Brain Macrophage contributions to CNS pathologies, including MS, Alzheimer and Parkinson disease and Multiple sclerosis (MS)
Collaboration with:
Marco Prinz, University of Freiburg, Germany
Pablo Blinder, TAU, Israel
Reuven Stein, TAU, Israel
Susanne Wolf, MDC, Berlin
Soyon Hong, UCL, London, UK
Kia Movahedi, VIB, Brussels, Belgium
Microglia contributions to brain pathologies
Contributions of perivascular macrophages to brain pathologies
Modules ensuring microglia quiescence and restoration of the microglia ground state following activation, with a particular focus on the IL-10 axis
Contributions of IL-23 producing monocytes to the generation of pathogenic T cells in the MS model EAE
Comparative analysis of HSC-derived engrafted brain macrophages and host microglia in health and disease
development of novel animal models that allow the functional dissection of parenchymal and perivascular brain macrophages
The role CX3C chemokine axis in intercellular communication.
Contributions of Dendritic cell, Macrophages and Monocytes Contributions to Gut Health and Inflammatory Bowel Disease (IBD).
Studying Molecular Cues guiding Mononuclear Phagocyte Differentiation
Definition of monocyte development in physiology and pathophysiology (IBD, obesity)
Study of differentiation of monocytes into tissue macrophages in small and large intestine and blood
Definition of functional conytributions of classical monocyte subsets including neutrophil - and DC- like cells.
Studying Interactions of Macrophages with Sympathetic Nerve System
Collaboration with:
Avraham Yaron, Weizmann Institute
Competitive Fungal commensalism as a therapeutic strategy to curb candidiasis
Collaboration with:
Neta Shlezinger, HU
Bernhard Hube,Leibniz-HKI, Jena, Germany
Petra Bacher, University of Kiel, Germany
