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January 01, 2013
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Date:24ThursdayMay 2018Lecture
Chemical and Biological Physics Guest Seminar
More information Time 11:00 - 11:00Title Spintronics in hybrid perovskitesLocation Perlman Chemical Sciences BuildingLecturer Prof. Valy Vardeny
Dep. of Physics, University of UtahOrganizer Department of Chemical and Biological PhysicsContact -
Date:24ThursdayMay 2018Colloquia
Tricks and Traps:Low Energy Searches for High Energy Physics
More information Time 11:15 - 12:30Title PHYSICS MEMORIAL COLLOQUIUM IN HONOR OF PROF. MICHA HASSLocation Edna and K.B. Weissman Building of Physical SciencesLecturer Dr. Guy Ron
Hebrew University of JerusalemOrganizer Faculty of PhysicsContact Abstract Show full text abstract about Trapped radioactive atoms and ions have become a standard to...» Trapped radioactive atoms and ions have become a standard tool of the trade
for precision studies of beyond SM physics. decay studies, in particular,
o er the possibility of detecting deviations from standard model predictions
of the weak interaction which signal new physics. These 'precision frontier'
searches are complementary to the high energy searches performed by the
LHC and other high energy/high luminosity facilities.
I will present a general overview of magneto-optical, optical traps, and elec-
trostatic traps, and their use for weak interaction studies. I will further
present the new Hebrew University/Weizmann Institute/NRCN trapping
program (TRAPLAB), recent experimental results, and future plans. -
Date:24ThursdayMay 2018Lecture
Targeting Pancreas Cancer
More information Time 14:00 - 15:00Title Cancer Research ClubLocation Max and Lillian Candiotty BuildingLecturer Prof. David Kelsen
Memorial Sloan Kettering Cancer Center New YorkOrganizer Department of Immunology and Regenerative BiologyContact -
Date:27SundayMay 201828MondayMay 2018Conference
From Photosynthesis to Cancer Therapy
More information Time 08:00 - 08:00Location The David Lopatie Conference CentreChairperson Lilach AgemyHomepage -
Date:27SundayMay 2018Lecture
TBA
More information Time 11:00 - 11:00Location Sussman Family Building for Environmental SciencesLecturer Michal Sela-Adler
Department of Earth and Planetary Sciences Weizmann Institute of ScienceOrganizer Department of Earth and Planetary SciencesContact -
Date:27SundayMay 2018Lecture
Building the pathway for motion vision
More information Time 12:00 - 12:00Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Prof. Claude Desplan
NYU Biology http://www.nyu.edu/projects/desplan/Organizer Department of Molecular GeneticsContact -
Date:28MondayMay 201830WednesdayMay 2018Conference
Biological Physics Days
More information Time 08:00 - 08:00Location Institut Curie, ParisChairperson Efi EfratiOrganizer Clore Center for Biological PhysicsHomepage -
Date:28MondayMay 2018Colloquia
"Engineering by Evolution: Bringing New Chemistry to Life"
More information Time 11:00 - 12:15Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Frances Arnold
Caltech, USAOrganizer Faculty of ChemistryContact -
Date:28MondayMay 2018Lecture
From dragons’ sleep to sliders’ sight: reexamination of reptilian model systems
More information Time 12:30 - 12:30Location Gerhard M.J. Schmidt Lecture HallLecturer Dr. Mark Shein-Idelson
Dept of Neurobiology Faculty of Life Sciences Sagol School for Neuroscience Tel Aviv UniversityOrganizer Department of Brain SciencesContact Abstract Show full text abstract about Throughout the history of neuroscience, a large set of model...» Throughout the history of neuroscience, a large set of model systems has been used for studying a large variety of questions. These model systems were frequently chosen for their unique experimental advantages, but studying them also provided a wider perspective on basic questions: By examining the manifestation of a given biological phenomenon across different species, one could separate the salient or fundamental from the transient or variable. In my talk I will focus on two of our studies in reptiles: sleep in bearded dragons and visual processing in red eared sliders. I will show how we can use turtles for understanding structure function relations in neural circuits and how we can use lizards for exploring the organization of collective activity during sleep. In addition, I will show that such studies provide a new u! nderstanding of the evolution of brain dynamics.
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Date:28MondayMay 2018Lecture
Foundations of Computer Science Seminar
More information Time 14:30 - 16:00Location Jacob Ziskind BuildingLecturer Kevin Leyton-Brown
University of British ColumbiaOrganizer Department of Computer Science and Applied MathematicsContact -
Date:29TuesdayMay 2018Conference
IVS-MRS 2018 Student Conference
More information Time 08:00 - 08:00Location The David Lopatie Conference CentreChairperson Olga KraynisHomepage -
Date:29TuesdayMay 2018Lecture
Pancreatic Cancer Biology & Medicine
More information Time 09:30 - 09:30Location Max and Lillian Candiotty BuildingLecturer Dr. David Tuveson
MD, PhD Cold Spring Harbor LaboratoryOrganizer Department of Molecular Cell BiologyContact -
Date:29TuesdayMay 2018Lecture
How Malaria Parasite Tricks the Immune System
More information Time 10:00 - 10:30Location Nella and Leon Benoziyo Building for Biological SciencesLecturer Dr. Yifat Ofir-Birin
Dept. of Biomolecular Sciences-WISOrganizer Department of Biomolecular SciencesContact Abstract Show full text abstract about Our ability to cure infectious diseases is greatly limited b...» Our ability to cure infectious diseases is greatly limited by a lack of understanding of the way many pathogens evade the human innate immune system. This is indeed the case when it comes to the parasite Plasmodium falciparum (P. falciparum), the leading infectious agent of Malaria, one of the most devastating infectious diseases in humans.
We show that while growing within human red blood cells, the parasites secrete extracellular vesicles containing genomic DNA, RNA and proteins. These vesicles are taken up by human monocytes, the DNA species are then released within the host cytosol leading to cytosolic STING-dependent DNA sensing. Additionally, we provide the evidence that internalization of late stage (trophozoite) P. falciparum-derived vesicles by monocytes prompts the activation of a known master regulator transcription factor, NF-kB. The activated NF-kB is then translocated to the nucleus to induce transcription of a target gene. Our finding opens a new line of investigation concerning the function of the vesicle DNA and RNA cargo components. This newly discovered crosstalk mechanism strongly supports the existence of a 'manipulation strategy' of the host immune environment by the deadly pathogen, P. falciparum parasite.
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Date:29TuesdayMay 2018Lecture
Defining the microglia contributions to lysosomal storage disorders
More information Time 10:30 - 11:00Location Nella and Leon Benoziyo Building for Biological SciencesLecturer Dr. Soo-Min Cho
Members - Dept. of Biomolecular Sciences-WISOrganizer Department of Biomolecular SciencesContact Abstract Show full text abstract about Lysosomal storage disorders (LSD), such as Gaucher disease (...» Lysosomal storage disorders (LSD), such as Gaucher disease (GD) and Niemann–Pick type C (NPC) disease, display neuronal degeneration accompanied by neuroinflammation. In the brain, innate immunity is maintained by microglia, the major myeloid cell population in the CNS. FACS analysis of end stage LSD models showed minor monocyte infiltration indicating that CNS-resident microglia are the major myeloid player in these pathologies. I will further discuss the functional contribution of microglia to LSD pathophysiology based on RNAseq analysis of microglia from various LSD animal models.
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Date:29TuesdayMay 2018Lecture
Live demonstration of Redcap – a new system for working with secure clinical online questionnaires
More information Time 11:00 - 12:00Location Max and Lillian Candiotty BuildingLecturer Dr. Ron Rotkopf
Bioinformatics unit, Life Sciences Core FacilitiesOrganizer Department of Life Sciences Core FacilitiesContact Abstract Show full text abstract about Redcap – a new system for working with clinical online quest...» Redcap – a new system for working with clinical online questionnaires
Hello all,
We would like to bring to your attention that we have recently installed REDCap at
the Weizmann Institute. REDCap is a secure web application for building and
managing online surveys and databases, used by thousands of academic institutions
and hospitals around the world.
Using REDCap, you can easily create online questionnaires or surveys, and collect
responses from your collaborators anywhere, or even from survey participants who
are not logged in. This is particularly useful for clinical projects, but can be used for
any project that requires collecting data from multiple collaborators.
The REDCap interface is user-friendly, and no coding experience is needed to start a
new project and create your own questionnaires.
After the data is collected, it can be exported easily to Excel or any common statistical
packages (e.g. SPSS, SAS, Stata, R).
You can read more about REDCap at https://www.project-redcap.org/
The Weizmann installation of REDCap is at https://redcap.weizmann.ac.il/
If you just want to check it out without registering, a demo version is available (only
from within the institute) at http://demohealth.weizmann.ac.il/.
Do not enter any important/confidential data in the demo version!
If you have any questions, or would like to register to REDCap, please contact
Ron Rotkopf (ron.rotkopf@weizmann.ac.il) at the LSCF Bioinformatics unit.
The demonstration will be held at Candiotty auditorium on Tuesday, May 29th, at 11:00.
Registration is not required, but if you plan to come, please take a minute to answer this
anonymous survey:
http://j.mp/2rtn7a6
The survey was created in Redcap, and we will use it as an example of creating a
questionnaire and collecting data. -
Date:29TuesdayMay 2018Lecture
Enzyme rates in the omics era
More information Time 11:30 - 11:30Title From global characterization to a pivotal case studyLocation Nella and Leon Benoziyo Building for Biological SciencesLecturer Dan Davidi
Prof. Ron Milo’s lab., Dept. of Plant and Environmental Sciences, Weizmann Institute of ScienceOrganizer Department of Plant and Environmental SciencesContact Abstract Show full text abstract about Enzymes determine the rate of most biological processes. Dec...» Enzymes determine the rate of most biological processes. Decades of biochemistry have demonstrated how enzymes vary by orders of magnitude in their kinetic properties. Why are some enzymes faster than others and how are enzyme capacities related to physiological demands? I will talk about the interplay between enzyme kinetics and different evolutionary driving forces in an attempt to unravel which factors constrain and sculpt enzymatic rates. I will then move to examine the relevance of in-vitro kinetics to living systems, asking whether the rates of enzymes are similar between test-tubes and cells, and if not, why this is the case.
Lastly, I will focus on one particular enzyme with lousy kinetics. This enzyme is called Rubisco - the key carboxylating enzyme on the planet, and therefore the gateway into the organic world.
Instead of trying to improve Rubisco by directed evolution approaches, which have largely failed so far, I will describe our ongoing journey to find the best Rubisco Nature has to offer...
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Date:29TuesdayMay 2018Lecture
Synaptic and extrasynaptic neuron-glia interactions
More information Time 12:30 - 13:30Location Gerhard M.J. Schmidt Lecture HallLecturer Prof. Alexey Semyanov
Institute of Neuroscience University of Nizhny Novgorod, RussiaOrganizer Department of Brain SciencesContact Abstract Show full text abstract about Brain is often viewed as large neuronal connectome where the...» Brain is often viewed as large neuronal connectome where the information is encoded in the patterns of action potentials and stored in the changes of synaptic strength or appearance of new wiring routes. However, recent studies have demonstrated that astrocytes also possess complex patterns of calcium signals influenced by neuronal activity. Astrocytic calcium signals regulate various functions of these cells including release of gliotransmitters and morphological changes in the astrocytic processes (Tanaka et al., 2013). It has been tempting to suggest that information in astrocytes is encoded in the frequency of calcium events, similar to patters of neuronal action potentials. Synaptically released neurotransmitters thought to trigger new calcium events in perisynaptic astrocytic processes (PAPs) though activation of metabotropic glutamate receptors (mGluRs). In contrast, our recent findings suggest that PAPs are devoid of calcium stores that are required for mGluR-mediated calcium signaling (Patrushev et al., 2013). This makes unlikely any significant role of mGluRs in triggering calcium events in PAPs. Instead, we show that activation of ‘extrasynaptic’ astrocytic mGluRs increases proportion of spatially extended calcium events in the power-law based distribution of calcium event sizes (Wu et al., 2014). This effect takes place without any significant increase in the frequency of calcium events. These findings suggest that astrocytic response to surrounding neuronal activity is rather encoded in spatial characteristics of their calcium events and fundamentally different from temporal information coding in neurons (e.g. coincidence detection, action potentials sequences etc). Nevertheless, we cannot exclude local ionic changes in PAPs in response to synaptic activity. For example, potassium ions accumulate in the synaptic cleft of glutamatergic synapses during repetitive activity. We have demonstrated that the bulk of these ions is contributed by potassium efflux through postsynaptic NMDA receptors (Shih et al., 2013). Potassium mediated depolarization of presynaptic terminal increases glutamate release probability. Now we have found that accumulation of intracleft potassium during repetitive synaptic activity could also inhibit astrocytic glutamate uptake by depolarizing PAPs. This extends glutamate dwell-time in the synaptic cleft and boosts glutamate spillover effects. -
Date:29TuesdayMay 2018Lecture
Contrary to Dogma: Tau is not a stabilizer of microtubules in the axon
More information Time 13:00 - 13:00Location Arthur and Rochelle Belfer Building for Biomedical ResearchLecturer Prof. Peter W. Baas
Professor, Department of Neurobiology and Anatomy Director, Graduate Program in Neuroscience Drexel University College of Medicine, Philadelphia, USA http://drexel.edu/medicine/About/Departments/Neurobiology-Anatomy/Research/Baas-Lab/Organizer Department of Molecular GeneticsContact -
Date:29TuesdayMay 2018Lecture
Molecular Neuroscience Forum Seminar
More information Time 15:00 - 16:00Title Molecular mechanisms for synaptic control of gene transcriptionLocation Nella and Leon Benoziyo Building for Biological SciencesLecturer Michael R. Kreutz
Leibniz Institute for Neurobiology, Magdeburg and Center for Molecular Neurobiology, ZMNH, HamburgOrganizer Department of Biomolecular SciencesHomepage Contact -
Date:30WednesdayMay 2018Lecture
Nano safety and Education
More information Time 11:00 - 12:00Location Perlman Chemical Sciences BuildingLecturer Prof. Martin Himly
Dept. Of Bio-sciences, University of SalzburgOrganizer Department of Molecular Chemistry and Materials ScienceContact Abstract Show full text abstract about Nanotechnology has reached every-day life. A high number o...»
Nanotechnology has reached every-day life. A high number of all-day products either contain nanomaterials (NMs) or have been processed by nanotechnological work flows. New interactions with other all-day products, i.e. an every-growing number of modern lifestyle products (MLPs), become more and more likely. Moreover, the new generation has a high degree of creativity in using MLPs in different ways potentially resulting in not foreseen interactions of NMs with MLPs during the marketing process. Therefore, an interdisciplinary research project termed Nan-O-Style has been established investigating interactions between NMs in consumer products with substances from daily life with a special focus on MLPs used by adolescents. Furthermore, Nan-O-Style aims at the compilation of an education initiative about nanotechnology including teaching resources and international peer-teaching.
In order to achieve a high variety of perspectives, students from different types of Austrian higher schools (technical/scientific vs. economic vs. artistic) work in close contact with scientists from academia. Due to the within Nan-O-Style acquired competences and the established network between academic scientists, students and educational institutions, the students develop new models for interdisciplinary teaching in mathematical/scientific/technical (MINT) subjects and apply them as best practice examples. We particularly focus on schools with an economic or fashion background which typically have a higher share of girls. A number of pre-scientific projects in nano-technological, nano-biological or nano-educational topics are carried out.
This approach towards interdisciplinary MINT education thus strengthens the profile formation of the Paris Lodron University of Salzburg and further extends to the education of teachers. Previously, the educational EU framework projects www.NanoTOES.eu and www.NanoEIS.eu had been coordinated by Prof. Duschl and his group. Nan-O-Style is based on this background and therefore internationally connected to educational partners in Israel (ORT Moshinsky R&D Center, Tel Aviv, http://en.ort.org.il/), Spain (Nanoeduca, Barcelona, http://nanoeduca.cat/es/inicio/), and Germany (cc-NanoBioNet e.V, Saarbrücken, http://www.nanobionet.de/).
The Duschl group furthermore conducts nanosafety research involving advanced in vitro models of the human lung barrier, including air-liquid interface cultures (1), addressing potential modulations of the immune response towards NMs (2, 3). As allergens may be inhaled simultaneously to nanoparticles they can become part of the protein corona. The group investigates whether this poses a risk for people with an existing allergic condition (4).