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Prof. Avi Hofstein
Research and evaluationCollaboration with: R. MamlokFormative and summative of curriculum units that are developed by the chemistry group and the science for all studentsTeachers' and students' perceptions and attitudes towards science and technology.Non science oriented students' conception of key ideas and concept in chemistryThe development of modules for non-science oriented studentsAnalysis of learning difficulties and misconception in chemistry in the Israeli BagrutDevelopment of argumentation skills in inquiry laboratoriesMisconception regarding bonding and structure of moleculesAssessment of students' perception of the chemistry classroom and laboratory learning environmentHigh school chemistry curriculum development and implementationCollaboration with: Rachel mamlok-Naaman,The development and implementation of text books and teachers' guidePreparation of resources and units for the teaching of Industrial chemistry in Israel.Development of new instructional techniques to teach chemistry in high schools.Inquiry type experiments andThe use of internet for instruction.Development of CAI (computer Assisst Instruction)Development of introductory (basic) modules for a new syllabus in high school chemistry. (Development of modules for non-science oriented students in high schools
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Prof. Ed Bayer
Structural and functional aspects of the multi-enzyme cellulosome complex from cellulose-degrading bacteria.The cohesin-dockerin couple - Protein-protein interactions that mediate recognition and specificity in cellulosome assembly.Cellulose-binding domains as models for protein-sugar interactions.Bioinformatics of cellulases and cellulosome componentsComparative genomics of cellulosome components.Structure determination of cellulosome components.Enzymology of cellulosomes for conversion of biomass to biofuelsDesigner cellulosomes - Selective engineering of chimaeric cellulosome constructs for nanotechnology.Avidin-biotin system - Mutated avidins and streptavidins
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Prof. Hadassa Degani
Perfusion and angiogensis in lung cancer: The role of the bronchial and pulmonary vascular network using Fluorescence and magnetic resonance imaging methodsMolecular magnetic resonance imaging of the estrogen receptorCollaboration with: Professors David Milstein and Joel Sussman, Weizmann InstituteSynthesis of new, high affinity ligands of the estrogen receptor as probes for molecular imagingStructuaral studies (x-ray crystalography and NMR) of the estrogen receptor - targeted ligands complexFunctional activities and molecular imaging of the new targeted ligands in estrogen receptor positive huaman breast cancer cellsMechanisms of lymphatic metastasis in breast cancer; In vivo fluorescence and magnetic resonanc imagingAdvanced non invasive MRI methods for breast cancer detection and diagnosis ; clinical investigationsCollaboration with: Dr. Myra Shapiro, Meir medical Center3D Tracking of the mammary tree using diffusion tensor magnetic resonance imagingAdvanced methods for analysis of dynamic contrast enhanced MRI based on a combined model free and model based method.Hyperpolarized magnetic resonance spectroscopy and imaging of cancer metabolism; searching for novel metabolic markers of cancerCollaboration with: Professor Lucio Frydman, Weizmann InstituteRenal function through sodium grandients; Non-invasive, high resolution sodium MRI.Collaboration with: Dr. Edna Haran, Weizmann InstituteEstrogen regulation of angiogenesis and perfusion of breast cancer; from molecular mechanisms to functional MRI of the microvascular physiology
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Prof. Michael Elbaum
Cellular Biophysics and Molecular Transport MachinesSingle-molecule manipulations using optical tweezers.Dynamics of DNA uptake into the cell nucleus.Structure and function of the nuclear pore complex (with Z. Reich): application of atomic force microscopy and advanced optical spectroscopies.Anomalous diffusion in polymer networks and living cells (with R. Granek).Organization of forces driving cell movements (with A. Bershadsky): optical force measurements and particle tracking studies; influence of cell biochemistry on biophysical forces.Novel surface-patterning lithographies.
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Prof. David Wallach
Regulation of cell death and tissue damage:Proteins involved in the signaling for the cell-killing (apoptotic and necrotic), immunoregulatory, and inflammatory functions of cytokines of the tumor necrosis factor (TNF) family, and in the regulation of these functions.In vivo models for the functions of the signaling mechanisms activated by ligands of the TNF family and for their pathological aberrations.Natural antagonists to ligands of the TNF family, for protection against the deleterious effects of these cytokines in autoimmune and infectious diseases.Regulation of the activity of the NF kappa B transcription factors.The caspases, their functions and mechanisms of activation.Molecular mechanisms for chronic inflammatory skin diseases.Contributions of aberrations in the function of signaling proteins activated by ligands of the TNF family to cancercancer-cells' survival factors
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Prof. Ilan Koren
The twilight zone - convective clouds and their interaction with the free atmosphereCollaboration with: NOAA-ESRL Boulder CO.Anthropogenic Effects on Clouds and Precipitation and the Derived Climate ForcingCollaboration with: NASA-GSFC, UMBCCloud microphysics and dynamicsCloud classification and cloud textures and morphology
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