• Prof. Dan Tawfik

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    Evolution and mechanism of enzymes
    Molecular evolution in man-made cell-like compartments.
    Directed evolution of tailor-made hydrolases (esterases, phosphoesterases, organophosphate hydrolases, and amidases) and DNA-modifying enzymes.
    Structure, mechanism and evolution of serum paraoxonases (PONs)
    The role of promiscuity and conformational plasticity in protein evolution.
    Directed evolution of DNA-methyltransferases and DNase inhibitors
    The stability effects of mutations
    Protein evolvability
    Chaperones and protein evolution
  • Picture of Prof. David Tannor

    Prof. David Tannor

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    Control of chemical reactions with tailored femtosecond pulses.
    Laser cooling of molecules.
    Quantum theory of dissipation and chemical reactions in solution.
    Semiclassical theory of reactive scattering.

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  • Picture of Prof. Joel Sussman

    Prof. Joel Sussman

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    3D Structure Funciton Studies or proteins related to Autism
    Collaboration with:  Israel Silman
    3D Structure Fucntions studies of Paraoxonase
    Collaboration with:  Dan Tawfik & Israel Silman
    Application of ultra rapid X-ray diffraction methods to study the enzymatic mechanism of AChE in real time.
    Collaboration with:  Israel Silman
    Structure based drug design studies on AChE and beta-secretase, including studies of complexes with transition state analogs; potential drugs for the treatment of Alzheimer's disease; and snake neurotoxins.
    Collaboration with:  Israel Silman
    X-ray structural analysis and molecular biology studies on proteins from the nervous system, including acetylcholinesterase (AChE), human, torpedo, drosophila, and krait; butyrylcholinesterase; neural cell adhesion proteins with sequence similarity to ACh
    Collaboration with:  Israel Silman
    3D Structure Funciton of proteins related to Gaucher Disease
    Collaboration with:  Tony Futerman & Israel Silman
    Visualization of 3D Protein Structures via new web based tool Proteopedia
    Collaboration with:  Jaime Prilusky & Israel Silman

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  • Picture of Prof. Adi Stern

    Prof. Adi Stern

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    Quantum interference phenomena in the fractional Quantum Hall effect. Electronic transport in strong magnetic fields.
    Non-abelian electronic states - quantum Hall states, topological superconductors and Majorana fermions.
    Fractionalized topological phases - how to construct them, how to measure them, and how to use them for topological quantum computation
    Low density two dimensional electronic systems.
    One dimensional electronic systems - electronic transport in the presence of interactions.
  • Picture of Prof. Victor Steinberg

    Prof. Victor Steinberg

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    Physical hydrodynamics, hydrodynamics of complex fluids, dynamics of single flexible micro-objects (molecules, membranes, etc) in complex fluid flows
    Hydrodynamics of polymer solutions, Elastic turbulence and Turbulent mixing by polymers.
    Hydrodynamics and rheology of complex fluids (vesicle, capsule, worm-like micelle, etc suspensions)
    Dynamics and conformation of single polymer molecule, vesicle, micro-capsule, etc in complex fluid flows.
    Measurement of velocity and vorticity fields by sound scattering in a turbulent flow.
    Convective turbulence in a fluid near the gas-liquid critical point.
    Microfluidics: mixing, cell separation, random flows.
    Development of non-invasive local sensors for measurements of stress field in fluid flow

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  • Picture of Prof. Joel Stavans

    Prof. Joel Stavans

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    Statistical Mechanics
    Single-Molecule Biological Physics.
    RNA interference
    Homologous recombination
    Genetic Networks and Systems Biology
    Regulation of gene expression by small RNAs
    Developmental decision making
    Noise and adaptation

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  • Picture of Prof. Rotem Sorek

    Prof. Rotem Sorek

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    Microbial genomics and systems biology
    CRISPR-Cas, an antiviral microbial defense system
    Interactions between bacteria and phages
    Communication between viruses
    RNA-mediated regulation in bacteria
    Computational discovery of novel natural antimicrobials

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  • Picture of Prof. Uzy Smilansky

    Prof. Uzy Smilansky

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    Mathematical methods for Archaeological research.
    Semi-classical quantization.
    Chaotic scattering.
    Quantum chaos.

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  • Prof. Israel Silman

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    Localization and anchorage to the plasma membrane of acetylcholinestera.
    Regulation of folding and assembly of acetylcholinesterase.
    Three-dimensional structure of acetylcholinesterase and acetylcholinesterase-anticholinesterase complexes.
  • Picture of Prof. Yoram Shechter

    Prof. Yoram Shechter

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    Mechanism of insulin action: Post-binding events in insulin action
    Post-receptor agents mimicking insulin.
    Effect of vanadium <I>in vivo</I> and <I>in vitro</I>.
    Role of protein tyrosine kinases and protein phosphotyrosine phosphatases in insulin effects.
    Inhibitors of tyrosine kinases.
    Chemical modifications of peptides and protein drugs.
    Novel technologies to prolong life time of peptide and protein drugs.

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