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Prof. Idit Shachar
Analyze the pathway regulateing the survival cascades in Chronic lymphocytic leukemiaCollaboration with: Dr Michal Haran, Kaplan Medical centerFollow the mechanisms controlling homing of immune cells in health and disease.Determine the mechanisms regulating peripheral B cell maturation and survival in health and disease.
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Prof. Michael Sela
Importance of negligible amounts of a partner in antibody combinationsAn aptamer strategy to target oncogenic signaling in ErbB2 carrying human tumors.Collaboration with: G. Mahlknecht , Y. Yarden G. MahlknechtSynergy of antibodies towards decreasing pancreatic cancer.Collaboration with: R. Maron, B. Schechter, Y. YardenTowards vaccination: Generation of peptide mimotopes specific for anti ErbB-2 monoclonal antibodies.Collaboration with: E. Witsch, Y. YardenMechanism of action of Copolymer 1 (Copaxone), a therapeutic vaccine against multiple sclerosis.Collaboration with: R. ArnonEffective synergism by anti ErbB-2 mAb combinations comprising one mAb against the dimerization site of ErbB-2.Collaboration with: Y. YardenMonoclonal antibodies (mAbs) to ErbB-1 and ErbB-2 receptors and their role in potential anti-tumor strategy.Collaboration with: B. Schechter, Y. YardenSynergistic effects of combinations of mAb against distinct epitopes on EGFR/ErbB-1 and ErbB-2 receptors: accelerated receptor aggregation, down regulation and inhibition of tumor growth.Collaboration with: B. Schechter, Y. Yarden
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Prof. Menahem Segal
Intracellular calcium and structural/functional plasticity in cultured neurons.Collaboration with: Dr. Eduard KorkotianHuman Embryonic Stem Cells of Fragile X patientsCollaboration with: Prof. Dalit Ben Yosef (TAU)Network activity in cultured neuronsCollaboration with: Professor Elisha Moses (Physics)
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Prof. Michal Schwartz
The cross-talk between the immune and nervous systems autoimmunity as a mechanism of tissue repair: Molecular, cellular, physiological and behavioral aspects.Immunological aspects of neuronal loss in neurodegenerative and mental disorders (Alzheimers, ALS, Huntingdon, Glaucoma).Spinal cord injury and repairDevelopment of vaccination for neurodegenerative disorders.Neurogenesis (stem cells) and inflammation in the CNS.
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Prof. Oren Schuldiner
A genetic dissection of developmental axon regenerationMolecular mechanisms of neuronal remodeling during development: Developmental axon pruning in DrosophilaThe role of cell-cell interaction in regulating developmental axon pruningThe role of intracellular signaling in regulating developmental axon pruningThe role of trafficking in regulating developmental axon pruningGlia and their effect on neuronal growth and remodeling
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Prof. Maya Schuldiner
Uncovering tethers, functions and regulators of membrane contact sites in yeastMitochondria-ER contact sitesPeroxisome-Lipid Droplet contact sitesNucleus-Mitochondria contact sitesThe proteome of contact sitesGolgi contact sitesTargeting and translocation to OrganellesUncovering a role for the Ssh1, the alternative, translocon in yeastDeciphering targeting of proteins to mitochondriaTargeting of membrane proteins to peroxisomesTargeting of low-hydrophobicity SS proteins to the ERUncovering new peroxisomal proteins and their functionsCollaboration with: Dr. Einat ZalckvarMetabolite transport across the peroxisome membranePeroxisome contact sitesPeroxisome quality controlPeroxisome targetingNew peroxisomal enzymes and their functionsNovel methodologies for systematic exploration of yeast organelle protein functionsCreation of versatile yeast librariesHigh throughput electron microscopy techniquesTranslocation sensors
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Prof. Avigdor Scherz
Quantification of atoms, groups and molecules electronegati using metal substituted bacteriochlorophylls and application to chemical reactivity.Resolving the forces which drive membrane protein assembly.The mechenism behind generation of reactive oxygen species (ROS) by illuminating novel bacteriochlorophyll derivatives and their application in photodynamic therapy (PDT) of tumors.
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