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ינואר 01, 2013
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Date:27רביעייוני 201828חמישייוני 2018כנסים
Frontiers in Laser Sciences
More information שעה 08:00 - 08:00מיקום מרכז כנסים על-שם דויד לופאטייושב ראש Victor Armand Malkaדף בית -
Date:27רביעייוני 2018הרצאה
Hyperion Mass Cytometry Imaging System
More information שעה 09:00 - 11:00מיקום בניין ע"ש מקס ולילאן קנדיוטימרצה Dr. Roberto Spada
Field Application Specialist, Proteomics. Fluidigm Inc.מארגן המחלקה לתשתיות מחקר מדעי החייםצרו קשר -
Date:28חמישייוני 2018סימפוזיונים
The Information Theory of Deep Neural Networks: The statistical physics perspective
More information שעה 11:15 - 12:30מיקום בניין הפיזיקה ע"ש עדנה וק.ב. וייסמןמרצה Naftali Tishby
Hebrew University of Jerusalemמארגן הפקולטה לפיזיקהצרו קשר תקציר Show full text abstract about The surprising success of learning with deep neural networks...» The surprising success of learning with deep neural networks poses two fundamental challenges: understanding why these networks work so well and what this success tells us about the nature of intelligence and our biological brain. Our recent Information Theory of Deep Learning shows that large deep networks achieve the optimal tradeoff between training size and accuracy, and that this optimality is achieved through the noise in the learning process.
In this talk, I will focus on the statistical physics aspects of our theory and the interaction between the stochastic dynamics of the training algorithm (Stochastic Gradient Descent) and the phase structure of the Information Bottleneck problem. Specifically, I will describe the connections between the phase transition and the final location and representation of the hidden layers, and the role of these phase transitions in determining the weights of the network.
Based partly on joint works with Ravid Shwartz-Ziv, Noga Zaslavsky, and Shlomi Agmon.
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Date:01ראשוןיולי 201812חמישייולי 2018כנסים
PHYSICISTS WORKING ON CANCER
More information שעה 08:00 - 08:00מיקום ספרית הפיסיקה על שם נלה וליאון בנוזיויושב ראש Eytan Domanyמארגן הפקולטה לפיזיקהדף בית -
Date:01ראשוןיולי 201812חמישייולי 2018כנסים
PHYSICISTS WORKING ON CANCER
More information שעה 08:00 - 08:00מיקום ספרית הפיסיקה על שם נלה וליאון בנוזיויושב ראש Eytan Domanyמארגן הפקולטה לפיזיקהדף בית -
Date:01ראשוןיולי 201812חמישייולי 2018כנסים
PHYSICISTS WORKING ON CANCER
More information שעה 08:00 - 08:00מיקום ספרית הפיסיקה על שם נלה וליאון בנוזיויושב ראש Eytan Domanyמארגן הפקולטה לפיזיקהדף בית -
Date:01ראשוןיולי 201812חמישייולי 2018כנסים
Physicists working on Cancer
More information שעה 08:00 - 08:00מיקום בניין הפיזיקה ע"ש עדנה וק.ב. וייסמןיושב ראש Hadar Alperמארגן הפקולטה לפיזיקהדף בית -
Date:01ראשוןיולי 2018הרצאה
Microbial Interactions and Climate Reconstructions
More information שעה 11:00 - 11:00מיקום בניין משפחת זוסמןמרצה Prof. Einat Segev
Department of Plant and Environmental Sciences Weizmann Institute of Scienceמארגן המחלקה למדעי כדור הארץ וכוכבי הלכתצרו קשר תקציר Show full text abstract about Micro-algae greatly influence present and past oceans. Recen...» Micro-algae greatly influence present and past oceans. Recently we have come to realize that bacteria interact with micro-algae in various ways, ranging from pathogenicity to mutualism. My research investigates physical and chemical interactions between micro-algae and bacteria across multiple scales; from the chemical crosstalk to the influence these interactions have on the marine environment.
In my talk I will introduce Emiliania huxleyi, the most prevalent micro-alga in modern oceans. I will discuss the role of bacteria as hidden farmers that control the life cycle of algae, determining how fast algae will grow and how fast they will die. I will link laboratory findings to work conducted at sea and demonstrate the importance of these findings in the study of proxies for climate reconstructions.
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Date:01ראשוןיולי 2018הרצאה
Molecular Genetics Departmental Seminars 2017-2018
More information שעה 13:15 - 13:15כותרת "Induction of DNA damage response by a small viral RNA fragment"מיקום בניין ארתור ורושל בלפר למחקר ביורפואימרצה Dr. Karin Broennimann מארגן המחלקה לגנטיקה מולקולריתצרו קשר -
Date:02שנייולי 2018הרצאה
Mediterranean cyclones: impact on climate and dynamics
More information שעה 11:00 - 11:00מיקום בניין משפחת זוסמןמרצה Emmanouil Flaounas
National Observatory of Athensמארגן המחלקה למדעי כדור הארץ וכוכבי הלכתצרו קשר -
Date:03שלישייולי 2018הרצאה
Sensory processing across behavioral and neuromodulatory states
More information שעה 12:30 - 12:30מיקום אולם הרצאות ע"ש גרהרד שמידטמרצה Dr. Yuval Nir
Sagol School of Neuroscience & Sackler School of Medicine Tel-Aviv Universityמארגן המחלקה למדעי המוחצרו קשר תקציר Show full text abstract about "Sensory disconnection" – conditions when the same...» "Sensory disconnection" – conditions when the same sensory stimulus does not reliably affect behavior or subjective experience - is a defining feature of sleep, and similar processes may occur during light anesthesia or during cognitive lapses in wakefulness. What are the changes in brain activity that mediate sensory disconnection? In a series of studies in humans and rodents, we investigate how "disconnected" states affect sensory processing. The first set of studies reveals differences in neuronal responses to identical sensory stimuli across states. We find that in humans, cognitive lapses after sleep deprivation involve attenuated and delayed single-neuron responses in MTL co-occurring with local slow/theta waves. In the auditory domain, we show in both rodents and humans that responses in sleep and light anesthesia are preserved up to A1, challenging the classic "thalamic gating" notion, but robust attenuation occurs later in high-level cortical regions. In addition, sleep affects more strongly responses that require integration over long time intervals, and responses to high-frequency content. The second set of studies investigates the underlying mechanisms, testing the potential role of locus coeruleus-noradrenaline (LC-NE) neuromodulation. In rats, we test how NE signaling affects the probability to wake up from sleep in response to sounds. We establish a new approach for selective in-vivo LC optogenetics by showing effects on spiking activity, evoked sleep-wake transitions, and pupil dilation. Combined LC and auditory stimulation synergistically increases the probability of awakenings beyond independent effects of sound and laser alone, supporting a role for LC-NE activity in mediating sensory responses. We also tested the effects of NE levels on sensory perception and sensory-evoked activity (EEG, fMRI) in awake humans. Pharmacologically manipulating NE levels in double-blind placebo-controlled experiments, we found that NE modulates sensitivity and accuracy of visual perception without significant effects on decision bias (criterion). In addition, NE increased the fidelity of late EEG visual responses, and selectively modulated BOLD fMRI responses in high-order visual cortex, suggesting that NE plays an enabling causal role in visual awareness by affecting late visual processing. -
Date:03שלישייולי 2018הרצאה
MODELING PROTEIN CONFORMATIONAL CHANGES WITH CROSS-LINKS AND SAXS PROFILES
More information שעה 14:00 - 15:00מיקום בניין הלן ומילטון קימלמןמרצה Dr. Dina Schneidman
Hebrew Universityמארגן המחלקה לביולוגיה מבנית וכימיתצרו קשר תקציר Show full text abstract about Proteins generally populate multiple structural states in so...» Proteins generally populate multiple structural states in solution. Transitions between these states are important for function, such as allosteric signaling and enzyme catalysis. Structures solved by X-ray crystallography provide valuable, but static, atomic resolution structural information. In contrast, cross-linking mass spectrometry (XLMS) and small angle X-ray scattering (SAXS) datasets contain information about conformational and compositional states of the system. The challenge lies in the data interpretation since the cross-links in the data often comes from multiple structural states. We have developed a novel computational method that simultaneously uncovers the set of structural states that are consistent with a given dataset (XLMS or SAXS). The input is a single atomic structure, a list of flexible residues, and an experimental dataset. The method finds multi-state models (models that specify two or more co-existing structural states) that are consistent with the data. The method was applied on multiple SAXS and XLMS datasets, including large multi-domain proteins and proteins with long disordered fragments. The applicability of the method extends to other datasets, such as 2D class averages from Electron Microscopy, and residual dipolar couplings. -
Date:04רביעייולי 2018הרצאה
Department of Molecular Genetics seminar for thesis defense
More information שעה 15:00 - 15:00כותרת Ovarian Stem Cell Organization of Their Environmentמיקום בניין ארתור ורושל בלפר למחקר ביורפואימרצה Doreen Ben-Zvi מארגן המחלקה לגנטיקה מולקולריתצרו קשר -
Date:05חמישייולי 2018הרצאה
“2C OR NOT 2C? THE ROLE OF SHORT CHAIN FATTY ACID CATABOLISM IN PSEUDOMONAS AERUGINOSA VIRULENCE AND PATHOGENICITY”
More information שעה 10:00 - 11:00כותרת Host Pathogen Interactions Clubמיקום בניין ע"ש מקס ולילאן קנדיוטימרצה Prof. Martin Welch
University of Cambridge, UKמארגן המחלקה לאימונולוגיה ורגנרציה ביולוגיתצרו קשר -
Date:05חמישייולי 2018הרצאה
Chemical and Biological Physics Special Guest Seminar
More information שעה 11:00 - 12:00כותרת The Distribution of Delay Times in Scattering of Ultra–Short Radiation Pulsesמיקום בניין פרלמן למדעי הכימיהמרצה Prof. Uzy Smilansky
Department of Physics of Complex Systems Weizmann Institute of Scienceמארגן המחלקה לפיזיקה כימית וביולוגיתצרו קשר תקציר Show full text abstract about When an ultra-short pulse of radiation is scattered on a com...» When an ultra-short pulse of radiation is scattered on a complex medium, the emerging radiation pulse is broadened in time. This can be intuitively explained as due to the existence of a large number of paths of varying lengths through which the radiation can traverse the scattering medium. Recently, novel methods to produce ultra-short light pulses were introduced, and they opened a new horizon for experiments were the distribution of delay-times induced by scattering from complex targets can be measured. These developments emphasize the need for theoretical tools to aid planning of new experiments and interpret the measured results. I shall review a general approach for studying the delay-time distribution in both the classical and the quantum (wave) dynamical frameworks. In particular, I shall discuss the delay time distribution in scattering from a random medium where, due to Anderson Localization, there is no classical analogue to this genuine wave phenomenon. -
Date:05חמישייולי 2018סימפוזיונים
Gene Surfing and Survival of the Luckiest
More information שעה 11:15 - 12:30מיקום בניין הפיזיקה ע"ש עדנה וק.ב. וייסמןמרצה David R. Nelson
Lyman Laboratory Harvard Universityמארגן הפקולטה לפיזיקהצרו קשר תקציר Show full text abstract about Range expansions play a crucial role in our evolutionary his...» Range expansions play a crucial role in our evolutionary history and also in human health. Descriptions of stochastic processes similar to Fokker-Planck equations are crucial for understanding the effects of mutations, number fluctuations and selective advantages. Mutations optimally positioned at the front of a growing population can increase their abundance by -
Date:10שלישייולי 2018הרצאה
Algebraic Geometry and Representation Theory Seminar
More information שעה 11:15 - 12:30כותרת Some comments on the lowest degree appearances of representations.מיקום בניין יעקב זיסקינדמרצה Prof. Anthony Joseph
WISמארגן הפקולטה למתמטיקה ומדעי המחשבצרו קשר תקציר Show full text abstract about TBA ...» TBA -
Date:11רביעייולי 2018הרצאה
“Determination of Nanocatalyst Structure “on-the-Fly” by a Neural Network Approach”
More information שעה 11:00 - 12:00מיקום בניין פרלמן למדעי הכימיהמרצה Prof. Anatoly Frenkel
Department of Materials Science and Chemical Engineering, Stony Brook Universityמארגן המחלקה לכימיה מולקולרית ולמדע חומריםצרו קשר תקציר Show full text abstract about Tracking the structure of heterogeneous catalysts under oper...» Tracking the structure of heterogeneous catalysts under operando conditions remains a challenge due to the paucity of experimental techniques that can provide atomic-level information for catalytic metal species. Here we report on the use of X-ray absorption spectroscopy (XANES and EXAFS) and supervised machine learning (SML) for determining the three-dimensional geometry of metal catalysts. Artificial neural network (NN) is used to unravel the hidden relationship between the XANES features and catalyst geometry. In the case of EXAFS, NN is used to obtained the radial distribution function directly from the spectra. Our approach allows one to solve the structure of a metal catalyst from its experimental XANES and EXAFS spectra. These applications are demonstrated by reconstructing the average size, shape and morphology of well-defined platinum nanoparticles1 and monitoring structural changes in bulk Fe during its structural phase transition from BCC to FCC upon heating.2 This method is applicable to the determination of nanomaterial structure in operando studies It also allows on-the-fly analysis, and is a promising approach for high-throughput and time-dependent studies.
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Date:12חמישייולי 2018סימפוזיונים
Students Colloquium
More information שעה 11:15 - 12:30מיקום בניין הפיזיקה ע"ש עדנה וק.ב. וייסמןמרצה Adam Rubin, Gadi Afek, Yehonathan Drori, Dr. Efrat Gerchkovitz
Wizmann Instituteמארגן הפקולטה לפיזיקהצרו קשר -
Date:12חמישייולי 2018הרצאה
Single-molecule Visualization of Long-range Epigenetic Regulation
More information שעה 14:00 - 15:00מיקום בניין ע"ש מקס ולילאן קנדיוטימרצה Prof. Yuval Ebenstein
Department of Physical Chemistry School of Chemistry Tel Aviv Universityמארגן המחלקה לאימונולוגיה ורגנרציה ביולוגיתצרו קשר תקציר Show full text abstract about Epigenetic regulation by DNA methylation is well established...» Epigenetic regulation by DNA methylation is well established in the context of the classical Promoter:Coding box.
Recent genome-wide association studies (GWAS) indicate that the methylation state of distant enhancers play a critical role in gene expression. In cancer, such distant epigenetic aberrations can have significant effects on carcinogenesis. In order to uncover these long-range interactions on the single-cell level, I present an epigenome-mapping technology based on fluorescent tagging of epigenetic marks on long individual DNA molecules. Information is read as a fluorescent genetic/epigenetic barcode that provides genome-scale profiles with extremely long reads.
I discuss our progress towards simultaneous recording of methylation and transcription information from the same molecules with the aim of discovering and characterizing epigenetic gene-regulation at a distance.
