אוגוסט 03, 2015
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Date:02ראשוןאוגוסט 2015אירועי תרבות
עלילות יחיא בתאילנד
More information שעה 21:00 - 22:30מיקום אולם ע"ש מיכאל וחנה ויקסדף בית צרו קשר -
Date:03שניאוגוסט 2015הרצאה
Co-translational assembly constrains the structure and folding of homomeric proteins
More information שעה 09:30 - 10:30מיקום אולם הרצאות ע"ש גרהרד שמידט
Lecture Hallמרצה Dr. Eviatar Natan
MRC Cambridge University UKמארגן המחלקה למדעים ביומולקולרייםצרו קשר תקציר Show full text abstract about Homomers are pervasive protein complexes in most proteomes t...» Homomers are pervasive protein complexes in most proteomes that involved in all major cellular functions. The three steps in homomer formation are: translation by the ribosome, folding, and assembly into a protein complex. We hypothesize that the relative rates of these three steps are crucial to avoid misassembly in the context of the high nascent chain concentration of the polysome, i.e., the super-complex of multiple translating ribosomes from same mRNA molecule. To examine this, we tested a library of constructs that differ, among other properties, in the N- versus C-terminal position of the assembly (oligomerization) domain. By analyzing the misassembly rates of these constructs in vivo, in vitro and in silico, and by computationally analyzing thousands of native homomers, we show a set of spatiotemporal constraints that act to preserve the integrity of homomers. In conclusion, our results suggest that there has been significant selection in evolution to maintain a balance between translation and assembly. -
Date:04שלישיאוגוסט 2015הרצאה
Solution-Based Electronic Materials: from Flexible Electronics to Cellular Interfaces
More information שעה 11:00 - 12:00מיקום בניין הלן ומילטון קימלמן
Dov Elad Roomמרצה Prof. Myung-Han Yoonמארגן המחלקה לכימיה מולקולרית ולמדע חומריםצרו קשר -
Date:05רביעיאוגוסט 2015הרצאה
G-INCPM Seminar - Dr. Eran Elinav, Dept. of Immunology, Weizmann Institute - "Host Microbiome Interactions in Health and Disease"
More information שעה 11:00 - 12:30מיקום המרכז הישראלי הלאומי לרפואה מותאמת אישית על-שם ננסי וסטיבן גרנד
Auditoriumמרצה Dr. Eran Elinav
The Department of Immunology, Weizmann Instituteמארגן המחלקה למדעים ביומולקולריים
System Biologyצרו קשר תקציר Show full text abstract about The mammalian intestine contains trillions of microbes, a co...» The mammalian intestine contains trillions of microbes, a community that is dominated by members of the domain Bacteria but also includes members of Archaea, Eukarya, and viruses. The vast repertoire of this microbiome functions in ways that benefit the host. The mucosal immune system co-evolves with the microbiota beginning at birth, acquiring the capacity to tolerate components of the community while maintaining the capacity to respond to invading pathogens. The gut microbiota is shaped and regulated by multiple factors including our genomic composition, the local intestinal niche and multiple environmental factors including our nutritional repertoire and bio-geographical location. Moreover, it has been recently highlighted that dysregulation of these genetic or environmental factors leads to aberrant host-microbiome interactions, ultimately predisposing to pathologies ranging from chronic inflammation, obesity, the metabolic syndrome and even cancer. We have identified various possible mechanisms participating in the reciprocal regulation between the host and the intestinal microbial ecosystem, and demonstrate that disruption of these factors, in mice and humans, lead to dysbiosis and susceptibility to common multi-factorial disease. Understanding the molecular basis of host-microbiome interactions may lead to development of new microbiome-targeting treatments.