רקע כללי
The research in the department of Biological Regulation is concentrated on molecular, cellular and physiological studies of processes that collectively control the action of cells, tissues, organs and the entire body. Extensive efforts are directed to the elucidation of the regulators and pathways of the transmission and translation of signals evoked by hormones, as well as growth and death signaling factors. These studies include: (i) characterization of interactions between growth factors, hormones and extra cellular matrix components with specific receptors; (ii) induction and mechanisms of action of programmed cell death, necrosis and cell survival; (iii) mediation of intracellular signaling via second messengers protein kinase cascades or through lipid mediators (iv) mechanisms of angiogenesis and oncogenesis and (v) role of proteases and protein degradation in cellular regulation. The results of these investigations advance our basic understanding of phenomena related to reproduction as well as tumor and vascular biology. In addition, it enables us to develop useful applications that intend to improve patient management.
A diversity of experimental methodologies is used in these projects. In particular unique non invasive methodologies of Magnetic Resonance Imaging (MRI) and Spectroscopy (MRS) are being developed in this department. The research groups include students from life sciences and chemistry, residents, physicians, and guest researchers from Israel and abroad. Several projects have already incorporated clinical assessment of experimental drugs and new diagnostic methods.