לוח שנה משולב

Brain oxytocin has been repeatedly shown to exert anxiolytic effects and to inhibit the activity of the HPA axis. These acute effects are mediated via activation of hypothalamic oxytocin receptors, which are GPCR, and subsequently of the MAPK pathway. In order to establish oxytocin as a potential psychotherapeutic option, effects of chronic neuropeptide treatment need to be studied. Chronic intracerebral infusion of oxytocin over 2 weeks dose-dependently increased anxiety-related behaviour and reduced oxytocin receptor binding within relevant brain regions. Thus, before oxytocin can be considered a therapeutic option to treat patients suffering from, for example, autism, schizophrenia, social phobia or drug addiction, thorough investigations are needed to reveal alterations of the endogenous oxytocin system. However, application of the low dose of oxytocin to male mice during 3-weeks exposure to an established chronic psychosocial stress paradigm - the chronic subordinate colony housing - attenuated the adverse chronic stress effects on immunological, physiological and emotional parameters further supporting ist stress-protective properties.
http://www.uni-regensburg.de/biologie-vorklinische-medizin/neurobiologie-tierphysiologie/team-mitarbeiter/prof-dr-inga-d-neumann/index.html