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Professor Emeritus Zvi Kam
Cellular BiophysicsCollaboration with: Benjamin Geiger, John Sedat, David Agard (UCSF)Quantitative analysis of structural features and dynamic changes in cells using microscope imagingHigh throughput high-definition microscopy application in systems cell biologyAdaptive optics methods applied to thick sample imagingCell level informatics
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Prof. Steffen Jung
Brain Macrophage contributions to CNS pathologies, including MS, Alzheimer and Parkinson disease and Multiple sclerosis (MS)Collaboration with: Marco Prinz, University of Freiburg, Germany Pablo Blinder, TAU, Israel Reuven Stein, TAU, Israel Susanne Wolf, MDC, Berlin Soyon Hong, UCL, London, UK Kia Movahedi, VIB, Brussels, BelgiumMicroglia contributions to brain pathologiesContributions of perivascular macrophages to brain pathologiesModules ensuring microglia quiescence and restoration of the microglia ground state following activation, with a particular focus on the IL-10 axisContributions of IL-23 producing monocytes to the generation of pathogenic T cells in the MS model EAEComparative analysis of HSC-derived engrafted brain macrophages and host microglia in health and diseasedevelopment of novel animal models that allow the functional dissection of parenchymal and perivascular brain macrophagesThe role CX3C chemokine axis in intercellular communication.Contributions of Dendritic cell, Macrophages and Monocytes Contributions to Gut Health and Inflammatory Bowel Disease (IBD).Studying Molecular Cues guiding Mononuclear Phagocyte DifferentiationDefinition of monocyte development in physiology and pathophysiology (IBD, obesity)Study of differentiation of monocytes into tissue macrophages in small and large intestine and bloodDefinition of functional conytributions of classical monocyte subsets including neutrophil - and DC- like cells.Studying Interactions of Macrophages with Sympathetic Nerve SystemCollaboration with: Avraham Yaron, Weizmann InstituteCompetitive Fungal commensalism as a therapeutic strategy to curb candidiasisCollaboration with: Neta Shlezinger, HU Bernhard Hube,Leibniz-HKI, Jena, Germany Petra Bacher, University of Kiel, Germany
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Prof. Ernesto Joselevich
Nanotubes and Nanowires: From Self-Organization to Functional NanosystemsNanometer-scale materials can have unique properties due to their reduced dimensions, and serve as building blocks for the assembly of miniature functional systems. In macroscopic functional systems, wires, tubes and rods play critical roles of transporting energy, forces, matter and information. Which materials could play analogous roles at the smallest possible scale? How does the reduced dimensionality determine the properties of molecular wires? How can they be organized and integrated into functional systems?Our research focuses on the organization of one-dimensional nanostructures, such as carbon nanotubes, inorganic nanotubes and nanowires, their integration into functional nanosystems (mechanical, electronic, electromechanical, optoelectronic, electromagnetic, thermal, etc.) and their characterization by mechanical, electrical and optical measurements at the nanometer scale.ProjectsGuided growth of horizontal nanowiresEpitaxial approaches to carbon nanotube organizationNon-equilibrium self-organization of complex nanostructuresNanotube torsion and NEMSSurface-directed self-assemblyPolymers as molecular wiresTheory of molecular wires
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Prof. Amnon Horovitz
Linear free energy relationships (LFER) analysis of allosteric transitions in proteins.Analysis of correlated mutations in proteinsCollaboration with: Ron Unger (Bar Ilan University)Allostery in the structure and function of GroEL and CCT chaperonins.Collaboration with: Keith Willison (Imperial College, London); Michal Sharon;Chaperonin-mediated protein folding.Collaboration with: Gilad HaranAnalysis of protein substrate specificity of chaperonins
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Prof. Eran Hornstein
molecular NeurodegenerationRNA and RNA -binding proteins in motor neurons and amyotrophic lateral sclerosis (ALS)Human genetics for neuroscience researchBiomarkers of neurodegenerationMulti-omics and machine learning for biomarkersbiomolecular condensates and stress granules in ALS
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