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Prof. Abraham Shanzer
Supramolecular chemistryBiomimetic ion binders, diagnostic tools in imaging technologies (fluorescent probes) and potential therapeutic agents. Synthesis, using classical and combinatorial chemistry methods and evaluation.Synthesis and properties of molecular based devices; molecular sensors, switches and logical gates for application in nanotechnology.Surface bound functional assemblies.
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Prof. Zippora Shakked
Crystal structure and solution studies of DNA oligomers.Collaboration with: Donald Crothers (Yale University)DNA regulatory elementsDNA bending by adenine-thymine tractsStructural and biochemical studies of proteins involved in transcriptional regulation.The tumor-suppressor protein p53 and its interaction with DNA and the basal transcription machineryThe leukemia-related RUNX1(AML1) transcription regulator
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Prof. Yechiel Shai
Membrane-protein interaction and molecular recognition within the membrane milieu. Implication to the function and structure of membrane proteins.Assembly and organization of pore forming toxins and ion channels in membranes: Studies with isolated fragments and intact proteins.Molecular mechanism of membrane fusion and its inhibition: Studies with HIV and Sendai Virus.Molecular basis for cell selectivity by cytolytic antimicrobial peptides.
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Prof. Idit Shachar
Analyze the pathway regulateing the survival cascades in Chronic lymphocytic leukemiaCollaboration with: Dr Michal Haran, Kaplan Medical centerFollow the mechanisms controlling homing of immune cells in health and disease.Determine the mechanisms regulating peripheral B cell maturation and survival in health and disease.
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Prof. Menahem Segal
Intracellular calcium and structural/functional plasticity in cultured neurons.Collaboration with: Dr. Eduard KorkotianHuman Embryonic Stem Cells of Fragile X patientsCollaboration with: Prof. Dalit Ben Yosef (TAU)Network activity in cultured neuronsCollaboration with: Professor Elisha Moses (Physics)
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Prof. Michal Schwartz
Brain-immune axis in Health and Diseases; from gene to behaviorCollaboration with: Prof. Ido AmitImmunotherapy to defeat Alzheimer’s diseaseMicrobiome and Alzheimer’s diseaseCollaboration with: Prof. Eran ElinavDiabetes as a risk factor in Alzheimer’s diseaseCollaboration with: Prof. Naomi Habib, Hebrew University; Prof. Anna Greka, Broad Institute, Boston, USA.The Spleen –Brain axis in Alzheimer’s diseaseFamilial Alzheimer’s diseaseCollaboration with: Prof. Judit Aaron, Rambam hospital; Prof. Falik, Hagalil Hospital.ALS profiling at the transcriptomic levelCollaboration with: Prof. Ido AmitImmuno-Proteasome in Alzheimer’s diseaseCollaboration with: Dr. Yifat Marbl
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Prof. Oren Schuldiner
A genetic dissection of developmental axon regenerationMolecular mechanisms of neuronal remodeling during development: Developmental axon pruning in DrosophilaThe role of cell-cell interaction in regulating developmental axon pruningThe role of intracellular signaling in regulating developmental axon pruningThe role of trafficking in regulating developmental axon pruningGlia and their effect on neuronal growth and remodeling
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