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Prof. Eytan Domany
Computational Physics: equilibrium and non-equilibrium statistical mechanics of spin glassesCollaboration with: A. P. Young (UCSC)Development of tools and algorithms for large scale data analysis. Bioinformatics.Analysis of high-throughput biological data (in particular, gene expression data)Collaboration with: Several research groups at Weizmann, in the USA and in Europe; see below.Controlled experiments on cell lines and mice (with D. Givol, V. Rotter, Y. Groner, L. Sachs; D. Gazit (Hadassa))Development of antigen chips, applications for autoimmune diseases (with I. Cohen)Studies human cancer samples; leukemia (with E. Canaani; G. Rechavi S. Izraeli (Sheba))Colorectal cancer; (with D. Notterman (UMDNJ), F. Barany (Cornell), P. Paty (MSK), A. Levine (Princeton))Prostate cancer; (with Z. Eshhar, A. Orr (TA Sourasky));Glioblastoma; (with M. Hegi, R. Stupp (CHUV))Breast and cervical cancer (with J-P Thiery, F. Radvanyi, X. Sastre, C. Rosty (Inst Curie))
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Prof. Rivka Dikstein
Transcription and translation control in health and diseaseCollaboration with: Yuki Yamaguchi, Idit Shachar, Nahum Sonenberg, Yuri Svitkin, Franck Martin, Katsura Asano, Igor Ulitsky, Michael Walker, Neta Regev-RudskyMechanism of rapid transcriptional induction of inflammatory genesThe transcription elongation factor Spt4/Spt5 as a drug target in neurodegenerative diseasesLinks between mammalian transcription and mRNA translationDeveloping pharmacological tools to address fundamental questions in mRNA translation and for therapeutic purposesMechanism of start site selection in transcription and translation and its role in cancer and neurodegenerative diseases
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Prof. Nava Dekel
Molecular characterization of the ovulatory cascadeMechanisms involved in successful implantation.Regulation of the meiotic cell cycle: use of rodent oocytes as a model system.Cell-to-cell communication: regulation of expression, posttranslational modification, degradation and function of the gap junction proteins, Cx43 and Cx37.
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Prof. Hadassa Degani
1. Advancements in pancreas MRICollaboration with: Dr. Talia Golan and her team, Sheba Medical CenterDeveloping a diffusion tensor imaging (DTI) protocol to characterize the normal ductal system of the pancreasDeveloping DTI and complementary methods that characterize malignant transformation in the pancreas2.The origin and characterization of water diffusion in tissues - at high b-valuesCollaboration with: Dr. Edna Haran,developing MRI-optimized protocols and analysis means for measuring water diffusion in tissues (breast, brain etc. ) using multi-b- values spanning a broad range.
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Prof. Irun R. Cohen
Development and clinical applications of an antigen microarray device and informatics analyses aimed at diagnosis, prognosis, monitoring and management of autoimmune and other inflammatory diseases – the ImmunArray Ltd iCHIP (Israel and USA); now in clinical use.Treatment of inflammatory bowel disease, arthritis and other autoimmune conditions using DNA plasmids encoding human HSP90 or HSP70 – Alma Bio Therapeutics (France).Treatment of ALS using a synthetic peptide that inhibits apoptosis and fosters cell growth – Immunity Pharma Ltd. (Israel); entering clinical trials.
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Prof. David Cahen
Sustainable Materials- Solar EnergyCollaboration with: @WIS: S. Cohen, G. Hodes, L. Kronik, L Houben, D. Oron; A. Kahn (Princeton); M. Bär (Helmholtz Centre Berlin, HZB and Erlangen); H. Bolink (Valencia);P. Nayak (TIFR-H); S Avashti (IISc); H. Ishii (Chiba); P. Schultz, JF. Guillemoles (IPVF-CNRS); T. Kirchartz (Duisburg-Jülich).sustainable resources Self-healing materials & concepts; New optoelectronic materials; Halide Perovskites; Between hard and soft matter.BioelectronicsCollaboration with: @ WIS: M. Sheves, I. Pecht M. Tornow (TU-Munich); G. Vattya (Budapest); J. Blumberger (Imp. College); L. Zotti (Sevilla); JC Cuevas (Madrid); H. Chen (Zhejiang U);Quantum effects in BIology Proteins as solid-state electronic materials; Electronic charge transport in and across proteins; Biomolecular electronics; Between soft & hard matter.
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