נחשף מנגנון תאי לזיהוי חלבונים שהמבנה שלהם נפרם; עשוי לסלול את הדרך לטיפולים חדשים בסרטן
https://wis-wander.weizmann.ac.il/chemistry/sticking-pin-cancer
https://heb.wis-wander.weizmann.ac.il/chemistry/n-12143
Cells with cancer-causing p53 proteins (red); the genetic material in the cell nuclei is in blue. Left: In the presence of a regular DNAJA2 chaperone, the structure of the p53 proteins is stabilized, so they do not bind with one another and therefore remain scattered throughout the cell. Right: In contrast, in the presence of a DNAJA2 variant without a “hairpin,” the cancer-causing p53 proteins form clusters (red dots) that the cell can recognize and destroy
08/20/2024
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