לוח שנה משולב

Following initial learning, information stored in memory undergoes a time- and experience-dependent evolution. Currently, the nature of this evolution at the neuronal ensemble level remains largely unknown. To obtain insight into this dynamic process we optically image memory-associated neuronal representations in large populations of single cells over long periods of time. Our work focuses on neural coding in the hippocampus, a brain structure that is important for memory of places and events. I will present new work in which we tracked the activity of large populations of hippocampal pyramidal neurons over weeks, as the mice repeatedly explored different familiar environments. Longitudinal analysis exposed ongoing environment-independent evolution of episodic representations, despite stable place code and constant remapping between the two environments. These dynamics time-stamped experienced events via neuronal ensembles that had cellular composition and activity patterns unique to specific points in time. Temporally close episodes shared a common timestamp regardless of the spatial context in which they occurred. Temporally remote episodes had distinct timestamps, even if they occurred within the same spatial context. I will discuss how these findings relate to current understanding of the role of the hippocampus in long-term episodic memory.

Bringing together the toughness of cellulose nano-fibers from the plant kingdom, the remarkable elasticity and resilience of resilin that enables flees to jump as high as 400 times their height from the insect kingdom combined with Human Recombinant Type I collagen produced in tobacco plants; These are the materials of the future; Nature's Gift.

I will describe the extent and timescale with which sensory cortices can be recruited and modified by inputs coming from various natural or artificial sensory input modalities or even when conveying high-level cognitive information. Our approach uses longitudinal studies in individuals with various degrees of visual deprivation, ranging from sighted-blindfolded to lifelong deprivation in patients with undeveloped retinas. I will describe the two main types of plasticity that we observed in the brain: (1) task-switching plasticity; and (2) task-selective sensory-independent organization. I will propose possible mechanisms that might give rise to such brain (re)-organization. In addition, I will show how we recently expanded our theoretical framework to include possible developmental mechanisms and implications for clinical rehabilitation including the development of a multisensory approach to restore vision (e.g. the multisensory bionic eye). By presenting an overview of our findings I will question classical theories of 'critical periods' by showing that "visual" regions do maintain their specific typical functionality and functional connectivity patterns even if "reawakened" in later periods in life including adulthood. Overall, through our approach and findings, new insights will emerge into the effects of learning and training on the (re)-organization principles of the human brain.
See also www.BrainVisionRehab.com
(Most relevant reviews: Reich et al., Curr Opin Neurol 2012; Hannagan et al. Trends Cogn Sci 2015; Heimler et al., Curr Opin Neurobiol 2015; Maidenbaum et al. Neurosci Biobehav Rev 2014; Murray, Matusz & Amedi Curr Biol 2015; Murray et al. Trends Neurosci 2016 (cond. accepted)).

Transport through quantum system is usually investigated in thermodynamic equilibrium. As systems shrink in size fluctuations get ever more important and may even dominate the electronic properties of quantum devices. A charge detector capacitively coupled to a semiconductor quantum dot can be used to measure the passing of individual electrons through the systems, i.e. to measure the current on the level of individual charge carriers. The tunneling barriers as well as the dot occupation can be tuned on time scales faster than typical relaxation times in order to measure level degeneracies, energy dependent tunneling rates and decay times. For situations far from equilibrium the Jarzynski relation gives a clear prediction how out-of-equilibrium properties can be related to equilibrium properties, such as the free energy of a system. These relations can be probed experimentally using time-dependent electron transport through semiconductor quantum dots. As an introduction to clean semiconductor systems I will review recent results on Fermionic cavities.

: I will review a set of biologically inspired NeuroImaging methods (i.e. methods that take into consideration the brain topography, neuronal adaptation and population receptive fields, brain functional connectivity and so on), that we developed and/or refined to shed light on maps and computations in the human brain. Starting from retinotopy, we used partial correlations resting-state functional connectivity analysis to show that the large-scale topographical biases in all 3 dimensions of retinotopy are preserved in individuals without any visual experience. I will discuss how this result challenges classical views of retinotopy as the key organizational principle for computations in the visual system, and further suggest plasticity principles beyond classical Hebbian learning. Next, we use virtual environments to show that key retinotopic regions (mainly in the dorsal visual stream) are recruited not only during vision-based navigation but even when early-blind and sighted-blindfolded learn to navigate these same environments using audition. I will then show how such approaches can be applied to study the whole-body somatosensory-motor system, and demonstrate that topographical gradients are far more widespread than previously known. These findings help to bridge gaps between animal and human studies, and have clinical relevance to improve and refine deep-brain-stimulation and imaging-based diagnostics. Finally, I will briefly present the development of crossmodal adaptation and multiphase spectral analysis to study topographical binding and crossmodal integration. Based on all of these results I will discuss the intriguing hypothesis that our brain is topographically organized for high-order cognitive functions as well, and discuss our plans to combine the aforementioned approaches with the use of the high-field imaging (7T) that is required to test it. I will conclude by summarizing the wide set of tools that enable us to investigate and gain novel insights into the nature of the Topographical Multisensory Human Brain mind.

(Most relevant papers for the talk: Striem-Amit et al. Neuron 2012; Cerbral Cortex 2012; Curr Biol 2014; Brain 2015; Zeharia et al. PNAS 2012; J Neurosci 2015; Saadon-Grosman et al. PNAS 2015; Murray, et al. Trends Neurosci 2016 (cond. accepted); Maidenbaum et al. (in preparation)); Siuda-Krzywicka et al. Elife 2016; Sabbah et al. NeuroImage 2016 (accepted).