity? How do neurons process information? I will present statistical, machine learning and information-theoretic tools that address such questions. In particular, I will discuss new solutions to the problem of classifying neuron types using genetic markers, amortizing spike-sorting in modern multi-electrode arrays and disentangling the simultaneous presence of synergy and redundancy in neural information processing circuits.
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Date:22WednesdayDecember 2021Lecture
M.Sc thesis: "Computational approach to excited state dynamics at the interfaces of layered transition-metal dichalcogenide heterostructures"
More information Time 15:00 - 16:00Location The David Lopatie Hall of Graduate StudiesLecturer Amir Kleiner Organizer Department of Molecular Chemistry and Materials ScienceContact Abstract Show full text abstract about Single layers of transition metal dichalcogenides are semico...» Single layers of transition metal dichalcogenides are semiconducting 2D materials which present unique electronic, excitonic and spin properties. Heterostructures composed of these materials show highly intriguing excited-state phenomena, along with a large degree of atomistic and structural tunability stemming from the underlying quantum selection rules dominating these phenomena. A predictive understanding of the effect of structural complexity on the nature of excited-state properties and interaction dynamics is crucial in order to design efficient devices for various applications, within the fields of photovoltaics, photocatalytics, optoelectronics, spintronics, and material-based quantum computing. In this research, we propose a study of the electronic and excitonic properties in heterostructures based on layered transition metal dichalcogenides and the role of structural complexities in their time-resolved relaxation mechanisms. For this, we will analyze decay processes induced by excitonic interactions with lattice vibrations, as well as other excitons and charged particles in the crystals. We will utilize predictive, Green’s-function based ab-initio methods implemented through advanced software and apply highly advanced computations using high-performance computing clusters worldwide. We will develop computational models based on these predictive approaches and on our findings to study the underlying mechanisms dominating the involved excitation processes and the light-matter interactions leading to them. Our research will be constantly driven and validated by collaborations with relevant experimental research.