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Prof. Abraham Shanzer
Supramolecular chemistryBiomimetic ion binders, diagnostic tools in imaging technologies (fluorescent probes) and potential therapeutic agents. Synthesis, using classical and combinatorial chemistry methods and evaluation.Synthesis and properties of molecular based devices; molecular sensors, switches and logical gates for application in nanotechnology.Surface bound functional assemblies.
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Prof. Zippora Shakked
Crystal structure and solution studies of DNA oligomers.Collaboration with: Donald Crothers (Yale University)DNA regulatory elementsDNA bending by adenine-thymine tractsStructural and biochemical studies of proteins involved in transcriptional regulation.The tumor-suppressor protein p53 and its interaction with DNA and the basal transcription machineryThe leukemia-related RUNX1(AML1) transcription regulator
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Prof. Yechiel Shai
Membrane-protein interaction and molecular recognition within the membrane milieu. Implication to the function and structure of membrane proteins.Assembly and organization of pore forming toxins and ion channels in membranes: Studies with isolated fragments and intact proteins.Molecular mechanism of membrane fusion and its inhibition: Studies with HIV and Sendai Virus.Molecular basis for cell selectivity by cytolytic antimicrobial peptides.
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Prof. Dan Shahar
Physics of electron's spinQuantum phase transitions: General transport studies and mesoscopics of the metal-insulator, superconductor-insulator and other transitions.Scanning tunneling experiments at ultra-low temperaturesFractional and integer quantum Hall effect and related phenomena.Experiments on materials at ultra low-temperatures.
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Prof. Idit Shachar
Analyze the pathway regulateing the survival cascades in Chronic lymphocytic leukemiaCollaboration with: Dr Michal Haran, Kaplan Medical centerFollow the mechanisms controlling homing of immune cells in health and disease.Determine the mechanisms regulating peripheral B cell maturation and survival in health and disease.
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Prof. Michael Sela
Importance of negligible amounts of a partner in antibody combinationsAn aptamer strategy to target oncogenic signaling in ErbB2 carrying human tumors.Collaboration with: G. Mahlknecht , Y. Yarden G. MahlknechtSynergy of antibodies towards decreasing pancreatic cancer.Collaboration with: R. Maron, B. Schechter, Y. YardenTowards vaccination: Generation of peptide mimotopes specific for anti ErbB-2 monoclonal antibodies.Collaboration with: E. Witsch, Y. YardenMechanism of action of Copolymer 1 (Copaxone), a therapeutic vaccine against multiple sclerosis.Collaboration with: R. ArnonEffective synergism by anti ErbB-2 mAb combinations comprising one mAb against the dimerization site of ErbB-2.Collaboration with: Y. YardenMonoclonal antibodies (mAbs) to ErbB-1 and ErbB-2 receptors and their role in potential anti-tumor strategy.Collaboration with: B. Schechter, Y. YardenSynergistic effects of combinations of mAb against distinct epitopes on EGFR/ErbB-1 and ErbB-2 receptors: accelerated receptor aggregation, down regulation and inhibition of tumor growth.Collaboration with: B. Schechter, Y. Yarden
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Prof. Rony Seger
The nuclear translocation of signaling protein as a drug target for cancer and inflammationThe nuclear translocation of ERKThe nuclear translocation of JNK and p38Develop peptide inhibitors of the nuclear translocation of ERK/JNK/p38 for the cure of cancer and inflammationDevelopment of small molecular weight inhibitors of the nuclear translocation of ERK for the cure of cancerThe subcellular localisation of AKTThe mechanisms and roles of MEK nuclear translocationERK1c in the regulation of Golgi fragmentationThe mechanisms of golgi translocation of ERK1cSubstrates of ERK1c in the GolgiMechanism of ERK1c-regulated Golgi architecture
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