יוני 25, 1994 - יוני 25, 2027

  • Date:23חמישינובמבר 2023

    Dissecting the role of peripheral immunity in Alzheimer’s Disease pathogenesis and disease course

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    שעה
    11:30 - 12:30
    כותרת
    Student Seminar PhD Thesis Defense ZOOM
    מרצה
    Tommaso Croese PhD Defense
    Advisor: Prof. Michal Schwartz Dept of Brain Sciences WIS
    מארגן
    המחלקה למדעי המוח
    צרו קשר
    פרטים נוספיםShow full text description of Zoom Link: https://weizmann.zoom.us/j/5420322495?pwd=ZmhUR0k...»
    Zoom Link: https://weizmann.zoom.us/j/5420322495?pwd=ZmhUR0kxWTB6aDh0bklBNFlzV1JNdz09
    Meeting ID: 542 032 2495
    Password: 862769

    תקצירShow full text abstract about Recent research has increasingly focused on the intricate in...»
    Recent research has increasingly focused on the intricate interactions between the brain and the immune system, a critical line of inquiry for understanding neurological disorders like Alzheimer's Disease (AD). AD, once defined primarily by amyloid-β and tau aggregations, is now being explored for its complex interplay with immune processes, offering a deeper understanding of its development.
    This study delves into the dynamic relationship between the brain and the immune system, utilizing human samples from individuals predisposed to AD and various preclinical models. Our findings reveal that both environmental and genetic risk factors for AD significantly influence immune phenotypes and functions, which in turn impact disease progression.
    Further, we discovered that disrupting brain-spleen communication alters myeloid cell fate and cognitive performance in 5xFAD mice. These insights demonstrate the profound and reciprocal influence between the brain and the immune system. They underscore the importance of these interactions in understanding not only AD but also a wider array of neurological conditions, suggesting that this interplay is crucial for comprehending the complexities of such diseases.

    Zoom Link: https://weizmann.zoom.us/j/5420322495?pwd=ZmhUR0kxWTB6aDh0bklBNFlzV1JNdz09
    Meeting ID: 542 032 2495
    Password: 862769
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