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אוקטובר 01, 2009
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Date:23חמישידצמבר 2010הרצאה
From Proteins and their Models to Therapy of Autoimmunity and Cancer
More information שעה 15:00 - 15:00מיקום אולם ע"ש דולפי ולולה אבנרמרצה Prof. Michael Sela
Dept. of Immunology WISצרו קשר -
Date:26ראשוןדצמבר 2010הרצאה
"Analysis of aerosol mixing state significance in remote sensing applications and radiative effect assessment"
More information שעה 11:00 - 11:00מיקום בניין משפחת זוסמןמרצה Dr. Yevgeny Derimian
Laboratoire de Optique Atmosphérique, Université de Lille, CNRS, Villeneuve d'Ascq, Franceמארגן המחלקה למדעי כדור הארץ וכוכבי הלכתצרו קשר -
Date:26ראשוןדצמבר 2010הרצאה
"Designing Functional Monomers: From Methodology to Applications"
More information שעה 11:00 - 11:00כותרת Organic Chemistry - Special Departmental Seminarמיקום בניין הלן ומילטון קימלמןמרצה Dr. Roey J. Amir
Department of Materials Research Laboratory UC Santa Barbara, USAמארגן המחלקה לכימיה מולקולרית ולמדע חומריםצרו קשר תקציר Show full text abstract about Abstract: The incorporation of functional monomers that can...» Abstract:
The incorporation of functional monomers that can alter their structure in response to external stimuli opens the way to new and exciting “smart” polymeric materials. The design principles, synthesis and application of several types of monomers with different functionalities and activities will be discussed in detail. Initially, a versatile synthetic strategy, which enables the facile incorporation of cleavable functional monomers into the carbon-carbon backbone of vinyl-based polymers, will be presented. By integrating these cyclic monomers into linear copolymer backbones, well-defined systems with programmable degradation profiles were obtained. Next, the polymerization of vinyl monomers with cleavable enzymatic substrates will be introduced. These water-soluble block copolymers become amphiphilic upon enzymatic activation and undergo self-assemble into colloidal nanostructures. Finally, the use of functional monomers to build trackable dendritic carriers with exceptionally high loading capacity will be discussed. Exciting cell study results that shed light on the fate of both the released payload and the carrier itself in living cells will also be presented. All projects will demonstrate the versatility and modularity of the use of responsive monomers in the bottom-up fabrication of novel polymeric scaffolds.
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Date:26ראשוןדצמבר 2010הרצאה
Review of research conducted by speakers
More information שעה 12:30 - 14:00מיקום בניין הפיזיקה ע"ש עדנה וק.ב. וייסמןמרצה Itay Rabinak, Prof. Eli Waxman מארגן מרכז לאסטרופיסיקה עש נלה וליאון בנוזיוצרו קשר -
Date:26ראשוןדצמבר 2010הרצאה
A switch mechanism from transformation to tumor suppression in the Hippo pathway
More information שעה 13:00 - 13:00מיקום בניין ארתור ורושל בלפר למחקר ביורפואימרצה Rom Keshet
Yosef Shaul's group, Dept. of Molecular Genetics, WISמארגן המחלקה לגנטיקה מולקולריתצרו קשר -
Date:26ראשוןדצמבר 2010הרצאה
Security and flatness
More information שעה 14:00 - 14:00מיקום בניין יעקב זיסקינדמרצה Eugene Gutkin
University of Torunמארגן הפקולטה למתמטיקה ומדעי המחשב -
Date:26ראשוןדצמבר 2010הרצאה
Metabolic Syndrome Research Club
More information שעה 15:00 - 15:00כותרת “The emerging role of autophagy in obesity”מיקום Botnar Auditorium, Belfer Buildingמרצה Prof. Assaf Rudich
Dept. of Clinical Biochemistry Ben-Gurion University , Beer-Shevaצרו קשר -
Date:26ראשוןדצמבר 2010הרצאה
Meeting on the Occasion of the 90th Birthday of Prof. Victor A. Zalgaller
More information שעה 16:00 - 18:00מיקום בניין יעקב זיסקינדמארגן הפקולטה למתמטיקה ומדעי המחשבדף בית צרו קשר -
Date:27שנידצמבר 2010הרצאה
Functional analysis of the regulatory sequences controlling myelin gene expression
More information שעה 09:30 - 09:30מיקום בניין וולפסון למחקר ביולוגימרצה Prof. Alan Peterson
Department of Human Genetics, McGill University Health Center, Montreal, Quebec, Canadaמארגן המחלקה לביולוגיה מולקולרית של התאצרו קשר תקציר Show full text abstract about Closely linked well-conserved cis regulatory modules are ass...» Closely linked well-conserved cis regulatory modules are associated with many myelin genes. A controlled strategy of transgenesis has made it possible to reveal the regulatory functions conferred by many such CRMs and to begin characterizing their fine-structure. Beyond their autonomous regulatory activities, we show that the CRMs associated with the MBP locus influence both the quantitative and qualitative regulatory output of each other in a developmentally contextual manner. Finally, we have integrated these functional observations into a computational approach leading to a systems based network model of oligodendrocyte gene regulation.
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Date:27שנידצמבר 2010הרצאה
Principal Series Representations for some Infinite Dimensional Lie Groups
More information שעה 11:00 - 11:00מיקום בניין יעקב זיסקינדמרצה Joseph A. Wolf
Univ. of California-Berkeleyמארגן הפקולטה למתמטיקה ומדעי המחשב -
Date:27שנידצמבר 2010הרצאה
Genetic dissection of rheumatoid arthritis – the end of the beginning
More information שעה 12:00 - 12:00מיקום בניין ארתור ורושל בלפר למחקר ביורפואימרצה Dr. Katherine Siminovitch
Mount Sinai Hospital Toronto, Ontarioמארגן המחלקה למדעי המוחצרו קשר תקציר Show full text abstract about In this talk I will review the rationale for searching for a...» In this talk I will review the rationale for searching for autoimmune disease susceptibility genes and in particular for genes conferring risk for rheumatoid arthritis(RA). I will then review the current state of knowledge on RA genes and will then focus on one of the few newly-discovered genes (PTPN22) for which we know the disease causal gene variant. This gene encodes a tyrosine phosphatase ,LYP, and I will present recent data from my lab in which we use an animal model to show how the RA-associated PTPN22/LYP variant causes T cell dysfunction that could predispose to autoimmunity. -
Date:27שנידצמבר 2010הרצאה
The hair follicle as a model system to study developmental processes, stem cell regulation and evolutionary change
More information שעה 14:00 - 14:00מיקום בניין ע"ש מקס ולילאן קנדיוטימרצה Dr. David Enshell-Seijffers
CBRC, Harvard Medical School and MGHמארגן המחלקה לאימונולוגיה ורגנרציה ביולוגיתצרו קשר -
Date:27שנידצמבר 2010הרצאה
Dynamics of Vortex filaments in Navier-Stokes and Quantum Fluids
More information שעה 14:15 - 14:15מיקום בניין הפיזיקה ע"ש עדנה וק.ב. וייסמןמרצה Norman Zabusky, WIS מארגן המחלקה לפיזיקה של מערכות מורכבותצרו קשר תקציר Show full text abstract about An over view of the dynamics of vortex filaments ,particular...» An over view of the dynamics of vortex filaments ,particularly the reconnection event. From the mathematical question of existence of finite-time singularity to the practical application of control of decay of antiparallel tubular vortex domains- and the important role of computer simulations to enhance understanding of reconnection and tubulence. Highlights include visualizations and animations of results from macroscopic and microscopic experiments and numerical simulations.
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Date:27שנידצמבר 2010הרצאה
May the optimal candidate win! Optimization under social choice constraints
More information שעה 14:30 - 14:30מיקום בניין יעקב זיסקינדמרצה Ariel Procaccia
Harvard Universityמארגן הפקולטה למתמטיקה ומדעי המחשב -
Date:27שנידצמבר 2010הרצאה
Connectivity and activity of C. elegans locomotion
More information שעה 15:00 - 15:00מיקום בניין לחקר המוח על-שם נלה וליאון בנוזיומרצה Dr. Gal Haspel
National Institute of Neurological Disorders and Stroke, NIHמארגן המחלקה למדעי המוחצרו קשר תקציר Show full text abstract about I study the neuronal basis of locomotion in the nematode C e...» I study the neuronal basis of locomotion in the nematode C elegans. With only 302 neurons in its nervous system, 75 of which are locomotion motorneurons, C. elegans offers a tractable network to study locomotion. In this talk I will describe my research, which uses a neuroethological approach to study both the behavior and the underlying connectivity and activity of neurons and muscle cells. -
Date:27שנידצמבר 2010הרצאה
Meetings at the Frontiers of Science
More information שעה 19:15 - 19:15מארגן יחידת שוהם במכון דוידסוןדף בית צרו קשר -
Date:28שלישידצמבר 2010הרצאה
Development of high affinity leptin antagonists and their eventual use for research and therapy
More information שעה 10:00 - 10:00מיקום בניין וולפסון למחקר ביולוגימרצה Prof. Arieh Gertler
The Hebrew University of Jerusalemמארגן המחלקה למדעים ביומולקולרייםצרו קשר -
Date:28שלישידצמבר 2010הרצאה
Regularity Properties in Free Boundary Problems
More information שעה 11:00 - 11:00מיקום בניין יעקב זיסקינדמרצה Nina Uraltseva
Saint Petersburg State Universityמארגן הפקולטה למתמטיקה ומדעי המחשב -
Date:28שלישידצמבר 2010הרצאה
"Pd-Ligand Controlled Routs to Four Important Classes of Heterocycles from a Single Common Precursor"
More information שעה 11:00 - 11:00כותרת Organic Chemistry - Departmental Seminarמיקום בניין הלן ומילטון קימלמןמרצה Dr. Dmitry Tsvelikhovsky
Department of Chemistry Massachusetts Institute of Technology, USAמארגן המחלקה לכימיה מולקולרית ולמדע חומריםצרו קשר -
Date:28שלישידצמבר 2010הרצאה
The ERG fusion in Prostate Cancer
More information שעה 12:15 - 12:15מיקום בניין וולפסון למחקר ביולוגימרצה Shlomi Madar מארגן המחלקה לביולוגיה מולקולרית של התאצרו קשר תקציר Show full text abstract about Prostate cancer is the most common non-dermatologic malignan...» Prostate cancer is the most common non-dermatologic malignancy in men in the Western world. Recently, a frequent chromosomal aberration fusing androgen regulated TMPRSS2 promoter and the ERG gene (T/ERG) was discovered in prostate cancer. Several studies demonstrated cooperation between T/ERG and other defective pathways in cancer progression. However, the unveiling of more specific pathways in which T/ERG takes part, requires further investigation. Using immortalized prostate epithelial cells we were able to show that T/ERG over-expressing cells undergo an Epithelial to Mesenchymal Transition (EMT), manifested by acquisition of mesenchymal morphology and markers as well as migration and invasion capabilities. These findings were corroborated in vivo, where the control cells gave rise to discrete nodules while the T/ERG-expressing cells formed malignant tumors, which expressed EMT markers. To further investigate the general transcription scheme induced by T/ERG, cells were subjected to a microarray analysis that revealed a distinct EMT expression program, including up-regulation of the EMT facilitators, ZEB1 and ZEB2, and down-regulation of the epithelial marker E-Cadherin. A chromatin immunoprecipitation assay revealed direct binding of T/ERG to the promoter of ZEB1 but not ZEB2. However, T/ERG was able to bind the promoters of the Zeb2 modulators, IL1R2 and SPINT1. This set of experiments further illuminates the mechanism by which the T/ERG fusion affects prostate cancer progression and might assist in targeting T/ERG and its downstream targets in future drug design efforts.