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אפריל 25, 2016

  • Date:29ראשוןמאי 201610שישייוני 2016

    Cosmological Probes of Fundamental Physics

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    שעה
    כל היום
    מיקום
    בניין הפיזיקה ע"ש עדנה וק.ב. וייסמן
    יושב ראש
    Kfir Blum
    צרו קשר
    כנסים
  • Date:29ראשוןמאי 2016

    G-INCPM-Special Seminar - Yael Malkinson Weiss, MD PhD, Executive Director Business Development, Ultragenyx Pharmaceutical, Novato CA - "Developing therapies for rare genetic diseases: weighing traditional versus novel therapeutic modalities"

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    שעה
    11:00 - 12:30
    מיקום
    המרכז הישראלי הלאומי לרפואה מותאמת אישית על-שם ננסי וסטיבן גרנד
    מרצהYael Malkinson Weiss, MD PhD
    Executive Director Business Development, Ultragenyx Pharmaceutical, Novato CA
    מארגן
    המחלקה למדעים ביומולקולריים
    צרו קשר
    תקצירShow full text abstract about Developing therapies for the treatment of rare genetic disea...»
    Developing therapies for the treatment of rare genetic disease is frequently perceived to be simpler and with a lower risk than that associated with larger indications. This perception stems from the fact that many of these are monogenic, with predictable genetic effects and clear mechanisms, thus it should be straightforward to replace the defective protein. Since the diseases are usually severe the benefit is large, and in many cases, the rarer the disease, the smaller the clinical trials that are required for registration are.
    However, there are over 7,000 genetic diseases with an even larger number of genes affected. The initial approach of protein replacement therapies can be successful but is limited to a relatively small diseases in which the defective proteins are localized in a subset of cellular organelles to which therapeutic proteins will naturally target (lysosome for example). Most of the diseases treatable with traditional protein replacement are becoming very crowded for how small the treatable patient population is. Thus - other solutions need to be considered for the thousands of diseases for which direct proteins replacement is not a viable approach.
    Ultragenyx is a biotech company focused on development of therapies for rare genetic diseases. The company’s approach to building its pipeline and deciding how and when to include traditional (protein replacement therapies, small molecules) or new (nucleic acid based therapies) therapeutic modalities will be presented and examples will be discussed.

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  • Date:29ראשוןמאי 2016

    The ins and outs of subaerial lithotrophic biofilm in arid and hyper-arid environments

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    שעה
    11:00 - 11:00
    מיקום
    בניין משפחת זוסמן
    מרצהNimrod Wieler
    Department of Environmental Hydrology & Microbiology Ben-Gurion University of the Negev
    מארגן
    המחלקה למדעי כדור הארץ וכוכבי הלכת
    צרו קשר
    תקצירShow full text abstract about Rock surfaces support microbial communities that may be invo...»
    Rock surfaces support microbial communities that may be involved in weathering processes. In arid and hyper-arid environments microbes dominate rock surfaces and were linked to weathering because the scarcity of water excludes classical mechanisms that erode rocks. We studied subaerial biofilms coating arid rocks, focusing on sedimentary rocks that feature comparable weathering morphologies but different lithologies. We hypothesized that weathering is fashioned by salt erosion and mediated by biofilms that play dual roles: stabilizing the rock surfaces by coating, and enhancing salt crystallization by preventing rapid desiccation (thus mitigating and facilitating erosion processes, respectively). We used a combination of microbial and geological techniques to characterize the rocks morphologies and their subaerial biofilms. Deep sequencing and microscopy analyses suggest that bacterial diversity is low, dominated by Proteobacteria, Cyanobacteria and Actinobacteria. Together these phyla formed laminar biofilms that secrete extracellular polymeric substances to aggregate microfabrics and mitigate desiccation, reducing water loss by over 40%. The biofilm was detected only in rocks exposed to the atmosphere, present distinct architecture and burrowed up to 9 mm beneath the surface, protected by sedimentary deposits. A closer inspection revealed that the composition of the biofilm was tightly linked to dust bacterial communities but distinct from soil communities. Moreover, the biofilm composition changed according to the rock location rather than its’ lithology, suggesting that microclimate (dew, relative humidity and radiation) play an important role in arid weathering. Our results contradict common dogmas that considered biofilms as degrading agents and propose their role as mitigators of geomorphic processes.
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  • Date:29ראשוןמאי 2016

    A systematic view on Influenza induced host shut-off

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    שעה
    13:00 - 13:00
    מיקום
    בניין ארתור ורושל בלפר למחקר ביורפואי
    מרצהJulie Tai
    Noam Stern-Ginossar's group, Dept. of Molecular Genetics, WIS
    מארגן
    המחלקה לגנטיקה מולקולרית
    צרו קשר
    הרצאה
  • Date:29ראשוןמאי 2016

    The Simple Physics Behind Energy Use

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    שעה
    13:00 - 13:00
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצהProf. Peter Rez
    Department of Physics, Arizona State University, USA
    מארגן
    בית הספר למחקר - מכון ויצמן למדע
    צרו קשר
    הרצאה
  • Date:29ראשוןמאי 2016

    Quantitative investigation of birdsong: from learning to performance

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    שעה
    13:00 - 13:00
    מיקום
    מעבדה על-שם דני נ. היינמן
    מרצהProf. Ofer Tchernichovski
    Department of Psychology Hunter College, NYC
    מארגן
    מרכז לפיזיקה ביולוגית עש קלור
    צרו קשר
    תקצירShow full text abstract about • Music maintains a characteristic balance between repetitio...»
    • Music maintains a characteristic balance between repetition and novelty. I will present evidence for a similar balance in singing performances of free-living Australian pied butcherbirds.
    • While acquiring motor skills, such as courtship songs and dances, animals must match their performance to a desired target. However, because both the structure and the temporal position of individual gestures are adjustable, the number of possible motor transformations increases exponentially with sequence length, and searching for the optimal transformation quickly becomes computationally intractable. We show how zebra finches cope with the computational complexity of song learning.
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  • Date:29ראשוןמאי 2016

    Antihydrogen - a tool to study matter-antimatter symmetry in the laboratory

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    שעה
    14:00 - 14:00
    מיקום
    בניין הפיזיקה ע"ש עדנה וק.ב. וייסמן
    מרצהEberhard Widmann
    President of the Austrian Physical Society Director, Stefan Meyer Institute for Subatomic Physics, Austrian Academy of Sciences
    מארגן
    המחלקה לפיזיקה של חלקיקים ואסטרופיזיקה
    צרו קשר
    תקצירShow full text abstract about Antihydrogen, the bound state of an antiproton and a positro...»
    Antihydrogen, the bound state of an antiproton and a positron, is the simplest atom consisting purely of antimatter. Its matter counterpart, hydrogen, is one of the best studied atomic systems in physics. Thus comparing the spectra of hydrogen and antihydrogen offers some of the most sensitive tests of matter-antimatter symmetry. Furthermore, the availability of neutral antimatter offers for the first time a precise measurement of its gravitational interaction that was so far not possible due to the dominance of the electro-magnetic interaction for charged antiparticles.

    The formation and experimental investigation of antihydrogen is the main physics goal of several col-laborations at the Antiproton Decelerator of CERN. The ASACUSA collaboration is pursuing a meas-urement of the ground-state hyperfine structure of antihydrogen in an atomic beam, a quantity which was measured in hydrogen using a maser to a relative precision of 10^{-12}. The AEgIS collaboration aims at using an ultra-cold beam of antihydrogen atoms and a classical moiré deflectometer to determine the gravitational interaction between matter and antimatter in a first step to percent level precision.

    After a first production of cold antihydrogen in 2002 and a first trapping in 2010 the experiments are still in the process of optimizing the antihydrogen production from trapped antiprotons and positrons. The status and prospect of these experiments will be reviewed.
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  • Date:29ראשוןמאי 2016

    Unraveling unconventional role for astroglial connexins in synaptic strength and memory

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    שעה
    15:00 - 15:00
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצהProf. Nathalie Rouach
    CIRB, College de France, Paris
    מארגן
    המחלקה למדעי המוח
    צרו קשר
    תקצירShow full text abstract about Astrocytes play active roles in brain physiology by dynamic ...»
    Astrocytes play active roles in brain physiology by dynamic interactions with neurons. Connexin 30, one of the two main astroglial gap-junction subunits, is thought to be involved in behavioral and basic cognitive processes. However, the underlying cellular and molecular mechanisms were unknown. We will show here in mice that connexin 30 controls hippocampal excitatory synaptic transmission through modulation of astroglial glutamate transport, which directly alters synaptic glutamate levels. Unexpectedly, we found that connexin 30 regulated cell adhesion and migration and that connexin 30 modulation of glutamate transport, occurring independently of its channel function, was mediated by morphological changes controlling insertion of astroglial processes into synaptic clefts. By setting excitatory synaptic strength, connexin 30 plays an important role in long-term synaptic plasticity and in hippocampus-based contextual memory. Taken together, these results establish connexin 30 as a critical regulator of synaptic strength by controlling the synaptic location of astroglial processes.
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  • Date:29ראשוןמאי 2016

    Braginsky Center for the Interface between the Sciences and the Humanities

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    שעה
    15:30 - 15:30
    כותרת
    Back to the Future: Recovering “The Age of Wonder”
    מיקום
    אולם ע"ש דולפי ולולה אבנר
    מרצהProf. David K. Campbell
    Boston University
    מארגן
    המחלקה לפיזיקה כימית וביולוגית
    צרו קשר
    תקצירShow full text abstract about In his remarkable and inspiring book “The Age of Wonder,” Ri...»
    In his remarkable and inspiring book “The Age of Wonder,” Richard Holmes describes the synergistic links between the sciences and humanities among (in particular) the English intellectuals in the period 1770-1830. “Natural philosophers” like Sir Humphrey Davy had regular interactions with poets like Samuel Taylor Coleridge, and authors like Mary Shelly wrote of dystopias that could result from the misapplication of science and technology. Modern intellectuals, contemplating the current clearly apparent divide between the humanities and the sciences, tend to look at this “age of wonder” through rose-colored glasses and to long for its return. But is this yearning realistic? In our increasingly complex and specialized world, can we truly expect to recover the close bond between these distinct ways of knowing the world? Can we construct an interdisciplinary technological humanism that meaningfully links the sciences and the humanities?

    In this talk I attempt to provide limited and subjective answers to these questions and to describe general developments and trends that I believe may give hope that we can indeed recover the “age of wonder.”
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  • Date:30שנימאי 2016

    Multi-level scalable proteomic interrogation of intact biological systems

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    שעה
    10:00 - 10:00
    מיקום
    בניין ארתור ורושל בלפר למחקר ביורפואי
    מרצהProf. Kwanghun Chung
    Department of Chemical Engineering Institute for Medical Engineering and Science (IMES)Picower Institute for Learning and Memory Massachusetts Institute of Technology http://www.chunglab.org/
    מארגן
    המחלקה למדעי המוח
    צרו קשר
    הרצאה
  • Date:30שנימאי 2016

    "Chemical Publishing in the 21st Century:Perspectives of a JACS Editor"

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    שעה
    11:00 - 12:15
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצהProf. Peter Stang
    Department of Chemistry, University of Utah
    מארגן
    הפקולטה לכימיה
    צרו קשר
    סימפוזיונים
  • Date:30שנימאי 2016

    The diphoton excess at the LHC

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    שעה
    11:00 - 11:00
    מיקום
    בניין הפיזיקה ע"ש עדנה וק.ב. וייסמן
    מרצהLiron Barak
    CERN
    מארגן
    המחלקה לפיזיקה של חלקיקים ואסטרופיזיקה
    צרו קשר
    תקצירShow full text abstract about “Early results from the Run-II of the Large Hadron Collider ...»
    “Early results from the Run-II of the Large Hadron Collider were recently presented by the ATLAS and CMS experiments. They show hints of an excess in the diphoton mass spectrum near 750 GeV. While these hints might turn out to be statistical fluctuations, they could also be first indications of physics beyond the Standard Model. I will explain in detail the experimental procedures that led to these exciting results. I will further describe the strategy in which we intend to investigate this excess in the near future and either reject or confirm the discovery of new physics.”
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  • Date:30שנימאי 2016

    Active DNA Demethylation in Development and Cancer

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    שעה
    12:00 - 13:30
    מיקום
    בניין קמיליה בוטנאר
    מרצהProf. Alfonso Bellacosa
    Cancer Epigenetics and Cancer Biology Programs, Fox Chase Cancer Center, Philadelphia USA
    מארגן
    המחלקה למדעים ביומולקולריים
    צרו קשר
    הרצאה
  • Date:30שנימאי 2016

    Geometric Heat Engines Without Power-Efficiency Tradeoff

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    שעה
    14:15 - 14:15
    מיקום
    בניין הפיזיקה ע"ש עדנה וק.ב. וייסמן
    מרצהProf. Oren Raz
    UNIVERSITY OF MARYLAND
    מארגן
    המחלקה לפיזיקה של מערכות מורכבות
    צרו קשר
    תקצירShow full text abstract about Thermodynamics places a limit on the efficiency of heat engi...»
    Thermodynamics places a limit on the efficiency of heat engines, but not on their output power or on how the power and efficiency change with the engine’s cycle time. In the talk I will present a geometrical description of the power and efficiency as a function of the cycle time, applicable to an important class of heat engine models. This geometrical description is used to design engine protocols that attain both the maximal power and maximal efficiency at the fast driving limit. Furthermore, using this method, we also prove that no protocol can exactly attain the Carnot efficiency at nonzero power.

    Ref: PRL 116, 160601 (2016)

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  • Date:30שנימאי 2016

    Measurement of the Proton Form Factor Ratio at Low Momentum Transfer

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    שעה
    14:45 - 15:45
    מיקום
    בניין הפיזיקה ע"ש עדנה וק.ב. וייסמן
    מרצהMoshe Friedman
    Hebrew University of Jerusalem
    מארגן
    המחלקה לפיזיקה של חלקיקים ואסטרופיזיקה
    צרו קשר
    תקצירShow full text abstract about The proton electric and magnetic form factors are basic char...»
    The proton electric and magnetic form factors are basic characteristics of the proton, and can be associated with the Fourier transforms of the charge and magnetic current densities in the nonrelativistic limit.
    Although QCD can make rigorous predictions when the four-momentum transfer squared, Q2, is very large, in the non-perturbative regime this task is too difficult, and several phenomenological models attempt to make predictions in this domain. Measurements of the proton form factors were traditionally based on cross section measurements using the Rosenbluth separation method to extract the electric and magnetic form factors. In this method, the magnetic form factor is suppressed as Q2 decreases, and precise data at very low Q2 is not available. During the last two decades, scattering experiments with polarized beams and targets have been used for precise measurements of the proton form factors at much lower Q2 . The second part of experiment E08-007 was dedicated to measure the ratio between the proton form factors at 0.01 <
    Q2 < 0.08 GeV2, lower than ever achieved, by using the double-spin asymmetry technique. The experiment was conducted during the spring of
    2012 at Hall A of the Thomas Jefferson National Accelerator Facility, using a 1-2 GeV polarized electron beam, scattering off a polarized solid ammonia target. Data analysis is currently in final stages.
    Recently, inconsistencies between different measurements of the proton radius have prompted intense theoretical and experimental activities to resolve the discrepancy. This experiment might improve our understanding of this problem. In this talk, I will describe the experimental system, the main challenges in the data analysis, and present preliminary results for the asymmetries and their uncertainties.
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  • Date:30שנימאי 2016

    pbar-p production near threshold in e^+e^- annihilation

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    שעה
    16:15 - 16:15
    מיקום
    בניין הפיזיקה ע"ש עדנה וק.ב. וייסמן
    מרצהVladimir Dmitriev
    Budker Institute of Nuclear Physics, Novosibirsk
    מארגן
    המחלקה לפיזיקה של חלקיקים ואסטרופיזיקה
    צרו קשר
    תקצירShow full text abstract about In the process $e^+e^- ightarrow par{p}$, measured by BAB...»
    In the process $e^+e^-
    ightarrow par{p}$, measured by BABAR (SLAC) and later on by CMD3 (BINP) collaborations, several unexpected features have been observed. First, a very rapid growth of the cross section near threshold, faster than just s-wave contribution. Second, a strong energy dependence of the ratio $|G_E(q^2)/G_M(q^2)|$ of the proton electromagnetic form factors in a rather narrow region of energy near threshold. Third, the energy dependence of the cross section is rather flat below 200 MeV in c.m. and starts to fall above this energy.
    We found that these effects can be explained by the influence of the final state interaction between slow moving nucleon and antinucleon. The final state interaction can be described by an optical potential. The imaginary part of the optical potential describes the process of nucleon-antinucleon annihilation into pions. Therefore, there is a contribution to the cross section of $e^+e^-
    ightarrow$ hadrons via production of virtual $Nar{N}$ with subsequent annihilation into mesons. Calculating this contribution one can obtain some restrictions on the imaginary part of $Nar{N}$ optical potential.
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  • Date:31שלישימאי 2016

    Joint Life Sciences - Chemistry mini symposium

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    שעה
    10:00 - 12:30
    כותרת
    Chemistry/Medicine 2016 Wolf Prize Laureates
    מיקום
    אולם ע"ש דולפי ולולה אבנר
    מרצהProf. C. Ronald Kahn, Harvard Medical School, USA
    Prof. Stuart L. Schreiber, Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA
    מארגן
    הפקולטה לכימיה
    צרו קשר
    סימפוזיונים
  • Date:31שלישימאי 2016

    Chemical Physics Department Guest Seminar

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    שעה
    10:00 - 10:00
    כותרת
    Optical control of electronic and nuclear states: Toward quantum computing in self-assembled dots
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצהProf. Duncan Steel
    University of Michigan, Ann Arbor
    מארגן
    המחלקה לפיזיקה כימית וביולוגית
    צרו קשר
    הרצאה
  • Date:31שלישימאי 2016

    Encoding of spatial and temporal properties of motor tics

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    שעה
    12:30 - 12:30
    מיקום
    אולם הרצאות ע"ש גרהרד שמידט
    מרצהProf. Izhar Bar-Gad
    Gonda Brain Research Center, Bar Ilan University
    מארגן
    המחלקה למדעי המוח
    צרו קשר
    תקצירShow full text abstract about Striatal disinhibition leads to spontaneous abnormal action ...»
    Striatal disinhibition leads to spontaneous abnormal action release manifesting as motor tics, resembling those expressed in Tourette syndrome patients. We utilized microstimulation within the motor cortex of freely-behaving rats before and after striatal disinhibition to study the spatial and temporal properties of tic expression. The spatial properties of these tics were dependent on the striatal organization while the temporal properties were dependent on the cortico-striatal activity. A data-driven computational model of cortico-striatal function closely replicated the temporal properties of abnormal action release. These converging experimental and computational findings suggest a clear functional dichotomy within the cortico-striatal network, pointing to disparate temporal (cortical) vs. spatial (striatal) encoding of action release.

    הרצאה
  • Date:31שלישימאי 2016

    Intrinsic limits to gene regulation by global crosstalk

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    שעה
    15:00 - 15:00
    מיקום
    בניין ארתור ורושל בלפר למחקר ביורפואי
    מרצהDr. Gasper Tkacik
    Institute of Science and Technology (IST), Austria
    מארגן
    המחלקה לגנטיקה מולקולרית
    צרו קשר
    הרצאה

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