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Prof. Yehiel Zick
Mode of action of galectin-8, a mammalian lectinThe molecular basis of Insulin Resistance: a Phosphorylation based Uncoupling of Insulin SignallingThe insulin receptor as a model system for transmembrane signaling: Mode of interaction of the insulin receptor with its downstream effector molecules.Mammalian lectins as regulators of cell adhesion, cell growth, and apoptosis.Receptor trafficking: Regulation of endocytosis and recycling of the insulin receptor.Role of Galectin-8 in bone remodeling
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Prof. Avi Hofstein
Research and evaluationCollaboration with: R. MamlokFormative and summative of curriculum units that are developed by the chemistry group and the science for all studentsTeachers' and students' perceptions and attitudes towards science and technology.Non science oriented students' conception of key ideas and concept in chemistryThe development of modules for non-science oriented studentsAnalysis of learning difficulties and misconception in chemistry in the Israeli BagrutDevelopment of argumentation skills in inquiry laboratoriesMisconception regarding bonding and structure of moleculesAssessment of students' perception of the chemistry classroom and laboratory learning environmentHigh school chemistry curriculum development and implementationCollaboration with: Rachel mamlok-Naaman,The development and implementation of text books and teachers' guidePreparation of resources and units for the teaching of Industrial chemistry in Israel.Development of new instructional techniques to teach chemistry in high schools.Inquiry type experiments andThe use of internet for instruction.Development of CAI (computer Assisst Instruction)Development of introductory (basic) modules for a new syllabus in high school chemistry. (Development of modules for non-science oriented students in high schools
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Prof. Ed Bayer
Structural and functional aspects of the multi-enzyme cellulosome complex from cellulose-degrading bacteria.The cohesin-dockerin couple - Protein-protein interactions that mediate recognition and specificity in cellulosome assembly.Cellulose-binding domains as models for protein-sugar interactions.Bioinformatics of cellulases and cellulosome componentsComparative genomics of cellulosome components.Structure determination of cellulosome components.Enzymology of cellulosomes for conversion of biomass to biofuelsDesigner cellulosomes - Selective engineering of chimaeric cellulosome constructs for nanotechnology.Avidin-biotin system - Mutated avidins and streptavidins
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Prof. Hadassa Degani
Perfusion and angiogensis in lung cancer: The role of the bronchial and pulmonary vascular network using Fluorescence and magnetic resonance imaging methodsMolecular magnetic resonance imaging of the estrogen receptorCollaboration with: Professors David Milstein and Joel Sussman, Weizmann InstituteSynthesis of new, high affinity ligands of the estrogen receptor as probes for molecular imagingStructuaral studies (x-ray crystalography and NMR) of the estrogen receptor - targeted ligands complexFunctional activities and molecular imaging of the new targeted ligands in estrogen receptor positive huaman breast cancer cellsMechanisms of lymphatic metastasis in breast cancer; In vivo fluorescence and magnetic resonanc imagingAdvanced non invasive MRI methods for breast cancer detection and diagnosis ; clinical investigationsCollaboration with: Dr. Myra Shapiro, Meir medical Center3D Tracking of the mammary tree using diffusion tensor magnetic resonance imagingAdvanced methods for analysis of dynamic contrast enhanced MRI based on a combined model free and model based method.Hyperpolarized magnetic resonance spectroscopy and imaging of cancer metabolism; searching for novel metabolic markers of cancerCollaboration with: Professor Lucio Frydman, Weizmann InstituteRenal function through sodium grandients; Non-invasive, high resolution sodium MRI.Collaboration with: Dr. Edna Haran, Weizmann InstituteEstrogen regulation of angiogenesis and perfusion of breast cancer; from molecular mechanisms to functional MRI of the microvascular physiology
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