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Prof. Yosef Shaul
The molecular basis of virus-host cell interaction. How HBV modifies cell behavior.Collaboration with: Charles Rice the Rockefeller universityproteasomes as a target in cancer therapyproteasome composition, dynamics, function and regulation and various conditions.proteasomal degradation of intrinsically disordered proteins (IUP or IDP). the concept of degradation by default
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Prof. Michal Sharon
Studying large protein complexes involved in the protein degradation pathway using a novel mass spectrometry approach.Developing novel methodological approaches for structural mass spectrometryStructure-function relationship of the signalosome complexInvestigation of the 20S ubiquitin-independent degradation pathway
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Prof. Abraham Shanzer
Supramolecular chemistryBiomimetic ion binders, diagnostic tools in imaging technologies (fluorescent probes) and potential therapeutic agents. Synthesis, using classical and combinatorial chemistry methods and evaluation.Synthesis and properties of molecular based devices; molecular sensors, switches and logical gates for application in nanotechnology.Surface bound functional assemblies.
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Prof. Zippora Shakked
Crystal structure and solution studies of DNA oligomers.Collaboration with: Donald Crothers (Yale University)DNA regulatory elementsDNA bending by adenine-thymine tractsStructural and biochemical studies of proteins involved in transcriptional regulation.The tumor-suppressor protein p53 and its interaction with DNA and the basal transcription machineryThe leukemia-related RUNX1(AML1) transcription regulator
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Prof. Yechiel Shai
Membrane-protein interaction and molecular recognition within the membrane milieu. Implication to the function and structure of membrane proteins.Assembly and organization of pore forming toxins and ion channels in membranes: Studies with isolated fragments and intact proteins.Molecular mechanism of membrane fusion and its inhibition: Studies with HIV and Sendai Virus.Molecular basis for cell selectivity by cytolytic antimicrobial peptides.
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