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ינואר 01, 2013
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Date:24חמישימאי 2018הרצאה
Chemical and Biological Physics Guest Seminar
More information שעה 11:00 - 11:00כותרת Spintronics in hybrid perovskitesמיקום בניין פרלמן למדעי הכימיהמרצה Prof. Valy Vardeny
Dep. of Physics, University of Utahמארגן המחלקה לפיזיקה כימית וביולוגיתצרו קשר -
Date:24חמישימאי 2018סימפוזיונים
Tricks and Traps:Low Energy Searches for High Energy Physics
More information שעה 11:15 - 12:30כותרת PHYSICS MEMORIAL COLLOQUIUM IN HONOR OF PROF. MICHA HASSמיקום בניין הפיזיקה ע"ש עדנה וק.ב. וייסמןמרצה Dr. Guy Ron
Hebrew University of Jerusalemמארגן הפקולטה לפיזיקהצרו קשר תקציר Show full text abstract about Trapped radioactive atoms and ions have become a standard to...» Trapped radioactive atoms and ions have become a standard tool of the trade
for precision studies of beyond SM physics. decay studies, in particular,
o er the possibility of detecting deviations from standard model predictions
of the weak interaction which signal new physics. These 'precision frontier'
searches are complementary to the high energy searches performed by the
LHC and other high energy/high luminosity facilities.
I will present a general overview of magneto-optical, optical traps, and elec-
trostatic traps, and their use for weak interaction studies. I will further
present the new Hebrew University/Weizmann Institute/NRCN trapping
program (TRAPLAB), recent experimental results, and future plans. -
Date:24חמישימאי 2018הרצאה
Targeting Pancreas Cancer
More information שעה 14:00 - 15:00כותרת Cancer Research Clubמיקום בניין ע"ש מקס ולילאן קנדיוטימרצה Prof. David Kelsen
Memorial Sloan Kettering Cancer Center New Yorkמארגן המחלקה לאימונולוגיה ורגנרציה ביולוגיתצרו קשר -
Date:27ראשוןמאי 201828שנימאי 2018כנסים
From Photosynthesis to Cancer Therapy
More information שעה 08:00 - 08:00מיקום מרכז כנסים על-שם דויד לופאטייושב ראש Lilach Agemyדף בית -
Date:27ראשוןמאי 2018הרצאה
TBA
More information שעה 11:00 - 11:00מיקום בניין משפחת זוסמןמרצה Michal Sela-Adler
Department of Earth and Planetary Sciences Weizmann Institute of Scienceמארגן המחלקה למדעי כדור הארץ וכוכבי הלכתצרו קשר -
Date:27ראשוןמאי 2018הרצאה
Building the pathway for motion vision
More information שעה 12:00 - 12:00מיקום בניין ארתור ורושל בלפר למחקר ביורפואימרצה Prof. Claude Desplan
NYU Biology http://www.nyu.edu/projects/desplan/מארגן המחלקה לגנטיקה מולקולריתצרו קשר -
Date:28שנימאי 201830רביעימאי 2018כנסים
Biological Physics Days
More information שעה 08:00 - 08:00מיקום Institut Curie, Parisיושב ראש Efi Efratiמארגן מרכז לפיזיקה ביולוגית עש קלורדף בית -
Date:28שנימאי 2018סימפוזיונים
"Engineering by Evolution: Bringing New Chemistry to Life"
More information שעה 11:00 - 12:15מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Prof. Frances Arnold
Caltech, USAמארגן הפקולטה לכימיהצרו קשר -
Date:28שנימאי 2018הרצאה
From dragons’ sleep to sliders’ sight: reexamination of reptilian model systems
More information שעה 12:30 - 12:30מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Dr. Mark Shein-Idelson
Dept of Neurobiology Faculty of Life Sciences Sagol School for Neuroscience Tel Aviv Universityמארגן המחלקה למדעי המוחצרו קשר תקציר Show full text abstract about Throughout the history of neuroscience, a large set of model...» Throughout the history of neuroscience, a large set of model systems has been used for studying a large variety of questions. These model systems were frequently chosen for their unique experimental advantages, but studying them also provided a wider perspective on basic questions: By examining the manifestation of a given biological phenomenon across different species, one could separate the salient or fundamental from the transient or variable. In my talk I will focus on two of our studies in reptiles: sleep in bearded dragons and visual processing in red eared sliders. I will show how we can use turtles for understanding structure function relations in neural circuits and how we can use lizards for exploring the organization of collective activity during sleep. In addition, I will show that such studies provide a new u! nderstanding of the evolution of brain dynamics.
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Date:28שנימאי 2018הרצאה
Foundations of Computer Science Seminar
More information שעה 14:30 - 16:00מיקום בניין יעקב זיסקינדמרצה Kevin Leyton-Brown
University of British Columbiaמארגן המחלקה למדעי המחשב ומתמטיקה שימושיתצרו קשר -
Date:29שלישימאי 2018כנסים
IVS-MRS 2018 Student Conference
More information שעה 08:00 - 08:00מיקום מרכז כנסים על-שם דויד לופאטייושב ראש Olga Kraynisדף בית -
Date:29שלישימאי 2018הרצאה
Pancreatic Cancer Biology & Medicine
More information שעה 09:30 - 09:30מיקום בניין ע"ש מקס ולילאן קנדיוטימרצה Dr. David Tuveson
MD, PhD Cold Spring Harbor Laboratoryמארגן המחלקה לביולוגיה מולקולרית של התאצרו קשר -
Date:29שלישימאי 2018הרצאה
How Malaria Parasite Tricks the Immune System
More information שעה 10:00 - 10:30מיקום בניין לביוכימיה על שם נלה וליאון בנוזיומרצה Dr. Yifat Ofir-Birin
Dept. of Biomolecular Sciences-WISמארגן המחלקה למדעים ביומולקולרייםצרו קשר תקציר Show full text abstract about Our ability to cure infectious diseases is greatly limited b...» Our ability to cure infectious diseases is greatly limited by a lack of understanding of the way many pathogens evade the human innate immune system. This is indeed the case when it comes to the parasite Plasmodium falciparum (P. falciparum), the leading infectious agent of Malaria, one of the most devastating infectious diseases in humans.
We show that while growing within human red blood cells, the parasites secrete extracellular vesicles containing genomic DNA, RNA and proteins. These vesicles are taken up by human monocytes, the DNA species are then released within the host cytosol leading to cytosolic STING-dependent DNA sensing. Additionally, we provide the evidence that internalization of late stage (trophozoite) P. falciparum-derived vesicles by monocytes prompts the activation of a known master regulator transcription factor, NF-kB. The activated NF-kB is then translocated to the nucleus to induce transcription of a target gene. Our finding opens a new line of investigation concerning the function of the vesicle DNA and RNA cargo components. This newly discovered crosstalk mechanism strongly supports the existence of a 'manipulation strategy' of the host immune environment by the deadly pathogen, P. falciparum parasite.
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Date:29שלישימאי 2018הרצאה
Defining the microglia contributions to lysosomal storage disorders
More information שעה 10:30 - 11:00מיקום בניין לביוכימיה על שם נלה וליאון בנוזיומרצה Dr. Soo-Min Cho
Members - Dept. of Biomolecular Sciences-WISמארגן המחלקה למדעים ביומולקולרייםצרו קשר תקציר Show full text abstract about Lysosomal storage disorders (LSD), such as Gaucher disease (...» Lysosomal storage disorders (LSD), such as Gaucher disease (GD) and Niemann–Pick type C (NPC) disease, display neuronal degeneration accompanied by neuroinflammation. In the brain, innate immunity is maintained by microglia, the major myeloid cell population in the CNS. FACS analysis of end stage LSD models showed minor monocyte infiltration indicating that CNS-resident microglia are the major myeloid player in these pathologies. I will further discuss the functional contribution of microglia to LSD pathophysiology based on RNAseq analysis of microglia from various LSD animal models.
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Date:29שלישימאי 2018הרצאה
Live demonstration of Redcap – a new system for working with secure clinical online questionnaires
More information שעה 11:00 - 12:00מיקום בניין ע"ש מקס ולילאן קנדיוטימרצה Dr. Ron Rotkopf
Bioinformatics unit, Life Sciences Core Facilitiesמארגן המחלקה לתשתיות מחקר מדעי החייםצרו קשר תקציר Show full text abstract about Redcap – a new system for working with clinical online quest...» Redcap – a new system for working with clinical online questionnaires
Hello all,
We would like to bring to your attention that we have recently installed REDCap at
the Weizmann Institute. REDCap is a secure web application for building and
managing online surveys and databases, used by thousands of academic institutions
and hospitals around the world.
Using REDCap, you can easily create online questionnaires or surveys, and collect
responses from your collaborators anywhere, or even from survey participants who
are not logged in. This is particularly useful for clinical projects, but can be used for
any project that requires collecting data from multiple collaborators.
The REDCap interface is user-friendly, and no coding experience is needed to start a
new project and create your own questionnaires.
After the data is collected, it can be exported easily to Excel or any common statistical
packages (e.g. SPSS, SAS, Stata, R).
You can read more about REDCap at https://www.project-redcap.org/
The Weizmann installation of REDCap is at https://redcap.weizmann.ac.il/
If you just want to check it out without registering, a demo version is available (only
from within the institute) at http://demohealth.weizmann.ac.il/.
Do not enter any important/confidential data in the demo version!
If you have any questions, or would like to register to REDCap, please contact
Ron Rotkopf (ron.rotkopf@weizmann.ac.il) at the LSCF Bioinformatics unit.
The demonstration will be held at Candiotty auditorium on Tuesday, May 29th, at 11:00.
Registration is not required, but if you plan to come, please take a minute to answer this
anonymous survey:
http://j.mp/2rtn7a6
The survey was created in Redcap, and we will use it as an example of creating a
questionnaire and collecting data. -
Date:29שלישימאי 2018הרצאה
Enzyme rates in the omics era
More information שעה 11:30 - 11:30כותרת From global characterization to a pivotal case studyמיקום בניין לביוכימיה על שם נלה וליאון בנוזיומרצה Dan Davidi
Prof. Ron Milo’s lab., Dept. of Plant and Environmental Sciences, Weizmann Institute of Scienceמארגן המחלקה למדעי הצמח והסביבהצרו קשר תקציר Show full text abstract about Enzymes determine the rate of most biological processes. Dec...» Enzymes determine the rate of most biological processes. Decades of biochemistry have demonstrated how enzymes vary by orders of magnitude in their kinetic properties. Why are some enzymes faster than others and how are enzyme capacities related to physiological demands? I will talk about the interplay between enzyme kinetics and different evolutionary driving forces in an attempt to unravel which factors constrain and sculpt enzymatic rates. I will then move to examine the relevance of in-vitro kinetics to living systems, asking whether the rates of enzymes are similar between test-tubes and cells, and if not, why this is the case.
Lastly, I will focus on one particular enzyme with lousy kinetics. This enzyme is called Rubisco - the key carboxylating enzyme on the planet, and therefore the gateway into the organic world.
Instead of trying to improve Rubisco by directed evolution approaches, which have largely failed so far, I will describe our ongoing journey to find the best Rubisco Nature has to offer...
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Date:29שלישימאי 2018הרצאה
Synaptic and extrasynaptic neuron-glia interactions
More information שעה 12:30 - 13:30מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Prof. Alexey Semyanov
Institute of Neuroscience University of Nizhny Novgorod, Russiaמארגן המחלקה למדעי המוחצרו קשר תקציר Show full text abstract about Brain is often viewed as large neuronal connectome where the...» Brain is often viewed as large neuronal connectome where the information is encoded in the patterns of action potentials and stored in the changes of synaptic strength or appearance of new wiring routes. However, recent studies have demonstrated that astrocytes also possess complex patterns of calcium signals influenced by neuronal activity. Astrocytic calcium signals regulate various functions of these cells including release of gliotransmitters and morphological changes in the astrocytic processes (Tanaka et al., 2013). It has been tempting to suggest that information in astrocytes is encoded in the frequency of calcium events, similar to patters of neuronal action potentials. Synaptically released neurotransmitters thought to trigger new calcium events in perisynaptic astrocytic processes (PAPs) though activation of metabotropic glutamate receptors (mGluRs). In contrast, our recent findings suggest that PAPs are devoid of calcium stores that are required for mGluR-mediated calcium signaling (Patrushev et al., 2013). This makes unlikely any significant role of mGluRs in triggering calcium events in PAPs. Instead, we show that activation of ‘extrasynaptic’ astrocytic mGluRs increases proportion of spatially extended calcium events in the power-law based distribution of calcium event sizes (Wu et al., 2014). This effect takes place without any significant increase in the frequency of calcium events. These findings suggest that astrocytic response to surrounding neuronal activity is rather encoded in spatial characteristics of their calcium events and fundamentally different from temporal information coding in neurons (e.g. coincidence detection, action potentials sequences etc). Nevertheless, we cannot exclude local ionic changes in PAPs in response to synaptic activity. For example, potassium ions accumulate in the synaptic cleft of glutamatergic synapses during repetitive activity. We have demonstrated that the bulk of these ions is contributed by potassium efflux through postsynaptic NMDA receptors (Shih et al., 2013). Potassium mediated depolarization of presynaptic terminal increases glutamate release probability. Now we have found that accumulation of intracleft potassium during repetitive synaptic activity could also inhibit astrocytic glutamate uptake by depolarizing PAPs. This extends glutamate dwell-time in the synaptic cleft and boosts glutamate spillover effects. -
Date:29שלישימאי 2018הרצאה
Contrary to Dogma: Tau is not a stabilizer of microtubules in the axon
More information שעה 13:00 - 13:00מיקום בניין ארתור ורושל בלפר למחקר ביורפואימרצה Prof. Peter W. Baas
Professor, Department of Neurobiology and Anatomy Director, Graduate Program in Neuroscience Drexel University College of Medicine, Philadelphia, USA http://drexel.edu/medicine/About/Departments/Neurobiology-Anatomy/Research/Baas-Lab/מארגן המחלקה לגנטיקה מולקולריתצרו קשר -
Date:29שלישימאי 2018הרצאה
Molecular Neuroscience Forum Seminar
More information שעה 15:00 - 16:00כותרת Molecular mechanisms for synaptic control of gene transcriptionמיקום בניין לביוכימיה על שם נלה וליאון בנוזיומרצה Michael R. Kreutz
Leibniz Institute for Neurobiology, Magdeburg and Center for Molecular Neurobiology, ZMNH, Hamburgמארגן המחלקה למדעים ביומולקולרייםדף בית צרו קשר -
Date:30רביעימאי 2018הרצאה
Nano safety and Education
More information שעה 11:00 - 12:00מיקום בניין פרלמן למדעי הכימיהמרצה Prof. Martin Himly
Dept. Of Bio-sciences, University of Salzburgמארגן המחלקה לכימיה מולקולרית ולמדע חומריםצרו קשר תקציר Show full text abstract about Nanotechnology has reached every-day life. A high number o...»
Nanotechnology has reached every-day life. A high number of all-day products either contain nanomaterials (NMs) or have been processed by nanotechnological work flows. New interactions with other all-day products, i.e. an every-growing number of modern lifestyle products (MLPs), become more and more likely. Moreover, the new generation has a high degree of creativity in using MLPs in different ways potentially resulting in not foreseen interactions of NMs with MLPs during the marketing process. Therefore, an interdisciplinary research project termed Nan-O-Style has been established investigating interactions between NMs in consumer products with substances from daily life with a special focus on MLPs used by adolescents. Furthermore, Nan-O-Style aims at the compilation of an education initiative about nanotechnology including teaching resources and international peer-teaching.
In order to achieve a high variety of perspectives, students from different types of Austrian higher schools (technical/scientific vs. economic vs. artistic) work in close contact with scientists from academia. Due to the within Nan-O-Style acquired competences and the established network between academic scientists, students and educational institutions, the students develop new models for interdisciplinary teaching in mathematical/scientific/technical (MINT) subjects and apply them as best practice examples. We particularly focus on schools with an economic or fashion background which typically have a higher share of girls. A number of pre-scientific projects in nano-technological, nano-biological or nano-educational topics are carried out.
This approach towards interdisciplinary MINT education thus strengthens the profile formation of the Paris Lodron University of Salzburg and further extends to the education of teachers. Previously, the educational EU framework projects www.NanoTOES.eu and www.NanoEIS.eu had been coordinated by Prof. Duschl and his group. Nan-O-Style is based on this background and therefore internationally connected to educational partners in Israel (ORT Moshinsky R&D Center, Tel Aviv, http://en.ort.org.il/), Spain (Nanoeduca, Barcelona, http://nanoeduca.cat/es/inicio/), and Germany (cc-NanoBioNet e.V, Saarbrücken, http://www.nanobionet.de/).
The Duschl group furthermore conducts nanosafety research involving advanced in vitro models of the human lung barrier, including air-liquid interface cultures (1), addressing potential modulations of the immune response towards NMs (2, 3). As allergens may be inhaled simultaneously to nanoparticles they can become part of the protein corona. The group investigates whether this poses a risk for people with an existing allergic condition (4).