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Prof. Menachem Rubinstein
Role of FABP4 in ER stress - imlications in the metabolic syndromeCollaboration with: Rinat OZCytokine receptors and binding proteinsCollaboration with: D. NovickLDL receptor as a cellular virus entry portCollaboration with: Danit Finkelshtein-Beker, Ariel Werman, Daniela NovickRegulation and role of endoplasmic reticulum stress in cell survival and cell deathCollaboration with: Efrat Dvash, Rina Vasserman, Ofir Meir, Chiara Riganti (University of Turin, Italy).Role of MGST2 in DNA damage and cell deathRole of MGST2 in chemotherapy-triggered cell deathRole of C/EBP beta in drug resistance of tumor cells
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Prof. Israel Rubinstein
Functional NanomaterialsCollaboration with: Dr. Alexander VaskevichSelf-assembled nanostructures on surfacesOligonucleotide layers on surfacesNanoplasmonic systems: Basic studies and sensing applicationsApplication of localized surface plasmon resonance (LSPR) spectroscopy to the study of metal oxidation and corrosion (with E. Sabatani, A. Tesler)Electromagnetic resonances in high-n dielectric particlesElectroless deposition of shape-controlled nanostructures (with F. Münch)
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Prof. Varda Rotter
Molecular mechanisms controlling the expression of p53 in normal cells and its deregulation in cancer cellsInvolvement of p53 in cell differentiation and apoptosis: <I>in vivo</I> and in vitro models.Cellular proteins that specifically complex with the p53 protein.Cellular proteins that are induced upstream or downstream to the p53 protein following genotoxic stress.
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Prof. Vered Rom-Kedar
Hamiltonian systems - theory and applicationsCollaboration with: M. Radnovic, A. Rapoport, E. Shlizerman, D. TuraevNear-integrable systemsThe Boltzmann ergodic hypothesis and soft billiards.Chaotic scattering.Resonant surface waves.Perturbed nonlinear Schrodinger equation.Mathematical models of the hematopoietic system and their medical implicationsCollaboration with: R. Malka, E. Shochat.Chaotic mixing of fluid flowsCollaboration with: R. Aharon, H. Gildor
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Dr. Michal Rivlin
Mechanisms underlying direction selectivity in the retinaComputations in retinal circuits and their adapting mechanismsConnectivity pattern between retinal neurons and their targetsVisual processing along the visual pathway and interpretation of retinal adaptation by retinal targetsRetinal function in pathological stsates
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Prof. Michel Revel
Applications of IL-6 Chimera and Interferon-beta in neurology, hematopoiesis, and oncology.Collaboration with: J. ChebathInterleukin-6 Chimera, a superactivator of the gp130 receptor system: role in nerve myelination, neuroprotection and in the development of neuro-glial cells from embryonic tissues and stem cells.Collaboration with: J. ChebathTransdifferentiation of neural crest cell derived melanoma into myelinating Schwann cell. Genes controlling cell growth, differentiation, melanogenesis and synthesis of myelin proteins.Collaboration with: J. Chebath
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Prof. Yair Reisner
Immature dendritic cells: investigating a novel granule mediated killing mechanism and the therapeutic potential for the prevention of Graft versus Host Disease.Crossing allogeneic and xenogeneic barriers by growing organs in-vivo from embryonic tissues : potential curative approaches for diabetes, hemophilia and lung diseases.Hematopoietic size control: A novel role for coagulation cascade factors in regulating the interplay between dynamic bone structure and long term survival and mobilization of hematopoietic stem cells.Developing a protocol for the production of human central memory CD8 T cells, to induce tolerance in allogeneic stem cell transplantation.Investigating the use of activated CD8 T cells as novel cell therapy for the treatment of autoimmune diseases.Role and mechanism of tolerance induction by activated CD8 T cells: A novel cell therapy for chimerism induction, stem cell transplant engraftment and enhanced Graft versus Lymphoma / Leukemia effect.
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Prof. Orly Reiner
Formation of the brain structure in human is a complex process. One of the most striking features of the human brain is characteristic convolutions. These convolutions are lacking in a severe human brain malformation known as lissencephaly (smooth brain).Identification of genes that are downstream to Lis1 mutation using microarray technology.Study of LIS1 and DCX functions through characterization of protein interactionsAnalysis of the developmental function of LIS1, DCX and Doublecortin-like-kinase using gene targeting in the mouse.Functional Analysis of Genes Involved in Lissencephaly.
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