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Prof. Joel Sussman
3D Structure Funciton Studies or proteins related to AutismCollaboration with: Israel Silman3D Structure Fucntions studies of ParaoxonaseCollaboration with: Dan Tawfik & Israel SilmanApplication of ultra rapid X-ray diffraction methods to study the enzymatic mechanism of AChE in real time.Collaboration with: Israel SilmanStructure based drug design studies on AChE and beta-secretase, including studies of complexes with transition state analogs; potential drugs for the treatment of Alzheimer's disease; and snake neurotoxins.Collaboration with: Israel SilmanX-ray structural analysis and molecular biology studies on proteins from the nervous system, including acetylcholinesterase (AChE), human, torpedo, drosophila, and krait; butyrylcholinesterase; neural cell adhesion proteins with sequence similarity to AChCollaboration with: Israel Silman3D Structure Funciton of proteins related to Gaucher DiseaseCollaboration with: Tony Futerman & Israel SilmanVisualization of 3D Protein Structures via new web based tool ProteopediaCollaboration with: Jaime Prilusky & Israel Silman
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Prof. Adi Stern
Quantum interference phenomena in the fractional Quantum Hall effect. Electronic transport in strong magnetic fields.Non-abelian electronic states - quantum Hall states, topological superconductors and Majorana fermions.Fractionalized topological phases - how to construct them, how to measure them, and how to use them for topological quantum computationLow density two dimensional electronic systems.One dimensional electronic systems - electronic transport in the presence of interactions.
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Prof. Victor Steinberg
Physical hydrodynamics, hydrodynamics of complex fluids, dynamics of single flexible micro-objects (molecules, membranes, etc) in complex fluid flowsCollaboration with: Prof. G. Falkovich, Prof. V. Lebedev, Prof. Y. Dubief, Prof. H. StarkHydrodynamics of polymer solutions, Elastic turbulence and Turbulent mixing by polymers.Hydrodynamics and rheology of complex fluids (vesicle, capsule, worm-like micelle, etc suspensions)Dynamics and conformation of single polymer molecule, vesicle, micro-capsule, etc in complex fluid flows.Microfluidics: mixing, cell separation, random flows.Development of non-invasive local sensors for measurements of stress field in fluid flow
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Prof. Yoram Shechter
Mechanism of insulin action: Post-binding events in insulin actionPost-receptor agents mimicking insulin.Effect of vanadium <I>in vivo</I> and <I>in vitro</I>.Role of protein tyrosine kinases and protein phosphotyrosine phosphatases in insulin effects.Inhibitors of tyrosine kinases.Chemical modifications of peptides and protein drugs.Novel technologies to prolong life time of peptide and protein drugs.
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Prof. Yosef Shaul
The molecular basis of virus-host cell interaction. How HBV modifies cell behavior.Collaboration with: Charles Rice the Rockefeller universityproteasomes as a target in cancer therapyproteasome composition, dynamics, function and regulation and various conditions.proteasomal degradation of intrinsically disordered proteins (IUP or IDP). the concept of degradation by default
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Prof. Michal Sharon
Studying large protein complexes involved in the protein degradation pathway using a novel mass spectrometry approach.Developing novel methodological approaches for structural mass spectrometryStructure-function relationship of the signalosome complexInvestigation of the 20S ubiquitin-independent degradation pathway
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